| BVF INC/IL | US$3118.2万 | 0.99% |
| Affinity Asset Advisors, LLC | US$2664.2万 | 1.38% |
| SAMSARA BIOCAPITAL, LLC | US$2647.6万 | 2.57% |
| Kynam Capital Management, LP | US$2173.5万 | 1.34% |
| ORBIMED ADVISORS LLC | US$1995.6万 | 0.41% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1794.6万 | 0.00% |
| PERCEPTIVE ADVISORS LLC | US$1781.8万 | 0.35% |
| RA CAPITAL MANAGEMENT, L.P. | US$1781.8万 | 0.19% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$1781.8万 | 0.29% |
| Point72 Asset Management, L.P. | US$1724.0万 | 0.02% |
| ADAR1 Capital Management, LLC | US$1306.4万 | 0.77% |
| Velan Capital Investment Management LP | US$1275.8万 | 7.99% |
| Balyasny Asset Management L.P. | US$1160.3万 | 0.02% |
| Woodline Partners LP | US$1139.5万 | 0.04% |
| UBS Group AG | US$978.6万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$836.3万 | 0.01% |
| Merck & Co., Inc. | US$678.4万 | 1.94% |
| ACUTA CAPITAL PARTNERS, LLC | US$671.1万 | 4.77% |
| BlackRock, Inc. | US$579.6万 | 0.00% |
| KVP Capital Advisors, LP | US$564.4万 | 4.22% |
| MARSHALL WACE, LLP | US$554.6万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$524.1万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$498.2万 | 0.01% |
| Opaleye Management Inc. | US$475.0万 | 0.63% |
| GEODE CAPITAL MANAGEMENT, LLC | US$427.2万 | 0.00% |
| CITADEL ADVISORS LLC | US$354.6万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$302.7万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$243.7万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$236.2万 | 0.00% |
| Eversept Partners, LP | US$182.2万 | 0.10% |
| Burkehill Global Management, LP | US$178.2万 | 0.09% |
| TWO SIGMA INVESTMENTS, LP | US$162.4万 | 0.00% |
| STATE STREET CORP | US$129.8万 | 0.00% |
| Fisher Asset Management, LLC | US$87.9万 | 0.00% |
| Trexquant Investment LP | US$85.5万 | 0.01% |
| NORTHERN TRUST CORP | US$82.6万 | 0.00% |
| JANE STREET GROUP, LLC | US$69.2万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$67.7万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$64.3万 | 0.04% |
| STEMPOINT CAPITAL LP | US$58.0万 | 0.11% |
| BANK OF AMERICA CORP /DE/ | US$47.0万 | 0.00% |
| CITIGROUP INC | US$46.9万 | 0.00% |
| Brevan Howard Capital Management LP | US$46.8万 | 0.00% |
| AJU IB Investment Co., Ltd. | US$43.6万 | 1.43% |
| Invesco Ltd. | US$42.8万 | 0.00% |
| RBF Capital, LLC | US$38.0万 | 0.02% |
| Hudson Bay Capital Management LP | US$36.8万 | 0.00% |
| Sigma Planning Corp | US$31.2万 | 0.01% |
| Jump Financial, LLC | US$30.9万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$26.3万 | 0.00% |
| MORGAN STANLEY | US$26.2万 | 0.00% |
| OMERS ADMINISTRATION Corp | US$21.7万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$21.4万 | 0.00% |
| XTX Topco Ltd | US$20.4万 | 0.00% |
| Persistent Asset Partners Ltd | US$18.5万 | 0.07% |
| State of Tennessee, Department of Treasury | US$18.4万 | 0.00% |
| Vanguard Global Advisers, LLC | US$17.9万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$3.2万 | 0.00% |
| FMR LLC | US$2.6万 | 0.00% |
| CWM, LLC | US$2.4万 | 0.00% |
| FNY Investment Advisers, LLC | US$2.4万 | 0.01% |
| Owl Creek Wealth Partners LLC | US$1.2万 | 0.00% |
| Physician Wealth Advisors, Inc. | US$4534.0 | 0.00% |
| BARCLAYS PLC | US$3462.0 | 0.00% |
| SIMPLEX TRADING, LLC | US$1544.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$1544.0 | 0.00% |
| Fortitude Family Office, LLC | US$1395.0 | 0.00% |
| Bogart Wealth, LLC | US$1246.0 | 0.00% |
| Parallel Advisors, LLC | US$1171.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$1096.0 | 0.00% |
| Avion Wealth | US$1000.0 | 0.00% |
| HighMark Wealth Management LLC | US$572.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$473.0 | 0.00% |
| Advisory Services Network, LLC | US$374.0 | 0.00% |
| Arax Advisory Partners | US$75.0 | 0.00% |
| FIFTH THIRD BANCORP | US$50.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$27.7 | 0.00% |
| ROYAL BANK OF CANADA | US$0.0 | 0.00% |