| Frazier Life Sciences Management, L.P. | US$1.4億 | 3.51% |
| TRV GP IV, LLC | US$1.3億 | 50.04% |
| ARCH Venture Management, LLC | US$1.2億 | 18.16% |
| Deep Track Capital, LP | US$1.0億 | 1.70% |
| JANUS HENDERSON GROUP PLC | US$8528.0萬 | 0.04% |
| Paradigm Biocapital Advisors LP | US$8192.0萬 | 1.67% |
| BlackRock, Inc. | US$7672.7萬 | 0.00% |
| a16z Capital Management, L.L.C. | US$5081.1萬 | 3.94% |
| Venrock Adviser, LLC | US$4782.1萬 | 1.78% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4285.4萬 | 0.00% |
| Alphabet Inc. | US$4144.9萬 | 1.03% |
| Logos Global Management LP | US$3686.5萬 | 1.84% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$3516.3萬 | 0.05% |
| General Catalyst Group Management, LLC | US$3092.2萬 | 16.85% |
| TRV GP V, LLC | US$2838.1萬 | 7.08% |
| FMR LLC | US$2579.7萬 | 0.00% |
| CITADEL ADVISORS LLC | US$2415.5萬 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$2290.6萬 | 0.61% |
| Casdin Capital, LLC | US$2265.2萬 | 1.72% |
| Cormorant Asset Management, LP | US$2238.8萬 | 1.12% |
| Woodline Partners LP | US$1940.9萬 | 0.07% |
| STATE STREET CORP | US$1900.6萬 | 0.00% |
| Driehaus Capital Management LLC | US$1898.9萬 | 0.14% |
| Caligan Partners LP | US$1835.7萬 | 1.22% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1791.3萬 | 0.00% |
| BESSEMER GROUP INC | US$1438.1萬 | 0.02% |
| Balyasny Asset Management L.P. | US$1376.5萬 | 0.02% |
| Ikarian Capital, LLC | US$1174.3萬 | 0.95% |
| FARALLON CAPITAL MANAGEMENT LLC | US$1113.4萬 | 0.06% |
| HHLR ADVISORS, LTD. | US$1092.6萬 | 0.65% |
| MARSHALL WACE, LLP | US$927.3萬 | 0.01% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$849.2萬 | 0.11% |
| WASHINGTON UNIVERSITY | US$838.2萬 | 5.23% |
| GOLDMAN SACHS GROUP INC | US$834.9萬 | 0.00% |
| Candriam S.C.A. | US$830.3萬 | 0.04% |
| Squadron Capital Management LLC | US$768.6萬 | 2.82% |
| Mass General Brigham, Inc | US$716.4萬 | 1.53% |
| Freestone Grove Partners LP | US$701.3萬 | 0.05% |
| SPHERA FUNDS MANAGEMENT LTD. | US$678.6萬 | 1.08% |
| Aberdeen Group plc | US$675.3萬 | 0.01% |
| NORTHERN TRUST CORP | US$631.0萬 | 0.00% |
| MORGAN STANLEY | US$611.4萬 | 0.00% |
| Spruce Street Capital LP | US$597.0萬 | 1.44% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$583.7萬 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$582.3萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$556.5萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$554.6萬 | 0.01% |
| Foresite Capital Management IV, LLC | US$468.3萬 | 1.98% |
| VANGUARD FIDUCIARY TRUST CO | US$450.7萬 | 0.00% |
| Holocene Advisors, LP | US$406.5萬 | 0.01% |
| Qube Research & Technologies Ltd | US$402.8萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$382.1萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$366.3萬 | 0.00% |
| Atika Capital Management LLC | US$332.8萬 | 0.52% |
| AMERIPRISE FINANCIAL INC | US$320.8萬 | 0.00% |
| Caption Management, LLC | US$304.5萬 | 0.02% |
| Integral Health Asset Management, LLC | US$298.5萬 | 0.14% |
| Alyeska Investment Group, L.P. | US$298.5萬 | 0.01% |
| Ally Bridge Group (NY) LLC | US$298.5萬 | 2.41% |
| HighVista Strategies LLC | US$298.1萬 | 0.82% |
| UBS Group AG | US$280.3萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$268.3萬 | 0.00% |
| Exome Asset Management LLC | US$264.2萬 | 1.37% |
| Invesco Ltd. | US$258.0萬 | 0.00% |
| SummitTX Capital, L.P. | US$250.0萬 | 0.08% |
| Bank of New York Mellon Corp | US$221.7萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$207.1萬 | 0.00% |
| Nuveen, LLC | US$189.1萬 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$180.9萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$178.9萬 | 0.00% |
| NOMURA HOLDINGS INC | US$178.5萬 | 0.00% |
| FRANKLIN RESOURCES INC | US$178.0萬 | 0.00% |
| JPMORGAN CHASE & CO | US$169.6萬 | 0.00% |
| ADAR1 Capital Management, LLC | US$149.5萬 | 0.09% |
| D. E. Shaw & Co., Inc. | US$136.2萬 | 0.00% |
