| Frazier Life Sciences Management, L.P. | $2.0億 | 5.11% |
| ORBIMED ADVISORS LLC | $1.1億 | 2.23% |
| NEA Management Company, LLC | $1.1億 | 6.13% |
| WELLINGTON MANAGEMENT GROUP LLP | $9527.6万 | 0.02% |
| BlackRock, Inc. | $8780.1万 | 0.00% |
| FMR LLC | $8766.0万 | 0.00% |
| Deep Track Capital, LP | $8231.3万 | 1.34% |
| NVP ASSOCIATES, LLC | $6377.0万 | 36.20% |
| Polar Capital Holdings Plc | $4842.2万 | 0.17% |
| BRAIDWELL LP | $4455.0万 | 1.49% |
| VANGUARD CAPITAL MANAGEMENT LLC | $4410.6万 | 0.00% |
| Aaron Wealth Advisors LLC | $3487.0万 | 1.98% |
| Cormorant Asset Management, LP | $3343.2万 | 1.68% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $3071.7万 | 0.00% |
| Driehaus Capital Management LLC | $3039.4万 | 0.22% |
| CITADEL ADVISORS LLC | $2889.6万 | 0.00% |
| Kynam Capital Management, LP | $2790.4万 | 1.72% |
| Woodline Partners LP | $2686.7万 | 0.10% |
| EVENTIDE ASSET MANAGEMENT, LLC | $2656.7万 | 0.44% |
| Caligan Partners LP | $2533.0万 | 1.69% |
| Parkman Healthcare Partners LLC | $2388.1万 | 2.46% |
| STATE STREET CORP | $2349.8万 | 0.00% |
| EcoR1 Capital, LLC | $2319.3万 | 0.98% |
| GEODE CAPITAL MANAGEMENT, LLC | $2001.6万 | 0.00% |
| TCG Crossover Management, LLC | $1940.3万 | 0.56% |
| MILLENNIUM MANAGEMENT LLC | $1684.8万 | 0.01% |
| STEMPOINT CAPITAL LP | $1490.9万 | 2.85% |
| GOLDMAN SACHS GROUP INC | $1367.0万 | 0.00% |
| UBS Group AG | $1035.5万 | 0.00% |
| Candriam S.C.A. | $878.7万 | 0.05% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $875.5万 | 0.00% |
| D. E. Shaw & Co., Inc. | $862.3万 | 0.01% |
| Rock Springs Capital Management LP | $859.6万 | 0.51% |
| Opaleye Management Inc. | $776.1万 | 1.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $641.5万 | 0.00% |
| Elmind Capital, LP | $629.8万 | 1.79% |
| NORTHERN TRUST CORP | $628.6万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $621.0万 | 0.08% |
| Soleus Capital Management, L.P. | $534.0万 | 0.22% |
| DAFNA Capital Management LLC | $523.8万 | 1.19% |
| VANGUARD FIDUCIARY TRUST CO | $507.9万 | 0.00% |
| Goelzer Investment Management, Inc. | $490.1万 | 0.24% |
| Affinity Asset Advisors, LLC | $447.8万 | 0.23% |
| Tetragon Partners GP Ltd | $434.3万 | 0.84% |
| JPMORGAN CHASE & CO | $395.9万 | 0.00% |
| Schonfeld Strategic Advisors LLC | $369.6万 | 0.03% |
| KVP Capital Advisors, LP | $362.7万 | 2.71% |
| TD Asset Management Inc | $346.3万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $343.5万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $305.6万 | 0.00% |
| Burkehill Global Management, LP | $298.5万 | 0.15% |
| Squarepoint Ops LLC | $290.2万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $270.5万 | 0.00% |
| Nuveen, LLC | $244.1万 | 0.00% |
| Bank of New York Mellon Corp | $239.5万 | 0.00% |
| PFM Health Sciences, LP | $214.6万 | 0.20% |
| VICTORY CAPITAL MANAGEMENT INC | $212.0万 | 0.00% |
| MARSHALL WACE, LLP | $187.2万 | 0.00% |
| XTX Topco Ltd | $158.8万 | 0.03% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $154.3万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $139.6万 | 0.00% |
| Swiss National Bank | $132.5万 | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $130.1万 | 0.33% |
| JANE STREET GROUP, LLC | $124.8万 | 0.00% |
| ALPS ADVISORS INC | $109.1万 | 0.01% |
| ALGERT GLOBAL LLC | $107.5万 | 0.02% |
| Creative Planning | $107.4万 | 0.00% |
| EXCHANGE TRADED CONCEPTS, LLC | $102.3万 | 0.01% |
| RHUMBLINE ADVISERS | $101.1万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $96.2万 | 0.00% |
| MORGAN STANLEY | $94.2万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | $85.8万 | 0.00% |
| ExodusPoint Capital Management, LP | $83.8万 | 0.01% |
| Invesco Ltd. | $82.2万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $81.8万 | 0.00% |
