| NOVO HOLDINGS A/S | US$7494.9万 | 6.07% |
| FCPM III SERVICES B.V. | US$6559.3万 | 9.08% |
| T. Rowe Price Investment Management, Inc. | US$5696.4万 | 0.04% |
| GOLDMAN SACHS GROUP INC | US$4055.6万 | 0.00% |
| BlackRock, Inc. | US$2723.7万 | 0.00% |
| Blue Owl Capital Holdings LP | US$2045.1万 | 5.49% |
| Nan Fung Group Holdings Ltd | US$1974.6万 | 16.28% |
| 5AM Venture Management, LLC | US$1931.4万 | 5.36% |
| Sanofi | US$1854.2万 | 5.52% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1463.4万 | 0.00% |
| Pivotal bioVenture Partners Investment Advisor LLC | US$1243.1万 | 4.44% |
| Velan Capital Investment Management LP | US$1002.1万 | 6.28% |
| GEODE CAPITAL MANAGEMENT, LLC | US$978.5万 | 0.00% |
| Siren, L.L.C. | US$914.9万 | 0.25% |
| Vestal Point Capital, LP | US$853.9万 | 0.24% |
| ADAR1 Capital Management, LLC | US$762.2万 | 0.45% |
| BAKER BROS. ADVISORS LP | US$741.4万 | 0.04% |
| STATE STREET CORP | US$689.4万 | 0.00% |
| Freestone Grove Partners LP | US$638.3万 | 0.05% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$544.3万 | 0.01% |
| RA CAPITAL MANAGEMENT, L.P. | US$504.8万 | 0.05% |
| UBS Group AG | US$480.8万 | 0.00% |
| FMR LLC | US$415.8万 | 0.00% |
| Board of Trustees of The Leland Stanford Junior University | US$405.0万 | 0.48% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$390.6万 | 2.79% |
| DAFNA Capital Management LLC | US$347.7万 | 0.79% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$327.6万 | 0.00% |
| NORTHERN TRUST CORP | US$297.2万 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | US$288.7万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$266.8万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$229.3万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$228.9万 | 0.00% |
| Tetragon Partners GP Ltd | US$227.9万 | 0.44% |
| SEVEN GRAND MANAGERS, LLC | US$203.3万 | 0.14% |
| STEMPOINT CAPITAL LP | US$203.3万 | 0.39% |
| Burkehill Global Management, LP | US$152.5万 | 0.08% |
| JANUS HENDERSON GROUP PLC | US$111.3万 | 0.00% |
| TD Asset Management Inc | US$97.1万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$93.9万 | 0.00% |
| Bank of New York Mellon Corp | US$80.2万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | US$74.7万 | 0.00% |
| MORGAN STANLEY | US$62.0万 | 0.00% |
| Nuveen, LLC | US$46.9万 | 0.00% |
| RHUMBLINE ADVISERS | US$41.4万 | 0.00% |
| Ghisallo Capital Management LLC | US$40.7万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$38.4万 | 0.00% |
| MARKET STREET WEALTH MANAGEMENT ADVISORS LLC | US$28.7万 | 0.05% |
| TWO SIGMA INVESTMENTS, LP | US$28.7万 | 0.00% |
| DEUTSCHE BANK AG\ | US$27.8万 | 0.00% |
| Invesco Ltd. | US$24.9万 | 0.00% |
| Walleye Capital LLC | US$23.5万 | 0.00% |
| XTX Topco Ltd | US$20.9万 | 0.00% |
| LMR Partners LLP | US$20.3万 | 0.00% |
| MetLife Investment Management, LLC | US$19.9万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$18.4万 | 0.00% |
| Vanguard Global Advisers, LLC | US$17.1万 | 0.00% |
| JPMORGAN CHASE & CO | US$14.7万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$14.6万 | 0.00% |
| BARCLAYS PLC | US$11.8万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$10.8万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$8.1万 | 0.00% |
| STRS OHIO | US$6.1万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$3.9万 | 0.00% |
| Legal & General Group Plc | US$3.7万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$2.8万 | 0.00% |
| Russell Investments Group, Ltd. | US$2.7万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$2.2万 | 0.00% |
| CITIGROUP INC | US$2.0万 | 0.00% |
| SBI Securities Co., Ltd. | US$1.1万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$7583.3 | 0.00% |
| Sterling Capital Management LLC | US$7522.0 | 0.00% |
| Farther Finance Advisors, LLC | US$2500.0 | 0.00% |
| GAMMA Investing LLC | US$1911.0 | 0.00% |
| CWM, LLC | US$1159.0 | 0.00% |
| Versant Capital Management, Inc | US$1017.0 | 0.00% |
| Root Financial Partners, LLC | US$569.0 | 0.00% |
| MAI Capital Management | US$244.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$122.0 | 0.00% |
| Allworth Financial LP | US$122.0 | 0.00% |
| True Wealth Design, LLC | US$61.0 | 0.00% |
| Arax Advisory Partners | US$20.0 | 0.00% |