| Frazier Life Sciences Management, L.P. | $4.0億 | 10.27% |
| T. Rowe Price Investment Management, Inc. | $3.4億 | 0.24% |
| BlackRock, Inc. | $3.3億 | 0.01% |
| Venrock Adviser, LLC | $2.7億 | 9.89% |
| RTW INVESTMENTS, LP | $2.6億 | 2.60% |
| Vivo Capital, LLC | $2.0億 | 16.34% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1.8億 | 0.00% |
| Siren, L.L.C. | $1.8億 | 5.04% |
| Logos Global Management LP | $1.8億 | 9.01% |
| Paradigm Biocapital Advisors LP | $1.7億 | 3.44% |
| STATE STREET CORP | $1.5億 | 0.01% |
| ARCH Venture Management, LLC | $1.1億 | 16.95% |
| GEODE CAPITAL MANAGEMENT, LLC | $9703.7万 | 0.01% |
| Cormorant Asset Management, LP | $9384.4万 | 4.71% |
| Affinity Asset Advisors, LLC | $8656.3万 | 4.47% |
| Balyasny Asset Management L.P. | $8323.0万 | 0.11% |
| GOLDMAN SACHS GROUP INC | $7888.1万 | 0.01% |
| JANUS HENDERSON GROUP PLC | $5998.8万 | 0.03% |
| 5AM Venture Management, LLC | $5640.3万 | 15.66% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | $5557.8万 | 1.42% |
| Commodore Capital LP | $5137.2万 | 2.97% |
| BANK OF AMERICA CORP /DE/ | $4944.4万 | 0.00% |
| a16z Capital Management, L.L.C. | $4631.5万 | 3.59% |
| Woodline Partners LP | $4581.4万 | 0.17% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $3397.8万 | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3071.3万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $2996.2万 | 3.06% |
| UBS Group AG | $2991.0万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $2937.4万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $2887.3万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2869.9万 | 0.00% |
| NORTHERN TRUST CORP | $2753.2万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $2677.0万 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | $2488.3万 | 0.01% |
| FMR LLC | $2410.9万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2392.3万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $2263.4万 | 0.04% |
| D. E. Shaw & Co., Inc. | $1973.2万 | 0.01% |
| Rock Springs Capital Management LP | $1785.4万 | 1.05% |
| MORGAN STANLEY | $1600.5万 | 0.00% |
| EcoR1 Capital, LLC | $1456.2万 | 0.62% |
| First Turn Management, LLC | $1403.8万 | 1.57% |
| JPMORGAN CHASE & CO | $1381.1万 | 0.00% |
| CITADEL ADVISORS LLC | $1233.2万 | 0.00% |
| Holocene Advisors, LP | $1230.8万 | 0.03% |
| Invesco Ltd. | $1229.6万 | 0.00% |
| Integral Health Asset Management, LLC | $1132.6万 | 0.54% |
| Point72 Asset Management, L.P. | $1121.8万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $1118.4万 | 0.01% |
| AMERIPRISE FINANCIAL INC | $1085.0万 | 0.00% |
| JANE STREET GROUP, LLC | $999.3万 | 0.00% |
| Caption Management, LLC | $991.0万 | 0.06% |
| ALLIANCEBERNSTEIN L.P. | $983.9万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | $963.3万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $932.0万 | 0.00% |
| ExodusPoint Capital Management, LP | $931.5万 | 0.08% |
| Bank of New York Mellon Corp | $905.5万 | 0.00% |
| Nuveen, LLC | $878.6万 | 0.00% |
| Ensign Peak Advisors, Inc | $810.2万 | 0.02% |
| MARSHALL WACE, LLP | $690.1万 | 0.01% |
| Spruce Street Capital LP | $683.7万 | 1.64% |
| Creative Planning | $677.7万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $674.2万 | 0.01% |
| Parkman Healthcare Partners LLC | $658.0万 | 0.68% |
| TD Asset Management Inc | $637.9万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | $616.4万 | 0.00% |
| Polymer Capital Management (HK) LTD | $578.7万 | 0.50% |
| ACUTA CAPITAL PARTNERS, LLC | $573.7万 | 4.08% |
| Atom Investors LP | $559.2万 | 0.40% |
| KVP Capital Advisors, LP | $550.1万 | 4.11% |
| Swiss National Bank | $544.9万 | 0.00% |
| Trexquant Investment LP | $487.1万 | 0.04% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $419.1万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $410.3万 | 0.00% |
| SIMPLEX TRADING, LLC | $408.9万 | 0.00% |
