| FMR LLC | $8.9億 | 0.05% |
| BlackRock, Inc. | $6.2億 | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $3.5億 | 4.11% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2.8億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $2.7億 | 0.01% |
| JANUS HENDERSON GROUP PLC | $2.3億 | 0.11% |
| STATE STREET CORP | $2.2億 | 0.01% |
| Fairmount Funds Management LLC | $2.1億 | 15.30% |
| RTW INVESTMENTS, LP | $2.1億 | 2.09% |
| TCG Crossover Management, LLC | $1.9億 | 5.45% |
| GOLDMAN SACHS GROUP INC | $1.7億 | 0.02% |
| Kynam Capital Management, LP | $1.6億 | 9.59% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.4億 | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | $1.4億 | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.2億 | 0.01% |
| LORD, ABBETT & CO. LLC | $1.2億 | 0.40% |
| Commodore Capital LP | $1.1億 | 6.43% |
| Invesco Ltd. | $9351.6万 | 0.01% |
| Octagon Capital Advisors LP | $9045.2万 | 10.01% |
| Holocene Advisors, LP | $8661.0万 | 0.21% |
| Sofinnova Investments, Inc. | $8135.1万 | 3.09% |
| Venrock Adviser, LLC | $7698.0万 | 2.87% |
| CITADEL ADVISORS LLC | $7341.7万 | 0.01% |
| D. E. Shaw & Co., Inc. | $7191.4万 | 0.04% |
| Pictet Asset Management Holding SA | $6882.6万 | 0.07% |
| Siren, L.L.C. | $6579.0万 | 1.82% |
| MARSHALL WACE, LLP | $6159.0万 | 0.06% |
| EMERALD ADVISERS, LLC | $6112.7万 | 1.93% |
| Candriam S.C.A. | $5836.2万 | 0.30% |
| Woodline Partners LP | $5810.3万 | 0.22% |
| Point72 Asset Management, L.P. | $5430.3万 | 0.07% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $5058.3万 | 5.16% |
| NORTHERN TRUST CORP | $4794.9万 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4781.7万 | 0.01% |
| FRED ALGER MANAGEMENT, LLC | $4771.6万 | 0.21% |
| Vestal Point Capital, LP | $4737.7万 | 1.32% |
| MILLENNIUM MANAGEMENT LLC | $4589.6万 | 0.02% |
| Elmind Capital, LP | $4506.2万 | 12.79% |
| VANGUARD FIDUCIARY TRUST CO | $4072.6万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $4017.6万 | 0.00% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $3960.0万 | 1.92% |
| Deep Track Capital, LP | $3849.0万 | 0.63% |
| First Turn Management, LLC | $3646.3万 | 4.07% |
| AMERICAN CENTURY COMPANIES INC | $3427.8万 | 0.02% |
| Balyasny Asset Management L.P. | $3297.0万 | 0.04% |
| J. Goldman & Co LP | $3260.8万 | 0.95% |
| Nuveen, LLC | $3200.8万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3094.1万 | 0.00% |
| Squadron Capital Management LLC | $3031.1万 | 11.11% |
| Affinity Asset Advisors, LLC | $2886.8万 | 1.49% |
| RENAISSANCE TECHNOLOGIES LLC | $2718.4万 | 0.04% |
| Redmile Group, LLC | $2648.3万 | 1.75% |
| Burkehill Global Management, LP | $2598.1万 | 1.29% |
| VOYA INVESTMENT MANAGEMENT LLC | $2556.3万 | 0.03% |
| MORGAN STANLEY | $2473.7万 | 0.00% |
| Saturn V Capital Management LP | $2411.9万 | 4.37% |
| Rock Springs Capital Management LP | $2402.4万 | 1.42% |
| Patient Square Capital LP | $2294.0万 | 4.07% |
| Ensign Peak Advisors, Inc | $2205.0万 | 0.04% |
| Fiera Capital Corp | $2148.7万 | 0.07% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $1730.1万 | 0.01% |
| Vivo Capital, LLC | $1625.4万 | 1.35% |
| SPHERA FUNDS MANAGEMENT LTD. | $1602.5万 | 2.54% |
| Qube Research & Technologies Ltd | $1516.5万 | 0.02% |
| Russell Investments Group, Ltd. | $1442.9万 | 0.02% |
| Bank of New York Mellon Corp | $1434.9万 | 0.00% |
| ExodusPoint Capital Management, LP | $1432.5万 | 0.12% |
| RAYMOND JAMES FINANCIAL INC | $1423.0万 | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | $1387.5万 | 0.29% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $1363.5万 | 0.02% |
| Defilade Capital Management, L.P. | $1357.1万 | 1.91% |
| Integral Health Asset Management, LLC | $1347.2万 | 0.64% |
| Weiss Asset Management LP | $1332.2万 | 0.23% |
| Longaeva Partners L.P. | $1289.4万 | 0.48% |
| Hennion & Walsh Asset Management, Inc. | $1256.6万 | 0.42% |
