| RA CAPITAL MANAGEMENT, L.P. | US$805.4万 | 0.09% |
| ORBIMED ADVISORS LLC | US$700.0万 | 0.14% |
| FRANKLIN RESOURCES INC | US$426.7万 | 0.00% |
| CITADEL ADVISORS LLC | US$260.0万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$229.2万 | 0.00% |
| Woodline Partners LP | US$213.2万 | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$186.8万 | 0.00% |
| Prosight Management, LP | US$170.4万 | 0.28% |
| RENAISSANCE TECHNOLOGIES LLC | US$158.4万 | 0.00% |
| Stonepine Capital Management, LLC | US$151.2万 | 0.61% |
| Alyeska Investment Group, L.P. | US$138.8万 | 0.00% |
| Carlyle Group Inc. | US$125.5万 | 0.01% |
| NEXTBio Capital Management LP | US$107.5万 | 0.50% |
| ACADIAN ASSET MANAGEMENT LLC | US$80.2万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$68.9万 | 0.00% |
| DAFNA Capital Management LLC | US$63.9万 | 0.15% |
| Burkehill Global Management, LP | US$42.6万 | 0.02% |
| Rangeley Capital, LLC | US$38.1万 | 0.37% |
| ADAR1 Capital Management, LLC | US$36.7万 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$36.0万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$34.3万 | 0.00% |
| Trexquant Investment LP | US$29.7万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$29.4万 | 0.00% |
| RBF Capital, LLC | US$26.3万 | 0.01% |
| UBS Group AG | US$26.1万 | 0.00% |
| JANE STREET GROUP, LLC | US$25.3万 | 0.00% |
| BlackRock, Inc. | US$24.9万 | 0.00% |
| STATE STREET CORP | US$24.7万 | 0.00% |
| BARCLAYS PLC | US$17.0万 | 0.00% |
| JOHNSON & JOHNSON | US$15.5万 | 0.02% |
| NORTHERN TRUST CORP | US$13.1万 | 0.00% |
| XTX Topco Ltd | US$13.0万 | 0.00% |
| OCCUDO QUANTITATIVE STRATEGIES LP | US$11.4万 | 0.01% |
| Vontobel Holding Ltd. | US$9.7万 | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | US$7.3万 | 0.00% |
| Vanguard Global Advisers, LLC | US$3.6万 | 0.00% |
| MORGAN STANLEY | US$2.4万 | 0.00% |
| FNY Investment Advisers, LLC | US$2.1万 | 0.01% |
| ROYAL BANK OF CANADA | US$1.1万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$9677.0 | 0.00% |
| SIMPLEX TRADING, LLC | US$9486.0 | 0.00% |
| Avion Wealth | US$1000.0 | 0.00% |
| SBI Securities Co., Ltd. | US$129.0 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$115.0 | 0.00% |
| JPMORGAN CHASE & CO | US$49.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$20.0 | 0.00% |
| DANSKE BANK A/S | US$7.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$3.4 | 0.00% |