| FMR LLC | $23.2億 | 0.12% |
| BlackRock, Inc. | $15.1億 | 0.03% |
| VANGUARD CAPITAL MANAGEMENT LLC | $11.6億 | 0.03% |
| BAILLIE GIFFORD & CO | $10.2億 | 1.04% |
| Capital World Investors | $9.5億 | 0.13% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7.9億 | 0.04% |
| STATE STREET CORP | $7.5億 | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6.4億 | 0.07% |
| GEODE CAPITAL MANAGEMENT, LLC | $4.8億 | 0.03% |
| TWO SIGMA INVESTMENTS, LP | $4.7億 | 0.38% |
| MORGAN STANLEY | $4.3億 | 0.03% |
| UBS Group AG | $4.2億 | 0.06% |
| Theleme Partners LLP | $4.1億 | 27.24% |
| JANE STREET GROUP, LLC | $3.7億 | 0.05% |
| CITADEL ADVISORS LLC | $3.6億 | 0.06% |
| GOLDMAN SACHS GROUP INC | $3.4億 | 0.04% |
| CITIGROUP INC | $3.2億 | 0.14% |
| D. E. Shaw & Co., Inc. | $2.7億 | 0.16% |
| Tidal Investments LLC | $2.6億 | 0.54% |
| IMC-Chicago, LLC | $2.6億 | 0.05% |
| Invesco Ltd. | $2.4億 | 0.04% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $2.4億 | 0.04% |
| Flagship Pioneering, LLC | $2.4億 | 20.26% |
| Alyeska Investment Group, L.P. | $2.1億 | 0.58% |
| NATIONAL BANK OF CANADA /FI/ | $1.7億 | 0.09% |
| NORTHERN TRUST CORP | $1.5億 | 0.02% |
| BANQUE PICTET & CIE SA | $1.4億 | 0.98% |
| FIRST TRUST ADVISORS LP | $1.2億 | 0.09% |
| WELLINGTON MANAGEMENT GROUP LLP | $1.2億 | 0.02% |
| Merck & Co., Inc. | $1.2億 | 33.56% |
| JPMORGAN CHASE & CO | $1.1億 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $1.1億 | 0.02% |
| Qube Research & Technologies Ltd | $1.1億 | 0.12% |
| FEDERATED HERMES, INC. | $1.0億 | 0.16% |
| VANGUARD FIDUCIARY TRUST CO | $9988.9万 | 0.03% |
| Caption Management, LLC | $9865.9万 | 0.58% |
| Squarepoint Ops LLC | $9606.3万 | 0.11% |
| SIMPLEX TRADING, LLC | $9544.2万 | 0.03% |
| Bank of New York Mellon Corp | $8591.3万 | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $8232.5万 | 0.02% |
| Douglas Lane & Associates, LLC | $6662.3万 | 0.96% |
| GROUP ONE TRADING LLC | $6490.2万 | 0.08% |
| MILLENNIUM MANAGEMENT LLC | $6210.3万 | 0.03% |
| Walleye Trading LLC | $5853.5万 | 0.10% |
| LMR Partners LLP | $5762.7万 | 0.13% |
| Two Seas Capital LP | $5588.0万 | 0.78% |
| Nuveen, LLC | $5477.2万 | 0.01% |
| BARCLAYS PLC | $5442.0万 | 0.01% |
| ROYAL BANK OF CANADA | $5272.3万 | 0.01% |
| PERCEPTIVE ADVISORS LLC | $5080.0万 | 0.99% |
| Allianz Asset Management GmbH | $5023.7万 | 0.05% |
| BANK OF AMERICA CORP /DE/ | $5010.7万 | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | $4933.3万 | 0.22% |
| Amundi | $4596.5万 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | $4476.5万 | 0.07% |
| Alphadyne Asset Management LP | $4423.2万 | 0.77% |
| DEUTSCHE BANK AG\ | $4116.1万 | 0.01% |
| Affinity Asset Advisors, LLC | $4064.0万 | 2.10% |
| Lingotto Investment Management LLP | $3880.6万 | 0.77% |
| Legal & General Group Plc | $3814.2万 | 0.01% |
| LETKO, BROSSEAU & ASSOCIATES INC | $3804.0万 | 0.61% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $3752.1万 | 0.00% |
| Vanguard Global Advisers, LLC | $3738.7万 | 0.02% |
| Point72 Asset Management, L.P. | $3628.4万 | 0.05% |
| Russell Investments Group, Ltd. | $3607.9万 | 0.04% |
| Swiss National Bank | $3536.2万 | 0.02% |
| Pictet Asset Management Holding SA | $3279.0万 | 0.03% |
| Step Capital Management Pte. Ltd. | $3276.6万 | 13.15% |
| California Public Employees Retirement System | $3191.1万 | 0.02% |
| HSBC HOLDINGS PLC | $2851.2万 | 0.01% |
| RHUMBLINE ADVISERS | $2846.6万 | 0.02% |
| CAPSTONE INVESTMENT ADVISORS, LLC | $2657.6万 | 0.05% |
| PEAK6 LLC | $2644.6万 | 0.06% |
| Telemark Asset Management, LLC | $2540.0万 | 2.35% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $2467.5万 | 0.10% |
| Trexquant Investment LP | $2458.6万 | 0.18% |
| OFI INVEST ASSET MANAGEMENT | $2415.6万 | 0.32% |
| Susquehanna Portfolio Strategies, LLC | $2392.9万 | 0.36% |
