| BlackRock, Inc. | $10.6億 | 0.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $5.6億 | 0.03% |
| Capital World Investors | $5.1億 | 0.07% |
| VANGUARD CAPITAL MANAGEMENT LLC | $5.0億 | 0.01% |
| LSV ASSET MANAGEMENT | $4.5億 | 0.97% |
| FMR LLC | $4.3億 | 0.02% |
| FRANKLIN RESOURCES INC | $3.7億 | 0.09% |
| DIMENSIONAL FUND ADVISORS LP | $3.6億 | 0.07% |
| STATE STREET CORP | $3.6億 | 0.01% |
| EcoR1 Capital, LLC | $3.2億 | 13.69% |
| Bank of New York Mellon Corp | $3.2億 | 0.06% |
| FULLER & THALER ASSET MANAGEMENT, INC. | $3.2億 | 1.07% |
| AMERIPRISE FINANCIAL INC | $3.0億 | 0.07% |
| CITADEL ADVISORS LLC | $2.5億 | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | $2.5億 | 0.11% |
| MILLENNIUM MANAGEMENT LLC | $2.4億 | 0.10% |
| GEODE CAPITAL MANAGEMENT, LLC | $2.3億 | 0.01% |
| JPMORGAN CHASE & CO | $2.2億 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $1.9億 | 0.01% |
| Swedbank AB | $1.9億 | 0.20% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $1.7億 | 0.19% |
| RENAISSANCE TECHNOLOGIES LLC | $1.5億 | 0.24% |
| Holocene Advisors, LP | $1.4億 | 0.33% |
| MORGAN STANLEY | $1.3億 | 0.01% |
| Allianz Asset Management GmbH | $1.2億 | 0.12% |
| Sofinnova Investments, Inc. | $1.1億 | 4.30% |
| GMT Capital Corp | $1.1億 | 5.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1.0億 | 0.09% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $9779.3万 | 1.01% |
| Pacer Advisors, Inc. | $9509.5万 | 0.27% |
| Boston Trust Walden Corp | $9238.1万 | 0.76% |
| NORTHERN TRUST CORP | $9235.5万 | 0.01% |
| GOLDENTREE ASSET MANAGEMENT LP | $8976.3万 | 5.32% |
| WELLINGTON MANAGEMENT GROUP LLP | $8658.8万 | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $8327.8万 | 0.01% |
| Polaris Capital Management, LLC | $7852.5万 | 6.42% |
| Alyeska Investment Group, L.P. | $7770.2万 | 0.22% |
| SYSTEMATIC FINANCIAL MANAGEMENT LP | $7696.5万 | 1.76% |
| VANGUARD FIDUCIARY TRUST CO | $7083.9万 | 0.02% |
| GW&K Investment Management, LLC | $7015.7万 | 0.62% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $6908.9万 | 0.15% |
| Point72 Asset Management, L.P. | $6889.6万 | 0.09% |
| UBS Group AG | $6752.9万 | 0.01% |
| Nuveen, LLC | $6543.9万 | 0.02% |
| AMERICAN CENTURY COMPANIES INC | $6213.3万 | 0.03% |
| Assenagon Asset Management S.A. | $6049.6万 | 0.09% |
| D. E. Shaw & Co., Inc. | $5635.4万 | 0.03% |
| JANE STREET GROUP, LLC | $5265.3万 | 0.01% |
| Qube Research & Technologies Ltd | $4963.6万 | 0.06% |
| VICTORY CAPITAL MANAGEMENT INC | $4851.0万 | 0.03% |
| GOLDMAN SACHS GROUP INC | $4732.3万 | 0.01% |
| Rockefeller Capital Management L.P. | $4710.6万 | 0.08% |
| Invesco Ltd. | $4627.2万 | 0.01% |
| BANK OF MONTREAL /CAN/ | $4523.3万 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4484.5万 | 0.01% |
| THOMPSON SIEGEL & WALMSLEY LLC | $4418.0万 | 0.77% |
| LOOMIS SAYLES & CO L P | $3892.6万 | 0.05% |
| SG Americas Securities, LLC | $3775.4万 | 0.04% |
| Quantinno Capital Management LP | $3616.3万 | 0.06% |
| RAYMOND JAMES FINANCIAL INC | $3459.1万 | 0.01% |
| ExodusPoint Capital Management, LP | $3379.8万 | 0.27% |
| PFM Health Sciences, LP | $3367.8万 | 3.07% |
| Jefferies Financial Group Inc. | $3319.7万 | 0.23% |
| PERCEPTIVE ADVISORS LLC | $3213.9万 | 0.63% |
| Retirement Systems of Alabama | $3200.0万 | 0.11% |
| Pictet Asset Management Holding SA | $3178.2万 | 0.03% |
| Krensavage Asset Management, LLC | $3172.6万 | 12.41% |
| RHUMBLINE ADVISERS | $3110.7万 | 0.03% |
| Saturn V Capital Management LP | $3080.8万 | 5.58% |
| WEDGE CAPITAL MANAGEMENT L L P/NC | $3024.9万 | 0.56% |
| Tri Locum Partners LP | $2999.5万 | 4.21% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $2793.5万 | 0.01% |
| SEI INVESTMENTS CO | $2784.4万 | 0.03% |
| Legal & General Group Plc | $2751.2万 | 0.01% |
| PANAGORA ASSET MANAGEMENT INC | $2712.8万 | 0.10% |
| Perpetual Ltd | $2663.4万 | 0.41% |
| STIFEL FINANCIAL CORP | $2637.5万 | 0.02% |
