| RTW INVESTMENTS, LP | $2.8億 | 2.77% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2.7億 | 0.41% |
| Boxer Capital Management, LLC | $2.3億 | 29.87% |
| TCG Crossover Management, LLC | $2.2億 | 6.30% |
| FMR LLC | $2.1億 | 0.01% |
| FARALLON CAPITAL MANAGEMENT LLC | $1.9億 | 1.08% |
| BlackRock, Inc. | $1.8億 | 0.00% |
| Woodline Partners LP | $1.7億 | 0.63% |
| Nextech Invest, Ltd. | $1.5億 | 10.70% |
| TRV GP IV, LLC | $1.3億 | 49.96% |
| Siren, L.L.C. | $1.2億 | 3.28% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1.1億 | 0.00% |
| GOLDMAN SACHS GROUP INC | $1.1億 | 0.01% |
| STATE STREET CORP | $9731.8万 | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $8675.1万 | 1.02% |
| Paradigm Biocapital Advisors LP | $8388.2万 | 1.71% |
| Holocene Advisors, LP | $8227.0万 | 0.20% |
| Balyasny Asset Management L.P. | $8005.4万 | 0.10% |
| Logos Global Management LP | $6276.0万 | 3.13% |
| Deep Track Capital, LP | $5753.0万 | 0.94% |
| GEODE CAPITAL MANAGEMENT, LLC | $5599.0万 | 0.00% |
| Caligan Partners LP | $5039.2万 | 3.35% |
| Bellevue Group AG | $5020.8万 | 1.19% |
| JANUS HENDERSON GROUP PLC | $5006.7万 | 0.02% |
| Vivo Capital, LLC | $4507.8万 | 3.75% |
| MORGAN STANLEY | $3090.9万 | 0.00% |
| Cormorant Asset Management, LP | $2981.1万 | 1.50% |
| FRANKLIN RESOURCES INC | $2711.8万 | 0.01% |
| Candriam S.C.A. | $2655.3万 | 0.14% |
| Nantahala Capital Management, LLC | $2615.9万 | 0.96% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1885.9万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1860.8万 | 0.00% |
| NORTHERN TRUST CORP | $1805.3万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1754.5万 | 0.00% |
| PERCEPTIVE ADVISORS LLC | $1690.7万 | 0.33% |
| BESSEMER GROUP INC | $1482.0万 | 0.02% |
| ArrowMark Colorado Holdings LLC | $1481.9万 | 0.39% |
| UBS Group AG | $1463.0万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $1386.8万 | 0.00% |
| Invesco Ltd. | $1214.3万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $1195.3万 | 0.16% |
| Point72 Asset Management, L.P. | $1117.0万 | 0.01% |
| AMERIPRISE FINANCIAL INC | $1058.9万 | 0.00% |
| Seven Fleet Capital Management LP | $1050.2万 | 3.33% |
| DIMENSIONAL FUND ADVISORS LP | $1023.7万 | 0.00% |
| Soleus Capital Management, L.P. | $941.4万 | 0.38% |
| Integral Health Asset Management, LLC | $941.4万 | 0.45% |
| ACUTA CAPITAL PARTNERS, LLC | $924.3万 | 6.57% |
| T. Rowe Price Investment Management, Inc. | $920.6万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $890.4万 | 0.00% |
| PFM Health Sciences, LP | $849.9万 | 0.77% |
| Sofinnova Investments, Inc. | $826.5万 | 0.31% |
| Rock Springs Capital Management LP | $809.4万 | 0.48% |
| Nuveen, LLC | $754.8万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $743.1万 | 0.02% |
| Mass General Brigham, Inc | $741.0万 | 1.58% |
| SPHERA FUNDS MANAGEMENT LTD. | $718.7万 | 1.14% |
| CONGRESS ASSET MANAGEMENT CO | $714.1万 | 0.05% |
| BANK OF AMERICA CORP /DE/ | $684.4万 | 0.00% |
| Bank of New York Mellon Corp | $666.2万 | 0.00% |
| DV Trading LLC | $629.0万 | 0.15% |
| WELLINGTON MANAGEMENT GROUP LLP | $605.0万 | 0.00% |
| Parkman Healthcare Partners LLC | $556.7万 | 0.57% |
| CITADEL ADVISORS LLC | $522.8万 | 0.00% |
| KVP Capital Advisors, LP | $481.7万 | 3.60% |
| Cinctive Capital Management LP | $464.7万 | 0.30% |
| STEMPOINT CAPITAL LP | $420.3万 | 0.80% |
| TRV GP VI, LLC | $406.2万 | 3.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $398.6万 | 0.00% |
| Squarepoint Ops LLC | $374.3万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $367.1万 | 0.00% |
| Atle Fund Management AB | $363.0万 | 1.17% |
| TWO SIGMA INVESTMENTS, LP | $362.2万 | 0.00% |
| Informed Momentum Co LLC | $351.5万 | 0.41% |
| Fisher Asset Management, LLC | $339.7万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $336.9万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $313.9万 | 0.01% |
