| FMR LLC | $8.5億 | 0.04% |
| Siren, L.L.C. | $5.3億 | 14.75% |
| Redmile Group, LLC | $4.5億 | 29.51% |
| BlackRock, Inc. | $3.7億 | 0.01% |
| SAMSARA BIOCAPITAL, LLC | $3.4億 | 32.95% |
| WELLINGTON MANAGEMENT GROUP LLP | $3.3億 | 0.06% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $3.1億 | 0.04% |
| Orbis Allan Gray Ltd | $2.1億 | 0.87% |
| STATE STREET CORP | $2.0億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1.9億 | 0.00% |
| Bellevue Group AG | $1.8億 | 4.19% |
| JENNISON ASSOCIATES LLC | $1.6億 | 0.11% |
| JANUS HENDERSON GROUP PLC | $1.1億 | 0.05% |
| EVENTIDE ASSET MANAGEMENT, LLC | $1.1億 | 1.78% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.1億 | 0.01% |
| Hood River Capital Management LLC | $1.0億 | 1.01% |
| Polar Capital Holdings Plc | $9751.5万 | 0.35% |
| Driehaus Capital Management LLC | $9439.9万 | 0.69% |
| Holocene Advisors, LP | $9295.8万 | 0.22% |
| Woodline Partners LP | $7376.3万 | 0.28% |
| GOLDMAN SACHS GROUP INC | $6939.8万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $6570.9万 | 0.00% |
| Vestal Point Capital, LP | $6510.9万 | 1.82% |
| Paradigm Biocapital Advisors LP | $6027.4万 | 1.23% |
| Capital World Investors | $5548.9万 | 0.01% |
| MARSHALL WACE, LLP | $5212.3万 | 0.05% |
| STEMPOINT CAPITAL LP | $5149.3万 | 9.86% |
| CITADEL ADVISORS LLC | $4849.6万 | 0.01% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $4827.1万 | 0.06% |
| Pictet Asset Management Holding SA | $4301.9万 | 0.05% |
| FEDERATED HERMES, INC. | $3922.5万 | 0.06% |
| NORTHERN TRUST CORP | $3754.9万 | 0.00% |
| Rock Springs Capital Management LP | $3636.9万 | 2.14% |
| VOYA INVESTMENT MANAGEMENT LLC | $3566.1万 | 0.04% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $3548.1万 | 0.00% |
| Ensign Peak Advisors, Inc | $3526.0万 | 0.07% |
| AMERICAN CENTURY COMPANIES INC | $3476.1万 | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3446.2万 | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $3441.2万 | 0.05% |
| JANE STREET GROUP, LLC | $3423.4万 | 0.00% |
| Clearbridge Investments, LLC | $3399.0万 | 0.03% |
| UBS Group AG | $3341.8万 | 0.01% |
| LOOMIS SAYLES & CO L P | $3139.5万 | 0.04% |
| VANGUARD FIDUCIARY TRUST CO | $2895.8万 | 0.01% |
| Nuveen, LLC | $2859.4万 | 0.01% |
| Integral Health Asset Management, LLC | $2458.0万 | 1.18% |
| Eagle Health Investments LP | $2428.6万 | 4.25% |
| Fisher Asset Management, LLC | $2251.6万 | 0.01% |
| First Turn Management, LLC | $2194.5万 | 2.45% |
| ADAR1 Capital Management, LLC | $2002.2万 | 1.18% |
| Casdin Capital, LLC | $1720.6万 | 1.30% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $1669.5万 | 1.70% |
| ARMISTICE CAPITAL, LLC | $1656.5万 | 0.29% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1489.7万 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | $1403.5万 | 1.54% |
| RAYMOND JAMES FINANCIAL INC | $1246.7万 | 0.00% |
| DEUTSCHE BANK AG\ | $1188.7万 | 0.00% |
| Caption Management, LLC | $1179.8万 | 0.07% |
| Bank of New York Mellon Corp | $1143.8万 | 0.00% |
| Candriam S.C.A. | $1111.0万 | 0.06% |
| TD Asset Management Inc | $1096.6万 | 0.01% |
| MORGAN STANLEY | $1076.7万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $1042.0万 | 0.00% |
| BARCLAYS PLC | $949.0万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $878.4万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $872.0万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $854.2万 | 0.01% |
| Cinctive Capital Management LP | $848.2万 | 0.55% |
| Granahan Investment Management, LLC | $768.4万 | 0.37% |
| JPMORGAN CHASE & CO | $751.4万 | 0.00% |
| Balyasny Asset Management L.P. | $736.0万 | 0.01% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $720.7万 | 0.27% |
| SEI INVESTMENTS CO | $704.7万 | 0.01% |
| GordonMD Global Investments LP | $651.4万 | 4.54% |
| iA Global Asset Management Inc. | $605.7万 | 0.09% |
| Swiss National Bank | $605.7万 | 0.00% |
| Invesco Ltd. | $587.9万 | 0.00% |