| DEUTSCHE BANK AG\ | $68.5万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $68.0万 | 0.00% |
| Swiss Life Asset Management Ltd | $65.7万 | 0.00% |
| Cerity Partners LLC | $63.2万 | 0.00% |
| Legal & General Group Plc | $57.8万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $57.5万 | 0.00% |
| Koa Wealth Management, LLC | $53.5万 | 0.39% |
| Engineers Gate Manager LP | $51.9万 | 0.01% |
| Qube Research & Technologies Ltd | $51.3万 | 0.00% |
| Vanguard Global Advisers, LLC | $47.8万 | 0.00% |
| MetLife Investment Management, LLC | $47.8万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $44.0万 | 0.00% |
| Optimize Financial Inc | $43.3万 | 0.21% |
| CITIGROUP INC | $40.3万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $39.8万 | 0.00% |
| Jump Financial, LLC | $37.9万 | 0.01% |
| BARCLAYS PLC | $35.3万 | 0.00% |
| HighVista Strategies LLC | $34.2万 | 0.09% |
| CANADA PENSION PLAN INVESTMENT BOARD | $32.5万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $32.1万 | 0.00% |
| JANUS HENDERSON GROUP PLC | $30.8万 | 0.00% |
| Verition Fund Management LLC | $30.5万 | 0.00% |
| Aquatic Capital Management LLC | $30.3万 | 0.01% |
| Virtus Investment Advisers, LLC | $27.3万 | 0.08% |
| NEW YORK STATE COMMON RETIREMENT FUND | $26.9万 | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | $26.9万 | 0.21% |
| SEI INVESTMENTS CO | $26.8万 | 0.00% |
| Tidal Investments LLC | $26.5万 | 0.00% |
| Tema ETFs LLC | $26.5万 | 0.02% |
| ACADIAN ASSET MANAGEMENT LLC | $26.2万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $26.0万 | 0.00% |
| PROFUND ADVISORS LLC | $25.0万 | 0.01% |
| China Universal Asset Management Co., Ltd. | $23.8万 | 0.02% |
| Orion Porfolio Solutions, LLC | $23.7万 | 0.00% |
| State of New Jersey Common Pension Fund D | $22.9万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $22.4万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $22.4万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $21.6万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $20.4万 | 0.00% |
| GROUP ONE TRADING LLC | $18.7万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $18.2万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $16.7万 | 0.00% |
| KLP KAPITALFORVALTNING AS | $14.6万 | 0.00% |
| Russell Investments Group, Ltd. | $11.5万 | 0.00% |
| SG Americas Securities, LLC | $10.1万 | 0.00% |
| Rockefeller Capital Management L.P. | $9.6万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $7.0万 | 0.00% |
| Ameritas Investment Partners, Inc. | $6.9万 | 0.00% |
| Cygnus Capital Advisors, LLC | $5.4万 | 0.04% |
| CWM, LLC | $5.3万 | 0.00% |
| STRS OHIO | $4.8万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | $4.8万 | 0.00% |
| Tower Research Capital LLC (TRC) | $4.2万 | 0.00% |
| SIMPLEX TRADING, LLC | $3.9万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | $3.0万 | 0.00% |
| Sterling Capital Management LLC | $2.8万 | 0.00% |
| KBC Group NV | $2.4万 | 0.00% |
| ROYAL BANK OF CANADA | $2.2万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $1.4万 | 0.00% |
| GAMMA Investing LLC | $8925.0 | 0.00% |
| US BANCORP \DE\ | $8477.0 | 0.00% |
| OSAIC HOLDINGS, INC. | $8029.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | $6178.0 | 0.00% |
| SIGNATUREFD, LLC | $5343.0 | 0.00% |
| FIL Ltd | $5313.0 | 0.00% |
| Physician Wealth Advisors, Inc. | $3254.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $3099.6 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $2280.0 | 0.00% |
| Allworth Financial LP | $2090.0 | 0.00% |
| Parallel Advisors, LLC | $1821.0 | 0.00% |
| Larson Financial Group LLC | $1463.0 | 0.00% |
| Cornerstone Financial Management LLC | $1015.0 | 0.00% |
| EverSource Wealth Advisors, LLC | $746.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | $716.0 | 0.00% |
| Versant Capital Management, Inc | $716.0 | 0.00% |