| FMR LLC | $6.5億 | 0.03% |
| BlackRock, Inc. | $2.7億 | 0.00% |
| RA CAPITAL MANAGEMENT, L.P. | $2.2億 | 2.32% |
| WELLINGTON MANAGEMENT GROUP LLP | $2.2億 | 0.04% |
| Fairmount Funds Management LLC | $2.1億 | 15.38% |
| Avidity Partners Management LP | $1.8億 | 35.76% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1.7億 | 0.00% |
| Octagon Capital Advisors LP | $1.6億 | 18.08% |
| TCG Crossover Management, LLC | $1.4億 | 4.03% |
| CITADEL ADVISORS LLC | $1.4億 | 0.02% |
| STATE STREET CORP | $1.2億 | 0.00% |
| T. Rowe Price Investment Management, Inc. | $1.1億 | 0.07% |
| Venrock Adviser, LLC | $9902.6万 | 3.70% |
| FRED ALGER MANAGEMENT, LLC | $9750.9万 | 0.43% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $9625.3万 | 0.01% |
| Polar Capital Holdings Plc | $9029.9万 | 0.32% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $8558.3万 | 1.01% |
| FRANKLIN RESOURCES INC | $8125.0万 | 0.02% |
| Cormorant Asset Management, LP | $7972.4万 | 4.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $7690.5万 | 0.00% |
| BRAIDWELL LP | $7547.5万 | 2.52% |
| BAKER BROS. ADVISORS LP | $7151.4万 | 0.41% |
| FARALLON CAPITAL MANAGEMENT LLC | $7015.7万 | 0.40% |
| UBS Group AG | $6556.5万 | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $5494.6万 | 5.61% |
| Point72 Asset Management, L.P. | $5401.1万 | 0.07% |
| Catalio Capital Management, LP | $4702.1万 | 9.82% |
| GOLDMAN SACHS GROUP INC | $4598.9万 | 0.01% |
| JENNISON ASSOCIATES LLC | $4071.3万 | 0.03% |
| Balyasny Asset Management L.P. | $3978.5万 | 0.05% |
| ALLIANCEBERNSTEIN L.P. | $3816.3万 | 0.01% |
| Woodline Partners LP | $3637.6万 | 0.14% |
| SAMLYN CAPITAL, LLC | $3617.9万 | 0.62% |
| MPM BIOIMPACT LLC | $3558.1万 | 2.75% |
| Affinity Asset Advisors, LLC | $3356.8万 | 1.73% |
| Logos Global Management LP | $3356.8万 | 1.68% |
| Artisan Partners Limited Partnership | $3206.8万 | 0.05% |
| BARCLAYS PLC | $3185.7万 | 0.01% |
| Spruce Street Capital LP | $3132.5万 | 7.53% |
| Sio Capital Management, LLC | $3105.4万 | 4.45% |
| Bain Capital Life Sciences Investors, LLC | $3041.8万 | 2.74% |
| AMERIPRISE FINANCIAL INC | $3008.3万 | 0.01% |
| Vivo Capital, LLC | $2970.8万 | 2.47% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2932.0万 | 0.00% |
| MARSHALL WACE, LLP | $2869.5万 | 0.03% |
| DIMENSIONAL FUND ADVISORS LP | $2729.6万 | 0.01% |
| Driehaus Capital Management LLC | $2662.9万 | 0.20% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $2563.3万 | 0.00% |
| NORTHERN TRUST CORP | $2549.1万 | 0.00% |
| LORD, ABBETT & CO. LLC | $2511.0万 | 0.08% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2410.2万 | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | $2221.3万 | 1.13% |
| MILLENNIUM MANAGEMENT LLC | $2198.4万 | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | $2095.3万 | 0.01% |
| RTW INVESTMENTS, LP | $2081.7万 | 0.21% |
| Freestone Grove Partners LP | $2013.6万 | 0.14% |
| EVENTIDE ASSET MANAGEMENT, LLC | $1890.4万 | 0.31% |
| First Turn Management, LLC | $1854.0万 | 2.07% |
| Nuveen, LLC | $1825.1万 | 0.00% |
| Candriam S.C.A. | $1791.9万 | 0.09% |
| Ensign Peak Advisors, Inc | $1714.8万 | 0.03% |
| Jefferies Financial Group Inc. | $1698.6万 | 0.12% |
| BANK OF AMERICA CORP /DE/ | $1584.2万 | 0.00% |
| Bank of New York Mellon Corp | $1581.2万 | 0.00% |
| PFM Health Sciences, LP | $1444.6万 | 1.32% |
| Artia Global Partners LP | $1367.8万 | 2.74% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $1342.7万 | 0.02% |
| Caption Management, LLC | $1291.5万 | 0.08% |
| Walleye Capital LLC | $1288.9万 | 0.05% |
| Integral Health Asset Management, LLC | $1258.8万 | 0.60% |
| D. E. Shaw & Co., Inc. | $1255.5万 | 0.01% |
| Tri Locum Partners LP | $1221.4万 | 1.71% |
| Invesco Ltd. | $1097.2万 | 0.00% |
| Russell Investments Group, Ltd. | $1083.1万 | 0.01% |
| Atika Capital Management LLC | $1080.9万 | 1.70% |
