| BAKER BROS. ADVISORS LP | $11.2億 | 6.44% |
| JANUS HENDERSON GROUP PLC | $10.5億 | 0.50% |
| RTW INVESTMENTS, LP | $10.4億 | 10.38% |
| Avoro Capital Advisors LLC | $9.5億 | 9.36% |
| BlackRock, Inc. | $8.2億 | 0.01% |
| PAULSON & CO. INC. | $7.3億 | 23.42% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4.4億 | 0.02% |
| VANGUARD CAPITAL MANAGEMENT LLC | $4.3億 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | $3.6億 | 0.07% |
| STATE STREET CORP | $3.2億 | 0.01% |
| CITADEL ADVISORS LLC | $3.2億 | 0.05% |
| FMR LLC | $2.7億 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | $2.4億 | 0.01% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $1.8億 | 0.59% |
| Invesco Ltd. | $1.7億 | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.7億 | 0.02% |
| Polar Capital Holdings Plc | $1.5億 | 0.54% |
| GOLDMAN SACHS GROUP INC | $1.5億 | 0.02% |
| ARMISTICE CAPITAL, LLC | $1.4億 | 2.46% |
| Hood River Capital Management LLC | $1.3億 | 1.31% |
| LORD, ABBETT & CO. LLC | $1.3億 | 0.41% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1.3億 | 0.01% |
| JANE STREET GROUP, LLC | $1.3億 | 0.02% |
| Point72 Asset Management, L.P. | $1.2億 | 0.16% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1.1億 | 0.02% |
| MORGAN STANLEY | $1.0億 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $9921.2万 | 0.01% |
| Pictet Asset Management Holding SA | $9791.4万 | 0.10% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $9701.5万 | 0.15% |
| Artisan Partners Limited Partnership | $9607.8万 | 0.15% |
| Fiera Capital Corp | $9109.0万 | 0.31% |
| Rock Springs Capital Management LP | $8951.3万 | 5.28% |
| AMERICAN CENTURY COMPANIES INC | $8581.5万 | 0.04% |
| Erste Asset Management GmbH | $8096.1万 | 0.75% |
| NORTHERN TRUST CORP | $7810.9万 | 0.01% |
| Caption Management, LLC | $7328.6万 | 0.43% |
| ALLIANCEBERNSTEIN L.P. | $7305.3万 | 0.02% |
| Bank of New York Mellon Corp | $7114.4万 | 0.01% |
| TORONTO DOMINION BANK | $6829.2万 | 0.10% |
| VANGUARD FIDUCIARY TRUST CO | $6704.6万 | 0.02% |
| D. E. Shaw & Co., Inc. | $6665.8万 | 0.04% |
| Woodline Partners LP | $6590.4万 | 0.25% |
| UBS Group AG | $6165.4万 | 0.01% |
| Driehaus Capital Management LLC | $5808.4万 | 0.43% |
| Tri Locum Partners LP | $5406.8万 | 7.59% |
| AMERIPRISE FINANCIAL INC | $5139.6万 | 0.01% |
| DEUTSCHE BANK AG\ | $5133.5万 | 0.02% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $4963.2万 | 0.21% |
| 683 Capital Management, LLC | $4711.2万 | 2.46% |
| Logos Global Management LP | $4449.5万 | 2.22% |
| Candriam S.C.A. | $4446.8万 | 0.23% |
| ALKEON CAPITAL MANAGEMENT LLC | $4187.8万 | 0.07% |
| NEW YORK STATE COMMON RETIREMENT FUND | $3932.8万 | 0.05% |
| FRANKLIN RESOURCES INC | $3875.8万 | 0.01% |
| GROUP ONE TRADING LLC | $3816.1万 | 0.07% |
| RENAISSANCE TECHNOLOGIES LLC | $3762.2万 | 0.06% |
| Squarepoint Ops LLC | $3668.7万 | 0.04% |
| RAYMOND JAMES FINANCIAL INC | $3412.8万 | 0.01% |
| CITIGROUP INC | $3381.0万 | 0.01% |
| ArrowMark Colorado Holdings LLC | $3268.6万 | 0.87% |
| Nuveen, LLC | $3248.7万 | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | $3139.3万 | 0.03% |
| Affinity Asset Advisors, LLC | $2879.1万 | 1.49% |
| EULAV Asset Management | $2565.0万 | 0.82% |
| Russell Investments Group, Ltd. | $2329.7万 | 0.03% |
| Mirae Asset Global Investments Co., Ltd. | $2142.4万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $2138.5万 | 0.01% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $2013.9万 | 0.02% |
| EMERALD ADVISERS, LLC | $1971.1万 | 0.62% |
| GROUPAMA ASSET MANAGMENT | $1844.6万 | 0.27% |
| JPMORGAN CHASE & CO | $1835.1万 | 0.00% |
| PFM Health Sciences, LP | $1787.4万 | 1.63% |
| Rockefeller Capital Management L.P. | $1771.9万 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $1721.1万 | 0.02% |
| WELLS FARGO & COMPANY/MN | $1686.2万 | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | $1668.3万 | 0.24% |
| Vestal Point Capital, LP | $1647.3万 | 0.46% |
