| BVF INC/IL | $8125.8万 | 2.59% |
| MORGAN STANLEY | $5339.7万 | 0.00% |
| FMR LLC | $4087.4万 | 0.00% |
| BlackRock, Inc. | $2029.4万 | 0.00% |
| Woodline Partners LP | $2007.7万 | 0.08% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1724.7万 | 0.00% |
| Opaleye Management Inc. | $941.1万 | 1.24% |
| GW&K Investment Management, LLC | $728.2万 | 0.06% |
| GEODE CAPITAL MANAGEMENT, LLC | $721.0万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $642.8万 | 0.00% |
| STATE STREET CORP | $605.9万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $418.2万 | 0.00% |
| TLS Advisors LLC | $360.3万 | 8.55% |
| CITADEL ADVISORS LLC | $345.8万 | 0.00% |
| NORTHERN TRUST CORP | $293.3万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $269.1万 | 0.00% |
| Bank of New York Mellon Corp | $235.2万 | 0.00% |
| UBS Group AG | $227.5万 | 0.00% |
| Stonepine Capital Management, LLC | $218.0万 | 0.87% |
| Simcoe Capital LLC | $213.5万 | 1.96% |
| VANGUARD FIDUCIARY TRUST CO | $209.1万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | $184.0万 | 0.01% |
| HighVista Strategies LLC | $146.9万 | 0.41% |
| CM Management, LLC | $125.5万 | 1.05% |
| RBF Capital, LLC | $94.1万 | 0.05% |
| STATE OF WISCONSIN INVESTMENT BOARD | $90.6万 | 0.00% |
| Quadrature Capital Ltd | $89.4万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $85.2万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $81.8万 | 0.00% |
| JANE STREET GROUP, LLC | $79.1万 | 0.00% |
| GOLDMAN SACHS GROUP INC | $75.3万 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $75.3万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $55.1万 | 0.01% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | $53.3万 | 0.50% |
| ExodusPoint Capital Management, LP | $46.0万 | 0.00% |
| Nuveen, LLC | $39.9万 | 0.00% |
| RHUMBLINE ADVISERS | $36.7万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | $34.6万 | 0.00% |
| DIVERSIFIED MANAGEMENT INC | $31.4万 | 0.05% |
| REGIONS FINANCIAL CORP | $29.0万 | 0.00% |
| DEUTSCHE BANK AG\ | $26.5万 | 0.00% |
| Caption Management, LLC | $23.3万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $21.4万 | 0.00% |
| Invesco Ltd. | $21.3万 | 0.00% |
| MetLife Investment Management, LLC | $17.8万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $14.4万 | 0.00% |
| Vanguard Global Advisers, LLC | $12.7万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $12.1万 | 0.00% |
| JPMORGAN CHASE & CO | $12.1万 | 0.00% |
| OSAIC HOLDINGS, INC. | $10.8万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $9.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $7.4万 | 0.00% |
| BARCLAYS PLC | $6.2万 | 0.00% |
| State of Alaska, Department of Revenue | $3.2万 | 0.00% |
| ROYAL BANK OF CANADA | $3.1万 | 0.00% |
| Ameritas Investment Partners, Inc. | $3.0万 | 0.00% |
| Legal & General Group Plc | $2.7万 | 0.00% |
| Russell Investments Group, Ltd. | $2.6万 | 0.00% |
| CITIGROUP INC | $2.4万 | 0.00% |
| Costello Asset Management, INC | $1.9万 | 0.01% |
| Tower Research Capital LLC (TRC) | $1.8万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1.6万 | 0.00% |
| NATIXIS | $1.2万 | 0.00% |
| Truvestments Capital LLC | $9097.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $8878.0 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $5960.0 | 0.00% |
| GAMMA Investing LLC | $4768.0 | 0.00% |
| Sterling Capital Management LLC | $4549.0 | 0.00% |
| CWM, LLC | $3545.0 | 0.00% |
| Optiver Holding B.V. | $2823.0 | 0.00% |
| US BANCORP \DE\ | $2102.0 | 0.00% |
| EverSource Wealth Advisors, LLC | $1850.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | $784.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $687.9 | 0.00% |
| MH & ASSOCIATES SECURITIES MANAGEMENT CORP /ADV | $628.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | $596.0 | 0.00% |
| SBI Securities Co., Ltd. | $439.0 | 0.00% |
| Root Financial Partners, LLC | $408.0 | 0.00% |
| Larson Financial Group LLC | $314.0 | 0.00% |
| True Wealth Design, LLC | $126.0 | 0.00% |
| Allworth Financial LP | $95.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | $94.0 | 0.00% |
| TD Waterhouse Canada Inc. | $33.0 | 0.00% |
| MAI Capital Management | $32.0 | 0.00% |