| DEERFIELD MANAGEMENT COMPANY, L.P. | $17.7億 | 20.85% |
| FMR LLC | $9.5億 | 0.05% |
| Paradigm Biocapital Advisors LP | $5.5億 | 11.15% |
| BlackRock, Inc. | $4.9億 | 0.01% |
| JPMORGAN CHASE & CO | $3.0億 | 0.02% |
| RA CAPITAL MANAGEMENT, L.P. | $2.6億 | 2.75% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2.6億 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | $2.5億 | 0.05% |
| VANGUARD CAPITAL MANAGEMENT LLC | $2.5億 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $2.1億 | 0.02% |
| STATE STREET CORP | $2.1億 | 0.01% |
| Polar Capital Holdings Plc | $1.9億 | 0.67% |
| PERCEPTIVE ADVISORS LLC | $1.6億 | 3.16% |
| T. Rowe Price Investment Management, Inc. | $1.4億 | 0.10% |
| Deep Track Capital, LP | $1.4億 | 2.30% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.3億 | 0.01% |
| JANUS HENDERSON GROUP PLC | $1.3億 | 0.06% |
| Bellevue Group AG | $1.1億 | 2.57% |
| Commodore Capital LP | $8540.2万 | 4.94% |
| ALLIANCEBERNSTEIN L.P. | $7886.5万 | 0.03% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $7672.4万 | 0.12% |
| BRAIDWELL LP | $7175.9万 | 2.39% |
| Woodline Partners LP | $6254.2万 | 0.24% |
| AMERIPRISE FINANCIAL INC | $5775.8万 | 0.01% |
| GOLDMAN SACHS GROUP INC | $5503.2万 | 0.01% |
| Vestal Point Capital, LP | $4935.2万 | 1.38% |
| Driehaus Capital Management LLC | $4929.7万 | 0.36% |
| Hood River Capital Management LLC | $4917.6万 | 0.49% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4618.5万 | 0.01% |
| FRANKLIN RESOURCES INC | $4453.9万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | $4416.3万 | 0.02% |
| NORTHERN TRUST CORP | $4398.9万 | 0.01% |
| Pictet Asset Management Holding SA | $4205.4万 | 0.04% |
| Invesco Ltd. | $4182.9万 | 0.01% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $4052.4万 | 0.42% |
| Candriam S.C.A. | $4008.9万 | 0.21% |
| First Turn Management, LLC | $3794.2万 | 4.24% |
| VANGUARD FIDUCIARY TRUST CO | $3730.9万 | 0.01% |
| UBS Group AG | $3719.9万 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $3636.1万 | 3.71% |
| Tri Locum Partners LP | $3160.6万 | 4.44% |
| Jones Hill Capital LP | $3082.0万 | 6.61% |
| Affinity Asset Advisors, LLC | $3073.5万 | 1.59% |
| BANK OF AMERICA CORP /DE/ | $2218.2万 | 0.00% |
| MORGAN STANLEY | $2057.1万 | 0.00% |
| LORD, ABBETT & CO. LLC | $2047.8万 | 0.07% |
| ArrowMark Colorado Holdings LLC | $1914.3万 | 0.51% |
| CITADEL ADVISORS LLC | $1889.9万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $1828.1万 | 0.02% |
| Bank of New York Mellon Corp | $1654.7万 | 0.00% |
| Nicholas Investment Partners, LP | $1636.3万 | 1.18% |
| TD Asset Management Inc | $1411.4万 | 0.01% |
| RAYMOND JAMES FINANCIAL INC | $1408.0万 | 0.00% |
| Defilade Capital Management, L.P. | $1331.3万 | 1.87% |
| Aberdeen Group plc | $1266.0万 | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1251.8万 | 0.00% |
| Nuveen, LLC | $1125.1万 | 0.00% |
| Squarepoint Ops LLC | $1073.7万 | 0.01% |
| Ensign Peak Advisors, Inc | $1048.2万 | 0.02% |
| TWO SIGMA INVESTMENTS, LP | $1046.2万 | 0.01% |
| Fisher Asset Management, LLC | $999.1万 | 0.00% |
| Russell Investments Group, Ltd. | $947.7万 | 0.01% |
| JANE STREET GROUP, LLC | $942.9万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $911.8万 | 0.01% |
| Parkman Healthcare Partners LLC | $902.4万 | 0.93% |
| DEUTSCHE BANK AG\ | $899.0万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $838.7万 | 0.04% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $837.8万 | 0.01% |
| Rhenman & Partners Asset Management AB | $831.9万 | 1.03% |
| Swiss National Bank | $808.3万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $730.4万 | 0.01% |
| Burkehill Global Management, LP | $717.2万 | 0.36% |
| NEUBERGER BERMAN GROUP LLC | $661.8万 | 0.01% |
| RHUMBLINE ADVISERS | $654.3万 | 0.01% |
| ExodusPoint Capital Management, LP | $652.8万 | 0.05% |
| HighVista Strategies LLC | $579.9万 | 1.60% |