| GILDER GAGNON HOWE & CO LLC | $1538.5万 | 0.18% |
| Swiss National Bank | $1529.6万 | 0.01% |
| SIMPLEX TRADING, LLC | $1528.5万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | $1462.4万 | 0.03% |
| Integral Health Asset Management, LLC | $1308.7万 | 0.63% |
| IMC-Chicago, LLC | $1308.4万 | 0.00% |
| Clearbridge Investments, LLC | $1279.7万 | 0.01% |
| SEI INVESTMENTS CO | $1266.7万 | 0.01% |
| Rhenman & Partners Asset Management AB | $1258.9万 | 1.55% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1245.6万 | 0.00% |
| California Public Employees Retirement System | $1214.3万 | 0.01% |
| WCM INVESTMENT MANAGEMENT, LLC | $1190.6万 | 0.03% |
| FIRST TRUST ADVISORS LP | $1163.8万 | 0.01% |
| MARSHALL WACE, LLP | $1146.5万 | 0.01% |
| RHUMBLINE ADVISERS | $1139.3万 | 0.01% |
| Tao Capital Management LP | $1099.3万 | 9.25% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $965.9万 | 0.02% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $892.4万 | 0.01% |
| FEDERATED HERMES, INC. | $884.8万 | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $863.7万 | 0.42% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $853.3万 | 0.01% |
| Assenagon Asset Management S.A. | $839.3万 | 0.01% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $835.6万 | 0.06% |
| AQR CAPITAL MANAGEMENT LLC | $835.1万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $809.3万 | 0.00% |
| Cinctive Capital Management LP | $802.3万 | 0.52% |
| Walleye Capital LLC | $760.4万 | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | $737.6万 | 0.01% |
| HighTower Advisors, LLC | $728.4万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $703.1万 | 0.02% |
| Rheos Capital Works Inc. | $691.8万 | 0.46% |
| NEUBERGER BERMAN GROUP LLC | $672.6万 | 0.01% |
| JOURNEY STRATEGIC WEALTH LLC | $671.6万 | 0.17% |
| ROYAL BANK OF CANADA | $655.7万 | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | $641.8万 | 0.00% |
| TD Asset Management Inc | $633.0万 | 0.01% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $631.8万 | 0.07% |
| Creative Planning | $628.4万 | 0.00% |
| Legal & General Group Plc | $618.1万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $608.8万 | 0.01% |
| Rafferty Asset Management, LLC | $547.1万 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $526.2万 | 0.01% |
| Eversept Partners, LP | $523.5万 | 0.28% |
| PEAK6 LLC | $518.3万 | 0.01% |
| EFG International AG | $514.7万 | 0.11% |
| LPL Financial LLC | $492.4万 | 0.00% |
| MetLife Investment Management, LLC | $486.8万 | 0.02% |
| SPHERA FUNDS MANAGEMENT LTD. | $473.2万 | 0.75% |
| Hennion & Walsh Asset Management, Inc. | $451.0万 | 0.15% |
| DIMENSIONAL FUND ADVISORS LP | $446.0万 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $442.6万 | 0.28% |
| ALGERT GLOBAL LLC | $427.2万 | 0.06% |
| Vanguard Global Advisers, LLC | $421.2万 | 0.00% |
| DekaBank Deutsche Girozentrale | $411.1万 | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $366.4万 | 0.01% |
| PRUDENTIAL FINANCIAL INC | $363.3万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $327.2万 | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | $305.5万 | 0.00% |
| Nan Fung Group Holdings Ltd | $296.9万 | 2.45% |
| Entropy Technologies, LP | $294.5万 | 0.14% |
| ExodusPoint Capital Management, LP | $291.6万 | 0.02% |
| Pathstone Holdings, LLC | $285.7万 | 0.01% |
| Handelsbanken Fonder AB | $280.6万 | 0.01% |
| BAMCO INC /NY/ | $277.4万 | 0.01% |
| CASTLEARK MANAGEMENT LLC | $277.2万 | 0.09% |
| State of New Jersey Common Pension Fund D | $264.1万 | 0.01% |
| PROFUND ADVISORS LLC | $254.5万 | 0.09% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $244.6万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $243.0万 | 0.02% |
| MARTINGALE ASSET MANAGEMENT L P | $234.8万 | 0.06% |
| ASSETMARK, INC | $229.8万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $223.6万 | 0.17% |
| INTECH INVESTMENT MANAGEMENT LLC | $221.8万 | 0.02% |