| RA CAPITAL MANAGEMENT, L.P. | US$4.0億 | 4.21% |
| TPG GP A, LLC | US$2.6億 | 7.08% |
| ORBIMED ADVISORS LLC | US$1.4億 | 2.90% |
| VIKING GLOBAL INVESTORS LP | US$1.3億 | 0.36% |
| Atlas Venture Life Science Advisors, LLC | US$1.2億 | 15.20% |
| ENAVATE SCIENCES GP, LLC | US$9934.4萬 | 28.26% |
| JENNISON ASSOCIATES LLC | US$5817.9萬 | 0.04% |
| JPMORGAN CHASE & CO | US$5370.7萬 | 0.00% |
| BlackRock, Inc. | US$5195.1萬 | 0.00% |
| CITADEL ADVISORS LLC | US$4678.2萬 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$4127.3萬 | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$3891.1萬 | 0.46% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$3032.4萬 | 0.00% |
| STATE STREET CORP | US$3031.7萬 | 0.00% |
| PERCEPTIVE ADVISORS LLC | US$2639.7萬 | 0.52% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$2587.6萬 | 0.43% |
| Aberdeen Group plc | US$2261.8萬 | 0.04% |
| BAKER BROS. ADVISORS LP | US$1603.6萬 | 0.09% |
| GEODE CAPITAL MANAGEMENT, LLC | US$1563.4萬 | 0.00% |
| Siren, L.L.C. | US$1202.7萬 | 0.33% |
| Sio Capital Management, LLC | US$1180.0萬 | 1.69% |
| Soleus Capital Management, L.P. | US$1176.6萬 | 0.48% |
| GOLDMAN SACHS GROUP INC | US$1055.1萬 | 0.00% |
| Ensign Peak Advisors, Inc | US$1024.8萬 | 0.02% |
| Candriam S.C.A. | US$949.4萬 | 0.05% |
| Kalehua Capital Management LLC | US$790.1萬 | 5.59% |
| FRANKLIN RESOURCES INC | US$703.5萬 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$601.4萬 | 0.01% |
| UBS Group AG | US$591.9萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$569.6萬 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$565.4萬 | 4.04% |
| MILLENNIUM MANAGEMENT LLC | US$563.8萬 | 0.00% |
| Point72 Asset Management, L.P. | US$547.4萬 | 0.01% |
| Alyeska Investment Group, L.P. | US$546.1萬 | 0.02% |
| GordonMD Global Investments LP | US$545.2萬 | 3.80% |
| MORGAN STANLEY | US$533.3萬 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$482.1萬 | 0.00% |
| Artia Global Partners LP | US$480.0萬 | 0.96% |
| NORTHERN TRUST CORP | US$468.2萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$449.7萬 | 0.00% |
| Rock Springs Capital Management LP | US$398.6萬 | 0.23% |
| Rhenman & Partners Asset Management AB | US$350.8萬 | 0.43% |
| TD Asset Management Inc | US$332.7萬 | 0.00% |
| AMERIPRISE FINANCIAL INC | US$328.6萬 | 0.00% |
| FMR LLC | US$326.3萬 | 0.00% |
| Driehaus Capital Management LLC | US$307.2萬 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$258.4萬 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$203.9萬 | 0.00% |
| Integral Health Asset Management, LLC | US$200.5萬 | 0.10% |
| SEVEN GRAND MANAGERS, LLC | US$200.5萬 | 0.13% |
| Ishara Investments LP | US$197.2萬 | 1.87% |
| Russell Investments Group, Ltd. | US$194.1萬 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | US$184.7萬 | 0.00% |
| Qube Research & Technologies Ltd | US$169.3萬 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$158.0萬 | 0.16% |
| ALPS ADVISORS INC | US$146.8萬 | 0.01% |
| STEMPOINT CAPITAL LP | US$146.5萬 | 0.28% |
| Bank of New York Mellon Corp | US$135.4萬 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | US$107.3萬 | 0.01% |
| Maven Securities LTD | US$100.2萬 | 0.02% |
| Nuveen, LLC | US$95.1萬 | 0.00% |
| XTX Topco Ltd | US$94.4萬 | 0.02% |
| Rafferty Asset Management, LLC | US$88.7萬 | 0.00% |
| BARCLAYS PLC | US$73.7萬 | 0.00% |
| RHUMBLINE ADVISERS | US$73.4萬 | 0.00% |
| CITIGROUP INC | US$72.4萬 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | US$67.5萬 | 0.00% |
| Squarepoint Ops LLC | US$61.0萬 | 0.00% |
| Walleye Capital LLC | US$60.5萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$53.1萬 | 0.00% |
| Longaeva Partners L.P. | US$50.9萬 | 0.02% |
| KENNEDY CAPITAL MANAGEMENT LLC | US$49.2萬 | 0.01% |
| Vanguard Global Advisers, LLC | US$44.9萬 | 0.00% |
| Invesco Ltd. | US$43.2萬 | 0.00% |
| PROFUND ADVISORS LLC | US$39.8萬 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$36.3萬 | 0.00% |
| MetLife Investment Management, LLC | US$34.3萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$31.8萬 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$29.3萬 | 0.00% |
| ExodusPoint Capital Management, LP | US$28.8萬 | 0.00% |
| VARCOV Co. | US$26.3萬 | 0.10% |
| Virtus Investment Advisers, LLC | US$25.6萬 | 0.07% |
| Quarry LP | US$25.3萬 | 0.05% |
| Hudson Bay Capital Management LP | US$24.8萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$23.6萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$22.0萬 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | US$22.0萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$21.2萬 | 0.00% |
| AlphaCentric Advisors LLC | US$19.3萬 | 0.19% |
| Police & Firemen's Retirement System of New Jersey | US$17.0萬 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$16.5萬 | 0.00% |
| Cygnus Capital Advisors, LLC | US$15.2萬 | 0.10% |
| STRS OHIO | US$11.6萬 | 0.00% |
| Tower Research Capital LLC (TRC) | US$9.4萬 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | US$9.3萬 | 0.00% |
| Legal & General Group Plc | US$5.7萬 | 0.00% |
| Ameritas Investment Partners, Inc. | US$5.2萬 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | US$4.0萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$3.5萬 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1.6萬 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | US$1.5萬 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$1.0萬 | 0.00% |
| Rockefeller Capital Management L.P. | US$9661.0 | 0.00% |
| GAMMA Investing LLC | US$9541.0 | 0.00% |
| Farther Finance Advisors, LLC | US$8095.0 | 0.00% |
| Quantbot Technologies LP | US$7136.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$4650.0 | 0.00% |
| Sterling Capital Management LLC | US$4209.0 | 0.00% |
| CWM, LLC | US$2686.0 | 0.00% |
| US BANCORP \DE\ | US$2045.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$1443.0 | 0.00% |
| Allworth Financial LP | US$1163.0 | 0.00% |
| Hughes Financial Services, LLC | US$1042.0 | 0.00% |
| ROYAL BANK OF CANADA | US$1000.0 | 0.00% |
| SIGNATUREFD, LLC | US$962.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$922.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$641.0 | 0.00% |
| Fortitude Family Office, LLC | US$601.0 | 0.00% |
| Root Financial Partners, LLC | US$401.0 | 0.00% |
| MAI Capital Management | US$81.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$40.0 | 0.00% |
| Covestor Ltd | US$0.0 | 0.00% |