| FMR LLC | $9.7億 | 0.05% |
| BAKER BROS. ADVISORS LP | $7.2億 | 4.14% |
| Avoro Capital Advisors LLC | $6.2億 | 6.12% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $5.0億 | 0.06% |
| BVF INC/IL | $4.6億 | 14.60% |
| T. Rowe Price Investment Management, Inc. | $4.6億 | 0.31% |
| BlackRock, Inc. | $4.2億 | 0.01% |
| Atlas Venture Life Science Advisors, LLC | $3.8億 | 48.26% |
| WELLINGTON MANAGEMENT GROUP LLP | $3.2億 | 0.06% |
| Siren, L.L.C. | $2.7億 | 7.36% |
| VANGUARD CAPITAL MANAGEMENT LLC | $2.4億 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2.4億 | 0.01% |
| STATE STREET CORP | $2.0億 | 0.01% |
| Capital Research Global Investors | $1.4億 | 0.02% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.4億 | 0.01% |
| Driehaus Capital Management LLC | $8692.0万 | 0.64% |
| UBS Group AG | $8527.7万 | 0.01% |
| GOLDMAN SACHS GROUP INC | $7399.6万 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $7295.1万 | 0.02% |
| Holocene Advisors, LP | $6969.4万 | 0.17% |
| ALLIANCEBERNSTEIN L.P. | $6909.8万 | 0.02% |
| Merck & Co., Inc. | $6431.4万 | 18.40% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $6328.8万 | 0.65% |
| Commodore Capital LP | $6246.8万 | 3.61% |
| EVENTIDE ASSET MANAGEMENT, LLC | $5221.3万 | 0.86% |
| DIMENSIONAL FUND ADVISORS LP | $4935.9万 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $4674.0万 | 0.55% |
| FEDERATED HERMES, INC. | $4470.0万 | 0.07% |
| JENNISON ASSOCIATES LLC | $4239.5万 | 0.03% |
| Rock Springs Capital Management LP | $4138.4万 | 2.44% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4125.0万 | 0.01% |
| NORTHERN TRUST CORP | $4118.2万 | 0.01% |
| Pictet Asset Management Holding SA | $3876.0万 | 0.04% |
| VANGUARD FIDUCIARY TRUST CO | $3559.7万 | 0.01% |
| Octagon Capital Advisors LP | $3539.8万 | 3.92% |
| FRANKLIN RESOURCES INC | $3013.2万 | 0.01% |
| Alyeska Investment Group, L.P. | $2854.3万 | 0.08% |
| BRAIDWELL LP | $2811.5万 | 0.94% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2790.2万 | 0.04% |
| Boxer Capital Management, LLC | $2741.1万 | 3.60% |
| BANK OF AMERICA CORP /DE/ | $2410.5万 | 0.00% |
| TD Asset Management Inc | $2391.3万 | 0.02% |
| Nextech Invest, Ltd. | $2322.9万 | 1.63% |
| TWO SIGMA INVESTMENTS, LP | $2136.4万 | 0.02% |
| First Turn Management, LLC | $2121.2万 | 2.37% |
| RTW INVESTMENTS, LP | $1999.0万 | 0.20% |
| GILDER GAGNON HOWE & CO LLC | $1960.9万 | 0.24% |
| Polar Capital Holdings Plc | $1792.4万 | 0.06% |
| MORGAN STANLEY | $1771.6万 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $1740.8万 | 0.01% |
| Woodline Partners LP | $1695.7万 | 0.06% |
| Candriam S.C.A. | $1679.7万 | 0.09% |
| VOYA INVESTMENT MANAGEMENT LLC | $1655.9万 | 0.02% |
| Bank of New York Mellon Corp | $1609.2万 | 0.00% |
| TimesSquare Capital Management, LLC | $1406.3万 | 0.24% |
| Freestone Grove Partners LP | $1305.7万 | 0.09% |
| CITADEL ADVISORS LLC | $1296.8万 | 0.00% |
| Foresite Capital Management VI LLC | $1218.8万 | 2.65% |
| Eagle Health Investments LP | $1214.5万 | 2.12% |
| WCM INVESTMENT MANAGEMENT, LLC | $1211.1万 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1116.1万 | 0.00% |
| Nuveen, LLC | $1066.9万 | 0.00% |
| Deer Management Co. LLC | $1048.6万 | 1.69% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1000.7万 | 0.01% |
| JPMORGAN CHASE & CO | $996.8万 | 0.00% |
| Ensign Peak Advisors, Inc | $948.2万 | 0.02% |
| Invesco Ltd. | $919.6万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $868.5万 | 0.02% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $859.6万 | 0.01% |
| Patient Square Capital LP | $832.9万 | 1.48% |
| Swiss National Bank | $787.1万 | 0.00% |
| FIRST TRUST ADVISORS LP | $779.7万 | 0.01% |
| DEUTSCHE BANK AG\ | $765.3万 | 0.00% |
| ARMISTICE CAPITAL, LLC | $698.6万 | 0.12% |
| Burkehill Global Management, LP | $624.7万 | 0.31% |
| Yiheng Capital Management, L.P. | $611.7万 | 2.65% |