| DIADEMA PARTNERS LP | $1242.3万 | 2.11% |
| ORBIMED ADVISORS LLC | $1239.8万 | 0.25% |
| Assenagon Asset Management S.A. | $1138.0万 | 0.02% |
| SummitTX Capital, L.P. | $1130.8万 | 0.35% |
| Atika Capital Management LLC | $1128.5万 | 1.78% |
| UBS Group AG | $1121.9万 | 0.00% |
| FEDERATED HERMES, INC. | $1099.5万 | 0.02% |
| Exome Asset Management LLC | $1072.1万 | 5.54% |
| Aberdeen Group plc | $1049.6万 | 0.02% |
| AMERIPRISE FINANCIAL INC | $970.4万 | 0.00% |
| Nantahala Capital Management, LLC | $962.3万 | 0.35% |
| Evergreen Quality Fund GP, Ltd. | $962.3万 | 0.22% |
| Alyeska Investment Group, L.P. | $962.3万 | 0.03% |
| Tidal Investments LLC | $952.1万 | 0.02% |
| NWI MANAGEMENT LP | $930.2万 | 0.53% |
| JPMORGAN CHASE & CO | $929.7万 | 0.00% |
| JANE STREET GROUP, LLC | $910.6万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $884.3万 | 0.13% |
| Squarepoint Ops LLC | $870.9万 | 0.01% |
| F/m Investments LLC | $870.4万 | 0.58% |
| SUPERSTRING CAPITAL MANAGEMENT LP | $866.6万 | 6.19% |
| Boxer Capital Management, LLC | $866.0万 | 1.14% |
| NEW YORK STATE COMMON RETIREMENT FUND | $859.2万 | 0.01% |
| Hudson Bay Capital Management LP | $799.0万 | 0.03% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $777.3万 | 0.29% |
| Cormorant Asset Management, LP | $769.8万 | 0.39% |
| SEI INVESTMENTS CO | $760.2万 | 0.01% |
| HighVista Strategies LLC | $758.4万 | 2.09% |
| Man Group plc | $749.8万 | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $730.5万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $685.8万 | 0.01% |
| Tema ETFs LLC | $680.0万 | 0.46% |
| RHUMBLINE ADVISERS | $674.6万 | 0.01% |
| Fisher Asset Management, LLC | $644.4万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $637.0万 | 0.00% |
| Swiss National Bank | $636.6万 | 0.00% |
| SEB Asset Management AB | $632.9万 | 0.03% |
| OSTERWEIS CAPITAL MANAGEMENT INC | $580.5万 | 0.30% |
| Seven Fleet Capital Management LP | $575.0万 | 1.82% |
| ALLIANCEBERNSTEIN L.P. | $558.8万 | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $525.2万 | 0.01% |
| NEXTBio Capital Management LP | $504.9万 | 2.34% |
| DEUTSCHE BANK AG\ | $490.6万 | 0.00% |
| Rafferty Asset Management, LLC | $481.2万 | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | $470.5万 | 0.06% |
| Informed Momentum Co LLC | $469.3万 | 0.54% |
| PERCEPTIVE ADVISORS LLC | $466.0万 | 0.09% |
| Caption Management, LLC | $461.9万 | 0.03% |
| ALGERT GLOBAL LLC | $446.7万 | 0.07% |
| Schonfeld Strategic Advisors LLC | $432.9万 | 0.03% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $431.3万 | 1.09% |
| Creative Planning | $426.3万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $421.2万 | 0.00% |
| Trexquant Investment LP | $413.5万 | 0.03% |
| WELLS FARGO & COMPANY/MN | $410.5万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $406.1万 | 0.00% |
| Knott David M Jr | $400.3万 | 2.38% |
| Pier Capital, LLC | $389.9万 | 0.64% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $388.7万 | 0.00% |
| Parkman Healthcare Partners LLC | $385.4万 | 0.40% |
| Nicholas Investment Partners, LP | $366.3万 | 0.26% |
| Persistent Asset Partners Ltd | $356.1万 | 1.33% |
| Atom Investors LP | $337.5万 | 0.24% |
| VANGUARD ASSET MANAGEMENT, Ltd | $337.2万 | 0.00% |
| TimesSquare Capital Management, LLC | $327.2万 | 0.06% |
| PRINCIPAL FINANCIAL GROUP INC | $323.1万 | 0.00% |
| Legal & General Group Plc | $312.7万 | 0.00% |
| SONA ASSET MANAGEMENT (US) LLC | $307.9万 | 0.06% |
| SECTOR GAMMA AS | $307.9万 | 0.73% |
| MetLife Investment Management, LLC | $302.6万 | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $289.7万 | 0.00% |
| LPL Financial LLC | $285.4万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $271.2万 | 0.01% |
| Vanguard Global Advisers, LLC | $267.9万 | 0.00% |
| Cinctive Capital Management LP | $264.7万 | 0.17% |