| FMR LLC | $21.6億 | 0.11% |
| MORGAN STANLEY | $14.4億 | 0.09% |
| BlackRock, Inc. | $12.3億 | 0.02% |
| QVT Financial LP | $7.0億 | 51.04% |
| UBS Group AG | $6.3億 | 0.09% |
| VANGUARD CAPITAL MANAGEMENT LLC | $5.7億 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $5.5億 | 0.03% |
| STATE STREET CORP | $4.5億 | 0.02% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $3.5億 | 0.55% |
| GOLDMAN SACHS GROUP INC | $3.1億 | 0.04% |
| GEODE CAPITAL MANAGEMENT, LLC | $2.8億 | 0.02% |
| Two Seas Capital LP | $2.8億 | 3.90% |
| FARALLON CAPITAL MANAGEMENT LLC | $2.7億 | 1.53% |
| PERCEPTIVE ADVISORS LLC | $2.3億 | 4.48% |
| Patient Square Capital LP | $2.3億 | 40.13% |
| DIMENSIONAL FUND ADVISORS LP | $2.1億 | 0.04% |
| Assenagon Asset Management S.A. | $2.0億 | 0.30% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.9億 | 0.02% |
| VIKING GLOBAL INVESTORS LP | $1.8億 | 0.52% |
| Darwin Global Management, Ltd. | $1.8億 | 4.76% |
| Invesco Ltd. | $1.8億 | 0.03% |
| NATIONAL BANK OF CANADA /FI/ | $1.7億 | 0.17% |
| AQR CAPITAL MANAGEMENT LLC | $1.6億 | 0.07% |
| Rubric Capital Management LP | $1.4億 | 1.47% |
| BAKER BROS. ADVISORS LP | $1.3億 | 0.77% |
| NORTHERN TRUST CORP | $9751.7万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $9577.1万 | 0.01% |
| Qube Research & Technologies Ltd | $9559.0万 | 0.11% |
| ADAR1 Capital Management, LLC | $9102.0万 | 5.36% |
| BANK OF AMERICA CORP /DE/ | $8763.8万 | 0.01% |
| JANUS HENDERSON GROUP PLC | $8579.0万 | 0.04% |
| JENNISON ASSOCIATES LLC | $8262.4万 | 0.06% |
| VANGUARD FIDUCIARY TRUST CO | $7786.8万 | 0.02% |
| Affinity Asset Advisors, LLC | $7756.0万 | 4.01% |
| Bank of New York Mellon Corp | $7578.2万 | 0.01% |
| CITADEL ADVISORS LLC | $7543.3万 | 0.01% |
| Pictet Asset Management Holding SA | $7404.9万 | 0.08% |
| SB INVESTMENT ADVISERS (UK) LTD | $7400.7万 | 0.96% |
| BlackBarn Capital Partners LP | $6329.8万 | 5.09% |
| MARSHALL WACE, LLP | $6224.0万 | 0.06% |
| DME Capital Management, LP | $5962.9万 | 1.87% |
| Clearbridge Investments, LLC | $5555.4万 | 0.05% |
| Candriam S.C.A. | $5545.5万 | 0.29% |
| Integral Health Asset Management, LLC | $5540.0万 | 2.65% |
| Nuveen, LLC | $5415.5万 | 0.01% |
| Woodline Partners LP | $4847.5万 | 0.18% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $4823.9万 | 0.01% |
| MAVERICK CAPITAL LTD | $4506.6万 | 0.52% |
| PENN DAVIS MCFARLAND INC | $4411.6万 | 4.32% |
| CITIGROUP INC | $4404.6万 | 0.02% |
| Polar Capital Holdings Plc | $4371.9万 | 0.16% |
| Amundi | $4102.3万 | 0.01% |
| JPMORGAN CHASE & CO | $4060.6万 | 0.00% |
| Whitefort Capital Management, LP | $3930.6万 | 11.59% |
| Gotham Asset Management, LLC | $3922.6万 | 0.12% |
| BARCLAYS PLC | $3921.9万 | 0.01% |
| D. E. Shaw & Co., Inc. | $3857.9万 | 0.02% |
| Parkside Financial Bank & Trust | $3681.8万 | 2.82% |
| BANK OF NOVA SCOTIA | $3629.8万 | 0.06% |
| JANE STREET GROUP, LLC | $3298.0万 | 0.00% |
| First Turn Management, LLC | $3296.6万 | 3.68% |
| RHUMBLINE ADVISERS | $3083.7万 | 0.03% |
| Ensign Peak Advisors, Inc | $2822.2万 | 0.05% |
| PRINCIPAL FINANCIAL GROUP INC | $2785.3万 | 0.01% |
| Point72 Asset Management, L.P. | $2700.8万 | 0.03% |
| WELLINGTON MANAGEMENT GROUP LLP | $2668.3万 | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $2562.8万 | 0.11% |
| Davern Capital Partners, LP | $2419.3万 | 6.64% |
| Man Group plc | $2360.6万 | 0.04% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2337.9万 | 0.00% |
| ALGERT GLOBAL LLC | $2292.0万 | 0.34% |
| MILLENNIUM MANAGEMENT LLC | $2226.5万 | 0.01% |
| Cormorant Asset Management, LP | $2077.5万 | 1.04% |
| Swiss National Bank | $2059.3万 | 0.01% |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | $2008.3万 | 0.13% |
| TD Asset Management Inc | $1981.3万 | 0.02% |
| Russell Investments Group, Ltd. | $1958.9万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1936.6万 | 0.02% |