| RHUMBLINE ADVISERS | $597.0万 | 0.01% |
| NEUBERGER BERMAN GROUP LLC | $592.3万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $566.3万 | 0.00% |
| ALPS ADVISORS INC | $553.5万 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $536.9万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $468.8万 | 0.00% |
| Rafferty Asset Management, LLC | $460.9万 | 0.02% |
| FIFTH THIRD BANCORP | $426.8万 | 0.01% |
| Ikarian Capital, LLC | $419.8万 | 0.34% |
| Russell Investments Group, Ltd. | $406.6万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $374.7万 | 0.00% |
| Informed Momentum Co LLC | $352.7万 | 0.41% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $343.7万 | 0.00% |
| Moody Aldrich Partners LLC | $318.1万 | 0.57% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $317.5万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $309.7万 | 0.01% |
| Legal & General Group Plc | $306.0万 | 0.00% |
| Monashee Investment Management LLC | $292.3万 | 1.59% |
| HARBOR CAPITAL ADVISORS, INC. | $282.8万 | 0.23% |
| Rockefeller Capital Management L.P. | $269.6万 | 0.00% |
| Sio Capital Management, LLC | $268.5万 | 0.39% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $267.0万 | 0.01% |
| MetLife Investment Management, LLC | $262.4万 | 0.01% |
| Nan Fung Group Holdings Ltd | $257.2万 | 2.12% |
| SEVEN GRAND MANAGERS, LLC | $249.9万 | 0.17% |
| ExodusPoint Capital Management, LP | $235.9万 | 0.02% |
| Creative Planning | $235.3万 | 0.00% |
| Nicholas Investment Partners, LP | $227.8万 | 0.16% |
| Vanguard Global Advisers, LLC | $226.1万 | 0.00% |
| Neo Ivy Capital Management | $225.2万 | 0.59% |
| WELLS FARGO & COMPANY/MN | $222.9万 | 0.00% |
| E Fund Management Co., Ltd. | $218.5万 | 0.06% |
| Erste Asset Management GmbH | $214.6万 | 0.02% |
| PROFUND ADVISORS LLC | $209.4万 | 0.08% |
| JANE STREET GROUP, LLC | $206.1万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $182.1万 | 0.00% |
| DARK FOREST CAPITAL MANAGEMENT LP | $181.2万 | 0.16% |
| JANUS HENDERSON GROUP PLC | $175.4万 | 0.00% |
| BAMCO INC /NY/ | $166.6万 | 0.01% |
| AJU IB Investment Co., Ltd. | $163.6万 | 5.36% |
| LBP AM SA | $157.3万 | 0.02% |
| Handelsbanken Fonder AB | $149.9万 | 0.00% |
| State of New Jersey Common Pension Fund D | $135.9万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $132.9万 | 0.00% |
| Knights of Columbus Asset Advisors LLC | $132.2万 | 0.07% |
| Police & Firemen's Retirement System of New Jersey | $129.0万 | 0.01% |
| Odyssean, LLC | $123.4万 | 0.45% |
| BOOTHBAY FUND MANAGEMENT, LLC | $123.3万 | 0.02% |
| China Universal Asset Management Co., Ltd. | $120.7万 | 0.09% |
| BARCLAYS PLC | $118.7万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $114.7万 | 0.02% |
| INTECH INVESTMENT MANAGEMENT LLC | $113.9万 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | $113.8万 | 0.02% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $113.6万 | 0.00% |
| Man Group plc | $111.1万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $109.2万 | 0.01% |
| GUGGENHEIM CAPITAL LLC | $109.0万 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $108.5万 | 0.01% |
| Squarepoint Ops LLC | $106.9万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $105.4万 | 0.07% |
| Schonfeld Strategic Advisors LLC | $104.8万 | 0.01% |
| Vanguard Investments Australia, Ltd. | $103.7万 | 0.00% |
| CITIGROUP INC | $102.1万 | 0.00% |
| B. Metzler seel. Sohn & Co. AG | $100.6万 | 0.01% |
| ProShare Advisors LLC | $99.6万 | 0.00% |
| SEI INVESTMENTS CO | $93.5万 | 0.00% |
| Proficio Capital Partners LLC | $90.3万 | 0.05% |
| KLP KAPITALFORVALTNING AS | $87.5万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $74.5万 | 0.00% |
| Vident Advisory, LLC | $70.3万 | 0.01% |
| BRANDYWINE MANAGERS, LLC | $63.1万 | 0.37% |
| Keudell/Morrison Wealth Management | $58.2万 | 0.12% |
| GLENMEDE TRUST CO NA | $56.5万 | 0.00% |
| Blackstone Inc. | $55.5万 | 0.00% |