| T. Rowe Price Investment Management, Inc. | $8.7億 | 0.60% |
| FMR LLC | $7.8億 | 0.04% |
| Venrock Adviser, LLC | $7.1億 | 26.68% |
| WELLINGTON MANAGEMENT GROUP LLP | $3.7億 | 0.07% |
| BlackRock, Inc. | $3.4億 | 0.01% |
| RTW INVESTMENTS, LP | $2.3億 | 2.33% |
| VANGUARD CAPITAL MANAGEMENT LLC | $2.1億 | 0.01% |
| JANUS HENDERSON GROUP PLC | $2.0億 | 0.09% |
| STATE STREET CORP | $1.8億 | 0.01% |
| Driehaus Capital Management LLC | $1.6億 | 1.19% |
| PERCEPTIVE ADVISORS LLC | $1.3億 | 2.53% |
| Paradigm Biocapital Advisors LP | $1.1億 | 2.32% |
| Affinity Asset Advisors, LLC | $1.1億 | 5.59% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.0億 | 0.01% |
| UBS Group AG | $9631.8万 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $9622.1万 | 0.01% |
| Vestal Point Capital, LP | $9258.7万 | 2.59% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $8959.8万 | 0.92% |
| JPMORGAN CHASE & CO | $8741.6万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $7582.6万 | 0.01% |
| ALLIANCEBERNSTEIN L.P. | $7474.8万 | 0.02% |
| MERCER GLOBAL ADVISORS INC /ADV | $6998.1万 | 0.10% |
| CITADEL ADVISORS LLC | $5493.0万 | 0.01% |
| GOLDMAN SACHS GROUP INC | $5492.9万 | 0.01% |
| MORGAN STANLEY | $5008.4万 | 0.00% |
| JENNISON ASSOCIATES LLC | $4924.1万 | 0.03% |
| Remedium Capital Partners, LLC | $4912.1万 | 17.47% |
| First Light Asset Management, LLC | $4853.9万 | 4.35% |
| EVENTIDE ASSET MANAGEMENT, LLC | $4691.8万 | 0.78% |
| Polar Capital Holdings Plc | $4538.3万 | 0.16% |
| First Turn Management, LLC | $4324.4万 | 4.83% |
| BRAIDWELL LP | $4028.9万 | 1.34% |
| NOVO HOLDINGS A/S | $3787.7万 | 3.07% |
| FEDERATED HERMES, INC. | $3726.5万 | 0.06% |
| Balyasny Asset Management L.P. | $3692.2万 | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3540.9万 | 0.01% |
| FRANKLIN RESOURCES INC | $3413.4万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $3335.9万 | 0.00% |
| Caption Management, LLC | $3328.1万 | 0.19% |
| NORTHERN TRUST CORP | $3290.0万 | 0.00% |
| Opaleye Management Inc. | $3282.6万 | 4.32% |
| GREAT POINT PARTNERS LLC | $3148.0万 | 7.23% |
| VANGUARD FIDUCIARY TRUST CO | $3105.5万 | 0.01% |
| LOOMIS SAYLES & CO L P | $3053.5万 | 0.04% |
| Capital World Investors | $2934.8万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2680.0万 | 0.00% |
| Fairmount Funds Management LLC | $2513.7万 | 1.82% |
| Deep Track Capital, LP | $2398.8万 | 0.39% |
| TWO SIGMA INVESTMENTS, LP | $2368.4万 | 0.02% |
| Woodline Partners LP | $2197.8万 | 0.08% |
| Pictet Asset Management Holding SA | $2197.3万 | 0.02% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2104.3万 | 0.03% |
| Candriam S.C.A. | $1881.5万 | 0.10% |
| DIADEMA PARTNERS LP | $1872.8万 | 3.19% |
| TD Asset Management Inc | $1555.4万 | 0.01% |
| BARCLAYS PLC | $1356.8万 | 0.00% |
| Aberdeen Group plc | $1206.8万 | 0.02% |
| NOMURA HOLDINGS INC | $1122.5万 | 0.03% |
| Nicholas Investment Partners, LP | $1102.6万 | 0.80% |
| Nuveen, LLC | $1078.3万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $1077.5万 | 0.02% |
| Bank of New York Mellon Corp | $1066.9万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | $1032.5万 | 0.22% |
| ArrowMark Colorado Holdings LLC | $920.9万 | 0.24% |
| SEVEN GRAND MANAGERS, LLC | $841.7万 | 0.56% |
| VICTORY CAPITAL MANAGEMENT INC | $800.8万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $779.3万 | 0.00% |
| DEUTSCHE BANK AG\ | $769.5万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $760.9万 | 0.01% |
| JANE STREET GROUP, LLC | $739.0万 | 0.00% |
| Ensign Peak Advisors, Inc | $692.7万 | 0.01% |
| MARSHALL WACE, LLP | $675.1万 | 0.01% |
| SIMPLEX TRADING, LLC | $654.9万 | 0.00% |
| Parkman Healthcare Partners LLC | $653.9万 | 0.67% |
| Swiss National Bank | $636.3万 | 0.00% |
| Granahan Investment Management, LLC | $632.0万 | 0.31% |
