| BlackRock, Inc. | US$10.6億 | 0.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$5.6億 | 0.03% |
| Capital World Investors | US$5.1億 | 0.07% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$5.0億 | 0.01% |
| LSV ASSET MANAGEMENT | US$4.5億 | 0.97% |
| FMR LLC | US$4.3億 | 0.02% |
| FRANKLIN RESOURCES INC | US$3.7億 | 0.09% |
| DIMENSIONAL FUND ADVISORS LP | US$3.6億 | 0.07% |
| STATE STREET CORP | US$3.6億 | 0.01% |
| EcoR1 Capital, LLC | US$3.2億 | 13.69% |
| Bank of New York Mellon Corp | US$3.2億 | 0.06% |
| FULLER & THALER ASSET MANAGEMENT, INC. | US$3.2億 | 1.07% |
| AMERIPRISE FINANCIAL INC | US$3.0億 | 0.07% |
| CITADEL ADVISORS LLC | US$2.5億 | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | US$2.5億 | 0.11% |
| MILLENNIUM MANAGEMENT LLC | US$2.4億 | 0.10% |
| GEODE CAPITAL MANAGEMENT, LLC | US$2.3億 | 0.01% |
| JPMORGAN CHASE & CO | US$2.2億 | 0.01% |
| BANK OF AMERICA CORP /DE/ | US$1.9億 | 0.01% |
| Swedbank AB | US$1.9億 | 0.20% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | US$1.7億 | 0.19% |
| RENAISSANCE TECHNOLOGIES LLC | US$1.5億 | 0.24% |
| Holocene Advisors, LP | US$1.4億 | 0.33% |
| MORGAN STANLEY | US$1.3億 | 0.01% |
| Allianz Asset Management GmbH | US$1.2億 | 0.12% |
| Sofinnova Investments, Inc. | US$1.1億 | 4.30% |
| GMT Capital Corp | US$1.1億 | 5.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$1.0億 | 0.09% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | US$9779.3萬 | 1.01% |
| Pacer Advisors, Inc. | US$9509.5萬 | 0.27% |
| Boston Trust Walden Corp | US$9238.1萬 | 0.76% |
| NORTHERN TRUST CORP | US$9235.5萬 | 0.01% |
| GOLDENTREE ASSET MANAGEMENT LP | US$8976.3萬 | 5.32% |
| WELLINGTON MANAGEMENT GROUP LLP | US$8658.8萬 | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$8327.8萬 | 0.01% |
| Polaris Capital Management, LLC | US$7852.5萬 | 6.42% |
| Alyeska Investment Group, L.P. | US$7770.2萬 | 0.22% |
| SYSTEMATIC FINANCIAL MANAGEMENT LP | US$7696.5萬 | 1.76% |
| VANGUARD FIDUCIARY TRUST CO | US$7083.9萬 | 0.02% |
| GW&K Investment Management, LLC | US$7015.7萬 | 0.62% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$6908.9萬 | 0.15% |
| Point72 Asset Management, L.P. | US$6889.6萬 | 0.09% |
| UBS Group AG | US$6752.9萬 | 0.01% |
| Nuveen, LLC | US$6543.9萬 | 0.02% |
| AMERICAN CENTURY COMPANIES INC | US$6213.3萬 | 0.03% |
| Assenagon Asset Management S.A. | US$6049.6萬 | 0.09% |
| D. E. Shaw & Co., Inc. | US$5635.4萬 | 0.03% |
| JANE STREET GROUP, LLC | US$5265.3萬 | 0.01% |
| Qube Research & Technologies Ltd | US$4963.6萬 | 0.06% |
| VICTORY CAPITAL MANAGEMENT INC | US$4851.0萬 | 0.03% |
| GOLDMAN SACHS GROUP INC | US$4732.3萬 | 0.01% |
| Rockefeller Capital Management L.P. | US$4710.6萬 | 0.08% |
| Invesco Ltd. | US$4627.2萬 | 0.01% |
| BANK OF MONTREAL /CAN/ | US$4523.3萬 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$4484.5萬 | 0.01% |
| THOMPSON SIEGEL & WALMSLEY LLC | US$4418.0萬 | 0.77% |
| LOOMIS SAYLES & CO L P | US$3892.6萬 | 0.05% |
| SG Americas Securities, LLC | US$3775.4萬 | 0.04% |
| Quantinno Capital Management LP | US$3616.3萬 | 0.06% |
| RAYMOND JAMES FINANCIAL INC | US$3459.1萬 | 0.01% |
| ExodusPoint Capital Management, LP | US$3379.8萬 | 0.27% |
| PFM Health Sciences, LP | US$3367.8萬 | 3.07% |
| Jefferies Financial Group Inc. | US$3319.7萬 | 0.23% |
| PERCEPTIVE ADVISORS LLC | US$3213.9萬 | 0.63% |
| Retirement Systems of Alabama | US$3200.0萬 | 0.11% |
| Pictet Asset Management Holding SA | US$3178.2萬 | 0.03% |
| Krensavage Asset Management, LLC | US$3172.6萬 | 12.41% |
| RHUMBLINE ADVISERS | US$3110.7萬 | 0.03% |
| Saturn V Capital Management LP | US$3080.8萬 | 5.58% |
| WEDGE CAPITAL MANAGEMENT L L P/NC | US$3024.9萬 | 0.56% |
| Tri Locum Partners LP | US$2999.5萬 | 4.21% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$2793.5萬 | 0.01% |
| SEI INVESTMENTS CO | US$2784.4萬 | 0.03% |
| Legal & General Group Plc | US$2751.2萬 | 0.01% |
| PANAGORA ASSET MANAGEMENT INC | US$2712.8萬 | 0.10% |
| Perpetual Ltd | US$2663.4萬 | 0.41% |
| STIFEL FINANCIAL CORP | US$2637.5萬 | 0.02% |
| PRINCIPAL FINANCIAL GROUP INC | US$2561.7萬 | 0.01% |
