| MPM BIOIMPACT LLC | US$2798.0万 | 2.16% |
| Nextech Invest, Ltd. | US$1943.9万 | 1.37% |
| Deep Track Capital, LP | US$1943.9万 | 0.32% |
| Soleus Capital Management, L.P. | US$1824.3万 | 0.74% |
| Octagon Capital Advisors LP | US$1375.5万 | 1.52% |
| Blue Owl Capital Holdings LP | US$1333.3万 | 3.58% |
| Avidity Partners Management LP | US$1309.5万 | 2.65% |
| FRANKLIN RESOURCES INC | US$996.5万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$899.2万 | 0.00% |
| MARSHALL WACE, LLP | US$772.5万 | 0.01% |
| TCG Crossover Management, LLC | US$702.9万 | 0.20% |
| GREAT POINT PARTNERS LLC | US$586.5万 | 1.35% |
| MILLENNIUM MANAGEMENT LLC | US$373.2万 | 0.00% |
| Squadron Capital Management LLC | US$288.2万 | 1.06% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$286.6万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$262.0万 | 0.00% |
| Sio Capital Management, LLC | US$240.5万 | 0.34% |
| BlackRock, Inc. | US$221.8万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$158.3万 | 0.00% |
| Cormorant Asset Management, LP | US$138.7万 | 0.07% |
| JANE STREET GROUP, LLC | US$114.5万 | 0.00% |
| ADAR1 Capital Management, LLC | US$92.0万 | 0.05% |
| VANGUARD FIDUCIARY TRUST CO | US$89.4万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$75.3万 | 0.00% |
| Woodline Partners LP | US$65.5万 | 0.00% |
| STATE STREET CORP | US$61.2万 | 0.00% |
| Seven Fleet Capital Management LP | US$50.0万 | 0.16% |
| RENAISSANCE TECHNOLOGIES LLC | US$47.9万 | 0.00% |
| CITADEL ADVISORS LLC | US$36.7万 | 0.00% |
| HighTower Advisors, LLC | US$33.1万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$30.1万 | 0.00% |
| Pathstone Holdings, LLC | US$28.9万 | 0.00% |
| HRT FINANCIAL LP | US$27.5万 | 0.00% |
| Mill Creek Capital Advisors, LLC | US$27.4万 | 0.01% |
| NORTHERN TRUST CORP | US$27.1万 | 0.00% |
| Velan Capital Investment Management LP | US$26.2万 | 0.16% |
| Clear Harbor Asset Management, LLC | US$24.3万 | 0.02% |
| WINTON GROUP Ltd | US$21.3万 | 0.01% |
| OMERS ADMINISTRATION Corp | US$21.1万 | 0.00% |
| Brevan Howard Capital Management LP | US$16.1万 | 0.00% |
| Point72 Asset Management, L.P. | US$15.0万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | US$13.3万 | 0.00% |
| Corient Private Wealth LLC | US$7.0万 | 0.00% |
| Virtu Financial LLC | US$6.1万 | 0.00% |
| Cerity Partners LLC | US$5.2万 | 0.00% |
| Sanctuary Advisors, LLC | US$5.1万 | 0.00% |
| Vanguard Global Advisers, LLC | US$3.3万 | 0.00% |
| TWO SIGMA SECURITIES, LLC | US$3.3万 | 0.00% |
| CITIGROUP INC | US$3.2万 | 0.00% |
| Qube Research & Technologies Ltd | US$3.0万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$2.8万 | 0.00% |
| Legacy Capital Wealth Partners, LLC | US$2.7万 | 0.01% |
| JPMORGAN CHASE & CO | US$2.6万 | 0.00% |
| MORGAN STANLEY | US$2.4万 | 0.00% |
| UBS Group AG | US$1.6万 | 0.00% |
| FNY Investment Advisers, LLC | US$1.5万 | 0.01% |
| Strive Financial Group ,LLC | US$4000.0 | 0.00% |
| Farther Finance Advisors, LLC | US$3975.0 | 0.00% |
| Tower Research Capital LLC (TRC) | US$3228.0 | 0.00% |
| SBI Securities Co., Ltd. | US$204.0 | 0.00% |