| BAKER BROS. ADVISORS LP | $9.5億 | 5.48% |
| BlackRock, Inc. | $4.8億 | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1.9億 | 0.01% |
| STATE STREET CORP | $1.9億 | 0.01% |
| RTW INVESTMENTS, LP | $1.6億 | 1.58% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1.3億 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $7713.7万 | 0.00% |
| FIRST TRUST ADVISORS LP | $7443.5万 | 0.05% |
| DIMENSIONAL FUND ADVISORS LP | $7022.2万 | 0.01% |
| Palo Alto Investors LP | $6394.6万 | 9.78% |
| Point72 Asset Management, L.P. | $5799.4万 | 0.07% |
| BRAIDWELL LP | $5500.9万 | 1.84% |
| Pictet Asset Management Holding SA | $4473.6万 | 0.05% |
| RENAISSANCE TECHNOLOGIES LLC | $3838.1万 | 0.06% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $3493.7万 | 0.02% |
| GOLDMAN SACHS GROUP INC | $3467.7万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | $3458.7万 | 0.00% |
| Frazier Life Sciences Management, L.P. | $3201.4万 | 0.82% |
| Artisan Partners Limited Partnership | $2964.6万 | 0.05% |
| FRED ALGER MANAGEMENT, LLC | $2842.9万 | 0.12% |
| NORTHERN TRUST CORP | $2832.8万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $2612.3万 | 0.00% |
| MORGAN STANLEY | $2433.4万 | 0.00% |
| Nuveen, LLC | $2308.3万 | 0.01% |
| Rockefeller Capital Management L.P. | $2286.9万 | 0.04% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $2270.1万 | 0.01% |
| Allspring Global Investments Holdings, LLC | $2131.2万 | 0.04% |
| Qube Research & Technologies Ltd | $2115.4万 | 0.02% |
| JANE STREET GROUP, LLC | $1961.9万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $1949.4万 | 0.00% |
| DEUTSCHE BANK AG\ | $1870.8万 | 0.01% |
| Invesco Ltd. | $1862.1万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $1725.4万 | 0.01% |
| PRINCIPAL FINANCIAL GROUP INC | $1710.1万 | 0.01% |
| Logos Global Management LP | $1669.5万 | 0.83% |
| Bank of New York Mellon Corp | $1639.6万 | 0.00% |
| Fisher Asset Management, LLC | $1631.4万 | 0.01% |
| D. E. Shaw & Co., Inc. | $1624.6万 | 0.01% |
| Allianz Asset Management GmbH | $1573.0万 | 0.02% |
| MILLENNIUM MANAGEMENT LLC | $1570.4万 | 0.01% |
| PANAGORA ASSET MANAGEMENT INC | $1532.9万 | 0.06% |
| Woodline Partners LP | $1505.7万 | 0.06% |
| CITADEL ADVISORS LLC | $1466.2万 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1412.8万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $1390.3万 | 0.00% |
| RICE HALL JAMES & ASSOCIATES, LLC | $1374.5万 | 0.77% |
| VOYA INVESTMENT MANAGEMENT LLC | $1366.3万 | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1272.8万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $1175.1万 | 0.01% |
| Caption Management, LLC | $1159.5万 | 0.07% |
| JUPITER ASSET MANAGEMENT LTD | $1093.2万 | 0.06% |
| UBS Group AG | $998.5万 | 0.00% |
| Public Sector Pension Investment Board | $997.1万 | 0.03% |
| Hudson Bay Capital Management LP | $991.7万 | 0.03% |
| GLENMEDE TRUST CO NA | $903.5万 | 0.04% |
| PRUDENTIAL FINANCIAL INC | $862.9万 | 0.01% |
| Squarepoint Ops LLC | $824.6万 | 0.01% |
| RHUMBLINE ADVISERS | $791.3万 | 0.01% |
| FMR LLC | $779.9万 | 0.00% |
| Balyasny Asset Management L.P. | $696.7万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | $655.0万 | 0.02% |
| Legal & General Group Plc | $639.7万 | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | $570.3万 | 0.91% |
| JPMORGAN CHASE & CO | $554.3万 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | $548.3万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $540.2万 | 0.00% |
| STEMPOINT CAPITAL LP | $540.0万 | 1.03% |
| GREAT LAKES ADVISORS, LLC | $538.3万 | 0.04% |
| Trexquant Investment LP | $525.2万 | 0.04% |
| Swiss National Bank | $521.8万 | 0.00% |
| FRANKLIN RESOURCES INC | $512.1万 | 0.00% |
| ROYAL BANK OF CANADA | $496.9万 | 0.00% |
| NORDEA INVESTMENT MANAGEMENT AB | $494.3万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $460.5万 | 0.00% |
| Edgestream Partners, L.P. | $425.9万 | 0.14% |