| Propel Bio Management, LLC | US$130.7萬 | 0.82% |
| ALPS ADVISORS INC | US$116.9萬 | 0.01% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$107.9萬 | 0.00% |
| DAFNA Capital Management LLC | US$104.5萬 | 0.24% |
| Aquatic Capital Management LLC | US$104.4萬 | 0.03% |
| JANE STREET GROUP, LLC | US$98.2萬 | 0.00% |
| Russell Investments Group, Ltd. | US$97.1萬 | 0.00% |
| Parkman Healthcare Partners LLC | US$95.1萬 | 0.10% |
| RHUMBLINE ADVISERS | US$94.1萬 | 0.00% |
| TWINBEECH CAPITAL LP | US$92.5萬 | 0.10% |
| Seven Fleet Capital Management LP | US$91.7萬 | 0.29% |
| MILLENNIUM MANAGEMENT LLC | US$89.2萬 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | US$83.4萬 | 0.00% |
| Walleye Capital LLC | US$83.4萬 | 0.00% |
| XTX Topco Ltd | US$80.2萬 | 0.01% |
| Foresite Capital Management V, LLC | US$77.3萬 | 0.29% |
| FIRST TRUST ADVISORS LP | US$76.1萬 | 0.00% |
| Blackstone Inc. | US$74.6萬 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | US$64.9萬 | 0.01% |
| DEUTSCHE BANK AG\ | US$60.5萬 | 0.00% |
| ACUTA CAPITAL PARTNERS, LLC | US$57.7萬 | 0.41% |
| Verition Fund Management LLC | US$57.1萬 | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | US$54.1萬 | 0.04% |
| Caitong International Asset Management Co., Ltd | US$53.1萬 | 0.10% |
| GILDER GAGNON HOWE & CO LLC | US$52.2萬 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | US$47.3萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$47.2萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$45.4萬 | 0.00% |
| Engineers Gate Manager LP | US$45.1萬 | 0.01% |
| DIADEMA PARTNERS LP | US$44.8萬 | 0.08% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$43.5萬 | 0.00% |
| MetLife Investment Management, LLC | US$43.4萬 | 0.00% |
| Squarepoint Ops LLC | US$40.6萬 | 0.00% |
| Ground Swell Capital, LLC | US$40.6萬 | 0.80% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$37.1萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$35.8萬 | 0.03% |
| WELLS FARGO & COMPANY/MN | US$31.0萬 | 0.00% |
| Falcon Wealth Planning | US$28.8萬 | 0.02% |
| AMERICAN CENTURY COMPANIES INC | US$28.8萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$28.4萬 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$28.1萬 | 0.00% |
| BARCLAYS PLC | US$27.6萬 | 0.00% |
| PEAK6 LLC | US$27.5萬 | 0.00% |
| CAPSTONE INVESTMENT ADVISORS, LLC | US$27.3萬 | 0.00% |
| IFP Advisors, Inc | US$26.8萬 | 0.01% |
| Persistent Asset Partners Ltd | US$26.2萬 | 0.10% |
| CITIGROUP INC | US$25.6萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$24.5萬 | 0.00% |
| Hudson Bay Capital Management LP | US$24.3萬 | 0.00% |
| Voleon Capital Management LP | US$21.8萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$21.2萬 | 0.00% |
| AXQ CAPITAL, LP | US$21.2萬 | 0.03% |
| Virtus Investment Advisers, LLC | US$20.9萬 | 0.06% |
| MANGROVE PARTNERS IM, LLC | US$20.1萬 | 0.02% |
| STRS OHIO | US$18.8萬 | 0.00% |
| Legal & General Group Plc | US$17.3萬 | 0.00% |
| Tower Research Capital LLC (TRC) | US$8.3萬 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$7.5萬 | 0.00% |
| Ameritas Investment Partners, Inc. | US$6.5萬 | 0.00% |
| CWM, LLC | US$6.4萬 | 0.00% |
| ROYAL BANK OF CANADA | US$6.1萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$4.3萬 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$4.2萬 | 0.00% |
| SIMPLEX TRADING, LLC | US$3.6萬 | 0.00% |
| FEDERATED HERMES, INC. | US$3.3萬 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$3.2萬 | 0.00% |
| Sterling Capital Management LLC | US$2.5萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$1.3萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.1萬 | 0.00% |
| GAMMA Investing LLC | US$1.1萬 | 0.00% |
| Farther Finance Advisors, LLC | US$1.0萬 | 0.00% |
| Kemnay Advisory Services Inc. | US$9134.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$6060.0 | 0.00% |
| SIGNATUREFD, LLC | US$5045.0 | 0.00% |
| SMA Capital LLC | US$4000.0 | 0.00% |