| EcoR1 Capital, LLC | $5.8億 | 24.41% |
| Rubric Capital Management LP | $1.8億 | 1.86% |
| BlackRock, Inc. | $1.1億 | 0.00% |
| BVF INC/IL | $9350.3万 | 2.98% |
| PERCEPTIVE ADVISORS LLC | $8789.2万 | 1.72% |
| MORGAN STANLEY | $6211.3万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $4777.7万 | 0.06% |
| VANGUARD CAPITAL MANAGEMENT LLC | $4270.8万 | 0.00% |
| CITADEL ADVISORS LLC | $3131.3万 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | $2851.9万 | 0.01% |
| Nextech Invest, Ltd. | $2789.3万 | 1.96% |
| STATE STREET CORP | $2533.5万 | 0.00% |
| Capricorn Fund Managers Ltd | $2522.1万 | 3.93% |
| DEUTSCHE BANK AG\ | $2306.8万 | 0.01% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $1862.7万 | 0.01% |
| Assenagon Asset Management S.A. | $1822.9万 | 0.03% |
| FMR LLC | $1670.6万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $1652.4万 | 0.00% |
| Nuveen, LLC | $1631.8万 | 0.00% |
| GOLDMAN SACHS GROUP INC | $1501.1万 | 0.00% |
| MPM BIOIMPACT LLC | $1415.4万 | 1.09% |
| Prosight Management, LP | $1349.8万 | 2.21% |
| Qube Research & Technologies Ltd | $1281.9万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1251.7万 | 0.00% |
| Redmile Group, LLC | $1231.1万 | 0.82% |
| Hillsdale Investment Management Inc. | $865.4万 | 0.24% |
| SummitTX Capital, L.P. | $804.9万 | 0.25% |
| NORTHERN TRUST CORP | $801.8万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $799.7万 | 0.00% |
| ROYCE & ASSOCIATES LP | $749.2万 | 0.07% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $688.4万 | 0.00% |
| PICTON MAHONEY ASSET MANAGEMENT | $642.8万 | 0.05% |
| Granahan Investment Management, LLC | $627.9万 | 0.30% |
| HRT FINANCIAL LP | $595.6万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $592.8万 | 0.00% |
| D. E. Shaw & Co., Inc. | $590.0万 | 0.00% |
| JANE STREET GROUP, LLC | $568.3万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | $518.0万 | 0.02% |
| Man Group plc | $475.5万 | 0.01% |
| WELLS FARGO & COMPANY/MN | $474.8万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $463.6万 | 0.00% |
| FEDERATED HERMES, INC. | $456.8万 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | $441.7万 | 0.00% |
| UBS Group AG | $430.1万 | 0.00% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $409.8万 | 0.03% |
| KENNEDY CAPITAL MANAGEMENT LLC | $371.2万 | 0.08% |
| XTX Topco Ltd | $360.3万 | 0.06% |
| DIADEMA PARTNERS LP | $355.9万 | 0.61% |
| WELLINGTON MANAGEMENT GROUP LLP | $347.3万 | 0.00% |
| Invesco Ltd. | $314.6万 | 0.00% |
| Bank of New York Mellon Corp | $310.8万 | 0.00% |
| CITIGROUP INC | $286.3万 | 0.00% |
| JPMORGAN CHASE & CO | $276.2万 | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $263.4万 | 0.66% |
| Tidal Investments LLC | $262.7万 | 0.01% |
| Tema ETFs LLC | $262.7万 | 0.18% |
| Fisher Asset Management, LLC | $254.0万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $249.9万 | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | $227.0万 | 0.00% |
| KORNITZER CAPITAL MANAGEMENT INC /KS | $222.4万 | 0.05% |
| VANGUARD FIDUCIARY TRUST CO | $211.3万 | 0.00% |
| Squarepoint Ops LLC | $208.2万 | 0.00% |
| MACKENZIE FINANCIAL CORP | $207.1万 | 0.00% |
| Verdad Advisers, LP | $207.1万 | 2.33% |
| PRINCIPAL FINANCIAL GROUP INC | $196.7万 | 0.00% |
| FRANKLIN RESOURCES INC | $194.5万 | 0.00% |
| STIFEL FINANCIAL CORP | $192.2万 | 0.00% |
| RHUMBLINE ADVISERS | $188.8万 | 0.00% |
| CREDIT AGRICOLE S A | $187.8万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $185.9万 | 0.00% |
| Swiss National Bank | $185.8万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $177.4万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $165.5万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $147.2万 | 0.00% |
| Dana Investment Advisors, Inc. | $140.5万 | 0.04% |
| Campbell & CO Investment Adviser LLC | $137.4万 | 0.08% |
| DLD Asset Management, LP | $132.8万 | 0.12% |
| MILLENNIUM MANAGEMENT LLC | $125.2万 | 0.00% |
