| ORBIMED ADVISORS LLC | $4.9億 | 10.02% |
| RA CAPITAL MANAGEMENT, L.P. | $3.3億 | 3.48% |
| Paradigm Biocapital Advisors LP | $2.3億 | 4.74% |
| BAKER BROS. ADVISORS LP | $2.1億 | 1.19% |
| BlackRock, Inc. | $2.0億 | 0.00% |
| JANUS HENDERSON GROUP PLC | $1.9億 | 0.09% |
| NOVO HOLDINGS A/S | $1.7億 | 13.65% |
| Driehaus Capital Management LLC | $1.4億 | 1.04% |
| Siren, L.L.C. | $1.4億 | 3.87% |
| PERCEPTIVE ADVISORS LLC | $1.4億 | 2.72% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1.2億 | 0.00% |
| Cormorant Asset Management, LP | $1.0億 | 5.16% |
| BRAIDWELL LP | $7394.9万 | 2.47% |
| MORGAN STANLEY | $7075.0万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $5639.1万 | 0.00% |
| STATE STREET CORP | $5408.0万 | 0.00% |
| MPM BIOIMPACT LLC | $5231.2万 | 4.04% |
| Integral Health Asset Management, LLC | $5040.0万 | 2.41% |
| Bellevue Group AG | $4814.8万 | 1.15% |
| Soleus Capital Management, L.P. | $4567.2万 | 1.85% |
| ALLIANCEBERNSTEIN L.P. | $4273.6万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $4181.2万 | 0.00% |
| UBS Group AG | $4130.0万 | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | $3841.3万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | $3613.6万 | 0.02% |
| FMR LLC | $3203.7万 | 0.00% |
| First Light Asset Management, LLC | $3155.8万 | 2.83% |
| Aberdeen Group plc | $2602.1万 | 0.04% |
| Qube Research & Technologies Ltd | $2601.6万 | 0.03% |
| VICTORY CAPITAL MANAGEMENT INC | $2485.5万 | 0.02% |
| Artisan Partners Limited Partnership | $2076.1万 | 0.03% |
| MARSHALL WACE, LLP | $2042.4万 | 0.02% |
| GOLDMAN SACHS GROUP INC | $1983.9万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1878.4万 | 0.00% |
| NORTHERN TRUST CORP | $1816.2万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1755.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $1643.4万 | 0.00% |
| Opaleye Management Inc. | $1575.0万 | 2.07% |
| CITADEL ADVISORS LLC | $1523.8万 | 0.00% |
| Candriam S.C.A. | $1409.4万 | 0.07% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $1273.2万 | 0.02% |
| Sofinnova Investments, Inc. | $1217.5万 | 0.46% |
| Squadron Capital Management LLC | $1102.5万 | 4.04% |
| MILLENNIUM MANAGEMENT LLC | $1080.0万 | 0.00% |
| Nuveen, LLC | $1057.7万 | 0.00% |
| Parkman Healthcare Partners LLC | $1016.9万 | 1.05% |
| STEMPOINT CAPITAL LP | $916.2万 | 1.75% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $892.4万 | 0.02% |
| Sio Capital Management, LLC | $847.3万 | 1.22% |
| KENNEDY CAPITAL MANAGEMENT LLC | $832.2万 | 0.18% |
| JANE STREET GROUP, LLC | $778.9万 | 0.00% |
| Woodline Partners LP | $706.5万 | 0.03% |
| DEUTSCHE BANK AG\ | $698.9万 | 0.00% |
| DIADEMA PARTNERS LP | $669.4万 | 1.14% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $657.3万 | 0.24% |
| SEB Asset Management AB | $650.5万 | 0.03% |
| Granahan Investment Management, LLC | $632.7万 | 0.31% |
| AMERIPRISE FINANCIAL INC | $632.1万 | 0.00% |
| Bank of New York Mellon Corp | $606.2万 | 0.00% |
| Caption Management, LLC | $594.3万 | 0.03% |
| BARCLAYS PLC | $558.3万 | 0.00% |
| NEUBERGER BERMAN GROUP LLC | $531.3万 | 0.00% |
| Ally Bridge Group (NY) LLC | $507.2万 | 4.10% |
| EVENTIDE ASSET MANAGEMENT, LLC | $472.1万 | 0.08% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $471.2万 | 0.00% |
| Freestone Grove Partners LP | $467.5万 | 0.03% |
| JPMORGAN CHASE & CO | $446.9万 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $439.9万 | 0.00% |
| Invesco Ltd. | $436.0万 | 0.00% |
| KVP Capital Advisors, LP | $419.0万 | 3.13% |
| Quantum Private Wealth, LLC | $367.4万 | 1.13% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $361.4万 | 0.00% |
| MOODY ALDRICH PARTNERS LLC | $359.5万 | 0.65% |
| DAFNA Capital Management LLC | $353.5万 | 0.80% |
| D. E. Shaw & Co., Inc. | $330.3万 | 0.00% |
