| RA CAPITAL MANAGEMENT, L.P. | $23.5億 | 24.92% |
| Avoro Capital Advisors LLC | $11.6億 | 11.39% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $11.0億 | 4.62% |
| FMR LLC | $8.9億 | 0.05% |
| Artisan Partners Limited Partnership | $7.4億 | 1.19% |
| FRANKLIN RESOURCES INC | $4.7億 | 0.11% |
| Capital International Investors | $4.5億 | 0.11% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $4.3億 | 0.14% |
| WELLINGTON MANAGEMENT GROUP LLP | $4.0億 | 0.08% |
| PERCEPTIVE ADVISORS LLC | $3.5億 | 6.84% |
| AMERICAN CENTURY COMPANIES INC | $3.2億 | 0.16% |
| Capital World Investors | $2.1億 | 0.03% |
| PRINCIPAL FINANCIAL GROUP INC | $2.1億 | 0.11% |
| AMERIPRISE FINANCIAL INC | $2.0億 | 0.05% |
| BlackRock, Inc. | $1.5億 | 0.00% |
| Polar Capital Holdings Plc | $1.5億 | 0.53% |
| MORGAN STANLEY | $1.4億 | 0.01% |
| GOLDMAN SACHS GROUP INC | $1.3億 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $1.3億 | 0.22% |
| JPMORGAN CHASE & CO | $1.2億 | 0.01% |
| FIL Ltd | $1.0億 | 0.08% |
| Vestal Point Capital, LP | $8577.4万 | 2.40% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8517.0万 | 0.01% |
| Spyglass Capital Management LLC | $8416.6万 | 5.96% |
| Invesco Ltd. | $8282.5万 | 0.01% |
| SEI INVESTMENTS CO | $8031.8万 | 0.07% |
| FRED ALGER MANAGEMENT, LLC | $6973.9万 | 0.31% |
| WELLS FARGO & COMPANY/MN | $6134.5万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | $5932.4万 | 0.02% |
| Tri Locum Partners LP | $5840.2万 | 8.20% |
| Pictet Asset Management Holding SA | $5690.7万 | 0.06% |
| Caption Management, LLC | $5649.6万 | 0.33% |
| Candriam S.C.A. | $5267.1万 | 0.27% |
| Bank of New York Mellon Corp | $5230.5万 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | $5156.5万 | 0.04% |
| TD Asset Management Inc | $4986.1万 | 0.04% |
| Aberdeen Group plc | $4806.9万 | 0.08% |
| ARS Investment Partners, LLC | $4790.9万 | 2.49% |
| UBS Group AG | $4742.5万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $4540.4万 | 0.00% |
| Rock Springs Capital Management LP | $4437.4万 | 2.62% |
| MILLENNIUM MANAGEMENT LLC | $4323.6万 | 0.02% |
| Allspring Global Investments Holdings, LLC | $4204.7万 | 0.07% |
| ORBIMED ADVISORS LLC | $4162.4万 | 0.85% |
| PFM Health Sciences, LP | $3989.8万 | 3.64% |
| NEW YORK STATE COMMON RETIREMENT FUND | $3913.8万 | 0.05% |
| RICE HALL JAMES & ASSOCIATES, LLC | $3394.0万 | 1.89% |
| LORD, ABBETT & CO. LLC | $3323.8万 | 0.11% |
| DEUTSCHE BANK AG\ | $3092.1万 | 0.01% |
| Frazier Life Sciences Management, L.P. | $3049.7万 | 0.78% |
| BRAUN STACEY ASSOCIATES INC | $2996.2万 | 1.00% |
| Catalio Capital Management, LP | $2953.2万 | 6.17% |
| ODDO BHF ASSET MANAGEMENT SAS | $2942.8万 | 1.16% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $2851.3万 | 2.91% |
| Chevy Chase Trust Holdings, LLC | $2824.1万 | 0.08% |
| SG Americas Securities, LLC | $2762.8万 | 0.03% |
| RENAISSANCE TECHNOLOGIES LLC | $2683.7万 | 0.04% |
| Integral Health Asset Management, LLC | $2630.4万 | 1.26% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $2613.8万 | 0.10% |
| Woodline Partners LP | $2343.8万 | 0.09% |
| Perpetual Ltd | $2301.9万 | 0.35% |
| Troluce Capital Advisors LLC | $2278.2万 | 1.40% |
| Resolute Capital Asset Partners LLC | $2255.9万 | 11.87% |
| Affinity Asset Advisors, LLC | $2172.9万 | 1.12% |
| Cormorant Asset Management, LP | $2172.9万 | 1.09% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2092.2万 | 0.01% |
| STATE STREET CORP | $1997.6万 | 0.00% |
| Eagle Health Investments LP | $1981.9万 | 3.47% |
| LOOMIS SAYLES & CO L P | $1839.1万 | 0.02% |
| NATIONAL BANK OF CANADA /FI/ | $1830.2万 | 0.02% |
| JANE STREET GROUP, LLC | $1747.5万 | 0.00% |
| First Turn Management, LLC | $1745.2万 | 1.95% |
| GEODE CAPITAL MANAGEMENT, LLC | $1668.4万 | 0.00% |
| Synergy Asset Management, LLC | $1611.5万 | 1.71% |
| Voleon Capital Management LP | $1551.7万 | 0.33% |