| Russell Investments Group, Ltd. | $118.8万 | 0.00% |
| ROYAL BANK OF CANADA | $118.7万 | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | $114.5万 | 0.02% |
| North Growth Management Ltd. | $114.0万 | 0.17% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $107.1万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $106.2万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $101.2万 | 0.00% |
| Manatuck Hill Partners, LLC | $100.2万 | 0.27% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $99.5万 | 0.00% |
| Quantinno Capital Management LP | $99.3万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $98.5万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $94.9万 | 0.00% |
| HSBC HOLDINGS PLC | $94.0万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $93.6万 | 0.00% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $93.0万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $92.3万 | 0.00% |
| HighTower Advisors, LLC | $90.8万 | 0.00% |
| Persistent Asset Partners Ltd | $90.0万 | 0.34% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $88.9万 | 0.00% |
| HighVista Strategies LLC | $85.3万 | 0.24% |
| Vinva Investment Management Ltd | $85.1万 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | $82.0万 | 0.02% |
| Creative Planning | $81.1万 | 0.00% |
| MARSHALL WACE, LLP | $80.7万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $79.1万 | 0.00% |
| Engineers Gate Manager LP | $79.0万 | 0.01% |
| SBI Okasan Asset Management Co.Ltd. | $77.5万 | 0.03% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $76.2万 | 0.00% |
| STRS OHIO | $75.4万 | 0.00% |
| MetLife Investment Management, LLC | $74.3万 | 0.00% |
| JOURNEY STRATEGIC WEALTH LLC | $72.7万 | 0.02% |
| OXFORD ASSET MANAGEMENT LLP | $69.6万 | 0.30% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $68.6万 | 0.00% |
| ExodusPoint Capital Management, LP | $68.5万 | 0.01% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $68.5万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $65.8万 | 0.00% |
| Legal & General Group Plc | $65.6万 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | $65.2万 | 0.00% |
| Walleye Capital LLC | $61.5万 | 0.00% |
| RITHOLTZ WEALTH MANAGEMENT | $60.7万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $58.5万 | 0.00% |
| Walleye Trading LLC | $57.6万 | 0.00% |
| Headlands Technologies LLC | $57.2万 | 0.07% |
| Duncan Williams Asset Management, LLC | $55.3万 | 0.15% |
| PRUDENTIAL FINANCIAL INC | $55.0万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $51.4万 | 0.03% |
| Jackson Creek Investment Advisors LLC | $46.8万 | 0.14% |
| BARCLAYS PLC | $46.0万 | 0.00% |
| JANUS HENDERSON GROUP PLC | $45.6万 | 0.00% |
| BANK OF MONTREAL /CAN/ | $43.7万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $43.5万 | 0.00% |
| State of Wyoming | $42.9万 | 0.05% |
| Quadrature Capital Ltd | $41.9万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $38.4万 | 0.00% |
| AGF MANAGEMENT LTD | $37.6万 | 0.00% |
| Amundi | $35.3万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $34.3万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $33.3万 | 0.03% |
| Freestone Grove Partners LP | $32.4万 | 0.00% |
| State of New Jersey Common Pension Fund D | $32.0万 | 0.00% |
| Northwest & Ethical Investments L.P. | $31.6万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | $31.4万 | 0.00% |
| Abacus Wealth Partners, LLC | $29.2万 | 0.03% |
| Janney Montgomery Scott LLC | $28.8万 | 0.00% |
| JAMES INVESTMENT RESEARCH, INC. | $27.4万 | 0.03% |
| Ewing Morris & Co. Investment Partners Ltd. | $27.2万 | 0.12% |
| Virtus Investment Advisers, LLC | $26.8万 | 0.07% |
| LAZARD ASSET MANAGEMENT LLC | $26.5万 | 0.00% |
| ProShare Advisors LLC | $26.5万 | 0.00% |
| SG Americas Securities, LLC | $26.1万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $25.7万 | 0.00% |
| PSP Research LLC | $25.0万 | 0.18% |