| FMR LLC | US$8.9億 | 0.05% |
| BlackRock, Inc. | US$6.2億 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$3.5億 | 4.11% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$2.8億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$2.7億 | 0.01% |
| JANUS HENDERSON GROUP PLC | US$2.3億 | 0.11% |
| STATE STREET CORP | US$2.2億 | 0.01% |
| Fairmount Funds Management LLC | US$2.1億 | 15.30% |
| RTW INVESTMENTS, LP | US$2.1億 | 2.09% |
| TCG Crossover Management, LLC | US$1.9億 | 5.45% |
| GOLDMAN SACHS GROUP INC | US$1.7億 | 0.02% |
| Kynam Capital Management, LP | US$1.6億 | 9.59% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1.4億 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | US$1.4億 | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1.2億 | 0.01% |
| LORD, ABBETT & CO. LLC | US$1.2億 | 0.40% |
| Commodore Capital LP | US$1.1億 | 6.43% |
| Invesco Ltd. | US$9351.6萬 | 0.01% |
| Octagon Capital Advisors LP | US$9045.2萬 | 10.01% |
| Holocene Advisors, LP | US$8661.0萬 | 0.21% |
| Sofinnova Investments, Inc. | US$8135.1萬 | 3.09% |
| Venrock Adviser, LLC | US$7698.0萬 | 2.87% |
| CITADEL ADVISORS LLC | US$7341.7萬 | 0.01% |
| D. E. Shaw & Co., Inc. | US$7191.4萬 | 0.04% |
| Pictet Asset Management Holding SA | US$6882.6萬 | 0.07% |
| Siren, L.L.C. | US$6579.0萬 | 1.82% |
| MARSHALL WACE, LLP | US$6159.0萬 | 0.06% |
| EMERALD ADVISERS, LLC | US$6112.7萬 | 1.93% |
| Candriam S.C.A. | US$5836.2萬 | 0.30% |
| Woodline Partners LP | US$5810.3萬 | 0.22% |
| Point72 Asset Management, L.P. | US$5430.3萬 | 0.07% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$5058.3萬 | 5.16% |
| NORTHERN TRUST CORP | US$4794.9萬 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$4781.7萬 | 0.01% |
| FRED ALGER MANAGEMENT, LLC | US$4771.6萬 | 0.21% |
| Vestal Point Capital, LP | US$4737.7萬 | 1.32% |
| MILLENNIUM MANAGEMENT LLC | US$4589.6萬 | 0.02% |
| Elmind Capital, LP | US$4506.2萬 | 12.79% |
| VANGUARD FIDUCIARY TRUST CO | US$4072.6萬 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$4017.6萬 | 0.00% |
| EMERALD MUTUAL FUND ADVISERS TRUST | US$3960.0萬 | 1.92% |
| Deep Track Capital, LP | US$3849.0萬 | 0.63% |
| First Turn Management, LLC | US$3646.3萬 | 4.07% |
| AMERICAN CENTURY COMPANIES INC | US$3427.8萬 | 0.02% |
| Balyasny Asset Management L.P. | US$3297.0萬 | 0.04% |
| J. Goldman & Co LP | US$3260.8萬 | 0.95% |
| Nuveen, LLC | US$3200.8萬 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$3094.1萬 | 0.00% |
| Squadron Capital Management LLC | US$3031.1萬 | 11.11% |
| Affinity Asset Advisors, LLC | US$2886.8萬 | 1.49% |
| RENAISSANCE TECHNOLOGIES LLC | US$2718.4萬 | 0.04% |
| Redmile Group, LLC | US$2648.3萬 | 1.75% |
| Burkehill Global Management, LP | US$2598.1萬 | 1.29% |
| VOYA INVESTMENT MANAGEMENT LLC | US$2556.3萬 | 0.03% |
| MORGAN STANLEY | US$2473.7萬 | 0.00% |
| Saturn V Capital Management LP | US$2411.9萬 | 4.37% |
| Rock Springs Capital Management LP | US$2402.4萬 | 1.42% |
| Patient Square Capital LP | US$2294.0萬 | 4.07% |
| Ensign Peak Advisors, Inc | US$2205.0萬 | 0.04% |
| Fiera Capital Corp | US$2148.7萬 | 0.07% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | US$1730.1萬 | 0.01% |
| Vivo Capital, LLC | US$1625.4萬 | 1.35% |
| SPHERA FUNDS MANAGEMENT LTD. | US$1602.5萬 | 2.54% |
| Qube Research & Technologies Ltd | US$1516.5萬 | 0.02% |
| Russell Investments Group, Ltd. | US$1442.9萬 | 0.02% |
| Bank of New York Mellon Corp | US$1434.9萬 | 0.00% |
| ExodusPoint Capital Management, LP | US$1432.5萬 | 0.12% |
| RAYMOND JAMES FINANCIAL INC | US$1423.0萬 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$1387.5萬 | 0.29% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$1363.5萬 | 0.02% |
| Defilade Capital Management, L.P. | US$1357.1萬 | 1.91% |
| Integral Health Asset Management, LLC | US$1347.2萬 | 0.64% |
| Weiss Asset Management LP | US$1332.2萬 | 0.23% |
| Longaeva Partners L.P. | US$1289.4萬 | 0.48% |
| Hennion & Walsh Asset Management, Inc. | US$1256.6萬 | 0.42% |