| CASTLEARK MANAGEMENT LLC | $1546.6万 | 0.51% |
| CITADEL ADVISORS LLC | $1546.2万 | 0.00% |
| Trexquant Investment LP | $1498.6万 | 0.11% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $1482.6万 | 0.01% |
| PEAK6 LLC | $1372.4万 | 0.03% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1346.3万 | 0.01% |
| CITIGROUP INC | $1228.3万 | 0.01% |
| Qube Research & Technologies Ltd | $1206.6万 | 0.01% |
| Defilade Capital Management, L.P. | $1187.0万 | 1.67% |
| Empowered Funds, LLC | $1169.6万 | 0.07% |
| D. E. Shaw & Co., Inc. | $1124.5万 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | $1042.8万 | 0.01% |
| NORTHERN TRUST CORP | $1028.6万 | 0.00% |
| NOMURA ASSET MANAGEMENT CO LTD | $994.6万 | 0.03% |
| Russell Investments Group, Ltd. | $921.1万 | 0.01% |
| SEB Asset Management AB | $884.4万 | 0.04% |
| Diversified Trust Co | $850.0万 | 0.16% |
| BARCLAYS PLC | $810.9万 | 0.00% |
| FIRST TRUST ADVISORS LP | $712.2万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | $703.8万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | $701.4万 | 0.00% |
| Walleye Trading LLC | $672.5万 | 0.01% |
| Nicholas Investment Partners, LP | $614.5万 | 0.44% |
| Brevan Howard Capital Management LP | $597.0万 | 0.05% |
| Matisse Capital | $596.5万 | 2.54% |
| ADAR1 Capital Management, LLC | $572.1万 | 0.34% |
| CAPITAL INTERNATIONAL SARL | $566.1万 | 0.09% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | $548.9万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | $545.2万 | 0.12% |
| DAFNA Capital Management LLC | $530.1万 | 1.21% |
| SECTOR GAMMA AS | $487.3万 | 1.15% |
| SIT INVESTMENT ASSOCIATES INC | $459.6万 | 0.09% |
| STIFEL FINANCIAL CORP | $448.2万 | 0.00% |
| Atika Capital Management LLC | $437.4万 | 0.69% |
| Artia Global Partners LP | $405.8万 | 0.81% |
| Jain Global LLC | $393.6万 | 0.02% |
| CAPITAL INTERNATIONAL LTD /CA/ | $375.0万 | 0.14% |
| Handelsbanken Fonder AB | $353.8万 | 0.01% |
| Calamos Advisors LLC | $352.0万 | 0.01% |
| LPL Financial LLC | $347.2万 | 0.00% |
| Rhenman & Partners Asset Management AB | $343.1万 | 0.42% |
| Sterling Capital Management LLC | $341.5万 | 0.06% |
| Henry James International Management Inc. | $338.2万 | 1.22% |
| Nan Fung Group Holdings Ltd | $311.1万 | 2.57% |
| Ensign Peak Advisors, Inc | $310.2万 | 0.01% |
| Legal & General Group Plc | $301.2万 | 0.00% |
| Advisors Asset Management, Inc. | $279.1万 | 0.05% |
| Seven Fleet Capital Management LP | $278.6万 | 0.88% |
| XTX Topco Ltd | $276.1万 | 0.05% |
| Aquatic Capital Management LLC | $272.1万 | 0.08% |
| Dorsey Wright & Associates | $271.7万 | 0.34% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $270.5万 | 2.40% |
| TORONTO DOMINION BANK | $269.9万 | 0.00% |
| Quantedge Capital Pte Ltd | $251.6万 | 1.38% |
| China Universal Asset Management Co., Ltd. | $249.9万 | 0.19% |
| Squarepoint Ops LLC | $247.0万 | 0.00% |
| Erste Asset Management GmbH | $244.6万 | 0.02% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | $243.4万 | 0.09% |
| Capital International, Inc./CA/ | $237.7万 | 0.02% |
| DIVERSIFY WEALTH MANAGEMENT, LLC | $235.2万 | 0.04% |
| FIRST NATIONAL BANK OF OMAHA | $229.8万 | 0.07% |
| ASSETMARK, INC | $220.4万 | 0.00% |
| Engineers Gate Manager LP | $220.3万 | 0.03% |
| CIBC Bancorp USA Inc. | $214.6万 | 0.00% |
| GUGGENHEIM CAPITAL LLC | $212.3万 | 0.02% |
| Morse Asset Management, Inc | $206.5万 | 0.43% |
| RAYMOND JAMES FINANCIAL INC | $197.9万 | 0.00% |
| Gilbert & Cook, Inc. | $196.3万 | 0.25% |
| HUSSMAN STRATEGIC ADVISORS, INC. | $192.1万 | 0.42% |
| SPHERA FUNDS MANAGEMENT LTD. | $183.0万 | 0.29% |
| Creative Planning | $181.9万 | 0.00% |
| Vinva Investment Management Ltd | $181.4万 | 0.02% |
| Crossmark Global Holdings, Inc. | $178.0万 | 0.03% |
| Mirae Asset Global Investments Co., Ltd. | $168.1万 | 0.00% |
| OPPENHEIMER ASSET MANAGEMENT INC. | $168.0万 | 0.02% |