| ALGERT GLOBAL LLC | $304.7万 | 0.05% |
| RHUMBLINE ADVISERS | $264.9万 | 0.00% |
| Schonfeld Strategic Advisors LLC | $252.5万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $226.4万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $224.4万 | 0.00% |
| Rafferty Asset Management, LLC | $219.6万 | 0.01% |
| HighVista Strategies LLC | $218.0万 | 0.60% |
| TD Asset Management Inc | $214.6万 | 0.00% |
| DEUTSCHE BANK AG\ | $188.2万 | 0.00% |
| Swiss National Bank | $183.7万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $158.4万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $132.3万 | 0.01% |
| JPMORGAN CHASE & CO | $129.3万 | 0.00% |
| MetLife Investment Management, LLC | $127.0万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $123.3万 | 0.00% |
| Vanguard Global Advisers, LLC | $116.6万 | 0.00% |
| Creative Planning | $110.7万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $110.5万 | 0.00% |
| Atom Investors LP | $110.4万 | 0.08% |
| ADAR1 Capital Management, LLC | $104.6万 | 0.06% |
| ALLIANCEBERNSTEIN L.P. | $104.2万 | 0.00% |
| PROFUND ADVISORS LLC | $99.9万 | 0.04% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $99.8万 | 0.00% |
| SmartHarvest Portfolios, LLC | $97.0万 | 0.40% |
| STATE OF WISCONSIN INVESTMENT BOARD | $94.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $87.8万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $79.4万 | 0.01% |
| Rockefeller Capital Management L.P. | $76.0万 | 0.00% |
| Janney Montgomery Scott LLC | $75.3万 | 0.00% |
| Legal & General Group Plc | $74.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $70.0万 | 0.00% |
| JANE STREET GROUP, LLC | $68.6万 | 0.00% |
| ALLSTATE CORP | $67.0万 | 0.01% |
| SEI INVESTMENTS CO | $66.9万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $63.5万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | $61.9万 | 0.00% |
| Virtus Investment Advisers, LLC | $61.0万 | 0.17% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $57.1万 | 0.00% |
| EverSource Wealth Advisors, LLC | $54.4万 | 0.02% |
| Harvest Investment Services, LLC | $53.1万 | 0.10% |
| SG Americas Securities, LLC | $50.7万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $50.0万 | 0.04% |
| Vanguard Personalized Indexing Management, LLC | $49.2万 | 0.00% |
| Persistent Asset Partners Ltd | $48.4万 | 0.18% |
| ProShare Advisors LLC | $46.3万 | 0.00% |
| BARCLAYS PLC | $45.3万 | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | $44.7万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $44.0万 | 0.00% |
| Entropy Technologies, LP | $43.2万 | 0.02% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $42.8万 | 0.38% |
| Jain Global LLC | $42.6万 | 0.00% |
| CITIGROUP INC | $41.1万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $40.1万 | 0.00% |
| Gotham Asset Management, LLC | $40.0万 | 0.00% |
| Quantinno Capital Management LP | $38.6万 | 0.00% |
| Alyeska Investment Group, L.P. | $36.0万 | 0.00% |
| State of New Jersey Common Pension Fund D | $31.8万 | 0.00% |
| PSP Research LLC | $30.1万 | 0.21% |
| XTX Topco Ltd | $29.5万 | 0.01% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $29.3万 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | $29.1万 | 0.00% |
| E Fund Management Co., Ltd. | $27.6万 | 0.01% |
| Russell Investments Group, Ltd. | $26.9万 | 0.00% |
| MANGROVE PARTNERS IM, LLC | $26.3万 | 0.02% |
| Tower Research Capital LLC (TRC) | $26.2万 | 0.01% |
| SummitTX Capital, L.P. | $26.2万 | 0.01% |
| Bleakley Financial Group, LLC | $25.9万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $25.6万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $25.6万 | 0.00% |
| Bridgefront Capital, LLC | $22.7万 | 0.06% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $22.3万 | 0.00% |
| XPONANCE LLC | $21.4万 | 0.00% |
| Hudson Bay Capital Management LP | $21.3万 | 0.00% |