| BVF INC/IL | US$8125.8萬 | 2.59% |
| MORGAN STANLEY | US$5339.7萬 | 0.00% |
| FMR LLC | US$4087.4萬 | 0.00% |
| BlackRock, Inc. | US$2029.4萬 | 0.00% |
| Woodline Partners LP | US$2007.7萬 | 0.08% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$1724.7萬 | 0.00% |
| Opaleye Management Inc. | US$941.1萬 | 1.24% |
| GW&K Investment Management, LLC | US$728.2萬 | 0.06% |
| GEODE CAPITAL MANAGEMENT, LLC | US$721.0萬 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | US$642.8萬 | 0.00% |
| STATE STREET CORP | US$605.9萬 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$418.2萬 | 0.00% |
| TLS Advisors LLC | US$360.3萬 | 8.55% |
| CITADEL ADVISORS LLC | US$345.8萬 | 0.00% |
| NORTHERN TRUST CORP | US$293.3萬 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | US$269.1萬 | 0.00% |
| Bank of New York Mellon Corp | US$235.2萬 | 0.00% |
| UBS Group AG | US$227.5萬 | 0.00% |
| Stonepine Capital Management, LLC | US$218.0萬 | 0.87% |
| Simcoe Capital LLC | US$213.5萬 | 1.96% |
| VANGUARD FIDUCIARY TRUST CO | US$209.1萬 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | US$184.0萬 | 0.01% |
| HighVista Strategies LLC | US$146.9萬 | 0.41% |
| CM Management, LLC | US$125.5萬 | 1.05% |
| RBF Capital, LLC | US$94.1萬 | 0.05% |
| STATE OF WISCONSIN INVESTMENT BOARD | US$90.6萬 | 0.00% |
| Quadrature Capital Ltd | US$89.4萬 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$85.2萬 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$81.8萬 | 0.00% |
| JANE STREET GROUP, LLC | US$79.1萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$75.3萬 | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$75.3萬 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$55.1萬 | 0.01% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | US$53.3萬 | 0.50% |
| ExodusPoint Capital Management, LP | US$46.0萬 | 0.00% |
| Nuveen, LLC | US$39.9萬 | 0.00% |
| RHUMBLINE ADVISERS | US$36.7萬 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$34.6萬 | 0.00% |
| DIVERSIFIED MANAGEMENT INC | US$31.4萬 | 0.05% |
| REGIONS FINANCIAL CORP | US$29.0萬 | 0.00% |
| DEUTSCHE BANK AG\ | US$26.5萬 | 0.00% |
| Caption Management, LLC | US$23.3萬 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$21.4萬 | 0.00% |
| Invesco Ltd. | US$21.3萬 | 0.00% |
| MetLife Investment Management, LLC | US$17.8萬 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | US$14.4萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$12.7萬 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$12.1萬 | 0.00% |
| JPMORGAN CHASE & CO | US$12.1萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$10.8萬 | 0.00% |
| Police & Firemen's Retirement System of New Jersey | US$9.0萬 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$7.4萬 | 0.00% |
| BARCLAYS PLC | US$6.2萬 | 0.00% |
| State of Alaska, Department of Revenue | US$3.2萬 | 0.00% |
| ROYAL BANK OF CANADA | US$3.1萬 | 0.00% |
| Ameritas Investment Partners, Inc. | US$3.0萬 | 0.00% |
| Legal & General Group Plc | US$2.7萬 | 0.00% |
| Russell Investments Group, Ltd. | US$2.6萬 | 0.00% |
| CITIGROUP INC | US$2.4萬 | 0.00% |
| Costello Asset Management, INC | US$1.9萬 | 0.01% |
| Tower Research Capital LLC (TRC) | US$1.8萬 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | US$1.6萬 | 0.00% |
| NATIXIS | US$1.2萬 | 0.00% |
| Truvestments Capital LLC | US$9097.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | US$8878.0 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | US$5960.0 | 0.00% |
| GAMMA Investing LLC | US$4768.0 | 0.00% |
| Sterling Capital Management LLC | US$4549.0 | 0.00% |
| CWM, LLC | US$3545.0 | 0.00% |
| Optiver Holding B.V. | US$2823.0 | 0.00% |
| US BANCORP \DE\ | US$2102.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$1850.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | US$784.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$687.9 | 0.00% |
| MH & ASSOCIATES SECURITIES MANAGEMENT CORP /ADV | US$628.0 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$596.0 | 0.00% |
| SBI Securities Co., Ltd. | US$439.0 | 0.00% |
| Root Financial Partners, LLC | US$408.0 | 0.00% |
| Larson Financial Group LLC | US$314.0 | 0.00% |
| True Wealth Design, LLC | US$126.0 | 0.00% |
| Allworth Financial LP | US$95.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | US$94.0 | 0.00% |
| TD Waterhouse Canada Inc. | US$33.0 | 0.00% |
| MAI Capital Management | US$32.0 | 0.00% |