| FMR LLC | $3.1億 | 0.02% |
| BVF INC/IL | $1.8億 | 5.87% |
| Two Seas Capital LP | $1.4億 | 1.97% |
| VANGUARD CAPITAL MANAGEMENT LLC | $8612.8万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $6696.7万 | 0.05% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6498.5万 | 0.01% |
| Prosight Management, LP | $5288.3万 | 8.67% |
| BlackRock, Inc. | $4983.6万 | 0.00% |
| CITADEL ADVISORS LLC | $4787.8万 | 0.01% |
| MORGAN STANLEY | $4744.3万 | 0.00% |
| ARMISTICE CAPITAL, LLC | $4158.7万 | 0.74% |
| Invesco Ltd. | $4082.9万 | 0.01% |
| Sofinnova Investments, Inc. | $3666.2万 | 1.39% |
| Woodline Partners LP | $2988.3万 | 0.11% |
| LORD, ABBETT & CO. LLC | $2914.6万 | 0.10% |
| MILLENNIUM MANAGEMENT LLC | $2908.8万 | 0.01% |
| Bronte Capital Management Pty Ltd. | $2883.4万 | 2.86% |
| EMERALD ADVISERS, LLC | $2839.2万 | 0.90% |
| Qube Research & Technologies Ltd | $2810.9万 | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | $2496.2万 | 0.00% |
| UBS Group AG | $2303.6万 | 0.00% |
| GREAT POINT PARTNERS LLC | $2276.9万 | 5.23% |
| Vestal Point Capital, LP | $2050.6万 | 0.57% |
| 22NW, LP | $2022.6万 | 13.86% |
| PRIMECAP MANAGEMENT CO/CA/ | $2008.5万 | 0.02% |
| ORBIMED ADVISORS LLC | $1978.6万 | 0.41% |
| GILDER GAGNON HOWE & CO LLC | $1955.3万 | 0.23% |
| Nearwater Capital Markets, Ltd | $1881.5万 | 0.44% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $1842.7万 | 0.89% |
| Caption Management, LLC | $1834.7万 | 0.11% |
| STATE STREET CORP | $1760.8万 | 0.00% |
| BRAIDWELL LP | $1602.3万 | 0.53% |
| JPMORGAN CHASE & CO | $1566.7万 | 0.00% |
| Patient Square Capital LP | $1511.0万 | 2.68% |
| JANE STREET GROUP, LLC | $1474.6万 | 0.00% |
| Quinn Opportunity Partners LLC | $1289.7万 | 0.67% |
| Creek Drive Management Group LLC | $1269.2万 | 2.89% |
| VANGUARD FIDUCIARY TRUST CO | $1218.2万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1208.8万 | 0.00% |
| DAFNA Capital Management LLC | $1188.5万 | 2.70% |
| ADAR1 Capital Management, LLC | $1160.2万 | 0.68% |
| MARSHALL WACE, LLP | $1011.5万 | 0.01% |
| AMERIPRISE FINANCIAL INC | $983.8万 | 0.00% |
| GOLDMAN SACHS GROUP INC | $913.3万 | 0.00% |
| Squadron Capital Management LLC | $899.4万 | 3.30% |
| SEVEN GRAND MANAGERS, LLC | $899.4万 | 0.60% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | $880.1万 | 0.75% |
| Squarepoint Ops LLC | $772.6万 | 0.01% |
| Russell Investments Group, Ltd. | $764.5万 | 0.01% |
| Tetragon Partners GP Ltd | $741.4万 | 1.44% |
| Monashee Investment Management LLC | $719.5万 | 3.91% |
| ING GROEP NV | $719.5万 | 0.04% |
| Connor, Clark & Lunn Investment Management Ltd. | $710.5万 | 0.02% |
| DEUTSCHE BANK AG\ | $659.6万 | 0.00% |
| Moody Aldrich Partners LLC | $644.1万 | 1.16% |
| Stonepine Capital Management, LLC | $611.6万 | 2.45% |
| NORTHERN TRUST CORP | $565.5万 | 0.00% |
| Jump Financial, LLC | $556.9万 | 0.07% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $521.6万 | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | $510.1万 | 4.01% |
| HRT FINANCIAL LP | $508.4万 | 0.01% |
| Voleon Capital Management LP | $468.1万 | 0.10% |
| F/m Investments LLC | $439.6万 | 0.29% |
| Rhenman & Partners Asset Management AB | $424.5万 | 0.52% |
| BANK OF AMERICA CORP /DE/ | $424.2万 | 0.00% |
| Aquatic Capital Management LLC | $410.2万 | 0.12% |
| Cambridge Investment Research Advisors, Inc. | $403.3万 | 0.01% |
| Trexquant Investment LP | $399.1万 | 0.03% |
| FRED ALGER MANAGEMENT, LLC | $382.6万 | 0.02% |
| Alyeska Investment Group, L.P. | $359.8万 | 0.01% |
| Brevan Howard Capital Management LP | $348.8万 | 0.03% |
| LMR Partners LLP | $347.5万 | 0.01% |
| Swiss National Bank | $344.6万 | 0.00% |
| Atom Investors LP | $311.0万 | 0.22% |
| SummitTX Capital, L.P. | $306.7万 | 0.10% |