| Rafferty Asset Management, LLC | $404.4万 | 0.02% |
| ALLIANCEBERNSTEIN L.P. | $398.9万 | 0.00% |
| Birchview Capital, LP | $380.6万 | 2.17% |
| ENVESTNET ASSET MANAGEMENT INC | $378.3万 | 0.00% |
| HUSSMAN STRATEGIC ADVISORS, INC. | $374.0万 | 0.81% |
| ALPS ADVISORS INC | $362.4万 | 0.02% |
| CONGRESS ASSET MANAGEMENT CO | $357.9万 | 0.03% |
| STATE OF WISCONSIN INVESTMENT BOARD | $348.2万 | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | $340.7万 | 0.00% |
| Axecap Investments, LLC | $340.4万 | 2.34% |
| BESSEMER GROUP INC | $335.0万 | 0.01% |
| Tetragon Partners GP Ltd | $321.9万 | 0.62% |
| VICTORY CAPITAL MANAGEMENT INC | $319.4万 | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $317.7万 | 0.01% |
| Bridgewater Associates, LP | $315.7万 | 0.01% |
| ALGERT GLOBAL LLC | $312.7万 | 0.05% |
| MARTINGALE ASSET MANAGEMENT L P | $311.6万 | 0.08% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $307.7万 | 0.00% |
| Man Group plc | $288.0万 | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $286.5万 | 0.01% |
| Erste Asset Management GmbH | $281.7万 | 0.03% |
| Ishara Investments LP | $273.8万 | 2.59% |
| SEGALL BRYANT & HAMILL, LLC | $269.4万 | 0.04% |
| WELLS FARGO & COMPANY/MN | $263.8万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $254.0万 | 0.00% |
| Emerald Investment Advisers, LLC | $244.9万 | 0.22% |
| SEI INVESTMENTS CO | $236.8万 | 0.00% |
| CANADA LIFE ASSURANCE Co | $230.2万 | 0.00% |
| Nan Fung Group Holdings Ltd | $229.2万 | 1.89% |
| MACKENZIE FINANCIAL CORP | $225.6万 | 0.00% |
| Hennion & Walsh Asset Management, Inc. | $224.2万 | 0.08% |
| NATIXIS ADVISORS, LLC | $223.5万 | 0.00% |
| Stonepine Capital Management, LLC | $222.6万 | 0.89% |
| State of Alaska, Department of Revenue | $217.0万 | 0.02% |
| DekaBank Deutsche Girozentrale | $216.9万 | 0.00% |
| Thrivent Financial for Lutherans | $211.1万 | 0.00% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $206.2万 | 0.00% |
| HOHIMER WEALTH MANAGEMENT, LLC | $204.3万 | 0.24% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $190.5万 | 0.00% |
| PROFUND ADVISORS LLC | $188.2万 | 0.07% |
| Phocas Financial Corp. | $181.1万 | 0.28% |
| AMERICAN CENTURY COMPANIES INC | $176.4万 | 0.00% |
| Sofinnova Investments, Inc. | $174.9万 | 0.07% |
| WESBANCO BANK INC | $174.1万 | 0.05% |
| Assenagon Asset Management S.A. | $173.9万 | 0.00% |
| SG Americas Securities, LLC | $171.9万 | 0.00% |
| MARSHALL WACE, LLP | $169.6万 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $159.6万 | 0.00% |
| Illinois Municipal Retirement Fund | $158.5万 | 0.02% |
| MetLife Investment Management, LLC | $152.9万 | 0.01% |
| Verdad Advisers, LP | $152.0万 | 1.71% |
| CANADA PENSION PLAN INVESTMENT BOARD | $151.6万 | 0.00% |
| CITIGROUP INC | $150.2万 | 0.00% |
| Engineers Gate Manager LP | $147.0万 | 0.02% |
| NOMURA HOLDINGS INC | $133.6万 | 0.00% |
| BURNEY CO/ | $133.5万 | 0.04% |
| Handelsbanken Fonder AB | $126.3万 | 0.00% |
| Louisiana State Employees Retirement System | $123.5万 | 0.02% |
| GUGGENHEIM CAPITAL LLC | $119.8万 | 0.01% |
| JANUS HENDERSON GROUP PLC | $114.5万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $114.0万 | 0.07% |
| WELLINGTON MANAGEMENT GROUP LLP | $111.3万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $111.2万 | 0.00% |
| Vanguard Global Advisers, LLC | $110.7万 | 0.00% |
| Empowered Funds, LLC | $109.0万 | 0.01% |
| State of Tennessee, Department of Treasury | $109.0万 | 0.00% |
| Creative Planning | $105.7万 | 0.00% |
| Russell Investments Group, Ltd. | $104.5万 | 0.00% |
| STRS OHIO | $103.7万 | 0.00% |
| Freestone Grove Partners LP | $103.4万 | 0.01% |
| Diversified Trust Co | $99.8万 | 0.02% |
| HSBC HOLDINGS PLC | $97.7万 | 0.00% |
| VIRTUS ADVISERS, LLC | $95.7万 | 0.45% |
| State of New Jersey Common Pension Fund D | $90.1万 | 0.00% |
| Gotham Asset Management, LLC | $89.8万 | 0.00% |