| JPMORGAN CHASE & CO | US$37.0億 | 0.24% |
| BlackRock, Inc. | US$27.3億 | 0.05% |
| Darwin Global Management, Ltd. | US$25.8億 | 68.33% |
| FMR LLC | US$21.5億 | 0.11% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$17.0億 | 0.09% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$15.8億 | 0.04% |
| BAKER BROS. ADVISORS LP | US$12.1億 | 6.97% |
| Artisan Partners Limited Partnership | US$10.7億 | 1.71% |
| D. E. Shaw & Co., Inc. | US$9.2億 | 0.55% |
| Capital International Investors | US$9.1億 | 0.21% |
| STATE STREET CORP | US$9.1億 | 0.03% |
| RTW INVESTMENTS, LP | US$7.9億 | 7.88% |
| GEODE CAPITAL MANAGEMENT, LLC | US$7.3億 | 0.05% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$5.1億 | 0.06% |
| AMERIPRISE FINANCIAL INC | US$5.0億 | 0.12% |
| FRANKLIN RESOURCES INC | US$4.3億 | 0.10% |
| CITADEL ADVISORS LLC | US$4.3億 | 0.07% |
| Invesco Ltd. | US$3.3億 | 0.05% |
| Orbis Allan Gray Ltd | US$3.1億 | 1.29% |
| UBS Group AG | US$2.8億 | 0.04% |
| BANK OF AMERICA CORP /DE/ | US$2.5億 | 0.02% |
| Integral Health Asset Management, LLC | US$2.5億 | 11.73% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | US$2.4億 | 1.01% |
| SEI INVESTMENTS CO | US$2.3億 | 0.21% |
| Capital World Investors | US$2.2億 | 0.03% |
| VANGUARD FIDUCIARY TRUST CO | US$2.2億 | 0.06% |
| MORGAN STANLEY | US$2.2億 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | US$2.1億 | 0.09% |
| NORTHERN TRUST CORP | US$2.1億 | 0.03% |
| Castle Hook Partners LP | US$2.1億 | 4.04% |
| Bank of New York Mellon Corp | US$2.1億 | 0.04% |
| Paradigm Biocapital Advisors LP | US$2.1億 | 4.19% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$2.0億 | 0.04% |
| Duquesne Family Office LLC | US$1.9億 | 5.59% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$1.9億 | 0.32% |
| Pictet Asset Management Holding SA | US$1.8億 | 0.19% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$1.8億 | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$1.7億 | 0.03% |
| Fiera Capital Corp | US$1.7億 | 0.57% |
| NWI MANAGEMENT LP | US$1.7億 | 9.43% |
| GOLDMAN SACHS GROUP INC | US$1.5億 | 0.02% |
| AMERICAN CENTURY COMPANIES INC | US$1.5億 | 0.08% |
| PRINCIPAL FINANCIAL GROUP INC | US$1.5億 | 0.08% |
| Artia Global Partners LP | US$1.5億 | 29.74% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | US$1.5億 | 0.49% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$1.5億 | 0.23% |
| FIL Ltd | US$1.4億 | 0.11% |
| Amundi | US$1.3億 | 0.04% |
| Legal & General Group Plc | US$1.3億 | 0.03% |
| RAYMOND JAMES FINANCIAL INC | US$1.2億 | 0.04% |
| ALLIANCEBERNSTEIN L.P. | US$1.2億 | 0.04% |
| Hood River Capital Management LLC | US$1.1億 | 1.13% |
| AQR CAPITAL MANAGEMENT LLC | US$1.1億 | 0.05% |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | US$1.1億 | 2.87% |
| Clearbridge Investments, LLC | US$1.1億 | 0.09% |
| Swiss National Bank | US$1.0億 | 0.06% |
| GW&K Investment Management, LLC | US$1.0億 | 0.90% |
| JENNISON ASSOCIATES LLC | US$9888.0萬 | 0.07% |
| WELLS FARGO & COMPANY/MN | US$9768.4萬 | 0.02% |
| TimesSquare Capital Management, LLC | US$9562.6萬 | 1.62% |
| DEUTSCHE BANK AG\ | US$9197.6萬 | 0.03% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$8929.3萬 | 1.48% |
| FEDERATED HERMES, INC. | US$8801.6萬 | 0.14% |
| Nuveen, LLC | US$8744.2萬 | 0.02% |
| ROYAL BANK OF CANADA | US$8553.7萬 | 0.02% |
| Sumitomo Mitsui Trust Group, Inc. | US$8197.0萬 | 0.05% |
| Ensign Peak Advisors, Inc | US$8172.0萬 | 0.15% |
| Affinity Asset Advisors, LLC | US$7849.0萬 | 4.05% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$7678.3萬 | 0.79% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$7645.2萬 | 0.09% |
| JANE STREET GROUP, LLC | US$7450.0萬 | 0.01% |
| CITIGROUP INC | US$7085.4萬 | 0.03% |
| JANUS HENDERSON GROUP PLC | US$6856.4萬 | 0.03% |
| SAMLYN CAPITAL, LLC | US$6822.1萬 | 1.16% |
| Palo Alto Investors LP | US$6790.5萬 | 10.39% |
| Candriam S.C.A. | US$6569.2萬 | 0.34% |
| DIMENSIONAL FUND ADVISORS LP | US$6547.4萬 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$6525.2萬 | 0.01% |
