| T. Rowe Price Investment Management, Inc. | US$6343.6万 | 0.04% |
| ORBIMED ADVISORS LLC | US$4054.8万 | 0.83% |
| Redmile Group, LLC | US$3562.0万 | 2.36% |
| Prosight Management, LP | US$3217.9万 | 5.28% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$2986.7万 | 0.05% |
| NEXTBio Capital Management LP | US$2025.4万 | 9.40% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1464.2万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1146.4万 | 0.00% |
| CLARK ESTATES INC/NY | US$948.8万 | 2.28% |
| PINNACLE ASSOCIATES LTD | US$879.8万 | 0.11% |
| Aberdeen Group plc | US$745.4万 | 0.01% |
| Point72 Asset Management, L.P. | US$663.0万 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$582.4万 | 0.00% |
| 683 Capital Management, LLC | US$514.4万 | 0.27% |
| MILLENNIUM MANAGEMENT LLC | US$491.1万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$460.4万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$415.4万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$388.7万 | 0.01% |
| MARSHALL WACE, LLP | US$373.9万 | 0.00% |
| BlackRock, Inc. | US$328.4万 | 0.00% |
| S&G Foundation | US$280.2万 | 0.15% |
| JANE STREET GROUP, LLC | US$267.4万 | 0.00% |
| FMR LLC | US$252.4万 | 0.00% |
| TD Asset Management Inc | US$246.0万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$208.7万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$203.2万 | 0.00% |
| DIADEMA PARTNERS LP | US$188.8万 | 0.32% |
| ALGERT GLOBAL LLC | US$183.9万 | 0.03% |
| SPHERA FUNDS MANAGEMENT LTD. | US$180.5万 | 0.29% |
| STATE STREET CORP | US$169.6万 | 0.00% |
| Hudson Bay Capital Management LP | US$147.1万 | 0.01% |
| MORGAN STANLEY | US$128.7万 | 0.00% |
| DEUTSCHE BANK AG\ | US$125.2万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$123.1万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$117.2万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$100.1万 | 0.00% |
| CITADEL ADVISORS LLC | US$95.2万 | 0.00% |
| XTX Topco Ltd | US$91.6万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$91.5万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$89.6万 | 0.00% |
| Qube Research & Technologies Ltd | US$81.5万 | 0.00% |
| NORTHERN TRUST CORP | US$81.1万 | 0.00% |
| BARCLAYS PLC | US$77.1万 | 0.00% |
| HRT FINANCIAL LP | US$58.3万 | 0.00% |
| Bank of New York Mellon Corp | US$57.7万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$51.4万 | 0.00% |
| Brevan Howard Capital Management LP | US$51.1万 | 0.00% |
| LBJ Family Wealth Advisors, Ltd. | US$49.0万 | 0.29% |
| CITIGROUP INC | US$48.2万 | 0.00% |
| Persistent Asset Partners Ltd | US$47.7万 | 0.18% |
| Pathstone Holdings, LLC | US$47.6万 | 0.00% |
| Hillsdale Investment Management Inc. | US$42.1万 | 0.01% |
| Davis Asset Management, L.P. | US$31.0万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | US$30.9万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$27.2万 | 0.01% |
| HSBC HOLDINGS PLC | US$26.9万 | 0.00% |
| EP Wealth Advisors, LLC | US$26.5万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$26.3万 | 0.00% |
| PIPER SANDLER & CO. | US$25.4万 | 0.00% |
| Invesco Ltd. | US$23.7万 | 0.00% |
| UBS Group AG | US$23.3万 | 0.00% |
| OMERS ADMINISTRATION Corp | US$21.4万 | 0.00% |
| Squarepoint Ops LLC | US$20.0万 | 0.00% |
| Dynamic Technology Lab Private Ltd | US$19.0万 | 0.03% |
| Vanguard Global Advisers, LLC | US$16.9万 | 0.00% |
| RITHOLTZ WEALTH MANAGEMENT | US$16.7万 | 0.00% |
| Jump Financial, LLC | US$15.9万 | 0.00% |
| BENJAMIN EDWARDS INC | US$15.0万 | 0.00% |
| Mallini Complete Financial Planning LLC | US$14.6万 | 0.12% |
| CHOREO, LLC | US$13.0万 | 0.00% |
| Diametric Capital, LP | US$11.9万 | 0.03% |
| Catalyst Funds Management Pty Ltd | US$11.5万 | 0.02% |
| Engineers Gate Manager LP | US$10.3万 | 0.00% |
| Verdad Advisers, LP | US$8.6万 | 0.10% |
| Creative Planning | US$7.9万 | 0.00% |
| Quadrature Capital Ltd | US$7.8万 | 0.00% |
| Schonfeld Strategic Advisors LLC | US$7.4万 | 0.00% |
| US BANCORP \DE\ | US$5.2万 | 0.00% |
| JPMORGAN CHASE & CO | US$1478.0 | 0.00% |
| Optiver Holding B.V. | US$424.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$362.7 | 0.00% |
| SBI Securities Co., Ltd. | US$322.0 | 0.00% |
| CWM, LLC | US$251.0 | 0.00% |
| ROYAL BANK OF CANADA | US$0.0 | 0.00% |