| BAKER BROS. ADVISORS LP | $8449.7万 | 0.49% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $6213.0万 | 0.01% |
| RTW INVESTMENTS, LP | $5628.0万 | 0.56% |
| BlackRock, Inc. | $4773.0万 | 0.00% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | $3229.7万 | 0.82% |
| STATE STREET CORP | $2893.4万 | 0.00% |
| FCPM III SERVICES B.V. | $2148.4万 | 2.97% |
| VANGUARD CAPITAL MANAGEMENT LLC | $2110.7万 | 0.00% |
| D. E. Shaw & Co., Inc. | $1787.4万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1775.5万 | 0.00% |
| GOLDMAN SACHS GROUP INC | $1742.1万 | 0.00% |
| FMR LLC | $1564.8万 | 0.00% |
| Erste Asset Management GmbH | $1526.4万 | 0.14% |
| GEODE CAPITAL MANAGEMENT, LLC | $1378.5万 | 0.00% |
| ADAR1 Capital Management, LLC | $1287.5万 | 0.76% |
| TORONTO DOMINION BANK | $1217.1万 | 0.02% |
| Caption Management, LLC | $1089.7万 | 0.06% |
| Boxer Capital Management, LLC | $898.9万 | 1.18% |
| DIMENSIONAL FUND ADVISORS LP | $871.9万 | 0.00% |
| Sofinnova Investments, Inc. | $776.8万 | 0.30% |
| EcoR1 Capital, LLC | $765.0万 | 0.32% |
| CITADEL ADVISORS LLC | $630.2万 | 0.00% |
| DIADEMA PARTNERS LP | $586.0万 | 1.00% |
| JPMORGAN CHASE & CO | $568.8万 | 0.00% |
| Sio Capital Management, LLC | $550.8万 | 0.79% |
| Jefferies Financial Group Inc. | $546.4万 | 0.04% |
| TUDOR INVESTMENT CORP ET AL | $521.7万 | 0.01% |
| JANE STREET GROUP, LLC | $500.5万 | 0.00% |
| MORGAN STANLEY | $494.4万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $468.0万 | 0.00% |
| NORTHERN TRUST CORP | $450.7万 | 0.00% |
| UBS Group AG | $444.6万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $422.7万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $369.8万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $363.5万 | 0.00% |
| Candriam S.C.A. | $301.4万 | 0.02% |
| Eversept Partners, LP | $295.9万 | 0.16% |
| RENAISSANCE TECHNOLOGIES LLC | $291.8万 | 0.00% |
| Woodline Partners LP | $291.5万 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | $263.7万 | 0.00% |
| BARCLAYS PLC | $256.0万 | 0.00% |
| MOORE CAPITAL MANAGEMENT, LP | $238.0万 | 0.05% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $235.1万 | 0.00% |
| Ikarian Capital, LLC | $229.5万 | 0.19% |
| SummitTX Capital, L.P. | $221.0万 | 0.07% |
| Quinn Opportunity Partners LLC | $220.2万 | 0.11% |
| AQR CAPITAL MANAGEMENT LLC | $195.5万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | $193.9万 | 0.00% |
| ALGERT GLOBAL LLC | $191.1万 | 0.03% |
| Omega Fund Management, LLC | $191.0万 | 1.17% |
| Ally Bridge Group (NY) LLC | $188.9万 | 1.53% |
| DLD Asset Management, LP | $185.8万 | 0.17% |
| TD Asset Management Inc | $185.6万 | 0.00% |
| Bank of New York Mellon Corp | $156.7万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | $151.1万 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | $150.2万 | 0.16% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $147.1万 | 0.00% |
| Invesco Ltd. | $146.1万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | $138.7万 | 0.01% |
| J. Goldman & Co LP | $134.2万 | 0.04% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $131.5万 | 0.13% |
| ACADIAN ASSET MANAGEMENT LLC | $129.8万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $116.9万 | 0.02% |
| SG Americas Securities, LLC | $116.0万 | 0.00% |
| Engineers Gate Manager LP | $115.1万 | 0.01% |
| READYSTATE ASSET MANAGEMENT LP | $105.9万 | 0.05% |
| XTX Topco Ltd | $100.5万 | 0.02% |
| Hudson Bay Capital Management LP | $100.2万 | 0.00% |
| Seven Fleet Capital Management LP | $92.1万 | 0.29% |
| Rafferty Asset Management, LLC | $90.6万 | 0.00% |
| Quantinno Capital Management LP | $83.0万 | 0.00% |
| Tidal Investments LLC | $81.8万 | 0.00% |
| Tema ETFs LLC | $81.8万 | 0.05% |
| SIMPLEX TRADING, LLC | $80.2万 | 0.00% |
| Jump Financial, LLC | $79.8万 | 0.01% |