| EFG International AG | $553.6万 | 0.12% |
| RHUMBLINE ADVISERS | $553.1万 | 0.00% |
| Rafferty Asset Management, LLC | $513.5万 | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $505.9万 | 0.00% |
| XTX Topco Ltd | $493.7万 | 0.09% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | $485.2万 | 0.17% |
| Artia Global Partners LP | $473.3万 | 0.95% |
| SPHERA FUNDS MANAGEMENT LTD. | $463.4万 | 0.74% |
| ALLIANCEBERNSTEIN L.P. | $443.5万 | 0.00% |
| Hudson Bay Capital Management LP | $410.2万 | 0.01% |
| Nicholas Investment Partners, LP | $405.6万 | 0.29% |
| Aisling Capital Management LP | $378.7万 | 0.80% |
| Trexquant Investment LP | $377.3万 | 0.03% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $368.3万 | 0.00% |
| StoneCrest Wealth Management, Inc. | $348.6万 | 1.47% |
| ExodusPoint Capital Management, LP | $329.7万 | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | $317.7万 | 0.00% |
| Man Group plc | $305.4万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $299.8万 | 0.00% |
| Moody Aldrich Partners LLC | $295.9万 | 0.53% |
| NOMURA HOLDINGS INC | $295.0万 | 0.01% |
| Ishara Investments LP | $282.2万 | 2.67% |
| POLEN CAPITAL MANAGEMENT LLC | $255.4万 | 0.02% |
| Squarepoint Ops LLC | $245.6万 | 0.00% |
| Legal & General Group Plc | $245.4万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $236.9万 | 0.04% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $235.1万 | 0.00% |
| MetLife Investment Management, LLC | $233.3万 | 0.01% |
| PROFUND ADVISORS LLC | $231.5万 | 0.08% |
| KVP Capital Advisors, LP | $221.2万 | 1.65% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $215.2万 | 0.00% |
| Jasper Ridge Partners, L.P. | $208.7万 | 0.05% |
| NEW YORK STATE COMMON RETIREMENT FUND | $193.4万 | 0.00% |
| CITIGROUP INC | $190.4万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $186.3万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $185.6万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | $184.1万 | 0.04% |
| GUGGENHEIM CAPITAL LLC | $179.3万 | 0.01% |
| Vanguard Global Advisers, LLC | $166.1万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $160.7万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $148.5万 | 0.00% |
| Creative Planning | $143.5万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $143.4万 | 0.00% |
| HRT FINANCIAL LP | $141.1万 | 0.00% |
| Shay Capital LLC | $137.6万 | 0.11% |
| FRANKLIN RESOURCES INC | $132.2万 | 0.00% |
| Scientech Research LLC | $129.2万 | 1.08% |
| Clearstead Advisors, LLC | $128.2万 | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | $127.2万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $125.5万 | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $124.1万 | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $122.9万 | 0.00% |
| D.A. DAVIDSON & CO. | $122.1万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | $116.1万 | 0.01% |
| Handelsbanken Fonder AB | $115.5万 | 0.00% |
| E. Ohman J:or Asset Management AB | $108.8万 | 0.03% |
| DNB Asset Management AS | $107.9万 | 0.00% |
| State of New Jersey Common Pension Fund D | $105.0万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $100.6万 | 0.06% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $97.1万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $95.8万 | 0.00% |
| Values First Advisors, Inc. | $92.7万 | 0.48% |
| Caitong International Asset Management Co., Ltd | $89.3万 | 0.17% |
| China Universal Asset Management Co., Ltd. | $89.0万 | 0.07% |
| ProShare Advisors LLC | $84.6万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $84.4万 | 0.00% |
| LPL Financial LLC | $83.4万 | 0.00% |
| Virtu Financial LLC | $81.3万 | 0.03% |
| Erste Asset Management GmbH | $80.1万 | 0.01% |
| DARK FOREST CAPITAL MANAGEMENT LP | $79.8万 | 0.07% |
| 683 Capital Management, LLC | $79.6万 | 0.04% |
| Vanguard Investments Australia, Ltd. | $77.2万 | 0.00% |
| Point72 Asset Management, L.P. | $74.7万 | 0.00% |