| JANUS HENDERSON GROUP PLC | $11.1億 | 0.53% |
| Orbis Allan Gray Ltd | $8.0億 | 3.36% |
| BlackRock, Inc. | $7.5億 | 0.01% |
| FMR LLC | $7.0億 | 0.04% |
| PERCEPTIVE ADVISORS LLC | $6.6億 | 12.82% |
| BAKER BROS. ADVISORS LP | $5.6億 | 3.24% |
| VANGUARD CAPITAL MANAGEMENT LLC | $3.9億 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $3.1億 | 3.66% |
| Driehaus Capital Management LLC | $3.1億 | 2.25% |
| Cormorant Asset Management, LP | $2.9億 | 14.33% |
| STATE STREET CORP | $2.8億 | 0.01% |
| MORGAN STANLEY | $2.7億 | 0.02% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2.6億 | 0.41% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2.4億 | 0.01% |
| GOLDMAN SACHS GROUP INC | $2.3億 | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | $2.1億 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $2.0億 | 0.02% |
| BANK OF AMERICA CORP /DE/ | $1.7億 | 0.01% |
| RA CAPITAL MANAGEMENT, L.P. | $1.2億 | 1.28% |
| Hood River Capital Management LLC | $1.2億 | 1.16% |
| Vivo Capital, LLC | $1.1億 | 9.08% |
| Soleus Capital Management, L.P. | $1.1億 | 4.31% |
| Logos Global Management LP | $9182.4万 | 4.58% |
| Pictet Asset Management Holding SA | $9142.8万 | 0.10% |
| FRANKLIN RESOURCES INC | $8896.4万 | 0.02% |
| NORTHERN TRUST CORP | $7343.8万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6941.5万 | 0.01% |
| Caption Management, LLC | $6733.8万 | 0.39% |
| Woodline Partners LP | $6444.2万 | 0.24% |
| T. Rowe Price Investment Management, Inc. | $5646.0万 | 0.04% |
| WELLINGTON MANAGEMENT GROUP LLP | $5617.4万 | 0.01% |
| ORBIMED ADVISORS LLC | $5557.8万 | 1.14% |
| Aberdeen Group plc | $5557.3万 | 0.09% |
| Affinity Asset Advisors, LLC | $5477.2万 | 2.83% |
| VANGUARD FIDUCIARY TRUST CO | $5474.1万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4643.3万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | $4132.3万 | 0.02% |
| Qube Research & Technologies Ltd | $4131.4万 | 0.05% |
| ArrowMark Colorado Holdings LLC | $3797.0万 | 1.01% |
| 683 Capital Management, LLC | $3631.1万 | 1.90% |
| UBS Group AG | $3494.0万 | 0.01% |
| Velan Capital Investment Management LP | $3247.1万 | 20.34% |
| JANE STREET GROUP, LLC | $3044.7万 | 0.00% |
| Bank of New York Mellon Corp | $2804.6万 | 0.01% |
| ACUTA CAPITAL PARTNERS, LLC | $2735.4万 | 19.45% |
| MetLife Investment Management, LLC | $2607.5万 | 0.13% |
| CITADEL ADVISORS LLC | $2464.8万 | 0.00% |
| Alyeska Investment Group, L.P. | $2325.5万 | 0.07% |
| Nuveen, LLC | $2321.2万 | 0.01% |
| Ikarian Capital, LLC | $2306.3万 | 1.87% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $2305.3万 | 2.35% |
| JPMORGAN CHASE & CO | $2216.5万 | 0.00% |
| Ensign Peak Advisors, Inc | $2203.2万 | 0.04% |
| 72 Investment Holdings, LLC | $2124.3万 | 42.83% |
| Sofinnova Investments, Inc. | $2051.7万 | 0.78% |
| Candriam S.C.A. | $2050.0万 | 0.11% |
| Invesco Ltd. | $1978.1万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $1889.8万 | 0.01% |
| DEUTSCHE BANK AG\ | $1861.6万 | 0.01% |
| STEMPOINT CAPITAL LP | $1812.9万 | 3.47% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $1719.4万 | 0.18% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $1528.2万 | 0.03% |
| Swiss National Bank | $1504.6万 | 0.01% |
| Boxer Capital Management, LLC | $1496.8万 | 1.97% |
| Exome Asset Management LLC | $1465.0万 | 7.58% |
| MARSHALL WACE, LLP | $1454.7万 | 0.01% |
| Ishara Investments LP | $1387.0万 | 13.13% |
| KVP Capital Advisors, LP | $1382.2万 | 10.32% |
| First Turn Management, LLC | $1367.4万 | 1.53% |
| California Public Employees Retirement System | $1358.4万 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | $1292.9万 | 0.01% |
| Integral Health Asset Management, LLC | $1288.8万 | 0.62% |
| EVENTIDE ASSET MANAGEMENT, LLC | $1243.4万 | 0.21% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1229.0万 | 0.00% |
| SummitTX Capital, L.P. | $1186.9万 | 0.37% |
| PFM Health Sciences, LP | $1141.8万 | 1.04% |