| RHUMBLINE ADVISERS | $67.1万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $66.9万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | $66.5万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $60.4万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $55.2万 | 0.00% |
| Walleye Capital LLC | $54.8万 | 0.00% |
| ZACKS INVESTMENT MANAGEMENT | $53.8万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | $52.8万 | 0.01% |
| Persistent Asset Partners Ltd | $52.6万 | 0.20% |
| ACT CAPITAL MANAGEMENT, LLC | $47.0万 | 0.37% |
| Corient Private Wealth LLC | $44.8万 | 0.00% |
| Nuveen, LLC | $44.1万 | 0.00% |
| DEUTSCHE BANK AG\ | $42.0万 | 0.00% |
| PROFUND ADVISORS LLC | $40.5万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $40.1万 | 0.00% |
| Creative Planning | $37.5万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $32.7万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $31.2万 | 0.00% |
| MetLife Investment Management, LLC | $29.3万 | 0.00% |
| FEDERATED HERMES, INC. | $28.5万 | 0.00% |
| Brevan Howard Capital Management LP | $27.5万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $25.7万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $24.3万 | 0.00% |
| Russell Investments Group, Ltd. | $24.1万 | 0.00% |
| Balyasny Asset Management L.P. | $23.6万 | 0.00% |
| GROUP ONE TRADING LLC | $23.5万 | 0.00% |
| Vanguard Global Advisers, LLC | $22.4万 | 0.00% |
| Quadrature Capital Ltd | $21.9万 | 0.00% |
| Virtus Investment Advisers, LLC | $20.5万 | 0.06% |
| DRW Securities, LLC | $20.2万 | 0.00% |
| AXQ CAPITAL, LP | $19.9万 | 0.03% |
| B Group, Inc. | $19.9万 | 0.15% |
| Graham Capital Management, L.P. | $19.5万 | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | $19.4万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $17.7万 | 0.00% |
| Ballentine Partners, LLC | $16.6万 | 0.00% |
| Velan Capital Investment Management LP | $15.3万 | 0.10% |
| Virtu Financial LLC | $14.4万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | $14.1万 | 0.00% |
| Cerity Partners LLC | $14.1万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $13.9万 | 0.00% |
| Centiva Capital, LP | $13.8万 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | $13.6万 | 0.00% |
| INCEPTIONR LLC | $13.2万 | 0.03% |
| CITIGROUP INC | $11.9万 | 0.00% |
| Blueshift Asset Management, LLC | $11.9万 | 0.04% |
| OSAIC HOLDINGS, INC. | $11.6万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $11.6万 | 0.00% |
| E Fund Management Co., Ltd. | $11.4万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $11.2万 | 0.01% |
| GRIFFIN ASSET MANAGEMENT, INC. | $11.0万 | 0.01% |
| ProShare Advisors LLC | $10.8万 | 0.00% |
| Magnetar Financial LLC | $10.3万 | 0.00% |
| HORIZON KINETICS ASSET MANAGEMENT LLC | $10.1万 | 0.00% |
| LPL Financial LLC | $10.0万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $9.8万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $9.6万 | 0.00% |
| CWM, LLC | $9.5万 | 0.00% |
| Polymer Capital Management (US) LLC | $9.0万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | $8.9万 | 0.00% |
| Summit Financial, LLC | $8.7万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $8.4万 | 0.00% |
| Tower Research Capital LLC (TRC) | $8.4万 | 0.00% |
| Walleye Trading LLC | $8.3万 | 0.00% |
| LETKO, BROSSEAU & ASSOCIATES INC | $8.3万 | 0.00% |
| Scientech Research LLC | $8.2万 | 0.07% |
| Quadcap Wealth Management, LLC | $7.7万 | 0.01% |
| Ameritas Investment Partners, Inc. | $4.7万 | 0.00% |
| Legal & General Group Plc | $4.6万 | 0.00% |
| Essential Partners LLC | $4.3万 | 0.01% |
| Allworth Financial LP | $4.0万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $3.3万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.0万 | 0.00% |
| Steward Partners Investment Advisory, LLC | $2.9万 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $2.6万 | 0.00% |