| RA CAPITAL MANAGEMENT, L.P. | US$23.5億 | 24.92% |
| Avoro Capital Advisors LLC | US$11.6億 | 11.39% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$11.0億 | 4.62% |
| FMR LLC | US$8.9億 | 0.05% |
| Artisan Partners Limited Partnership | US$7.4億 | 1.19% |
| FRANKLIN RESOURCES INC | US$4.7億 | 0.11% |
| Capital International Investors | US$4.5億 | 0.11% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$4.3億 | 0.14% |
| WELLINGTON MANAGEMENT GROUP LLP | US$4.0億 | 0.08% |
| PERCEPTIVE ADVISORS LLC | US$3.5億 | 6.84% |
| AMERICAN CENTURY COMPANIES INC | US$3.2億 | 0.16% |
| Capital World Investors | US$2.1億 | 0.03% |
| PRINCIPAL FINANCIAL GROUP INC | US$2.1億 | 0.11% |
| AMERIPRISE FINANCIAL INC | US$2.0億 | 0.05% |
| BlackRock, Inc. | US$1.5億 | 0.00% |
| Polar Capital Holdings Plc | US$1.5億 | 0.53% |
| MORGAN STANLEY | US$1.4億 | 0.01% |
| GOLDMAN SACHS GROUP INC | US$1.3億 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$1.3億 | 0.22% |
| JPMORGAN CHASE & CO | US$1.2億 | 0.01% |
| FIL Ltd | US$1.0億 | 0.08% |
| Vestal Point Capital, LP | US$8577.4萬 | 2.40% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$8517.0萬 | 0.01% |
| Spyglass Capital Management LLC | US$8416.6萬 | 5.96% |
| Invesco Ltd. | US$8282.5萬 | 0.01% |
| SEI INVESTMENTS CO | US$8031.8萬 | 0.07% |
| FRED ALGER MANAGEMENT, LLC | US$6973.9萬 | 0.31% |
| WELLS FARGO & COMPANY/MN | US$6134.5萬 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$5932.4萬 | 0.02% |
| Tri Locum Partners LP | US$5840.2萬 | 8.20% |
| Pictet Asset Management Holding SA | US$5690.7萬 | 0.06% |
| Caption Management, LLC | US$5649.6萬 | 0.33% |
| Candriam S.C.A. | US$5267.1萬 | 0.27% |
| Bank of New York Mellon Corp | US$5230.5萬 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$5156.5萬 | 0.04% |
| TD Asset Management Inc | US$4986.1萬 | 0.04% |
| Aberdeen Group plc | US$4806.9萬 | 0.08% |
| ARS Investment Partners, LLC | US$4790.9萬 | 2.49% |
| UBS Group AG | US$4742.5萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$4540.4萬 | 0.00% |
| Rock Springs Capital Management LP | US$4437.4萬 | 2.62% |
| MILLENNIUM MANAGEMENT LLC | US$4323.6萬 | 0.02% |
| Allspring Global Investments Holdings, LLC | US$4204.7萬 | 0.07% |
| ORBIMED ADVISORS LLC | US$4162.4萬 | 0.85% |
| PFM Health Sciences, LP | US$3989.8萬 | 3.64% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$3913.8萬 | 0.05% |
| RICE HALL JAMES & ASSOCIATES, LLC | US$3394.0萬 | 1.89% |
| LORD, ABBETT & CO. LLC | US$3323.8萬 | 0.11% |
| DEUTSCHE BANK AG\ | US$3092.1萬 | 0.01% |
| Frazier Life Sciences Management, L.P. | US$3049.7萬 | 0.78% |
| BRAUN STACEY ASSOCIATES INC | US$2996.2萬 | 1.00% |
| Catalio Capital Management, LP | US$2953.2萬 | 6.17% |
| ODDO BHF ASSET MANAGEMENT SAS | US$2942.8萬 | 1.16% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$2851.3萬 | 2.91% |
| Chevy Chase Trust Holdings, LLC | US$2824.1萬 | 0.08% |
| SG Americas Securities, LLC | US$2762.8萬 | 0.03% |
| RENAISSANCE TECHNOLOGIES LLC | US$2683.7萬 | 0.04% |
| Integral Health Asset Management, LLC | US$2630.4萬 | 1.26% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | US$2613.8萬 | 0.10% |
| Woodline Partners LP | US$2343.8萬 | 0.09% |
| Perpetual Ltd | US$2301.9萬 | 0.35% |
| Troluce Capital Advisors LLC | US$2278.2萬 | 1.40% |
| Resolute Capital Asset Partners LLC | US$2255.9萬 | 11.87% |
| Cormorant Asset Management, LP | US$2172.9萬 | 1.09% |
| Affinity Asset Advisors, LLC | US$2172.9萬 | 1.12% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | US$2092.2萬 | 0.01% |
| STATE STREET CORP | US$1997.6萬 | 0.00% |
| Eagle Health Investments LP | US$1981.9萬 | 3.47% |
| LOOMIS SAYLES & CO L P | US$1839.1萬 | 0.02% |
| NATIONAL BANK OF CANADA /FI/ | US$1830.2萬 | 0.02% |
| JANE STREET GROUP, LLC | US$1747.5萬 | 0.00% |
| First Turn Management, LLC | US$1745.2萬 | 1.95% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1668.4萬 | 0.00% |
| Synergy Asset Management, LLC | US$1611.5萬 | 1.71% |
| Voleon Capital Management LP | US$1551.7萬 | 0.33% |
