| SAMSARA BIOCAPITAL, LLC | US$3461.7万 | 3.36% |
| Redmile Group, LLC | US$2942.6万 | 1.95% |
| Casdin Capital, LLC | US$2863.4万 | 2.17% |
| RTW INVESTMENTS, LP | US$2746.7万 | 0.27% |
| EcoR1 Capital, LLC | US$2563.0万 | 1.09% |
| BlackRock, Inc. | US$2026.2万 | 0.00% |
| BAKER BROS. ADVISORS LP | US$1999.2万 | 0.11% |
| Trails Edge Capital Partners, LP | US$1578.1万 | 3.62% |
| Balyasny Asset Management L.P. | US$1448.3万 | 0.02% |
| TORONTO DOMINION BANK | US$1373.6万 | 0.02% |
| JENNISON ASSOCIATES LLC | US$1063.8万 | 0.01% |
| ArrowMark Colorado Holdings LLC | US$1058.0万 | 0.28% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1037.7万 | 0.00% |
| GREAT POINT PARTNERS LLC | US$1008.0万 | 2.32% |
| CITADEL ADVISORS LLC | US$833.1万 | 0.00% |
| FMR LLC | US$771.4万 | 0.00% |
| STATE STREET CORP | US$631.0万 | 0.00% |
| MORGAN STANLEY | US$575.0万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$562.6万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$412.9万 | 0.00% |
| UBS Group AG | US$374.3万 | 0.00% |
| BLAIR WILLIAM & CO/IL | US$339.1万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$308.9万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$217.2万 | 0.00% |
| DEUTSCHE BANK AG\ | US$214.2万 | 0.00% |
| Rock Springs Capital Management LP | US$210.3万 | 0.12% |
| NORTHERN TRUST CORP | US$196.8万 | 0.00% |
| Woodline Partners LP | US$169.0万 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | US$140.5万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$131.2万 | 0.00% |
| JPMORGAN CHASE & CO | US$125.3万 | 0.00% |
| DAFNA Capital Management LLC | US$114.2万 | 0.26% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$100.9万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$87.5万 | 0.00% |
| Raiffeisen Bank International AG | US$83.0万 | 0.01% |
| Driehaus Capital Management LLC | US$66.1万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$60.6万 | 0.00% |
| XTX Topco Ltd | US$55.3万 | 0.01% |
| Bank of New York Mellon Corp | US$52.5万 | 0.00% |
| Nuveen, LLC | US$50.8万 | 0.00% |
| JANE STREET GROUP, LLC | US$49.2万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$37.9万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$37.4万 | 0.00% |
| Mariner, LLC | US$33.6万 | 0.00% |
| RHUMBLINE ADVISERS | US$28.0万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$28.0万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$27.8万 | 0.00% |
| Virtus Investment Advisers, LLC | US$26.3万 | 0.07% |
| Brevan Howard Capital Management LP | US$25.7万 | 0.00% |
| NOMURA HOLDINGS INC | US$25.7万 | 0.00% |
| ALPS ADVISORS INC | US$25.4万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$23.0万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$21.9万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$21.8万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$20.8万 | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$16.1万 | 0.00% |
| MetLife Investment Management, LLC | US$12.0万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$10.7万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$10.2万 | 0.00% |
| Vanguard Global Advisers, LLC | US$9.8万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$8.6万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$8.5万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$7.8万 | 0.00% |
| BARCLAYS PLC | US$5.5万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$5.5万 | 0.00% |
| Russell Investments Group, Ltd. | US$3.2万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$2.6万 | 0.00% |
| CWM, LLC | US$2.1万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$2.0万 | 0.00% |
| CITIGROUP INC | US$1.9万 | 0.00% |
| Legal & General Group Plc | US$1.8万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$1.6万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1.2万 | 0.00% |
| GAMMA Investing LLC | US$1.1万 | 0.00% |
| Sterling Capital Management LLC | US$7540.0 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$6854.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$5887.0 | 0.00% |
| Farther Finance Advisors, LLC | US$3682.0 | 0.00% |
| SBI Securities Co., Ltd. | US$2520.0 | 0.00% |
| ROYAL BANK OF CANADA | US$2000.0 | 0.00% |
| Parallel Advisors, LLC | US$1935.0 | 0.00% |
| SIMPLEX TRADING, LLC | US$1794.0 | 0.00% |
| Optiver Holding B.V. | US$1351.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$1270.0 | 0.00% |
| Truvestments Capital LLC | US$927.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$907.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$888.0 | 0.00% |
| US BANCORP \DE\ | US$605.0 | 0.00% |
| Allworth Financial LP | US$605.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$543.1 | 0.00% |
| Investors Portfolio Services LLC | US$477.0 | 0.00% |
| Essential Partners LLC | US$403.0 | 0.00% |
| Arax Advisory Partners | US$282.0 | 0.00% |
| MAI Capital Management | US$222.0 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$161.0 | 0.00% |
| Sunbelt Securities, Inc. | US$40.0 | 0.00% |
| IFP Advisors, Inc | US$20.0 | 0.00% |
| Larson Financial Group LLC | US$20.0 | 0.00% |