| FMR LLC | US$1.8億 | 0.01% |
| SR One Capital Management, LP | US$9849.0萬 | 10.76% |
| NEA Management Company, LLC | US$7865.4萬 | 4.47% |
| ENAVATE SCIENCES GP, LLC | US$7662.0萬 | 21.80% |
| FEDERATED HERMES, INC. | US$6113.3萬 | 0.10% |
| Polar Capital Holdings Plc | US$4982.2萬 | 0.18% |
| Capital International Investors | US$4758.5萬 | 0.01% |
| Fairmount Funds Management LLC | US$4611.9萬 | 3.33% |
| BlackRock, Inc. | US$3983.4萬 | 0.00% |
| NVP ASSOCIATES, LLC | US$3594.2萬 | 20.40% |
| ALLIANCEBERNSTEIN L.P. | US$3258.2萬 | 0.01% |
| STATE STREET CORP | US$2875.7萬 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2436.0萬 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2434.7萬 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$2220.8萬 | 2.27% |
| EcoR1 Capital, LLC | US$1543.5萬 | 0.66% |
| Balyasny Asset Management L.P. | US$1304.1萬 | 0.02% |
| ArrowMark Colorado Holdings LLC | US$1288.2萬 | 0.34% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1282.4萬 | 0.00% |
| Pivotal bioVenture Partners Investment Advisor LLC | US$1157.3萬 | 4.14% |
| Woodline Partners LP | US$1154.5萬 | 0.04% |
| GREAT POINT PARTNERS LLC | US$1024.5萬 | 2.35% |
| Rock Springs Capital Management LP | US$981.6萬 | 0.58% |
| MARSHALL WACE, LLP | US$981.3萬 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$932.2萬 | 0.00% |
| NEXTBio Capital Management LP | US$834.3萬 | 3.87% |
| BANK OF AMERICA CORP /DE/ | US$759.2萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$745.8萬 | 0.00% |
| UBS Group AG | US$718.3萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$698.6萬 | 0.00% |
| Sio Capital Management, LLC | US$648.5萬 | 0.93% |
| TWO SIGMA INVESTMENTS, LP | US$537.7萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$520.0萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$491.5萬 | 0.00% |
| JENNISON ASSOCIATES LLC | US$488.8萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$438.7萬 | 0.00% |
| Jefferies Financial Group Inc. | US$430.0萬 | 0.03% |
| iA Global Asset Management Inc. | US$421.9萬 | 0.06% |
| SPHERA FUNDS MANAGEMENT LTD. | US$419.0萬 | 0.67% |
| Vestal Point Capital, LP | US$391.0萬 | 0.11% |
| NORTHERN TRUST CORP | US$380.5萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$350.7萬 | 0.00% |
| SEB Asset Management AB | US$320.3萬 | 0.01% |
| Maven Securities LTD | US$293.3萬 | 0.06% |
| Monashee Investment Management LLC | US$293.3萬 | 1.60% |
| CITADEL ADVISORS LLC | US$249.6萬 | 0.00% |
| Walleye Capital LLC | US$244.8萬 | 0.01% |
| Invesco Ltd. | US$221.9萬 | 0.00% |
| Atom Investors LP | US$209.2萬 | 0.15% |
| SEVEN GRAND MANAGERS, LLC | US$195.5萬 | 0.13% |
| MORGAN STANLEY | US$182.6萬 | 0.00% |
| Exome Asset Management LLC | US$157.8萬 | 0.82% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$151.5萬 | 0.01% |
| JANE STREET GROUP, LLC | US$142.5萬 | 0.00% |
| Birchview Capital, LP | US$136.9萬 | 0.78% |
| Nuveen, LLC | US$132.5萬 | 0.00% |
| Bank of New York Mellon Corp | US$119.0萬 | 0.00% |
| Jump Financial, LLC | US$117.3萬 | 0.02% |
| AQR CAPITAL MANAGEMENT LLC | US$99.6萬 | 0.00% |
| Rafferty Asset Management, LLC | US$94.2萬 | 0.00% |
| ALPS ADVISORS INC | US$85.4萬 | 0.00% |
| Squarepoint Ops LLC | US$83.8萬 | 0.00% |
| DAFNA Capital Management LLC | US$83.1萬 | 0.19% |
| Burkehill Global Management, LP | US$78.2萬 | 0.04% |
| J. Goldman & Co LP | US$71.9萬 | 0.02% |
| Swiss National Bank | US$61.8萬 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$61.4萬 | 0.00% |
| Voleon Capital Management LP | US$57.9萬 | 0.01% |
| BARCLAYS PLC | US$57.9萬 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | US$53.8萬 | 0.00% |