| PRINCIPAL FINANCIAL GROUP INC | $2561.7万 | 0.01% |
| Man Group plc | $2556.2万 | 0.05% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $2547.0万 | 0.04% |
| Aristotle Capital Management, LLC | $2468.0万 | 0.05% |
| CITIGROUP INC | $2369.7万 | 0.01% |
| California Public Employees Retirement System | $2355.2万 | 0.01% |
| Robeco Institutional Asset Management B.V. | $2326.9万 | 0.03% |
| Aberdeen Group plc | $2157.6万 | 0.03% |
| DekaBank Deutsche Girozentrale | $2144.3万 | 0.04% |
| CANADA PENSION PLAN INVESTMENT BOARD | $2126.8万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | $2103.2万 | 0.01% |
| STOREBRAND ASSET MANAGEMENT AS | $2063.2万 | 0.06% |
| Swiss National Bank | $2045.5万 | 0.01% |
| KBC Group NV | $1932.0万 | 0.05% |
| Engineers Gate Manager LP | $1758.0万 | 0.22% |
| Gotham Asset Management, LLC | $1732.2万 | 0.05% |
| FIRST TRUST ADVISORS LP | $1726.1万 | 0.01% |
| Walleye Capital LLC | $1715.9万 | 0.07% |
| ENVESTNET ASSET MANAGEMENT INC | $1688.4万 | 0.00% |
| Rhenman & Partners Asset Management AB | $1434.7万 | 1.77% |
| SummitTX Capital, L.P. | $1384.3万 | 0.43% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $1340.0万 | 0.04% |
| WELLS FARGO & COMPANY/MN | $1294.8万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $1210.7万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1203.4万 | 0.01% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | $1179.3万 | 0.05% |
| Schonfeld Strategic Advisors LLC | $1174.8万 | 0.08% |
| Illinois Municipal Retirement Fund | $1169.9万 | 0.15% |
| Tweedy, Browne Co LLC | $1138.3万 | 0.90% |
| NOMURA HOLDINGS INC | $1137.2万 | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1057.4万 | 0.00% |
| Amundi | $1051.9万 | 0.00% |
| Russell Investments Group, Ltd. | $1043.8万 | 0.01% |
| ACADIAN ASSET MANAGEMENT LLC | $1035.7万 | 0.01% |
| DIADEMA PARTNERS LP | $1035.1万 | 1.76% |
| VAN ECK ASSOCIATES CORP | $1018.6万 | 0.01% |
| Portman Square Capital LLP | $1002.0万 | 0.39% |
| ALGERT GLOBAL LLC | $992.9万 | 0.15% |
| Rokos Capital Management LLP | $983.3万 | 0.07% |
| Simplify Asset Management Inc. | $978.0万 | 0.15% |
| RENAISSANCE GROUP LLC | $967.3万 | 0.40% |
| Hennion & Walsh Asset Management, Inc. | $933.0万 | 0.31% |
| VANGUARD ASSET MANAGEMENT, Ltd | $928.7万 | 0.01% |
| GREAT LAKES ADVISORS, LLC | $925.3万 | 0.08% |
| CASTLEARK MANAGEMENT LLC | $921.4万 | 0.30% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $916.7万 | 0.03% |
| MARTINGALE ASSET MANAGEMENT L P | $883.3万 | 0.22% |
| SEB Asset Management AB | $876.5万 | 0.04% |
| Cerity Partners LLC | $864.8万 | 0.01% |
| ROYAL BANK OF CANADA | $855.6万 | 0.00% |
| BTC Capital Management, Inc. | $826.8万 | 0.56% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $818.6万 | 0.01% |
| Susquehanna Portfolio Strategies, LLC | $818.2万 | 0.12% |
| LAZARD ASSET MANAGEMENT LLC | $807.7万 | 0.01% |
| State of Alaska, Department of Revenue | $794.7万 | 0.09% |
| DEAN INVESTMENT ASSOCIATES, LLC | $792.4万 | 1.12% |
| Vanguard Global Advisers, LLC | $773.1万 | 0.00% |
| Faithward Advisors, LLC | $771.7万 | 1.10% |
| Mariner, LLC | $756.5万 | 0.01% |
| IFP Advisors, Inc | $740.1万 | 0.15% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $728.0万 | 0.01% |
| LPL Financial LLC | $683.5万 | 0.00% |
| HARVEY CAPITAL MANAGEMENT INC | $667.7万 | 1.52% |
| Cinctive Capital Management LP | $655.7万 | 0.43% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $651.0万 | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | $649.9万 | 0.06% |
| STATE OF WISCONSIN INVESTMENT BOARD | $642.9万 | 0.01% |
| Lighthouse Investment Partners, LLC | $637.6万 | 0.22% |
| NEW YORK STATE COMMON RETIREMENT FUND | $599.2万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $591.7万 | 0.01% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $569.5万 | 0.01% |
| MetLife Investment Management, LLC | $564.3万 | 0.03% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $563.7万 | 0.02% |