| Redmile Group, LLC | $8060.6万 | 5.34% |
| BlackRock, Inc. | $6059.9万 | 0.00% |
| FMR LLC | $5892.1万 | 0.00% |
| BVF INC/IL | $4818.8万 | 1.54% |
| STATE STREET CORP | $3833.3万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | $3300.0万 | 0.00% |
| Bain Capital Life Sciences Investors, LLC | $2887.8万 | 2.60% |
| Bellevue Group AG | $2857.1万 | 0.68% |
| MAK CAPITAL ONE LLC | $2617.1万 | 3.86% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2382.2万 | 0.04% |
| BANK OF AMERICA CORP /DE/ | $2360.0万 | 0.00% |
| Nuveen, LLC | $2352.5万 | 0.01% |
| Siren, L.L.C. | $2193.1万 | 0.61% |
| Balyasny Asset Management L.P. | $2153.3万 | 0.03% |
| AMERIPRISE FINANCIAL INC | $1910.8万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $1871.8万 | 0.00% |
| Qube Research & Technologies Ltd | $1725.3万 | 0.02% |
| Palo Alto Investors LP | $1633.2万 | 2.50% |
| MORGAN STANLEY | $1515.7万 | 0.00% |
| GREAT POINT PARTNERS LLC | $1385.0万 | 3.18% |
| Woodline Partners LP | $1294.8万 | 0.05% |
| Opaleye Management Inc. | $1291.8万 | 1.70% |
| GOLDMAN SACHS GROUP INC | $1192.7万 | 0.00% |
| Point72 Asset Management, L.P. | $1037.0万 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $821.6万 | 0.00% |
| Y-Intercept (Hong Kong) Ltd | $731.2万 | 0.14% |
| UBS Group AG | $718.0万 | 0.00% |
| Tetragon Partners GP Ltd | $716.0万 | 1.39% |
| MILLENNIUM MANAGEMENT LLC | $686.2万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $610.8万 | 0.00% |
| NORTHERN TRUST CORP | $602.1万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $511.5万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | $505.4万 | 0.11% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $500.5万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $492.3万 | 0.00% |
| CITADEL ADVISORS LLC | $491.6万 | 0.00% |
| MARSHALL WACE, LLP | $477.3万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $430.6万 | 0.00% |
| Invesco Ltd. | $422.7万 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | $419.6万 | 0.01% |
| Russell Investments Group, Ltd. | $394.1万 | 0.00% |
| D. E. Shaw & Co., Inc. | $389.4万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $387.1万 | 0.00% |
| Parkman Healthcare Partners LLC | $373.4万 | 0.39% |
| Ensign Peak Advisors, Inc | $346.3万 | 0.01% |
| Longaeva Partners L.P. | $343.7万 | 0.13% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $323.5万 | 0.04% |
| Ikarian Capital, LLC | $321.5万 | 0.26% |
| SIRIOS CAPITAL MANAGEMENT L P | $318.6万 | 0.39% |
| DEUTSCHE BANK AG\ | $311.4万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $301.5万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | $288.8万 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | $282.4万 | 0.10% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $275.0万 | 0.28% |
| DIADEMA PARTNERS LP | $269.3万 | 0.46% |
| Board of Trustees of The Leland Stanford Junior University | $267.3万 | 0.31% |
| TWO SIGMA INVESTMENTS, LP | $261.2万 | 0.00% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $256.0万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $253.5万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $237.6万 | 0.00% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $230.9万 | 0.03% |
| Trexquant Investment LP | $223.6万 | 0.02% |
| Bank of New York Mellon Corp | $218.8万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $199.6万 | 0.03% |
| JPMORGAN CHASE & CO | $160.7万 | 0.00% |
| Cinctive Capital Management LP | $148.8万 | 0.10% |
| Swiss National Bank | $130.7万 | 0.00% |
| Rafferty Asset Management, LLC | $112.6万 | 0.00% |
| SEI INVESTMENTS CO | $112.6万 | 0.00% |
| Rosalind Advisors, Inc. | $110.8万 | 0.45% |
| IEQ CAPITAL, LLC | $108.5万 | 0.01% |
| Ishara Investments LP | $96.5万 | 0.91% |
| Engineers Gate Manager LP | $96.5万 | 0.01% |
| J. Goldman & Co LP | $94.6万 | 0.03% |