| RHUMBLINE ADVISERS | US$52.4萬 | 0.00% |
| HRT FINANCIAL LP | US$50.3萬 | 0.00% |
| JPMORGAN CHASE & CO | US$45.8萬 | 0.00% |
| PROFUND ADVISORS LLC | US$41.9萬 | 0.02% |
| Quantinno Capital Management LP | US$41.3萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$40.7萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$40.7萬 | 0.00% |
| XTX Topco Ltd | US$37.8萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$37.7萬 | 0.00% |
| Aquatic Capital Management LLC | US$36.4萬 | 0.01% |
| ALLSTATE CORP | US$35.6萬 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$34.5萬 | 0.00% |
| Corient Private Wealth LLC | US$32.9萬 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$32.5萬 | 0.02% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$30.9萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$30.3萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$27.7萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$26.4萬 | 0.02% |
| Scientech Research LLC | US$25.3萬 | 0.21% |
| MetLife Investment Management, LLC | US$25.2萬 | 0.00% |
| Creative Planning | US$24.7萬 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | US$24.3萬 | 0.04% |
| SEI INVESTMENTS CO | US$24.2萬 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$20.8萬 | 0.00% |
| Legal & General Group Plc | US$20.4萬 | 0.00% |
| CITIGROUP INC | US$19.3萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$17.4萬 | 0.00% |
| Tower Research Capital LLC (TRC) | US$14.1萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$13.2萬 | 0.00% |
| Virtus Investment Advisers, LLC | US$13.1萬 | 0.04% |
| Police & Firemen's Retirement System of New Jersey | US$12.4萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$12.1萬 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$9.3萬 | 0.00% |
| Vanguard Investments Australia, Ltd. | US$8.2萬 | 0.00% |
| KLP KAPITALFORVALTNING AS | US$6.6萬 | 0.00% |
| STRS OHIO | US$5.5萬 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$5.5萬 | 0.00% |
| Russell Investments Group, Ltd. | US$5.3萬 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$4.7萬 | 0.00% |
| Ameritas Investment Partners, Inc. | US$3.8萬 | 0.00% |
| CWM, LLC | US$2.9萬 | 0.00% |
| HARBOUR INVESTMENTS, INC. | US$2.7萬 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$2.4萬 | 0.00% |
| US BANCORP \DE\ | US$1.9萬 | 0.00% |
| Sterling Capital Management LLC | US$1.5萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$1.3萬 | 0.00% |
| SIGNATUREFD, LLC | US$7234.0 | 0.00% |
| GROUP ONE TRADING LLC | US$5865.0 | 0.00% |
| Larson Financial Group LLC | US$5728.0 | 0.00% |
| J.Safra Asset Management Corp | US$5279.0 | 0.00% |
| Quantbot Technologies LP | US$5005.0 | 0.00% |
| GAMMA Investing LLC | US$4790.0 | 0.00% |
| FIFTH THIRD BANCORP | US$2092.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1954.8 | 0.00% |
| EverSource Wealth Advisors, LLC | US$1915.0 | 0.00% |
| Torren Management, LLC | US$1857.0 | 0.00% |
| Physician Wealth Advisors, Inc. | US$1799.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$1173.0 | 0.00% |
| Allworth Financial LP | US$509.0 | 0.00% |
| Cornerstone Financial Management LLC | US$508.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$411.0 | 0.00% |
| SBI Securities Co., Ltd. | US$391.0 | 0.00% |
| Bare Financial Services, Inc | US$274.0 | 0.00% |
| MAI Capital Management | US$235.0 | 0.00% |
| Sunbelt Securities, Inc. | US$215.0 | 0.00% |
| Ameritas Advisory Services, LLC | US$117.0 | 0.00% |
| Stone House Investment Management, LLC | US$98.0 | 0.00% |
| True Wealth Design, LLC | US$59.0 | 0.00% |
| Essential Partners LLC | US$39.0 | 0.00% |
| Covestor Ltd | US$0.0 | 0.00% |