| CASTLEARK MANAGEMENT LLC | US$1546.6萬 | 0.51% |
| CITADEL ADVISORS LLC | US$1546.2萬 | 0.00% |
| Trexquant Investment LP | US$1498.6萬 | 0.11% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$1482.6萬 | 0.01% |
| PEAK6 LLC | US$1372.4萬 | 0.03% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1346.3萬 | 0.01% |
| CITIGROUP INC | US$1228.3萬 | 0.01% |
| Qube Research & Technologies Ltd | US$1206.6萬 | 0.01% |
| Defilade Capital Management, L.P. | US$1187.0萬 | 1.67% |
| Empowered Funds, LLC | US$1169.6萬 | 0.07% |
| D. E. Shaw & Co., Inc. | US$1124.5萬 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1042.8萬 | 0.01% |
| NORTHERN TRUST CORP | US$1028.6萬 | 0.00% |
| NOMURA ASSET MANAGEMENT CO LTD | US$994.6萬 | 0.03% |
| Russell Investments Group, Ltd. | US$921.1萬 | 0.01% |
| SEB Asset Management AB | US$884.4萬 | 0.04% |
| Diversified Trust Co | US$850.0萬 | 0.16% |
| BARCLAYS PLC | US$810.9萬 | 0.00% |
| FIRST TRUST ADVISORS LP | US$712.2萬 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | US$703.8萬 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$701.4萬 | 0.00% |
| Walleye Trading LLC | US$672.5萬 | 0.01% |
| Nicholas Investment Partners, LP | US$614.5萬 | 0.44% |
| Brevan Howard Capital Management LP | US$597.0萬 | 0.05% |
| Matisse Capital | US$596.5萬 | 2.54% |
| ADAR1 Capital Management, LLC | US$572.1萬 | 0.34% |
| CAPITAL INTERNATIONAL SARL | US$566.1萬 | 0.09% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | US$548.9萬 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$545.2萬 | 0.12% |
| DAFNA Capital Management LLC | US$530.1萬 | 1.21% |
| SECTOR GAMMA AS | US$487.3萬 | 1.15% |
| SIT INVESTMENT ASSOCIATES INC | US$459.6萬 | 0.09% |
| STIFEL FINANCIAL CORP | US$448.2萬 | 0.00% |
| Atika Capital Management LLC | US$437.4萬 | 0.69% |
| Artia Global Partners LP | US$405.8萬 | 0.81% |
| Jain Global LLC | US$393.6萬 | 0.02% |
| CAPITAL INTERNATIONAL LTD /CA/ | US$375.0萬 | 0.14% |
| Handelsbanken Fonder AB | US$353.8萬 | 0.01% |
| Calamos Advisors LLC | US$352.0萬 | 0.01% |
| LPL Financial LLC | US$347.2萬 | 0.00% |
| Rhenman & Partners Asset Management AB | US$343.1萬 | 0.42% |
| Sterling Capital Management LLC | US$341.5萬 | 0.06% |
| Henry James International Management Inc. | US$338.2萬 | 1.22% |
| Nan Fung Group Holdings Ltd | US$311.1萬 | 2.57% |
| Ensign Peak Advisors, Inc | US$310.2萬 | 0.01% |
| Legal & General Group Plc | US$301.2萬 | 0.00% |
| Advisors Asset Management, Inc. | US$279.1萬 | 0.05% |
| Seven Fleet Capital Management LP | US$278.6萬 | 0.88% |
| XTX Topco Ltd | US$276.1萬 | 0.05% |
| Aquatic Capital Management LLC | US$272.1萬 | 0.08% |
| Dorsey Wright & Associates | US$271.7萬 | 0.34% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$270.5萬 | 2.40% |
| TORONTO DOMINION BANK | US$269.9萬 | 0.00% |
| Quantedge Capital Pte Ltd | US$251.6萬 | 1.38% |
| China Universal Asset Management Co., Ltd. | US$249.9萬 | 0.19% |
| Squarepoint Ops LLC | US$247.0萬 | 0.00% |
| Erste Asset Management GmbH | US$244.6萬 | 0.02% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | US$243.4萬 | 0.09% |
| Capital International, Inc./CA/ | US$237.7萬 | 0.02% |
| DIVERSIFY WEALTH MANAGEMENT, LLC | US$235.2萬 | 0.04% |
| FIRST NATIONAL BANK OF OMAHA | US$229.8萬 | 0.07% |
| ASSETMARK, INC | US$220.4萬 | 0.00% |
| Engineers Gate Manager LP | US$220.3萬 | 0.03% |
| CIBC Bancorp USA Inc. | US$214.6萬 | 0.00% |
| GUGGENHEIM CAPITAL LLC | US$212.3萬 | 0.02% |
| Morse Asset Management, Inc | US$206.5萬 | 0.43% |
| RAYMOND JAMES FINANCIAL INC | US$197.9萬 | 0.00% |
| Gilbert & Cook, Inc. | US$196.3萬 | 0.25% |
| HUSSMAN STRATEGIC ADVISORS, INC. | US$192.1萬 | 0.42% |
| SPHERA FUNDS MANAGEMENT LTD. | US$183.0萬 | 0.29% |
| Creative Planning | US$181.9萬 | 0.00% |
| Vinva Investment Management Ltd | US$181.4萬 | 0.02% |
| Crossmark Global Holdings, Inc. | US$178.0萬 | 0.03% |
| Mirae Asset Global Investments Co., Ltd. | US$168.1萬 | 0.00% |
| OPPENHEIMER ASSET MANAGEMENT INC. | US$168.0萬 | 0.02% |