| BVF INC/IL | $3.0億 | 9.50% |
| Deep Track Capital, LP | $1.2億 | 1.95% |
| Cormorant Asset Management, LP | $8351.5万 | 4.19% |
| JANUS HENDERSON GROUP PLC | $6430.4万 | 0.03% |
| D. E. Shaw & Co., Inc. | $4456.2万 | 0.03% |
| CITADEL ADVISORS LLC | $3880.3万 | 0.01% |
| MPM BIOIMPACT LLC | $3375.9万 | 2.61% |
| Weiss Asset Management LP | $3184.3万 | 0.54% |
| Logos Global Management LP | $2796.0万 | 1.40% |
| Point72 Asset Management, L.P. | $2550.9万 | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $2413.7万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2252.9万 | 0.00% |
| GOLDMAN SACHS GROUP INC | $2106.8万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $2092.0万 | 0.02% |
| Balyasny Asset Management L.P. | $1986.3万 | 0.03% |
| BlackRock, Inc. | $1904.7万 | 0.00% |
| Vivo Capital, LLC | $1864.0万 | 1.55% |
| JPMORGAN CHASE & CO | $1842.9万 | 0.00% |
| Candriam S.C.A. | $1525.0万 | 0.08% |
| BANK OF AMERICA CORP /DE/ | $1351.0万 | 0.00% |
| MORGAN STANLEY | $1145.4万 | 0.00% |
| Holocene Advisors, LP | $1118.4万 | 0.03% |
| MILLENNIUM MANAGEMENT LLC | $1073.8万 | 0.00% |
| JANE STREET GROUP, LLC | $1067.2万 | 0.00% |
| GREAT POINT PARTNERS LLC | $932.0万 | 2.14% |
| Jefferies Financial Group Inc. | $932.0万 | 0.06% |
| Trexquant Investment LP | $923.3万 | 0.07% |
| HRT FINANCIAL LP | $908.8万 | 0.02% |
| ADAR1 Capital Management, LLC | $889.4万 | 0.52% |
| Casdin Capital, LLC | $838.8万 | 0.64% |
| Longaeva Partners L.P. | $764.2万 | 0.28% |
| Walleye Capital LLC | $704.0万 | 0.03% |
| Voleon Capital Management LP | $695.3万 | 0.15% |
| Jump Financial, LLC | $607.6万 | 0.08% |
| First Turn Management, LLC | $588.2万 | 0.66% |
| RENAISSANCE TECHNOLOGIES LLC | $515.9万 | 0.01% |
| Boxer Capital Management, LLC | $512.6万 | 0.67% |
| Susquehanna Portfolio Strategies, LLC | $473.4万 | 0.07% |
| Rhenman & Partners Asset Management AB | $446.4万 | 0.55% |
| Granahan Investment Management, LLC | $411.2万 | 0.20% |
| Exome Asset Management LLC | $401.5万 | 2.08% |
| HighVista Strategies LLC | $361.5万 | 1.00% |
| ACUTA CAPITAL PARTNERS, LLC | $357.4万 | 2.54% |
| CONGRESS ASSET MANAGEMENT CO | $332.8万 | 0.02% |
| Kalehua Capital Management LLC | $327.6万 | 2.32% |
| Ishara Investments LP | $324.8万 | 3.08% |
| RICE HALL JAMES & ASSOCIATES, LLC | $312.7万 | 0.17% |
| ALGERT GLOBAL LLC | $281.9万 | 0.04% |
| READYSTATE ASSET MANAGEMENT LP | $268.9万 | 0.12% |
| FMR LLC | $267.6万 | 0.00% |
| TD Asset Management Inc | $266.0万 | 0.00% |
| Invesco Ltd. | $260.2万 | 0.00% |
| J. Goldman & Co LP | $255.2万 | 0.07% |
| Y-Intercept (Hong Kong) Ltd | $236.9万 | 0.04% |
| ExodusPoint Capital Management, LP | $224.3万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $221.7万 | 0.00% |
| Centiva Capital, LP | $216.0万 | 0.02% |
| XTX Topco Ltd | $208.9万 | 0.04% |
| MARSHALL WACE, LLP | $207.5万 | 0.00% |
| Squarepoint Ops LLC | $205.4万 | 0.00% |
| Headlands Technologies LLC | $181.1万 | 0.21% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $177.7万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $149.6万 | 0.09% |
| TUDOR INVESTMENT CORP ET AL | $143.5万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $138.2万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $134.6万 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $130.7万 | 0.00% |
| Lion Point Capital, LP | $125.8万 | 7.52% |
| Rock Springs Capital Management LP | $115.0万 | 0.07% |
| Swiss National Bank | $114.6万 | 0.00% |
| ALPS ADVISORS INC | $108.8万 | 0.01% |
| STATE STREET CORP | $105.3万 | 0.00% |
| Avidity Partners Management LP | $93.2万 | 0.19% |
| PRELUDE CAPITAL MANAGEMENT, LLC | $91.1万 | 0.07% |