| DIADEMA PARTNERS LP | US$1242.3萬 | 2.11% |
| ORBIMED ADVISORS LLC | US$1239.8萬 | 0.25% |
| Assenagon Asset Management S.A. | US$1138.0萬 | 0.02% |
| SummitTX Capital, L.P. | US$1130.8萬 | 0.35% |
| Atika Capital Management LLC | US$1128.5萬 | 1.78% |
| UBS Group AG | US$1121.9萬 | 0.00% |
| FEDERATED HERMES, INC. | US$1099.5萬 | 0.02% |
| Exome Asset Management LLC | US$1072.1萬 | 5.54% |
| Aberdeen Group plc | US$1049.6萬 | 0.02% |
| AMERIPRISE FINANCIAL INC | US$970.4萬 | 0.00% |
| Nantahala Capital Management, LLC | US$962.3萬 | 0.35% |
| Evergreen Quality Fund GP, Ltd. | US$962.3萬 | 0.22% |
| Alyeska Investment Group, L.P. | US$962.3萬 | 0.03% |
| Tidal Investments LLC | US$952.1萬 | 0.02% |
| NWI MANAGEMENT LP | US$930.2萬 | 0.53% |
| JPMORGAN CHASE & CO | US$929.7萬 | 0.00% |
| JANE STREET GROUP, LLC | US$910.6萬 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$884.3萬 | 0.13% |
| Squarepoint Ops LLC | US$870.9萬 | 0.01% |
| F/m Investments LLC | US$870.4萬 | 0.58% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$866.6萬 | 6.19% |
| Boxer Capital Management, LLC | US$866.0萬 | 1.14% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$859.2萬 | 0.01% |
| Hudson Bay Capital Management LP | US$799.0萬 | 0.03% |
| PEREGRINE CAPITAL MANAGEMENT LLC | US$777.3萬 | 0.29% |
| Cormorant Asset Management, LP | US$769.8萬 | 0.39% |
| SEI INVESTMENTS CO | US$760.2萬 | 0.01% |
| HighVista Strategies LLC | US$758.4萬 | 2.09% |
| Man Group plc | US$749.8萬 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | US$730.5萬 | 0.00% |
| PRUDENTIAL FINANCIAL INC | US$685.8萬 | 0.01% |
| Tema ETFs LLC | US$680.0萬 | 0.46% |
| RHUMBLINE ADVISERS | US$674.6萬 | 0.01% |
| Fisher Asset Management, LLC | US$644.4萬 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$637.0萬 | 0.00% |
| Swiss National Bank | US$636.6萬 | 0.00% |
| SEB Asset Management AB | US$632.9萬 | 0.03% |
| OSTERWEIS CAPITAL MANAGEMENT INC | US$580.5萬 | 0.30% |
| Seven Fleet Capital Management LP | US$575.0萬 | 1.82% |
| ALLIANCEBERNSTEIN L.P. | US$558.8萬 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | US$525.2萬 | 0.01% |
| NEXTBio Capital Management LP | US$504.9萬 | 2.34% |
| DEUTSCHE BANK AG\ | US$490.6萬 | 0.00% |
| Rafferty Asset Management, LLC | US$481.2萬 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$470.5萬 | 0.06% |
| Informed Momentum Co LLC | US$469.3萬 | 0.54% |
| PERCEPTIVE ADVISORS LLC | US$466.0萬 | 0.09% |
| Caption Management, LLC | US$461.9萬 | 0.03% |
| ALGERT GLOBAL LLC | US$446.7萬 | 0.07% |
| Schonfeld Strategic Advisors LLC | US$432.9萬 | 0.03% |
| PLATINUM INVESTMENT MANAGEMENT LTD | US$431.3萬 | 1.09% |
| Creative Planning | US$426.3萬 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | US$421.2萬 | 0.00% |
| Trexquant Investment LP | US$413.5萬 | 0.03% |
| WELLS FARGO & COMPANY/MN | US$410.5萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$406.1萬 | 0.00% |
| Knott David M Jr | US$400.3萬 | 2.38% |
| Pier Capital, LLC | US$389.9萬 | 0.64% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$388.7萬 | 0.00% |
| Parkman Healthcare Partners LLC | US$385.4萬 | 0.40% |
| Nicholas Investment Partners, LP | US$366.3萬 | 0.26% |
| Persistent Asset Partners Ltd | US$356.1萬 | 1.33% |
| Atom Investors LP | US$337.5萬 | 0.24% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$337.2萬 | 0.00% |
| TimesSquare Capital Management, LLC | US$327.2萬 | 0.06% |
| PRINCIPAL FINANCIAL GROUP INC | US$323.1萬 | 0.00% |
| Legal & General Group Plc | US$312.7萬 | 0.00% |
| SONA ASSET MANAGEMENT (US) LLC | US$307.9萬 | 0.06% |
| SECTOR GAMMA AS | US$307.9萬 | 0.73% |
| MetLife Investment Management, LLC | US$302.6萬 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$289.7萬 | 0.00% |
| LPL Financial LLC | US$285.4萬 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$271.2萬 | 0.01% |
| Vanguard Global Advisers, LLC | US$267.9萬 | 0.00% |
| Cinctive Capital Management LP | US$264.7萬 | 0.17% |