| Rafferty Asset Management, LLC | $407.7万 | 0.02% |
| RHUMBLINE ADVISERS | $392.6万 | 0.00% |
| STEMPOINT CAPITAL LP | $388.1万 | 0.74% |
| FRED ALGER MANAGEMENT, LLC | $383.2万 | 0.02% |
| Tema ETFs LLC | $367.1万 | 0.25% |
| Tidal Investments LLC | $367.1万 | 0.01% |
| Seven Fleet Capital Management LP | $360.0万 | 1.14% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $350.5万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $330.8万 | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | $323.6万 | 0.16% |
| Pictet Asset Management Holding SA | $314.5万 | 0.00% |
| HighVista Strategies LLC | $293.0万 | 0.81% |
| Cinctive Capital Management LP | $278.2万 | 0.18% |
| Longaeva Partners L.P. | $277.1万 | 0.10% |
| DEUTSCHE BANK AG\ | $264.3万 | 0.00% |
| NATIXIS | $264.0万 | 0.01% |
| XTX Topco Ltd | $238.8万 | 0.04% |
| NOMURA HOLDINGS INC | $224.9万 | 0.01% |
| Informed Momentum Co LLC | $223.2万 | 0.26% |
| Legal & General Group Plc | $215.7万 | 0.00% |
| Vanguard Global Advisers, LLC | $183.9万 | 0.00% |
| PROFUND ADVISORS LLC | $183.2万 | 0.07% |
| VANGUARD ASSET MANAGEMENT, Ltd | $180.8万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $173.4万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $170.6万 | 0.00% |
| MetLife Investment Management, LLC | $167.7万 | 0.01% |
| FRANKLIN RESOURCES INC | $164.8万 | 0.00% |
| SEVEN GRAND MANAGERS, LLC | $161.8万 | 0.11% |
| Burkehill Global Management, LP | $161.8万 | 0.08% |
| STATE OF WISCONSIN INVESTMENT BOARD | $159.5万 | 0.00% |
| J. Goldman & Co LP | $158.6万 | 0.05% |
| Squarepoint Ops LLC | $153.2万 | 0.00% |
| ALGERT GLOBAL LLC | $142.4万 | 0.02% |
| RAYMOND JAMES FINANCIAL INC | $133.8万 | 0.00% |
| Cresset Asset Management, LLC | $129.4万 | 0.01% |
| ArrowMark Colorado Holdings LLC | $127.9万 | 0.03% |
| Virtus Investment Advisers, LLC | $122.6万 | 0.34% |
| Harvest Investment Services, LLC | $119.3万 | 0.22% |
| Schonfeld Strategic Advisors LLC | $110.1万 | 0.01% |
| Hudson Bay Capital Management LP | $105.7万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $95.6万 | 0.01% |
| State of New Jersey Common Pension Fund D | $94.1万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $93.1万 | 0.01% |
| GILDER GAGNON HOWE & CO LLC | $91.6万 | 0.01% |
| Cerity Partners LLC | $90.2万 | 0.00% |
| Brevan Howard Capital Management LP | $89.2万 | 0.01% |
| China Universal Asset Management Co., Ltd. | $88.9万 | 0.07% |
| NEW YORK STATE COMMON RETIREMENT FUND | $88.6万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $83.3万 | 0.01% |
| CITIGROUP INC | $79.5万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $77.5万 | 0.00% |
| Vanguard Personalized Indexing Management, LLC | $75.9万 | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | $75.7万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $73.4万 | 0.00% |
| BARCLAYS PLC | $72.9万 | 0.00% |
| SG Americas Securities, LLC | $72.3万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $71.7万 | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $68.5万 | 0.00% |
| ProShare Advisors LLC | $66.9万 | 0.00% |
| KLP KAPITALFORVALTNING AS | $60.7万 | 0.00% |
| Verdad Advisers, LP | $53.5万 | 0.60% |
| STRS OHIO | $53.4万 | 0.00% |
| CWM, LLC | $53.0万 | 0.00% |
| E Fund Management Co., Ltd. | $52.8万 | 0.02% |
| Tower Research Capital LLC (TRC) | $52.3万 | 0.01% |
| SEI INVESTMENTS CO | $51.4万 | 0.00% |
| Marks Group Wealth Management, Inc | $48.3万 | 0.05% |
| Persistent Asset Partners Ltd | $45.7万 | 0.17% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $44.9万 | 0.00% |
| FORA Capital, LLC | $43.3万 | 0.03% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $41.7万 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $40.2万 | 0.36% |
| Quantbot Technologies LP | $37.6万 | 0.02% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $35.7万 | 0.00% |
| Quadrature Capital Ltd | $35.1万 | 0.00% |