| Man Group plc | US$2556.2萬 | 0.05% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$2547.0萬 | 0.04% |
| Aristotle Capital Management, LLC | US$2468.0萬 | 0.05% |
| CITIGROUP INC | US$2369.7萬 | 0.01% |
| California Public Employees Retirement System | US$2355.2萬 | 0.01% |
| Robeco Institutional Asset Management B.V. | US$2326.9萬 | 0.03% |
| Aberdeen Group plc | US$2157.6萬 | 0.03% |
| DekaBank Deutsche Girozentrale | US$2144.3萬 | 0.04% |
| CANADA PENSION PLAN INVESTMENT BOARD | US$2126.8萬 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | US$2103.2萬 | 0.01% |
| STOREBRAND ASSET MANAGEMENT AS | US$2063.2萬 | 0.06% |
| Swiss National Bank | US$2045.5萬 | 0.01% |
| KBC Group NV | US$1932.0萬 | 0.05% |
| Engineers Gate Manager LP | US$1758.0萬 | 0.22% |
| Gotham Asset Management, LLC | US$1732.2萬 | 0.05% |
| FIRST TRUST ADVISORS LP | US$1726.1萬 | 0.01% |
| Walleye Capital LLC | US$1715.9萬 | 0.07% |
| ENVESTNET ASSET MANAGEMENT INC | US$1688.4萬 | 0.00% |
| Rhenman & Partners Asset Management AB | US$1434.7萬 | 1.77% |
| SummitTX Capital, L.P. | US$1384.3萬 | 0.43% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | US$1340.0萬 | 0.04% |
| WELLS FARGO & COMPANY/MN | US$1294.8萬 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | US$1210.7萬 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1203.4萬 | 0.01% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | US$1179.3萬 | 0.05% |
| Schonfeld Strategic Advisors LLC | US$1174.8萬 | 0.08% |
| Illinois Municipal Retirement Fund | US$1169.9萬 | 0.15% |
| Tweedy, Browne Co LLC | US$1138.3萬 | 0.90% |
| NOMURA HOLDINGS INC | US$1137.2萬 | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1057.4萬 | 0.00% |
| Amundi | US$1051.9萬 | 0.00% |
| Russell Investments Group, Ltd. | US$1043.8萬 | 0.01% |
| ACADIAN ASSET MANAGEMENT LLC | US$1035.7萬 | 0.01% |
| DIADEMA PARTNERS LP | US$1035.1萬 | 1.76% |
| VAN ECK ASSOCIATES CORP | US$1018.6萬 | 0.01% |
| Portman Square Capital LLP | US$1002.0萬 | 0.39% |
| ALGERT GLOBAL LLC | US$992.9萬 | 0.15% |
| Rokos Capital Management LLP | US$983.3萬 | 0.07% |
| Simplify Asset Management Inc. | US$978.0萬 | 0.15% |
| RENAISSANCE GROUP LLC | US$967.3萬 | 0.40% |
| Hennion & Walsh Asset Management, Inc. | US$933.0萬 | 0.31% |
| VANGUARD ASSET MANAGEMENT, Ltd | US$928.7萬 | 0.01% |
| GREAT LAKES ADVISORS, LLC | US$925.3萬 | 0.08% |
| CASTLEARK MANAGEMENT LLC | US$921.4萬 | 0.30% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | US$916.7萬 | 0.03% |
| MARTINGALE ASSET MANAGEMENT L P | US$883.3萬 | 0.22% |
| SEB Asset Management AB | US$876.5萬 | 0.04% |
| Cerity Partners LLC | US$864.8萬 | 0.01% |
| ROYAL BANK OF CANADA | US$855.6萬 | 0.00% |
| BTC Capital Management, Inc. | US$826.8萬 | 0.56% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | US$818.6萬 | 0.01% |
| Susquehanna Portfolio Strategies, LLC | US$818.2萬 | 0.12% |
| LAZARD ASSET MANAGEMENT LLC | US$807.7萬 | 0.01% |
| State of Alaska, Department of Revenue | US$794.7萬 | 0.09% |
| DEAN INVESTMENT ASSOCIATES, LLC | US$792.4萬 | 1.12% |
| Vanguard Global Advisers, LLC | US$773.1萬 | 0.00% |
| Faithward Advisors, LLC | US$771.7萬 | 1.10% |
| Mariner, LLC | US$756.5萬 | 0.01% |
| IFP Advisors, Inc | US$740.1萬 | 0.15% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | US$728.0萬 | 0.01% |
| LPL Financial LLC | US$683.5萬 | 0.00% |
| HARVEY CAPITAL MANAGEMENT INC | US$667.7萬 | 1.52% |
| Cinctive Capital Management LP | US$655.7萬 | 0.43% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | US$651.0萬 | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | US$649.9萬 | 0.06% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$642.9萬 | 0.01% |
| Lighthouse Investment Partners, LLC | US$637.6萬 | 0.22% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$599.2萬 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | US$591.7萬 | 0.01% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | US$569.5萬 | 0.01% |
| MetLife Investment Management, LLC | US$564.3萬 | 0.03% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$563.7萬 | 0.02% |