| Tema ETFs LLC | $547.2万 | 0.37% |
| Tidal Investments LLC | $547.2万 | 0.01% |
| XTX Topco Ltd | $546.6万 | 0.10% |
| Connor, Clark & Lunn Investment Management Ltd. | $512.5万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $508.9万 | 0.01% |
| FIRST TRUST ADVISORS LP | $487.8万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $475.2万 | 0.01% |
| Rafferty Asset Management, LLC | $461.9万 | 0.02% |
| Granahan Investment Management, LLC | $440.6万 | 0.21% |
| Walleye Capital LLC | $429.0万 | 0.02% |
| VANGUARD ASSET MANAGEMENT, Ltd | $402.1万 | 0.00% |
| Creative Planning | $393.6万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $376.5万 | 0.00% |
| CITIGROUP INC | $375.9万 | 0.00% |
| Legal & General Group Plc | $353.3万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $342.8万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $335.5万 | 0.00% |
| BARCLAYS PLC | $316.0万 | 0.00% |
| SEI INVESTMENTS CO | $302.6万 | 0.00% |
| Hudson Bay Capital Management LP | $291.8万 | 0.01% |
| MetLife Investment Management, LLC | $280.7万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $274.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $269.5万 | 0.00% |
| Man Group plc | $248.5万 | 0.00% |
| FIFTH THIRD BANCORP | $242.0万 | 0.00% |
| Ikarian Capital, LLC | $241.7万 | 0.20% |
| ROYAL BANK OF CANADA | $241.4万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $238.4万 | 0.01% |
| Vanguard Global Advisers, LLC | $223.7万 | 0.00% |
| Legato Capital Management LLC | $220.3万 | 0.20% |
| PROFUND ADVISORS LLC | $210.5万 | 0.08% |
| Aquatic Capital Management LLC | $209.0万 | 0.06% |
| DIMENSIONAL FUND ADVISORS LP | $193.6万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $191.9万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $185.0万 | 0.00% |
| DekaBank Deutsche Girozentrale | $172.8万 | 0.00% |
| SG Americas Securities, LLC | $170.6万 | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | $167.2万 | 0.04% |
| ENVESTNET ASSET MANAGEMENT INC | $162.0万 | 0.00% |
| Quantinno Capital Management LP | $155.3万 | 0.00% |
| Bridgewater Associates, LP | $153.9万 | 0.01% |
| Empowered Funds, LLC | $150.1万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $146.7万 | 0.00% |
| Handelsbanken Fonder AB | $142.4万 | 0.00% |
| State of New Jersey Common Pension Fund D | $140.1万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | $138.7万 | 0.01% |
| China Universal Asset Management Co., Ltd. | $133.1万 | 0.10% |
| POLEN CAPITAL MANAGEMENT LLC | $130.6万 | 0.01% |
| GUGGENHEIM CAPITAL LLC | $129.6万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | $126.0万 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | $122.0万 | 0.03% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $120.5万 | 0.01% |
| STRS OHIO | $119.9万 | 0.00% |
| LPL Financial LLC | $118.6万 | 0.00% |
| Corient Private Wealth LLC | $115.1万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $112.6万 | 0.01% |
| Erste Asset Management GmbH | $111.2万 | 0.01% |
| ProShare Advisors LLC | $107.9万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $107.5万 | 0.00% |
| Trexquant Investment LP | $103.0万 | 0.01% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $101.8万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $101.8万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $96.6万 | 0.00% |
| Headlands Technologies LLC | $95.2万 | 0.11% |
| EVERGREEN CAPITAL MANAGEMENT LLC | $91.7万 | 0.02% |
| KLP KAPITALFORVALTNING AS | $90.2万 | 0.00% |
| Shay Capital LLC | $84.8万 | 0.07% |
| Entropy Technologies, LP | $84.6万 | 0.04% |
| PRUDENTIAL FINANCIAL INC | $80.5万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $80.2万 | 0.01% |
| FOX RUN MANAGEMENT, L.L.C. | $79.0万 | 0.14% |
| Vanguard Personalized Indexing Management, LLC | $73.2万 | 0.01% |
| INCEPTIONR LLC | $71.7万 | 0.17% |
| ADAR1 Capital Management, LLC | $71.1万 | 0.04% |