| MPM BIOIMPACT LLC | US$8651.4万 | 6.68% |
| EcoR1 Capital, LLC | US$8631.0万 | 3.66% |
| Blue Owl Capital Holdings LP | US$5655.7万 | 15.20% |
| WELLINGTON MANAGEMENT GROUP LLP | US$4145.2万 | 0.01% |
| T. Rowe Price Investment Management, Inc. | US$3799.5万 | 0.03% |
| BlackRock, Inc. | US$3778.6万 | 0.00% |
| RTW INVESTMENTS, LP | US$2848.2万 | 0.28% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$2798.5万 | 0.00% |
| RA CAPITAL MANAGEMENT, L.P. | US$2689.0万 | 0.28% |
| JANUS HENDERSON GROUP PLC | US$2602.2万 | 0.01% |
| BAKER BROS. ADVISORS LP | US$1782.5万 | 0.10% |
| Octagon Capital Advisors LP | US$1719.0万 | 1.90% |
| Merck & Co., Inc. | US$1704.6万 | 4.88% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1491.9万 | 0.00% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$907.0万 | 0.15% |
| GEODE CAPITAL MANAGEMENT, LLC | US$880.3万 | 0.00% |
| Avidity Partners Management LP | US$838.3万 | 1.70% |
| STATE STREET CORP | US$766.1万 | 0.00% |
| a16z Capital Management, L.L.C. | US$742.4万 | 0.58% |
| FMR LLC | US$691.2万 | 0.00% |
| UBS Group AG | US$632.0万 | 0.00% |
| ArrowMark Colorado Holdings LLC | US$589.4万 | 0.16% |
| Alyeska Investment Group, L.P. | US$518.8万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$289.8万 | 0.00% |
| Driehaus Capital Management LLC | US$268.4万 | 0.02% |
| NORTHERN TRUST CORP | US$267.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$227.9万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$215.3万 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$184.1万 | 0.00% |
| TD Asset Management Inc | US$180.6万 | 0.00% |
| Laurion Capital Management LP | US$178.9万 | 0.08% |
| SOROS FUND MANAGEMENT LLC | US$178.9万 | 0.02% |
| Woodline Partners LP | US$178.9万 | 0.01% |
| CITADEL ADVISORS LLC | US$134.2万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$125.1万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$84.1万 | 0.00% |
| Bank of New York Mellon Corp | US$76.7万 | 0.00% |
| MORGAN STANLEY | US$55.0万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$54.0万 | 0.00% |
| READYSTATE ASSET MANAGEMENT LP | US$53.7万 | 0.02% |
| Ghisallo Capital Management LLC | US$44.7万 | 0.01% |
| SEVEN GRAND MANAGERS, LLC | US$44.7万 | 0.03% |
| Nuveen, LLC | US$43.8万 | 0.00% |
| RHUMBLINE ADVISERS | US$37.6万 | 0.00% |
| D. E. Shaw & Co., Inc. | US$30.5万 | 0.00% |
| Zimmer Partners, LP | US$26.8万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | US$25.4万 | 0.00% |
| DEUTSCHE BANK AG\ | US$25.2万 | 0.00% |
| XTX Topco Ltd | US$25.0万 | 0.00% |
| Invesco Ltd. | US$21.7万 | 0.00% |
| MetLife Investment Management, LLC | US$20.8万 | 0.00% |
| BARCLAYS PLC | US$17.4万 | 0.00% |
| Vanguard Global Advisers, LLC | US$17.3万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$17.3万 | 0.00% |
| JPMORGAN CHASE & CO | US$13.8万 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$13.6万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$12.4万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$9.9万 | 0.00% |
| STRS OHIO | US$6.4万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$5.7万 | 0.00% |
| Legal & General Group Plc | US$3.3万 | 0.00% |
| Ameritas Investment Partners, Inc. | US$3.0万 | 0.00% |
| Russell Investments Group, Ltd. | US$2.8万 | 0.00% |
| CITIGROUP INC | US$1.8万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$1.8万 | 0.00% |
| SALEM INVESTMENT COUNSELORS INC | US$1.8万 | 0.00% |
| Sterling Capital Management LLC | US$7031.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$801.5 | 0.00% |
| CWM, LLC | US$376.0 | 0.00% |