| California Public Employees Retirement System | $1915.4万 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | $1879.5万 | 0.01% |
| SG Americas Securities, LLC | $1775.4万 | 0.02% |
| Dorsey Wright & Associates | $1598.7万 | 1.98% |
| Legal & General Group Plc | $1554.8万 | 0.00% |
| Retirement Systems of Alabama | $1531.2万 | 0.05% |
| ALLIANCEBERNSTEIN L.P. | $1467.7万 | 0.00% |
| Sofinnova Investments, Inc. | $1324.0万 | 0.50% |
| FIRST TRUST ADVISORS LP | $1262.7万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1220.6万 | 0.01% |
| AMERIPRISE FINANCIAL INC | $1214.8万 | 0.00% |
| ING GROEP NV | $1084.5万 | 0.07% |
| STEMPOINT CAPITAL LP | $1068.7万 | 2.05% |
| LPL Financial LLC | $1048.9万 | 0.00% |
| PDT Partners, LLC | $1042.9万 | 0.62% |
| VANGUARD ASSET MANAGEMENT, Ltd | $974.7万 | 0.01% |
| DIADEMA PARTNERS LP | $930.2万 | 1.58% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $902.3万 | 0.02% |
| VOYA INVESTMENT MANAGEMENT LLC | $871.0万 | 0.01% |
| Impax Asset Management Group plc | $831.0万 | 0.06% |
| Empowered Funds, LLC | $792.0万 | 0.05% |
| Nicholas Investment Partners, LP | $771.2万 | 0.56% |
| Consolidated Portfolio Review Corp | $766.0万 | 0.70% |
| Pine Ridge Advisers LLC | $766.0万 | 0.47% |
| Cinctive Capital Management LP | $760.4万 | 0.50% |
| WELLS FARGO & COMPANY/MN | $731.2万 | 0.00% |
| Engineers Gate Manager LP | $710.4万 | 0.09% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $708.9万 | 0.01% |
| XTX Topco Ltd | $707.5万 | 0.12% |
| NEW YORK STATE COMMON RETIREMENT FUND | $691.5万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $652.6万 | 0.01% |
| Pier Capital, LLC | $629.0万 | 1.04% |
| MetLife Investment Management, LLC | $613.2万 | 0.03% |
| Caption Management, LLC | $608.8万 | 0.04% |
| Vanguard Global Advisers, LLC | $575.4万 | 0.00% |
| PFM Health Sciences, LP | $574.6万 | 0.52% |
| Erste Asset Management GmbH | $565.2万 | 0.05% |
| WORLDQUANT MILLENNIUM ADVISORS LLC | $560.7万 | 0.02% |
| Mariner, LLC | $560.4万 | 0.01% |
| AMALGAMATED BANK | $555.3万 | 0.04% |
| MUFG Securities EMEA plc | $554.0万 | 0.08% |
| CWM, LLC | $503.9万 | 0.01% |
| Treasurer of the State of North Carolina | $503.5万 | 0.02% |
| Police & Firemen's Retirement System of New Jersey | $499.0万 | 0.04% |
| Prosight Management, LP | $498.6万 | 0.82% |
| Walleye Capital LLC | $491.4万 | 0.02% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $478.6万 | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | $475.1万 | 0.00% |
| Cetera Investment Advisers | $469.4万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $443.2万 | 0.01% |
| Rafferty Asset Management, LLC | $440.0万 | 0.02% |
| Allspring Global Investments Holdings, LLC | $395.7万 | 0.01% |
| YOUSIF CAPITAL MANAGEMENT, LLC | $379.4万 | 0.04% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $379.2万 | 0.00% |
| CenterBook Partners LP | $379.0万 | 0.20% |
| GREAT LAKES ADVISORS, LLC | $375.3万 | 0.03% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $374.6万 | 0.03% |
| AXQ CAPITAL, LP | $366.9万 | 0.47% |
| Louisiana State Employees Retirement System | $362.0万 | 0.06% |
| Artia Global Partners LP | $359.5万 | 0.72% |
| State of Tennessee, Department of Treasury | $358.1万 | 0.01% |
| State of New Jersey Common Pension Fund D | $355.6万 | 0.01% |
| Seven Fleet Capital Management LP | $355.0万 | 1.13% |
| China Universal Asset Management Co., Ltd. | $351.8万 | 0.27% |
| BAMCO INC /NY/ | $346.3万 | 0.01% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $342.3万 | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | $337.7万 | 0.07% |
| Creative Planning | $336.7万 | 0.00% |
| SEI INVESTMENTS CO | $333.3万 | 0.00% |
| Anfield Capital Management, LLC | $330.9万 | 0.91% |
| Illinois Municipal Retirement Fund | $330.7万 | 0.04% |
| Handelsbanken Fonder AB | $324.1万 | 0.01% |