| TD Asset Management Inc | $1132.4万 | 0.01% |
| Burkehill Global Management, LP | $1127.7万 | 0.56% |
| FIRST TRUST ADVISORS LP | $1074.0万 | 0.01% |
| B Group, Inc. | $1070.9万 | 7.94% |
| RHUMBLINE ADVISERS | $1059.3万 | 0.01% |
| Ally Bridge Group (NY) LLC | $1057.1万 | 8.54% |
| AMERIPRISE FINANCIAL INC | $1005.9万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $1004.0万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $983.0万 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $969.6万 | 0.01% |
| LORD, ABBETT & CO. LLC | $954.3万 | 0.03% |
| SEI INVESTMENTS CO | $951.3万 | 0.01% |
| J. Goldman & Co LP | $942.9万 | 0.27% |
| VOYA INVESTMENT MANAGEMENT LLC | $906.4万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $889.0万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $885.3万 | 0.01% |
| HighVista Strategies LLC | $848.1万 | 2.34% |
| NEUBERGER BERMAN GROUP LLC | $836.4万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | $816.4万 | 0.00% |
| University of Wisconsin Foundation | $812.4万 | 7.21% |
| CONGRESS ASSET MANAGEMENT CO | $800.3万 | 0.06% |
| Susquehanna Portfolio Strategies, LLC | $749.1万 | 0.11% |
| Russell Investments Group, Ltd. | $744.7万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | $708.8万 | 0.01% |
| Moody Aldrich Partners LLC | $698.8万 | 1.26% |
| Atom Investors LP | $682.9万 | 0.49% |
| Informed Momentum Co LLC | $612.0万 | 0.71% |
| Legal & General Group Plc | $595.5万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $567.0万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $566.6万 | 0.07% |
| Creative Planning | $524.7万 | 0.00% |
| ALGERT GLOBAL LLC | $520.9万 | 0.08% |
| Tetragon Partners GP Ltd | $514.0万 | 1.00% |
| Rafferty Asset Management, LLC | $489.3万 | 0.02% |
| Eversept Partners, LP | $476.8万 | 0.25% |
| ExodusPoint Capital Management, LP | $475.0万 | 0.04% |
| STATE OF WISCONSIN INVESTMENT BOARD | $471.8万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | $455.3万 | 0.00% |
| Allianz Asset Management GmbH | $452.0万 | 0.00% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $401.9万 | 0.05% |
| Squarepoint Ops LLC | $387.0万 | 0.00% |
| NOMURA HOLDINGS INC | $386.6万 | 0.01% |
| WELLS FARGO & COMPANY/MN | $374.2万 | 0.00% |
| Vanguard Global Advisers, LLC | $365.2万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $342.5万 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | $323.6万 | 0.02% |
| BRAIDWELL LP | $321.4万 | 0.11% |
| DRW Securities, LLC | $319.0万 | 0.04% |
| PRELUDE CAPITAL MANAGEMENT, LLC | $292.0万 | 0.22% |
| Erste Asset Management GmbH | $290.3万 | 0.03% |
| NEW YORK STATE COMMON RETIREMENT FUND | $281.9万 | 0.00% |
| Allspring Global Investments Holdings, LLC | $272.5万 | 0.00% |
| State of New Jersey Common Pension Fund D | $259.6万 | 0.01% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $238.0万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $231.8万 | 0.01% |
| PROFUND ADVISORS LLC | $228.1万 | 0.08% |
| Police & Firemen's Retirement System of New Jersey | $225.2万 | 0.02% |
| BARCLAYS PLC | $224.9万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $224.8万 | 0.02% |
| Vestmark Advisory Solutions, Inc. | $215.3万 | 0.02% |
| Trexquant Investment LP | $213.5万 | 0.02% |
| ARIZONA STATE RETIREMENT SYSTEM | $208.7万 | 0.01% |
| NISA INVESTMENT ADVISORS, LLC | $202.3万 | 0.01% |
| Vanguard Investments Australia, Ltd. | $191.3万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $190.2万 | 0.00% |
| CITIGROUP INC | $181.9万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $171.4万 | 0.00% |
| Quarry LP | $169.1万 | 0.30% |
| KLP KAPITALFORVALTNING AS | $167.5万 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $163.0万 | 0.01% |
| D. E. Shaw & Co., Inc. | $161.1万 | 0.00% |
| Ghisallo Capital Management LLC | $161.1万 | 0.04% |
| ProShare Advisors LLC | $160.7万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $159.2万 | 0.12% |