| Swiss National Bank | $327.3万 | 0.00% |
| Schonfeld Strategic Advisors LLC | $312.1万 | 0.02% |
| HighVista Strategies LLC | $289.6万 | 0.80% |
| ADAR1 Capital Management, LLC | $285.4万 | 0.17% |
| NEW YORK STATE COMMON RETIREMENT FUND | $280.2万 | 0.00% |
| ALPS ADVISORS INC | $275.1万 | 0.01% |
| Centiva Capital, LP | $264.4万 | 0.02% |
| RHUMBLINE ADVISERS | $263.2万 | 0.00% |
| DekaBank Deutsche Girozentrale | $257.4万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $231.3万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $218.7万 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $212.3万 | 0.00% |
| Artia Global Partners LP | $206.3万 | 0.41% |
| J. Goldman & Co LP | $193.5万 | 0.06% |
| FEDERATED HERMES, INC. | $178.9万 | 0.00% |
| HighMark Wealth Management LLC | $167.5万 | 0.68% |
| TWO SIGMA INVESTMENTS, LP | $160.2万 | 0.00% |
| Ishara Investments LP | $155.0万 | 1.47% |
| SEI INVESTMENTS CO | $154.6万 | 0.00% |
| Jain Global LLC | $146.2万 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $134.2万 | 0.14% |
| Legal & General Group Plc | $134.0万 | 0.00% |
| FRANKLIN RESOURCES INC | $131.4万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $123.3万 | 0.00% |
| Knights of Columbus Asset Advisors LLC | $121.0万 | 0.07% |
| MetLife Investment Management, LLC | $120.0万 | 0.01% |
| Longaeva Partners L.P. | $116.3万 | 0.04% |
| VANGUARD ASSET MANAGEMENT, Ltd | $112.6万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $111.7万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $103.6万 | 0.00% |
| ALGERT GLOBAL LLC | $102.4万 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $99.6万 | 0.00% |
| Creative Planning | $98.5万 | 0.00% |
| Handelsbanken Fonder AB | $98.0万 | 0.00% |
| DLD Asset Management, LP | $97.9万 | 0.09% |
| TUDOR INVESTMENT CORP ET AL | $94.2万 | 0.00% |
| Vanguard Global Advisers, LLC | $92.4万 | 0.00% |
| Persistent Asset Partners Ltd | $90.8万 | 0.34% |
| WELLINGTON MANAGEMENT GROUP LLP | $86.3万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $80.1万 | 0.06% |
| WELLS FARGO & COMPANY/MN | $79.5万 | 0.00% |
| LMR Partners LLP | $63.0万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $62.0万 | 0.00% |
| GLENMEDE TRUST CO NA | $60.6万 | 0.00% |
| XTX Topco Ltd | $60.2万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | $59.4万 | 0.01% |
| CITIGROUP INC | $58.3万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $58.2万 | 0.01% |
| State of New Jersey Common Pension Fund D | $57.0万 | 0.00% |
| Odyssean, LLC | $56.3万 | 0.21% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $53.1万 | 0.00% |
| Brooklyn Investment Group | $51.1万 | 0.02% |
| ENVESTNET ASSET MANAGEMENT INC | $49.5万 | 0.00% |
| AlphaCentric Advisors LLC | $49.2万 | 0.49% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $46.4万 | 0.00% |
| Point72 Asset Management, L.P. | $46.0万 | 0.00% |
| ProShare Advisors LLC | $45.9万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $45.8万 | 0.00% |
| Headlands Technologies LLC | $43.4万 | 0.05% |
| Vanguard Investments Australia, Ltd. | $43.1万 | 0.00% |
| Verdad Advisers, LP | $41.1万 | 0.46% |
| Hudson Bay Capital Management LP | $40.7万 | 0.00% |
| Bridgefront Capital, LLC | $37.2万 | 0.09% |
| Seven Fleet Capital Management LP | $36.9万 | 0.12% |
| Virtus Investment Advisers, LLC | $36.4万 | 0.10% |
| GUGGENHEIM CAPITAL LLC | $36.3万 | 0.00% |
| KLP KAPITALFORVALTNING AS | $35.6万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $33.4万 | 0.00% |
| Elmind Capital, LP | $31.5万 | 0.09% |
| SFMG, LLC | $31.5万 | 0.02% |
| Atom Investors LP | $31.3万 | 0.02% |
| Connecticut Capital Management Group, LLC | $31.0万 | 0.29% |
| AXQ CAPITAL, LP | $30.0万 | 0.04% |
| FIRST TRUST ADVISORS LP | $28.8万 | 0.00% |
| Lion Point Capital, LP | $28.7万 | 1.71% |