| Walleye Capital LLC | $2365.1万 | 0.10% |
| VOYA INVESTMENT MANAGEMENT LLC | $2230.5万 | 0.02% |
| Mitsubishi UFJ Asset Management Co., Ltd. | $2157.1万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2068.5万 | 0.02% |
| Mount Capital Ltd | $2007.6万 | 8.09% |
| HRT FINANCIAL LP | $1973.5万 | 0.05% |
| PRINCIPAL FINANCIAL GROUP INC | $1969.6万 | 0.01% |
| CWM, LLC | $1965.5万 | 0.05% |
| TUDOR INVESTMENT CORP ET AL | $1899.5万 | 0.04% |
| Mitsubishi UFJ Trust & Banking Corp | $1731.8万 | 0.04% |
| BANK OF MONTREAL /CAN/ | $1717.6万 | 0.01% |
| Leonteq Securities AG | $1622.4万 | 0.60% |
| VANGUARD ASSET MANAGEMENT, Ltd | $1619.4万 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1599.5万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $1534.7万 | 0.03% |
| SG Americas Securities, LLC | $1443.8万 | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | $1402.4万 | 0.01% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $1353.3万 | 0.03% |
| MARSHALL WACE, LLP | $1266.5万 | 0.01% |
| VAN ECK ASSOCIATES CORP | $1251.9万 | 0.01% |
| ALGERT GLOBAL LLC | $1206.1万 | 0.18% |
| Candriam S.C.A. | $1172.6万 | 0.06% |
| ALLIANCEBERNSTEIN L.P. | $1161.8万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1154.0万 | 0.03% |
| PLUSTICK MANAGEMENT LLC | $1117.6万 | 5.40% |
| DekaBank Deutsche Girozentrale | $1080.3万 | 0.02% |
| Woodline Partners LP | $1074.3万 | 0.04% |
| CREDIT AGRICOLE S A | $1020.0万 | 0.03% |
| Artia Global Partners LP | $1016.0万 | 2.03% |
| SHANDA ASSET MANAGEMENT HOLDINGS Ltd | $1016.0万 | 0.55% |
| RAYMOND JAMES FINANCIAL INC | $1001.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $984.3万 | 0.00% |
| TWIN FOCUS CAPITAL PARTNERS, LLC | $942.9万 | 1.08% |
| TD Asset Management Inc | $912.3万 | 0.01% |
| LPL Financial LLC | $904.4万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $898.1万 | 0.01% |
| Chevy Chase Trust Holdings, LLC | $870.3万 | 0.03% |
| PRUDENTIAL FINANCIAL INC | $868.2万 | 0.01% |
| Bank Pictet & Cie (Europe) AG | $856.5万 | 0.18% |
| Quantinno Capital Management LP | $853.8万 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $850.0万 | 0.07% |
| Vontobel Holding Ltd. | $830.2万 | 0.03% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $813.6万 | 0.02% |
| Eversept Partners, LP | $811.3万 | 0.43% |
| DIADEMA PARTNERS LP | $809.8万 | 1.38% |
| JANUS HENDERSON GROUP PLC | $809.5万 | 0.00% |
| Crawford Fund Management, LLC | $803.7万 | 1.55% |
| 683 Capital Management, LLC | $792.5万 | 0.41% |
| Treasurer of the State of North Carolina | $779.3万 | 0.02% |
| CANADA LIFE ASSURANCE Co | $754.6万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $748.3万 | 0.01% |
| GATEWAY INVESTMENT ADVISERS LLC | $743.0万 | 0.08% |
| AMERIPRISE FINANCIAL INC | $728.6万 | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $701.1万 | 0.01% |
| Centiva Capital, LP | $698.7万 | 0.05% |
| Banco Santander, S.A. | $675.8万 | 0.05% |
| SEI INVESTMENTS CO | $657.3万 | 0.01% |
| Compagnie Lombard Odier SCmA | $638.7万 | 0.08% |
| CHAPIN DAVIS, INC. | $637.7万 | 1.42% |
| Twin Tree Management, LP | $636.0万 | 0.13% |
| State of New Jersey Common Pension Fund D | $610.5万 | 0.02% |
| Rafferty Asset Management, LLC | $580.1万 | 0.02% |
| Handelsbanken Fonder AB | $566.9万 | 0.02% |
| CREDIT INDUSTRIEL ET COMMERCIAL | $553.9万 | 0.43% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $529.8万 | 0.02% |
| Parkman Healthcare Partners LLC | $508.0万 | 0.52% |
| TANG CAPITAL MANAGEMENT LLC | $508.0万 | 0.26% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $507.8万 | 0.02% |
| South Dakota Investment Council | $505.7万 | 0.10% |
| NEUBERGER BERMAN GROUP LLC | $505.7万 | 0.00% |
| Public Sector Pension Investment Board | $502.7万 | 0.02% |
| CIBC Bancorp USA Inc. | $500.5万 | 0.01% |