| TD Asset Management Inc | $978.3万 | 0.01% |
| LMR Partners LLP | $977.2万 | 0.02% |
| Hudson Bay Capital Management LP | $916.7万 | 0.03% |
| Atom Investors LP | $904.3万 | 0.65% |
| SummitTX Capital, L.P. | $839.6万 | 0.26% |
| SEVEN GRAND MANAGERS, LLC | $839.2万 | 0.56% |
| MORGAN STANLEY | $817.8万 | 0.00% |
| Cinctive Capital Management LP | $792.3万 | 0.52% |
| Patient Square Capital LP | $787.9万 | 1.40% |
| SEI INVESTMENTS CO | $774.1万 | 0.01% |
| ExodusPoint Capital Management, LP | $717.8万 | 0.06% |
| STEMPOINT CAPITAL LP | $717.5万 | 1.37% |
| MOODY ALDRICH PARTNERS LLC | $689.2万 | 1.24% |
| Rhenman & Partners Asset Management AB | $685.0万 | 0.85% |
| AMERICAN CENTURY COMPANIES INC | $663.8万 | 0.00% |
| Informed Momentum Co LLC | $643.2万 | 0.74% |
| Schonfeld Strategic Advisors LLC | $616.5万 | 0.04% |
| Swiss National Bank | $579.0万 | 0.00% |
| Nantahala Capital Management, LLC | $564.6万 | 0.21% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $547.5万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $507.2万 | 0.00% |
| Trexquant Investment LP | $495.8万 | 0.04% |
| NEUBERGER BERMAN GROUP LLC | $495.8万 | 0.00% |
| ADAR1 Capital Management, LLC | $461.6万 | 0.27% |
| Seven Fleet Capital Management LP | $455.3万 | 1.45% |
| Alyeska Investment Group, L.P. | $438.5万 | 0.01% |
| Nicholas Investment Partners, LP | $430.1万 | 0.31% |
| Burkehill Global Management, LP | $419.6万 | 0.21% |
| Evergreen Quality Fund GP, Ltd. | $419.6万 | 0.10% |
| NEW YORK STATE COMMON RETIREMENT FUND | $402.6万 | 0.01% |
| RHUMBLINE ADVISERS | $379.2万 | 0.00% |
| ALGERT GLOBAL LLC | $372.6万 | 0.06% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $344.8万 | 0.01% |
| LPL Financial LLC | $342.6万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $340.6万 | 0.00% |
| Squarepoint Ops LLC | $325.1万 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | $313.5万 | 0.00% |
| ALPS ADVISORS INC | $303.8万 | 0.01% |
| HighVista Strategies LLC | $298.6万 | 0.82% |
| Blackstone Inc. | $294.1万 | 0.01% |
| DEUTSCHE BANK AG\ | $264.0万 | 0.00% |
| Rafferty Asset Management, LLC | $262.0万 | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | $261.7万 | 0.00% |
| Qube Research & Technologies Ltd | $254.7万 | 0.00% |
| JPMORGAN CHASE & CO | $253.8万 | 0.00% |
| Rock Springs Capital Management LP | $224.5万 | 0.13% |
| DV Trading LLC | $222.8万 | 0.05% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $217.1万 | 0.02% |
| JANE STREET GROUP, LLC | $195.5万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $192.0万 | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $187.2万 | 0.00% |
| Engineers Gate Manager LP | $183.9万 | 0.02% |
| Legal & General Group Plc | $181.5万 | 0.00% |
| ArrowMark Colorado Holdings LLC | $174.5万 | 0.05% |
| SIG BROKERAGE, LP | $170.3万 | 0.04% |
| MetLife Investment Management, LLC | $163.9万 | 0.01% |
| Brevan Howard Capital Management LP | $163.1万 | 0.01% |
| ROYAL BANK OF CANADA | $160.1万 | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $158.7万 | 0.00% |
| BLAIR WILLIAM & CO/IL | $153.4万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $152.1万 | 0.00% |
| PEAK6 LLC | $150.4万 | 0.00% |
| Vanguard Global Advisers, LLC | $148.8万 | 0.00% |
| Darwin Global Management, Ltd. | $145.7万 | 0.04% |
| JANUS HENDERSON GROUP PLC | $138.4万 | 0.00% |
| BESSEMER GROUP INC | $135.4万 | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $131.4万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $126.6万 | 0.00% |
| PROFUND ADVISORS LLC | $119.6万 | 0.04% |
| WELLS FARGO & COMPANY/MN | $115.7万 | 0.00% |
| XTX Topco Ltd | $109.5万 | 0.02% |
| Fisher Asset Management, LLC | $105.9万 | 0.00% |
| Legato Capital Management LLC | $105.2万 | 0.10% |
| GLENMEDE TRUST CO NA | $104.6万 | 0.01% |
| Lisanti Capital Growth, LLC | $104.1万 | 0.26% |