| BlackRock, Inc. | $10.0億 | 0.02% |
| BAKER BROS. ADVISORS LP | $3.5億 | 2.03% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $3.4億 | 0.02% |
| STATE STREET CORP | $3.3億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $2.6億 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | $2.2億 | 0.34% |
| AMERICAN CENTURY COMPANIES INC | $2.1億 | 0.11% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.6億 | 0.02% |
| DIMENSIONAL FUND ADVISORS LP | $1.6億 | 0.03% |
| Commodore Capital LP | $1.5億 | 8.59% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.5億 | 0.01% |
| Deep Track Capital, LP | $1.3億 | 2.07% |
| JPMORGAN CHASE & CO | $1.2億 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | $1.1億 | 0.02% |
| FIRST TRUST ADVISORS LP | $1.0億 | 0.08% |
| PRIMECAP MANAGEMENT CO/CA/ | $8981.4万 | 0.07% |
| Nuveen, LLC | $8700.6万 | 0.02% |
| CITADEL ADVISORS LLC | $8243.4万 | 0.01% |
| Holocene Advisors, LP | $8194.1万 | 0.20% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7909.2万 | 0.01% |
| BVF INC/IL | $7072.0万 | 2.25% |
| Soleus Capital Management, L.P. | $6969.0万 | 2.82% |
| GOLDMAN SACHS GROUP INC | $6655.4万 | 0.01% |
| LOOMIS SAYLES & CO L P | $6310.3万 | 0.08% |
| MORGAN STANLEY | $6138.8万 | 0.00% |
| NORTHERN TRUST CORP | $6000.9万 | 0.01% |
| RTW INVESTMENTS, LP | $5913.5万 | 0.59% |
| Affinity Asset Advisors, LLC | $4773.6万 | 2.47% |
| FMR LLC | $4680.8万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | $4281.6万 | 0.00% |
| Avoro Capital Advisors LLC | $4243.2万 | 0.42% |
| VANGUARD FIDUCIARY TRUST CO | $3993.0万 | 0.01% |
| Artisan Partners Limited Partnership | $3931.1万 | 0.06% |
| Bank of New York Mellon Corp | $3664.9万 | 0.01% |
| MARSHALL WACE, LLP | $3533.6万 | 0.04% |
| PRINCIPAL FINANCIAL GROUP INC | $3387.5万 | 0.02% |
| PANAGORA ASSET MANAGEMENT INC | $3298.9万 | 0.12% |
| T. Rowe Price Investment Management, Inc. | $3162.2万 | 0.02% |
| Pictet Asset Management Holding SA | $3016.7万 | 0.03% |
| Driehaus Capital Management LLC | $2800.4万 | 0.21% |
| TWO SIGMA INVESTMENTS, LP | $2760.5万 | 0.02% |
| AMERIPRISE FINANCIAL INC | $2620.7万 | 0.01% |
| D. E. Shaw & Co., Inc. | $2511.6万 | 0.02% |
| Frazier Life Sciences Management, L.P. | $2477.5万 | 0.64% |
| Pacer Advisors, Inc. | $2434.8万 | 0.07% |
| Public Sector Pension Investment Board | $2395.3万 | 0.07% |
| Man Group plc | $2210.2万 | 0.04% |
| Bain Capital Life Sciences Investors, LLC | $2157.0万 | 1.95% |
| Balyasny Asset Management L.P. | $2074.8万 | 0.03% |
| SEGALL BRYANT & HAMILL, LLC | $2071.3万 | 0.30% |
| Woodline Partners LP | $1975.1万 | 0.07% |
| Invesco Ltd. | $1853.8万 | 0.00% |
| Prosight Management, LP | $1816.2万 | 2.98% |
| UBS Group AG | $1750.4万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $1627.7万 | 1.66% |
| RHUMBLINE ADVISERS | $1589.5万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1579.2万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1425.5万 | 0.00% |
| Fisher Asset Management, LLC | $1380.7万 | 0.00% |
| RICE HALL JAMES & ASSOCIATES, LLC | $1380.3万 | 0.77% |
| AQR CAPITAL MANAGEMENT LLC | $1357.7万 | 0.01% |
| Legal & General Group Plc | $1346.2万 | 0.00% |
| GLENMEDE TRUST CO NA | $1336.9万 | 0.07% |
| Logos Global Management LP | $1237.6万 | 0.62% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $1202.2万 | 0.02% |
| California Public Employees Retirement System | $1160.5万 | 0.01% |
| Spruce Street Capital LP | $1124.4万 | 2.70% |
| Swiss National Bank | $1097.2万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | $1092.4万 | 0.01% |
| ROYAL BANK OF CANADA | $1076.1万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $998.3万 | 0.00% |
| Squarepoint Ops LLC | $981.7万 | 0.01% |
| GENDELL JEFFREY L | $932.1万 | 0.13% |
| C WorldWide Group Holding A/S | $884.0万 | 0.19% |
| MACKENZIE FINANCIAL CORP | $881.1万 | 0.01% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $862.8万 | 0.32% |