| AQR CAPITAL MANAGEMENT LLC | $86.1万 | 0.00% |
| Mariner, LLC | $83.8万 | 0.00% |
| Qube Research & Technologies Ltd | $80.0万 | 0.00% |
| Nuveen, LLC | $62.3万 | 0.00% |
| Brevan Howard Capital Management LP | $60.6万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $54.6万 | 0.00% |
| Schonfeld Strategic Advisors LLC | $53.5万 | 0.00% |
| BARCLAYS PLC | $51.5万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $49.0万 | 0.00% |
| Optimize Financial Inc | $45.5万 | 0.22% |
| VANGUARD ASSET MANAGEMENT, Ltd | $44.4万 | 0.00% |
| GROUP ONE TRADING LLC | $40.2万 | 0.00% |
| Quarry LP | $39.6万 | 0.07% |
| Graham Capital Management, L.P. | $39.3万 | 0.01% |
| Legal & General Group Plc | $38.3万 | 0.00% |
| NORTHERN TRUST CORP | $36.3万 | 0.00% |
| AXQ CAPITAL, LP | $35.9万 | 0.05% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $35.8万 | 0.00% |
| Virtus Investment Advisers, LLC | $34.4万 | 0.09% |
| Vident Advisory, LLC | $33.9万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | $30.5万 | 0.00% |
| OSAIC HOLDINGS, INC. | $29.6万 | 0.00% |
| WINTON GROUP Ltd | $29.2万 | 0.01% |
| Jain Global LLC | $28.6万 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | $28.0万 | 0.05% |
| CITIGROUP INC | $25.5万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $23.5万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $23.3万 | 0.00% |
| Entropy Technologies, LP | $22.1万 | 0.01% |
| CAPTRUST FINANCIAL ADVISORS | $21.3万 | 0.00% |
| IMC-Chicago, LLC | $21.2万 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | $21.0万 | 0.00% |
| State of New Jersey Common Pension Fund D | $20.3万 | 0.00% |
| Virtu Financial LLC | $19.6万 | 0.01% |
| SIG BROKERAGE, LP | $18.6万 | 0.00% |
| Crystal Cove Asset Management, LLC | $18.6万 | 0.22% |
| SG Americas Securities, LLC | $17.4万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $16.7万 | 0.00% |
| KLP KAPITALFORVALTNING AS | $12.7万 | 0.00% |
| Ensign Peak Advisors, Inc | $8.4万 | 0.00% |
| Advisors Asset Management, Inc. | $7.3万 | 0.00% |
| UBS Group AG | $7.2万 | 0.00% |
| Russell Investments Group, Ltd. | $6.4万 | 0.00% |
| SIMPLEX TRADING, LLC | $5.7万 | 0.00% |
| Caitong International Asset Management Co., Ltd | $5.7万 | 0.01% |
| EverSource Wealth Advisors, LLC | $5.3万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $4.5万 | 0.00% |
| US BANCORP \DE\ | $4.3万 | 0.00% |
| SIGNATUREFD, LLC | $4.2万 | 0.00% |
| DEUTSCHE BANK AG\ | $3.8万 | 0.00% |
| Parallel Advisors, LLC | $3.1万 | 0.00% |
| DecisionPoint Financial, LLC | $2.3万 | 0.00% |
| Delos Wealth Advisors, LLC | $1.9万 | 0.01% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $1.7万 | 0.00% |
| Allworth Financial LP | $1.2万 | 0.00% |
| Farther Finance Advisors, LLC | $1.2万 | 0.00% |
| SUMMIT SECURITIES GROUP LLC | $9618.0 | 0.00% |
| Avion Wealth | $9000.0 | 0.00% |
| QUADRANT CAPITAL GROUP LLC | $7140.0 | 0.00% |
| CWM, LLC | $5667.0 | 0.00% |
| Basecamp Wealth Advisors LLC | $4660.0 | 0.00% |
| Steward Partners Investment Advisory, LLC | $4548.0 | 0.00% |
| SBI Securities Co., Ltd. | $3970.0 | 0.00% |
| ROYAL BANK OF CANADA | $2000.0 | 0.00% |
| Quantbot Technologies LP | $1845.0 | 0.00% |
| CVA Family Office, LLC | $1118.0 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $901.0 | 0.00% |
| Cornerstone Financial Management LLC | $522.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | $224.0 | 0.00% |
| Essential Partners LLC | $149.0 | 0.00% |
| MAI Capital Management | $131.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | $112.0 | 0.00% |
| HUNTINGTON NATIONAL BANK | $112.0 | 0.00% |
| Arax Advisory Partners | $93.0 | 0.00% |
| Sunbelt Securities, Inc. | $19.0 | 0.00% |