| Alyeska Investment Group, L.P. | $631.3万 | 0.02% |
| Rhenman & Partners Asset Management AB | $631.3万 | 0.78% |
| WCM INVESTMENT MANAGEMENT, LLC | $598.5万 | 0.01% |
| Boxer Capital Management, LLC | $589.2万 | 0.77% |
| AMERIPRISE FINANCIAL INC | $588.2万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $578.2万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $537.8万 | 0.01% |
| FIFTH THIRD BANCORP | $537.0万 | 0.01% |
| Rafferty Asset Management, LLC | $508.4万 | 0.02% |
| D. E. Shaw & Co., Inc. | $495.2万 | 0.00% |
| Russell Investments Group, Ltd. | $492.3万 | 0.01% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $490.8万 | 1.24% |
| Holocene Advisors, LP | $483.8万 | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $474.3万 | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $458.2万 | 0.01% |
| Lisanti Capital Growth, LLC | $439.9万 | 1.11% |
| RHUMBLINE ADVISERS | $409.7万 | 0.00% |
| ALPS ADVISORS INC | $383.7万 | 0.02% |
| XTX Topco Ltd | $361.1万 | 0.06% |
| SEI INVESTMENTS CO | $355.2万 | 0.00% |
| Man Group plc | $352.0万 | 0.01% |
| FIRST TRUST ADVISORS LP | $343.2万 | 0.00% |
| Invesco Ltd. | $326.3万 | 0.00% |
| Squarepoint Ops LLC | $322.8万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $321.2万 | 0.00% |
| KBC Group NV | $318.5万 | 0.01% |
| HighVista Strategies LLC | $301.0万 | 0.83% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $285.7万 | 0.00% |
| Burkehill Global Management, LP | $252.5万 | 0.13% |
| MOODY ALDRICH PARTNERS LLC | $244.8万 | 0.44% |
| VOYA INVESTMENT MANAGEMENT LLC | $238.9万 | 0.00% |
| Legal & General Group Plc | $230.8万 | 0.00% |
| PROFUND ADVISORS LLC | $228.3万 | 0.08% |
| NEW YORK STATE COMMON RETIREMENT FUND | $218.6万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $215.9万 | 0.00% |
| Maven Securities LTD | $210.4万 | 0.04% |
| Vanguard Global Advisers, LLC | $205.3万 | 0.00% |
| MetLife Investment Management, LLC | $204.1万 | 0.01% |
| Schonfeld Strategic Advisors LLC | $194.3万 | 0.01% |
| Persistent Asset Partners Ltd | $193.4万 | 0.72% |
| Erste Asset Management GmbH | $188.9万 | 0.02% |
| Handelsbanken Fonder AB | $177.6万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $172.2万 | 0.00% |
| BANQUE PICTET & CIE SA | $168.0万 | 0.01% |
| Humankind Investments LLC | $147.3万 | 0.84% |
| WELLS FARGO & COMPANY/MN | $139.1万 | 0.00% |
| Shay Capital LLC | $138.9万 | 0.12% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $134.0万 | 0.00% |
| BAMCO INC /NY/ | $126.3万 | 0.00% |
| CITIGROUP INC | $117.7万 | 0.00% |
| Point72 Asset Management, L.P. | $116.2万 | 0.00% |
| Creative Planning | $114.7万 | 0.00% |
| GUGGENHEIM CAPITAL LLC | $112.9万 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $108.1万 | 0.01% |
| Vestmark Advisory Solutions, Inc. | $106.4万 | 0.01% |
| INTECH INVESTMENT MANAGEMENT LLC | $102.8万 | 0.01% |
| LMR Partners LLP | $101.2万 | 0.00% |
| B. Metzler seel. Sohn & Co. AG | $98.4万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | $96.6万 | 0.00% |
| AlphaCentric Advisors LLC | $95.7万 | 0.96% |
| Police & Firemen's Retirement System of New Jersey | $93.7万 | 0.01% |
| State of New Jersey Common Pension Fund D | $93.2万 | 0.00% |
| GLENMEDE TRUST CO NA | $90.9万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $88.5万 | 0.01% |
| SG Americas Securities, LLC | $85.9万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $81.9万 | 0.06% |
| Vanguard Investments Australia, Ltd. | $81.2万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $78.7万 | 0.00% |
| Birchview Capital, LP | $75.8万 | 0.43% |
| ProShare Advisors LLC | $74.8万 | 0.00% |
| Marks Group Wealth Management, Inc | $69.4万 | 0.07% |
| AQR CAPITAL MANAGEMENT LLC | $67.6万 | 0.00% |
| DNB Asset Management AS | $67.3万 | 0.00% |
| Global Endowment Management, LP | $65.6万 | 0.07% |