| RTW INVESTMENTS, LP | $1.8億 | 1.82% |
| BlackRock, Inc. | $1.8億 | 0.00% |
| FMR LLC | $1.8億 | 0.01% |
| Lynx1 Capital Management LP | $1.6億 | 24.51% |
| Redmile Group, LLC | $1.4億 | 8.98% |
| MORGAN STANLEY | $1.1億 | 0.01% |
| BAKER BROS. ADVISORS LP | $1.1億 | 0.62% |
| TORONTO DOMINION BANK | $1.0億 | 0.15% |
| WELLINGTON MANAGEMENT GROUP LLP | $1.0億 | 0.02% |
| BVF INC/IL | $8294.8万 | 2.64% |
| VANGUARD CAPITAL MANAGEMENT LLC | $7669.8万 | 0.00% |
| STATE STREET CORP | $7412.3万 | 0.00% |
| Siren, L.L.C. | $6496.8万 | 1.80% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $6297.7万 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $5937.3万 | 0.70% |
| JANUS HENDERSON GROUP PLC | $5245.6万 | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | $4306.1万 | 0.00% |
| Polar Capital Holdings Plc | $3687.5万 | 0.13% |
| DIMENSIONAL FUND ADVISORS LP | $3222.9万 | 0.01% |
| Assenagon Asset Management S.A. | $2953.2万 | 0.04% |
| GOLDMAN SACHS GROUP INC | $2704.8万 | 0.00% |
| MPM BIOIMPACT LLC | $2497.5万 | 1.93% |
| Opaleye Management Inc. | $2279.2万 | 3.00% |
| Troluce Capital Advisors LLC | $2125.5万 | 1.30% |
| BAILLIE GIFFORD & CO | $1872.8万 | 0.02% |
| BANK OF AMERICA CORP /DE/ | $1768.3万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $1667.5万 | 0.01% |
| Candriam S.C.A. | $1634.6万 | 0.08% |
| TANG CAPITAL MANAGEMENT LLC | $1628.0万 | 0.83% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1506.5万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1423.4万 | 0.00% |
| Erste Asset Management GmbH | $1416.9万 | 0.13% |
| NORTHERN TRUST CORP | $1405.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $1162.2万 | 0.00% |
| Parkman Healthcare Partners LLC | $1095.7万 | 1.13% |
| Granahan Investment Management, LLC | $1092.7万 | 0.53% |
| Artisan Partners Limited Partnership | $1027.2万 | 0.02% |
| JPMORGAN CHASE & CO | $843.4万 | 0.00% |
| T. Rowe Price Investment Management, Inc. | $817.0万 | 0.01% |
| Caption Management, LLC | $765.7万 | 0.04% |
| Birchview Capital, LP | $683.8万 | 3.89% |
| CITADEL ADVISORS LLC | $584.2万 | 0.00% |
| FIRST TRUST ADVISORS LP | $532.2万 | 0.00% |
| UBS Group AG | $515.4万 | 0.00% |
| Invesco Ltd. | $488.5万 | 0.00% |
| Bank of New York Mellon Corp | $466.9万 | 0.00% |
| FRANKLIN RESOURCES INC | $464.9万 | 0.00% |
| DAFNA Capital Management LLC | $426.1万 | 0.97% |
| Susquehanna Portfolio Strategies, LLC | $388.2万 | 0.06% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $370.8万 | 0.00% |
| GILDER GAGNON HOWE & CO LLC | $366.7万 | 0.04% |
| Nuveen, LLC | $353.7万 | 0.00% |
| EcoR1 Capital, LLC | $325.6万 | 0.14% |
| JANE STREET GROUP, LLC | $281.5万 | 0.00% |
| Palo Alto Investors LP | $275.6万 | 0.42% |
| HUSSMAN STRATEGIC ADVISORS, INC. | $273.5万 | 0.59% |
| Rhenman & Partners Asset Management AB | $270.2万 | 0.33% |
| Swiss National Bank | $257.5万 | 0.00% |
| Quantedge Capital Pte Ltd | $255.9万 | 1.40% |
| TD Asset Management Inc | $242.2万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $225.4万 | 0.00% |
| RHUMBLINE ADVISERS | $219.2万 | 0.00% |
| PRINCIPAL FINANCIAL GROUP INC | $208.2万 | 0.00% |
| Harvest Investment Services, LLC | $204.6万 | 0.37% |
| HighVista Strategies LLC | $203.9万 | 0.56% |
| Rafferty Asset Management, LLC | $195.0万 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $189.5万 | 0.00% |
| Informed Momentum Co LLC | $169.3万 | 0.20% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $168.0万 | 0.00% |
| Woodline Partners LP | $163.2万 | 0.01% |
| Privium Fund Management B.V. | $162.8万 | 0.34% |
| D. E. Shaw & Co., Inc. | $162.7万 | 0.00% |
| Schonfeld Strategic Advisors LLC | $160.5万 | 0.01% |
| Creative Planning | $156.6万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $155.8万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $154.0万 | 0.02% |