| CAPITAL FUND MANAGEMENT S.A. | $859.4万 | 0.04% |
| Palo Alto Investors LP | $857.7万 | 1.31% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $847.5万 | 0.01% |
| Eagle Health Investments LP | $843.9万 | 1.48% |
| Senator Investment Group LP | $831.7万 | 0.38% |
| Atle Fund Management AB | $823.6万 | 2.66% |
| ACADIAN ASSET MANAGEMENT LLC | $805.5万 | 0.01% |
| Robeco Institutional Asset Management B.V. | $779.8万 | 0.01% |
| Engineers Gate Manager LP | $737.2万 | 0.09% |
| ALLIANCEBERNSTEIN L.P. | $730.1万 | 0.00% |
| ExodusPoint Capital Management, LP | $722.5万 | 0.06% |
| NEUBERGER BERMAN GROUP LLC | $697.4万 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | $688.7万 | 0.17% |
| Rock Springs Capital Management LP | $650.6万 | 0.38% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $649.9万 | 0.01% |
| FRANKLIN RESOURCES INC | $645.4万 | 0.00% |
| SG Americas Securities, LLC | $632.9万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $631.0万 | 0.01% |
| BARCLAYS PLC | $618.7万 | 0.00% |
| Hudson Bay Capital Management LP | $613.9万 | 0.02% |
| Rafferty Asset Management, LLC | $574.3万 | 0.02% |
| Tetragon Partners GP Ltd | $565.0万 | 1.10% |
| MOORE CAPITAL MANAGEMENT, LP | $560.5万 | 0.11% |
| BESSEMER GROUP INC | $560.1万 | 0.01% |
| SummitTX Capital, L.P. | $552.5万 | 0.17% |
| JANUS HENDERSON GROUP PLC | $544.7万 | 0.00% |
| SEI INVESTMENTS CO | $543.9万 | 0.01% |
| WEDGE CAPITAL MANAGEMENT L L P/NC | $534.8万 | 0.10% |
| DEUTSCHE BANK AG\ | $529.5万 | 0.00% |
| DAFNA Capital Management LLC | $493.2万 | 1.12% |
| STATE OF WISCONSIN INVESTMENT BOARD | $492.7万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | $486.6万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | $482.3万 | 0.00% |
| ALPS ADVISORS INC | $479.7万 | 0.02% |
| Rhenman & Partners Asset Management AB | $471.2万 | 0.58% |
| PRUDENTIAL FINANCIAL INC | $466.3万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $457.7万 | 0.01% |
| Assenagon Asset Management S.A. | $431.8万 | 0.01% |
| Knott David M Jr | $424.3万 | 2.53% |
| WELLS FARGO & COMPANY/MN | $417.0万 | 0.00% |
| Thrivent Financial for Lutherans | $389.7万 | 0.01% |
| Krensavage Asset Management, LLC | $381.3万 | 1.49% |
| Russell Investments Group, Ltd. | $347.5万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $329.3万 | 0.00% |
| Illinois Municipal Retirement Fund | $321.7万 | 0.04% |
| State of Alaska, Department of Revenue | $320.1万 | 0.03% |
| MetLife Investment Management, LLC | $314.2万 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $303.8万 | 0.00% |
| Exome Asset Management LLC | $297.4万 | 1.54% |
| Vident Advisory, LLC | $297.3万 | 0.03% |
| Bridgewater Associates, LP | $296.3万 | 0.01% |
| KLP KAPITALFORVALTNING AS | $290.3万 | 0.01% |
| Pathstone Holdings, LLC | $289.9万 | 0.01% |
| HRT FINANCIAL LP | $289.9万 | 0.01% |
| Vanguard Global Advisers, LLC | $288.7万 | 0.00% |
| STEMPOINT CAPITAL LP | $284.6万 | 0.54% |
| Allianz Asset Management GmbH | $284.2万 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $275.6万 | 0.02% |
| PROFUND ADVISORS LLC | $275.0万 | 0.10% |
| Focus Partners Wealth | $272.5万 | 0.00% |
| Creative Planning | $265.3万 | 0.00% |
| NATIXIS ADVISORS, LLC | $264.7万 | 0.00% |
| Louisiana State Employees Retirement System | $258.8万 | 0.05% |
| HighVista Strategies LLC | $258.8万 | 0.71% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $257.0万 | 0.03% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $253.8万 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $252.5万 | 0.00% |
| State of Tennessee, Department of Treasury | $236.7万 | 0.01% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $236.3万 | 0.01% |
| Federation des caisses Desjardins du Quebec | $233.9万 | 0.01% |
| Amundi | $228.8万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $215.6万 | 0.02% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $203.4万 | 0.00% |
| ROYCE & ASSOCIATES LP | $196.9万 | 0.02% |