| RA CAPITAL MANAGEMENT, L.P. | $4.0億 | 4.21% |
| TPG GP A, LLC | $2.6億 | 7.08% |
| ORBIMED ADVISORS LLC | $1.4億 | 2.90% |
| VIKING GLOBAL INVESTORS LP | $1.3億 | 0.36% |
| Atlas Venture Life Science Advisors, LLC | $1.2億 | 15.20% |
| ENAVATE SCIENCES GP, LLC | $9934.4万 | 28.26% |
| JENNISON ASSOCIATES LLC | $5817.9万 | 0.04% |
| JPMORGAN CHASE & CO | $5370.7万 | 0.00% |
| BlackRock, Inc. | $5195.1万 | 0.00% |
| CITADEL ADVISORS LLC | $4678.2万 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $4127.3万 | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $3891.1万 | 0.46% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $3032.4万 | 0.00% |
| STATE STREET CORP | $3031.7万 | 0.00% |
| PERCEPTIVE ADVISORS LLC | $2639.7万 | 0.52% |
| EVENTIDE ASSET MANAGEMENT, LLC | $2587.6万 | 0.43% |
| Aberdeen Group plc | $2261.8万 | 0.04% |
| BAKER BROS. ADVISORS LP | $1603.6万 | 0.09% |
| GEODE CAPITAL MANAGEMENT, LLC | $1563.4万 | 0.00% |
| Siren, L.L.C. | $1202.7万 | 0.33% |
| Sio Capital Management, LLC | $1180.0万 | 1.69% |
| Soleus Capital Management, L.P. | $1176.6万 | 0.48% |
| GOLDMAN SACHS GROUP INC | $1055.1万 | 0.00% |
| Ensign Peak Advisors, Inc | $1024.8万 | 0.02% |
| Candriam S.C.A. | $949.4万 | 0.05% |
| Kalehua Capital Management LLC | $790.1万 | 5.59% |
| FRANKLIN RESOURCES INC | $703.5万 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $601.4万 | 0.01% |
| UBS Group AG | $591.9万 | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $569.6万 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | $565.4万 | 4.04% |
| MILLENNIUM MANAGEMENT LLC | $563.8万 | 0.00% |
| Point72 Asset Management, L.P. | $547.4万 | 0.01% |
| Alyeska Investment Group, L.P. | $546.1万 | 0.02% |
| GordonMD Global Investments LP | $545.2万 | 3.80% |
| MORGAN STANLEY | $533.3万 | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $482.1万 | 0.00% |
| Artia Global Partners LP | $480.0万 | 0.96% |
| NORTHERN TRUST CORP | $468.2万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $449.7万 | 0.00% |
| Rock Springs Capital Management LP | $398.6万 | 0.23% |
| Rhenman & Partners Asset Management AB | $350.8万 | 0.43% |
| TD Asset Management Inc | $332.7万 | 0.00% |
| AMERIPRISE FINANCIAL INC | $328.6万 | 0.00% |
| FMR LLC | $326.3万 | 0.00% |
| Driehaus Capital Management LLC | $307.2万 | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $258.4万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | $203.9万 | 0.00% |
| SEVEN GRAND MANAGERS, LLC | $200.5万 | 0.13% |
| Integral Health Asset Management, LLC | $200.5万 | 0.10% |
| Ishara Investments LP | $197.2万 | 1.87% |
| Russell Investments Group, Ltd. | $194.1万 | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | $184.7万 | 0.00% |
| Qube Research & Technologies Ltd | $169.3万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $158.0万 | 0.16% |
| ALPS ADVISORS INC | $146.8万 | 0.01% |
| STEMPOINT CAPITAL LP | $146.5万 | 0.28% |
| Bank of New York Mellon Corp | $135.4万 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | $107.3万 | 0.01% |
| Maven Securities LTD | $100.2万 | 0.02% |
| Nuveen, LLC | $95.1万 | 0.00% |
| XTX Topco Ltd | $94.4万 | 0.02% |
| Rafferty Asset Management, LLC | $88.7万 | 0.00% |
| BARCLAYS PLC | $73.7万 | 0.00% |
| RHUMBLINE ADVISERS | $73.4万 | 0.00% |
| CITIGROUP INC | $72.4万 | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $67.5万 | 0.00% |
| Squarepoint Ops LLC | $61.0万 | 0.00% |
| Walleye Capital LLC | $60.5万 | 0.00% |
| DEUTSCHE BANK AG\ | $53.1万 | 0.00% |
| Longaeva Partners L.P. | $50.9万 | 0.02% |
| KENNEDY CAPITAL MANAGEMENT LLC | $49.2万 | 0.01% |
| Vanguard Global Advisers, LLC | $44.9万 | 0.00% |
| Invesco Ltd. | $43.2万 | 0.00% |
| PROFUND ADVISORS LLC | $39.8万 | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $36.3万 | 0.00% |
| MetLife Investment Management, LLC | $34.3万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $31.8万 | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $29.3万 | 0.00% |
| ExodusPoint Capital Management, LP | $28.8万 | 0.00% |
| VARCOV Co. | $26.3万 | 0.10% |
| Virtus Investment Advisers, LLC | $25.6万 | 0.07% |
| Quarry LP | $25.3万 | 0.05% |
| Hudson Bay Capital Management LP | $24.8万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $23.6万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $22.0万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $22.0万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $21.2万 | 0.00% |
| AlphaCentric Advisors LLC | $19.3万 | 0.19% |
| Police & Firemen's Retirement System of New Jersey | $17.0万 | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $16.5万 | 0.00% |
| Cygnus Capital Advisors, LLC | $15.2万 | 0.10% |
| STRS OHIO | $11.6万 | 0.00% |
| Tower Research Capital LLC (TRC) | $9.4万 | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $9.3万 | 0.00% |
| Legal & General Group Plc | $5.7万 | 0.00% |
| Ameritas Investment Partners, Inc. | $5.2万 | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | $4.0万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.5万 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $1.6万 | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $1.5万 | 0.00% |
| Steward Partners Investment Advisory, LLC | $1.0万 | 0.00% |
| Rockefeller Capital Management L.P. | $9661.0 | 0.00% |
| GAMMA Investing LLC | $9541.0 | 0.00% |
| Farther Finance Advisors, LLC | $8095.0 | 0.00% |
| Quantbot Technologies LP | $7136.0 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $4650.0 | 0.00% |
| Sterling Capital Management LLC | $4209.0 | 0.00% |
| CWM, LLC | $2686.0 | 0.00% |
| US BANCORP \DE\ | $2045.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | $1443.0 | 0.00% |
| Allworth Financial LP | $1163.0 | 0.00% |
| Hughes Financial Services, LLC | $1042.0 | 0.00% |
| ROYAL BANK OF CANADA | $1000.0 | 0.00% |
| SIGNATUREFD, LLC | $962.0 | 0.00% |
| EverSource Wealth Advisors, LLC | $922.0 | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | $641.0 | 0.00% |
| Fortitude Family Office, LLC | $601.0 | 0.00% |
| Root Financial Partners, LLC | $401.0 | 0.00% |
| MAI Capital Management | $81.0 | 0.00% |
| ROTHSCHILD INVESTMENT LLC | $40.0 | 0.00% |
| Covestor Ltd | $0.0 | 0.00% |