| LORD, ABBETT & CO. LLC | US$6496.0萬 | 0.21% |
| VICTORY CAPITAL MANAGEMENT INC | US$6479.4萬 | 0.04% |
| Polar Capital Holdings Plc | US$6019.3萬 | 0.21% |
| GATEWAY INVESTMENT ADVISERS LLC | US$5968.5萬 | 0.67% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$5887.9萬 | 0.05% |
| Sofinnova Investments, Inc. | US$5659.0萬 | 2.15% |
| California Public Employees Retirement System | US$5635.1萬 | 0.03% |
| Rock Springs Capital Management LP | US$5139.4萬 | 3.03% |
| MARSHALL WACE, LLP | US$5111.1萬 | 0.05% |
| National Pension Service | US$5099.9萬 | 0.04% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$4957.6萬 | 0.05% |
| Nearwater Capital Markets, Ltd | US$4905.6萬 | 1.16% |
| ENVESTNET ASSET MANAGEMENT INC | US$4904.4萬 | 0.01% |
| Bridgewater Associates, LP | US$4833.3萬 | 0.22% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$4800.1萬 | 0.07% |
| Allspring Global Investments Holdings, LLC | US$4661.2萬 | 0.08% |
| ProShare Advisors LLC | US$4629.9萬 | 0.07% |
| Aberdeen Group plc | US$4529.8萬 | 0.07% |
| BARCLAYS PLC | US$4508.8萬 | 0.01% |
| RHUMBLINE ADVISERS | US$4457.8萬 | 0.04% |
| NEUBERGER BERMAN GROUP LLC | US$4426.5萬 | 0.03% |
| TANG CAPITAL MANAGEMENT LLC | US$4251.5萬 | 2.16% |
| Mitsubishi UFJ Asset Management Co., Ltd. | US$4173.8萬 | 0.03% |
| First Turn Management, LLC | US$4063.1萬 | 4.54% |
| VOYA INVESTMENT MANAGEMENT LLC | US$3985.1萬 | 0.04% |
| AXIOM INVESTORS LLC /DE | US$3915.4萬 | 0.44% |
| TWO SIGMA INVESTMENTS, LP | US$3875.7萬 | 0.03% |
| Balyasny Asset Management L.P. | US$3803.6萬 | 0.05% |
| Evergreen Quality Fund GP, Ltd. | US$3801.8萬 | 0.87% |
| FIRST TRUST ADVISORS LP | US$3753.8萬 | 0.03% |
| Eagle Health Investments LP | US$3667.3萬 | 6.41% |
| Susquehanna Portfolio Strategies, LLC | US$3393.5萬 | 0.50% |
| LOOMIS SAYLES & CO L P | US$3188.3萬 | 0.04% |
| Defilade Capital Management, L.P. | US$3187.2萬 | 4.48% |
| Cormorant Asset Management, LP | US$3106.9萬 | 1.56% |
| Squarepoint Ops LLC | US$3045.0萬 | 0.04% |
| Davern Capital Partners, LP | US$2985.3萬 | 8.19% |
| Nicholas Investment Partners, LP | US$2984.9萬 | 2.15% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$2950.0萬 | 0.06% |
| TREMBLANT CAPITAL GROUP | US$2839.3萬 | 0.91% |
| Russell Investments Group, Ltd. | US$2765.7萬 | 0.03% |
| SEB Asset Management AB | US$2707.5萬 | 0.12% |
| TD Asset Management Inc | US$2672.3萬 | 0.02% |
| C WorldWide Group Holding A/S | US$2634.5萬 | 0.57% |
| Rhenman & Partners Asset Management AB | US$2612.4萬 | 3.22% |
| Engineers Gate Manager LP | US$2596.6萬 | 0.32% |
| Patient Square Capital LP | US$2575.4萬 | 4.57% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$2491.5萬 | 0.05% |
| Qube Research & Technologies Ltd | US$2428.5萬 | 0.03% |
| Woodline Partners LP | US$2427.5萬 | 0.09% |
| ExodusPoint Capital Management, LP | US$2422.3萬 | 0.20% |
| Long Focus Capital Management, LLC | US$2371.0萬 | 0.63% |
| Caption Management, LLC | US$2346.5萬 | 0.14% |
| Perpetual Ltd | US$2331.5萬 | 0.36% |
| LPL Financial LLC | US$2261.2萬 | 0.01% |
| SG Americas Securities, LLC | US$2242.7萬 | 0.02% |
| Man Group plc | US$2074.1萬 | 0.04% |
| FRED ALGER MANAGEMENT, LLC | US$2056.5萬 | 0.09% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$2008.3萬 | 0.03% |
| AVIVA PLC | US$1996.2萬 | 0.03% |
| Walleye Capital LLC | US$1990.3萬 | 0.08% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$1967.9萬 | 0.03% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$1961.6萬 | 0.02% |
| HSBC HOLDINGS PLC | US$1903.8萬 | 0.01% |
| Rafferty Asset Management, LLC | US$1898.0萬 | 0.08% |
| PFA Pension, Forsikringsaktieselskab | US$1877.0萬 | 0.06% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$1869.8萬 | 0.04% |
| DANSKE BANK A/S | US$1816.0萬 | 0.04% |
| NEOS Investment Management LLC | US$1805.7萬 | 0.09% |
| Vanguard Global Advisers, LLC | US$1782.4萬 | 0.01% |
| Vanguard Investments Australia, Ltd. | US$1730.1萬 | 0.05% |
| Driehaus Capital Management LLC | US$1723.7萬 | 0.13% |