| SUVRETTA CAPITAL MANAGEMENT, LLC | US$3710.8万 | 0.95% |
| JANUS HENDERSON GROUP PLC | US$3559.4万 | 0.02% |
| JOHNSON & JOHNSON | US$2584.8万 | 3.96% |
| FRANKLIN RESOURCES INC | US$2402.0万 | 0.01% |
| Balyasny Asset Management L.P. | US$2201.4万 | 0.03% |
| MILLENNIUM MANAGEMENT LLC | US$2005.3万 | 0.01% |
| BAKER BROS. ADVISORS LP | US$1855.6万 | 0.11% |
| RA CAPITAL MANAGEMENT, L.P. | US$1692.6万 | 0.18% |
| PERCEPTIVE ADVISORS LLC | US$1639.8万 | 0.32% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1585.7万 | 0.00% |
| FMR LLC | US$1064.2万 | 0.00% |
| Ikarian Capital, LLC | US$1055.1万 | 0.86% |
| GREAT POINT PARTNERS LLC | US$1045.1万 | 2.40% |
| Longaeva Partners L.P. | US$956.1万 | 0.35% |
| SECTORAL ASSET MANAGEMENT INC | US$950.2万 | 7.87% |
| HHLR ADVISORS, LTD. | US$874.2万 | 0.52% |
| BlackRock, Inc. | US$873.9万 | 0.00% |
| RED TREE MANAGEMENT, LLC | US$833.4万 | 7.45% |
| Versant Venture Management, LLC | US$708.7万 | 5.01% |
| Jones Hill Capital LP | US$670.0万 | 1.44% |
| Boxer Capital Management, LLC | US$645.2万 | 0.85% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$500.1万 | 0.00% |
| CITADEL ADVISORS LLC | US$457.4万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$401.1万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$394.1万 | 0.40% |
| GEODE CAPITAL MANAGEMENT, LLC | US$368.5万 | 0.00% |
| ADAR1 Capital Management, LLC | US$361.3万 | 0.21% |
| Qube Research & Technologies Ltd | US$303.7万 | 0.00% |
| UBS Group AG | US$300.9万 | 0.00% |
| MARSHALL WACE, LLP | US$295.6万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$290.4万 | 0.04% |
| SPHERA FUNDS MANAGEMENT LTD. | US$226.6万 | 0.36% |
| VANGUARD FIDUCIARY TRUST CO | US$201.0万 | 0.00% |
| Casdin Capital, LLC | US$193.7万 | 0.15% |
| Eversept Partners, LP | US$191.2万 | 0.10% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$188.1万 | 0.00% |
| Ishara Investments LP | US$185.5万 | 1.76% |
| JANE STREET GROUP, LLC | US$140.2万 | 0.00% |
| STATE STREET CORP | US$132.3万 | 0.00% |
| Verdad Advisers, LP | US$112.4万 | 1.26% |
| Point72 Asset Management, L.P. | US$110.9万 | 0.00% |
| MORGAN STANLEY | US$92.5万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$90.6万 | 0.00% |
| NORTHERN TRUST CORP | US$86.1万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$78.2万 | 0.00% |
| Squarepoint Ops LLC | US$78.2万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$72.6万 | 0.00% |
| 683 Capital Management, LLC | US$71.8万 | 0.04% |
| ACADIAN ASSET MANAGEMENT LLC | US$70.3万 | 0.00% |
| Strategies Wealth Advisors, LLC | US$65.3万 | 0.07% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$64.4万 | 0.01% |
| Trexquant Investment LP | US$62.4万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$62.0万 | 0.00% |
| BARCLAYS PLC | US$57.4万 | 0.00% |
| Hudson Bay Capital Management LP | US$55.9万 | 0.00% |
| Brevan Howard Capital Management LP | US$55.1万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$49.5万 | 0.00% |
| XTX Topco Ltd | US$46.8万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$46.6万 | 0.00% |
| Seven Fleet Capital Management LP | US$35.3万 | 0.11% |
| INDEPENDENT FINANCIAL GROUP, LLC | US$35.3万 | 0.01% |
| Jain Global LLC | US$30.0万 | 0.00% |
| HRT FINANCIAL LP | US$28.9万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$26.9万 | 0.00% |
| RBF Capital, LLC | US$26.1万 | 0.01% |
| Quarry LP | US$20.9万 | 0.04% |
| Engineers Gate Manager LP | US$19.5万 | 0.00% |
| OMERS ADMINISTRATION Corp | US$18.5万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$17.6万 | 0.01% |
| Cannon Global Investment Management, LLC | US$17.0万 | 0.33% |
| Quadrature Capital Ltd | US$16.7万 | 0.00% |
| ExodusPoint Capital Management, LP | US$16.2万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$14.8万 | 0.00% |
| Diametric Capital, LP | US$14.0万 | 0.04% |
| Vanguard Global Advisers, LLC | US$13.4万 | 0.00% |
| CITIGROUP INC | US$11.6万 | 0.00% |
| ROYAL BANK OF CANADA | US$7.6万 | 0.00% |
| JPMORGAN CHASE & CO | US$3.1万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$2.1万 | 0.00% |
| Federation des caisses Desjardins du Quebec | US$1.7万 | 0.00% |
| CWM, LLC | US$1.5万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$9547.0 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$6700.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$5208.2 | 0.00% |
| Torren Management, LLC | US$3317.0 | 0.00% |
| Banque Transatlantique SA | US$2946.0 | 0.00% |
| US BANCORP \DE\ | US$1606.0 | 0.00% |
| Cornerstone Financial Management LLC | US$836.0 | 0.00% |
| OSAIC HOLDINGS, INC. | US$78.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$13.0 | 0.00% |