| BOOTHBAY FUND MANAGEMENT, LLC | $92.1万 | 0.01% |
| RHUMBLINE ADVISERS | $88.5万 | 0.00% |
| ALGERT GLOBAL LLC | $85.8万 | 0.01% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $82.5万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $74.7万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $72.4万 | 0.00% |
| Schonfeld Strategic Advisors LLC | $68.3万 | 0.00% |
| DAFNA Capital Management LLC | $65.3万 | 0.15% |
| VICTORY CAPITAL MANAGEMENT INC | $64.0万 | 0.00% |
| Man Group plc | $60.5万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $59.8万 | 0.00% |
| SCS Capital Management LLC | $54.8万 | 0.01% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $54.2万 | 0.01% |
| JANE STREET GROUP, LLC | $51.7万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $51.4万 | 0.00% |
| PROFUND ADVISORS LLC | $50.4万 | 0.02% |
| J. Safra Sarasin Holding AG | $50.1万 | 0.01% |
| DNB Asset Management AS | $49.1万 | 0.00% |
| XTX Topco Ltd | $44.6万 | 0.01% |
| Legal & General Group Plc | $44.3万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $44.0万 | 0.00% |
| CAPTRUST FINANCIAL ADVISORS | $43.9万 | 0.00% |
| Persistent Asset Partners Ltd | $43.2万 | 0.16% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $41.4万 | 0.00% |
| MetLife Investment Management, LLC | $40.1万 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | $38.9万 | 0.00% |
| Squarepoint Ops LLC | $37.6万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $34.4万 | 0.00% |
| JANUS HENDERSON GROUP PLC | $32.8万 | 0.00% |
| Brevan Howard Capital Management LP | $32.4万 | 0.00% |
| AXQ CAPITAL, LP | $32.2万 | 0.04% |
| China Universal Asset Management Co., Ltd. | $32.0万 | 0.02% |
| STRS OHIO | $30.7万 | 0.00% |
| ADAR1 Capital Management, LLC | $30.5万 | 0.02% |
| Virtus Investment Advisers, LLC | $30.4万 | 0.08% |
| DRW Securities, LLC | $30.2万 | 0.00% |
| Vanguard Global Advisers, LLC | $29.9万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $29.8万 | 0.00% |
| Verdad Advisers, LP | $29.5万 | 0.33% |
| Mariner, LLC | $29.5万 | 0.00% |
| EntryPoint Capital, LLC | $28.5万 | 0.08% |
| BIT Capital GmbH | $27.7万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $27.6万 | 0.00% |
| Creative Planning | $25.4万 | 0.00% |
| Allegheny Financial Group | $23.8万 | 0.03% |
| CANADA PENSION PLAN INVESTMENT BOARD | $22.6万 | 0.00% |
| State of New Jersey Common Pension Fund D | $22.6万 | 0.00% |
| CWM, LLC | $22.0万 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $20.0万 | 0.00% |
| FIFTH THIRD BANCORP | $19.6万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $19.4万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $18.1万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $17.6万 | 0.01% |
| Lido Advisors, LLC | $17.2万 | 0.00% |
| CITIGROUP INC | $17.1万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $16.6万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $16.4万 | 0.00% |
| MIRABELLA FINANCIAL SERVICES LLP | $15.9万 | 0.02% |
| Virtu Financial LLC | $15.8万 | 0.01% |
| KLP KAPITALFORVALTNING AS | $14.6万 | 0.00% |
| ProShare Advisors LLC | $14.2万 | 0.00% |
| E Fund Management Co., Ltd. | $14.2万 | 0.00% |
| AlphaCentric Advisors LLC | $13.6万 | 0.14% |
| BARCLAYS PLC | $13.5万 | 0.00% |
| WINTON GROUP Ltd | $13.4万 | 0.00% |
| SBI Securities Co., Ltd. | $12.9万 | 0.00% |
| TD Asset Management Inc | $12.6万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $12.3万 | 0.00% |
| Cygnus Capital Advisors, LLC | $12.3万 | 0.08% |
| PRELUDE CAPITAL MANAGEMENT, LLC | $12.3万 | 0.01% |
| CANADA LIFE ASSURANCE Co | $12.1万 | 0.00% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $12.1万 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $11.9万 | 0.01% |
| Quarry LP | $11.8万 | 0.02% |
| PRUDENTIAL FINANCIAL INC | $11.2万 | 0.00% |
| Corient Private Wealth LLC | $10.9万 | 0.00% |