| Beutel, Goodman & Co Ltd. | US$2637.7万 | 0.18% |
| Affinity Asset Advisors, LLC | US$1150.4万 | 0.59% |
| Balyasny Asset Management L.P. | US$977.4万 | 0.01% |
| Vivo Capital, LLC | US$977.4万 | 0.81% |
| Ikarian Capital, LLC | US$879.5万 | 0.71% |
| GREAT POINT PARTNERS LLC | US$868.8万 | 2.00% |
| SCOTIA CAPITAL INC. | US$724.4万 | 0.03% |
| Point72 Asset Management, L.P. | US$700.5万 | 0.01% |
| UBS Group AG | US$552.1万 | 0.00% |
| Redmile Group, LLC | US$506.8万 | 0.34% |
| Rubric Capital Management LP | US$500.4万 | 0.05% |
| Squadron Capital Management LLC | US$492.3万 | 1.80% |
| Ally Bridge Group (NY) LLC | US$478.1万 | 3.86% |
| PFM Health Sciences, LP | US$391.6万 | 0.36% |
| AMERIPRISE FINANCIAL INC | US$379.6万 | 0.00% |
| Woodline Partners LP | US$319.0万 | 0.01% |
| Seven Fleet Capital Management LP | US$313.9万 | 1.00% |
| Alyeska Investment Group, L.P. | US$271.5万 | 0.01% |
| Velan Capital Investment Management LP | US$254.8万 | 1.60% |
| SummitTX Capital, L.P. | US$237.5万 | 0.07% |
| Aisling Capital Management LP | US$235.3万 | 0.49% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$234.5万 | 0.03% |
| DV Trading LLC | US$199.8万 | 0.05% |
| BANK OF AMERICA CORP /DE/ | US$194.2万 | 0.00% |
| ROYAL BANK OF CANADA | US$189.3万 | 0.00% |
| CITADEL ADVISORS LLC | US$166.6万 | 0.00% |
| MARSHALL WACE, LLP | US$114.5万 | 0.00% |
| CIBC WORLD MARKET INC. | US$109.0万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$67.1万 | 0.00% |
| Hudson Bay Capital Management LP | US$66.9万 | 0.00% |
| TD Waterhouse Canada Inc. | US$59.0万 | 0.00% |
| INGALLS & SNYDER LLC | US$54.8万 | 0.02% |
| 1832 Asset Management L.P. | US$43.4万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$38.4万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$36.6万 | 0.00% |
| DIADEMA PARTNERS LP | US$29.0万 | 0.05% |
| BANK OF MONTREAL /CAN/ | US$27.6万 | 0.00% |
| Persistent Asset Partners Ltd | US$27.5万 | 0.10% |
| JANE STREET GROUP, LLC | US$25.4万 | 0.00% |
| TORONTO DOMINION BANK | US$23.7万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$18.5万 | 0.00% |
| AXQ CAPITAL, LP | US$11.4万 | 0.01% |
| Integrated Wealth Concepts LLC | US$8.7万 | 0.00% |
| TCI Wealth Advisors, Inc. | US$8.0万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$7.8万 | 0.00% |
| Aptus Capital Advisors, LLC | US$7.6万 | 0.00% |
| GUARDIAN WEALTH ADVISORS, LLC / NC | US$7.6万 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$7.2万 | 0.01% |
| MORGAN STANLEY | US$6.4万 | 0.00% |
| Federation des caisses Desjardins du Quebec | US$4.9万 | 0.00% |
| JPMORGAN CHASE & CO | US$3788.0 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$812.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$465.5 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$7.0 | 0.00% |