| ALPS ADVISORS INC | $151.4万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $151.3万 | 0.00% |
| OMERS ADMINISTRATION Corp | $135.1万 | 0.01% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $132.9万 | 0.33% |
| ALLIANCEBERNSTEIN L.P. | $132.8万 | 0.00% |
| DEUTSCHE BANK AG\ | $132.2万 | 0.00% |
| Moran Wealth Management, LLC | $132.0万 | 0.04% |
| NEW YORK STATE COMMON RETIREMENT FUND | $127.5万 | 0.00% |
| LPL Financial LLC | $117.4万 | 0.00% |
| SG Americas Securities, LLC | $110.7万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $110.3万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $110.0万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $108.3万 | 0.00% |
| Legal & General Group Plc | $104.3万 | 0.00% |
| Blackstone Inc. | $99.6万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $99.2万 | 0.00% |
| PROFUND ADVISORS LLC | $87.9万 | 0.03% |
| NOMURA HOLDINGS INC | $87.6万 | 0.00% |
| Vanguard Global Advisers, LLC | $86.7万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | $85.3万 | 0.00% |
| MetLife Investment Management, LLC | $85.0万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $81.8万 | 0.00% |
| Cresset Asset Management, LLC | $79.8万 | 0.00% |
| Balyasny Asset Management L.P. | $77.7万 | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $76.2万 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $73.7万 | 0.00% |
| HSBC HOLDINGS PLC | $68.6万 | 0.00% |
| Allspring Global Investments Holdings, LLC | $68.3万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $64.7万 | 0.00% |
| CANADA LIFE ASSURANCE Co | $61.3万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $59.0万 | 0.00% |
| Jefferies Financial Group Inc. | $53.1万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $52.8万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $49.3万 | 0.04% |
| Campbell & CO Investment Adviser LLC | $49.0万 | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | $47.2万 | 0.00% |
| CIM, LLC | $46.3万 | 0.07% |
| State of New Jersey Common Pension Fund D | $44.5万 | 0.00% |
| State of Wyoming | $43.2万 | 0.05% |
| CITIGROUP INC | $41.4万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $40.8万 | 0.00% |
| CAPSTONE INVESTMENT ADVISORS, LLC | $39.8万 | 0.00% |
| PSP Research LLC | $39.1万 | 0.28% |
| Virtu Financial LLC | $36.0万 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | $35.8万 | 0.00% |
| HARBOR CAPITAL ADVISORS, INC. | $35.4万 | 0.03% |
| Dorsey & Whitney Trust CO LLC | $35.2万 | 0.02% |
| OSAIC HOLDINGS, INC. | $33.6万 | 0.00% |
| Quadrature Capital Ltd | $33.5万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $33.2万 | 0.00% |
| Vestcor Inc | $33.1万 | 0.01% |
| BARCLAYS PLC | $32.9万 | 0.00% |
| SEI INVESTMENTS CO | $32.5万 | 0.00% |
| Quantinno Capital Management LP | $31.8万 | 0.00% |
| ProShare Advisors LLC | $31.4万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $31.2万 | 0.00% |
| AVIVA PLC | $30.2万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $29.6万 | 0.00% |
| FARALLON CAPITAL MANAGEMENT LLC | $29.3万 | 0.00% |
| KLP KAPITALFORVALTNING AS | $28.7万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | $28.4万 | 0.00% |
| Tidal Investments LLC | $27.8万 | 0.00% |
| Tema ETFs LLC | $27.8万 | 0.02% |
| Virtus Investment Advisers, LLC | $27.4万 | 0.08% |
| VOYA INVESTMENT MANAGEMENT LLC | $26.7万 | 0.00% |
| XTX Topco Ltd | $26.2万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $24.9万 | 0.00% |
| Pictet Asset Management Holding SA | $24.7万 | 0.00% |
| E Fund Management Co., Ltd. | $24.5万 | 0.01% |
| STRS OHIO | $22.8万 | 0.00% |
| Generali Investments, Management Co LLC | $22.5万 | 0.05% |
| Swiss Life Asset Management Ltd | $21.3万 | 0.00% |
| Caitong International Asset Management Co., Ltd | $18.4万 | 0.03% |
| Tower Research Capital LLC (TRC) | $14.4万 | 0.00% |