| RENAISSANCE TECHNOLOGIES LLC | $300.6万 | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $265.5万 | 0.17% |
| Jain Global LLC | $260.3万 | 0.01% |
| Informed Momentum Co LLC | $259.9万 | 0.30% |
| Balyasny Asset Management L.P. | $257.9万 | 0.00% |
| ALGERT GLOBAL LLC | $250.3万 | 0.04% |
| Susquehanna Portfolio Strategies, LLC | $248.4万 | 0.04% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $244.8万 | 0.00% |
| BARCLAYS PLC | $232.8万 | 0.00% |
| IRIDIAN ASSET MANAGEMENT LLC/CT | $225.3万 | 0.91% |
| Birchview Capital, LP | $223.0万 | 1.27% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $216.9万 | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $206.4万 | 0.00% |
| Headlands Technologies LLC | $203.2万 | 0.23% |
| KVP Capital Advisors, LP | $193.5万 | 1.45% |
| Y-Intercept (Hong Kong) Ltd | $191.0万 | 0.04% |
| Erste Asset Management GmbH | $182.7万 | 0.02% |
| CITIGROUP INC | $180.2万 | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $178.3万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $153.5万 | 0.10% |
| BIT Capital GmbH | $151.8万 | 0.07% |
| ExodusPoint Capital Management, LP | $147.2万 | 0.01% |
| AWM Investment Company, Inc. | $143.9万 | 0.16% |
| Man Group plc | $139.9万 | 0.00% |
| Deuterium Capital Management, LLC | $129.5万 | 1.51% |
| WINTON GROUP Ltd | $121.7万 | 0.04% |
| Legal & General Group Plc | $119.9万 | 0.00% |
| IMC-Chicago, LLC | $117.7万 | 0.00% |
| ROYAL BANK OF CANADA | $116.4万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $114.5万 | 0.00% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $113.8万 | 0.00% |
| Steward Partners Investment Advisory, LLC | $111.7万 | 0.01% |
| HighVista Strategies LLC | $104.7万 | 0.29% |
| GLENMEDE TRUST CO NA | $99.8万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $98.4万 | 0.00% |
| Point72 Asset Management, L.P. | $96.2万 | 0.00% |
| Walleye Capital LLC | $92.7万 | 0.00% |
| Engineers Gate Manager LP | $88.5万 | 0.01% |
| FIFTH LANE CAPITAL, LP | $86.3万 | 1.05% |
| SECTORAL ASSET MANAGEMENT INC | $82.1万 | 0.68% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $81.2万 | 0.00% |
| Vanguard Global Advisers, LLC | $81.0万 | 0.00% |
| Scientech Research LLC | $79.4万 | 0.66% |
| ENVESTNET ASSET MANAGEMENT INC | $78.3万 | 0.00% |
| JANUS HENDERSON GROUP PLC | $77.1万 | 0.00% |
| OCCUDO QUANTITATIVE STRATEGIES LP | $76.1万 | 0.04% |
| Hudson Bay Capital Management LP | $74.3万 | 0.00% |
| Palumbo Wealth Management LLC | $73.2万 | 0.18% |
| ALLSTATE CORP | $70.8万 | 0.01% |
| State of New Jersey Common Pension Fund D | $59.6万 | 0.00% |
| Schonfeld Strategic Advisors LLC | $58.0万 | 0.00% |
| Diametric Capital, LP | $53.3万 | 0.14% |
| CenterBook Partners LP | $53.3万 | 0.03% |
| PEAK6 LLC | $50.4万 | 0.00% |
| Catalyst Funds Management Pty Ltd | $48.2万 | 0.08% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $48.2万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $47.9万 | 0.00% |
| Bank of New York Mellon Corp | $47.5万 | 0.00% |
| Neo Ivy Capital Management | $46.3万 | 0.12% |
| Vanguard Investments Australia, Ltd. | $45.7万 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | $44.8万 | 0.08% |
| GROUP ONE TRADING LLC | $42.8万 | 0.00% |
| Persistent Asset Partners Ltd | $41.9万 | 0.16% |
| SIMPLEX TRADING, LLC | $41.2万 | 0.00% |
| KLP KAPITALFORVALTNING AS | $37.4万 | 0.00% |
| Gainplan LLC | $36.0万 | 0.27% |
| Virtus Investment Advisers, LLC | $35.9万 | 0.10% |
| FNY Investment Advisers, LLC | $34.1万 | 0.15% |
| Entropy Technologies, LP | $33.0万 | 0.02% |
| LPL Financial LLC | $32.7万 | 0.00% |
| SEI INVESTMENTS CO | $32.2万 | 0.00% |
| OSAIC HOLDINGS, INC. | $31.6万 | 0.00% |
| Seven Fleet Capital Management LP | $30.9万 | 0.10% |
| XTX Topco Ltd | $29.5万 | 0.01% |
| FARALLON CAPITAL MANAGEMENT LLC | $28.8万 | 0.00% |