| RA CAPITAL MANAGEMENT, L.P. | US$7741.1万 | 0.82% |
| MPM BIOIMPACT LLC | US$1776.5万 | 1.37% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$1313.2万 | 0.00% |
| BRAIDWELL LP | US$1047.8万 | 0.35% |
| GREAT POINT PARTNERS LLC | US$913.9万 | 2.10% |
| MILLENNIUM MANAGEMENT LLC | US$874.2万 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$807.4万 | 0.00% |
| Kynam Capital Management, LP | US$687.3万 | 0.42% |
| MARSHALL WACE, LLP | US$529.6万 | 0.01% |
| Affinity Asset Advisors, LLC | US$479.5万 | 0.25% |
| SILVERARC CAPITAL MANAGEMENT, LLC | US$469.2万 | 0.48% |
| Driehaus Capital Management LLC | US$411.6万 | 0.03% |
| ADAR1 Capital Management, LLC | US$409.4万 | 0.24% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | US$314.6万 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | US$288.1万 | 0.32% |
| SPHERA FUNDS MANAGEMENT LTD. | US$287.2万 | 0.46% |
| BlackRock, Inc. | US$275.1万 | 0.00% |
| CITADEL ADVISORS LLC | US$236.8万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$214.5万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | US$212.8万 | 0.00% |
| DIADEMA PARTNERS LP | US$196.0万 | 0.33% |
| TD Asset Management Inc | US$171.3万 | 0.00% |
| MORGAN STANLEY | US$160.4万 | 0.00% |
| Longaeva Partners L.P. | US$149.2万 | 0.06% |
| RENAISSANCE TECHNOLOGIES LLC | US$148.9万 | 0.00% |
| SUPERSTRING CAPITAL MANAGEMENT LP | US$136.5万 | 0.97% |
| JANE STREET GROUP, LLC | US$127.4万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$108.7万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$107.1万 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$102.7万 | 0.00% |
| Verdad Advisers, LP | US$99.0万 | 1.11% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | US$92.0万 | 0.02% |
| STATE STREET CORP | US$90.4万 | 0.00% |
| Seven Fleet Capital Management LP | US$89.5万 | 0.28% |
| NORTHERN TRUST CORP | US$87.6万 | 0.00% |
| ArchPoint Investors | US$83.2万 | 0.20% |
| Peapod Lane Capital LLC | US$74.0万 | 0.61% |
| DIMENSIONAL FUND ADVISORS LP | US$71.5万 | 0.00% |
| Qube Research & Technologies Ltd | US$71.4万 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$63.2万 | 0.01% |
| 683 Capital Management, LLC | US$61.7万 | 0.03% |
| UBS Group AG | US$58.9万 | 0.00% |
| Persistent Asset Partners Ltd | US$49.5万 | 0.18% |
| LPL Financial LLC | US$41.4万 | 0.00% |
| Point72 Asset Management, L.P. | US$40.5万 | 0.00% |
| Brevan Howard Capital Management LP | US$38.8万 | 0.00% |
| Hudson Bay Capital Management LP | US$37.3万 | 0.00% |
| BANK OF AMERICA CORP /DE/ | US$36.3万 | 0.00% |
| XTX Topco Ltd | US$35.6万 | 0.01% |
| BARCLAYS PLC | US$33.5万 | 0.00% |
| Squarepoint Ops LLC | US$29.4万 | 0.00% |
| HRT FINANCIAL LP | US$25.4万 | 0.00% |
| CANTOR FITZGERALD, L. P. | US$20.6万 | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | US$16.8万 | 0.15% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$15.1万 | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | US$12.6万 | 0.02% |
| RAYMOND JAMES FINANCIAL INC | US$12.1万 | 0.00% |
| OMERS ADMINISTRATION Corp | US$11.4万 | 0.00% |
| BLAIR WILLIAM & CO/IL | US$8.2万 | 0.00% |
| Diametric Capital, LP | US$7.7万 | 0.02% |
| Vanguard Personalized Indexing Management, LLC | US$7.7万 | 0.00% |
| Susquehanna Portfolio Strategies, LLC | US$7.6万 | 0.00% |
| Vanguard Global Advisers, LLC | US$6.9万 | 0.00% |
| Balyasny Asset Management L.P. | US$4.8万 | 0.00% |
| FMR LLC | US$4.4万 | 0.00% |
| Tower Research Capital LLC (TRC) | US$4.0万 | 0.00% |
| CITIGROUP INC | US$4.0万 | 0.00% |
| OSAIC HOLDINGS, INC. | US$2.3万 | 0.00% |
| Advisory Services Network, LLC | US$1.4万 | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | US$3925.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$1995.3 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$1867.0 | 0.00% |
| Fortitude Family Office, LLC | US$630.0 | 0.00% |
| Russell Investments Group, Ltd. | US$541.0 | 0.00% |
| Allworth Financial LP | US$309.0 | 0.00% |
| JPMORGAN CHASE & CO | US$301.0 | 0.00% |
| CWM, LLC | US$123.0 | 0.00% |
| Arax Advisory Partners | US$110.0 | 0.00% |
| DEUTSCHE BANK AG\ | US$7.0 | 0.00% |
| ROYAL BANK OF CANADA | US$0.0 | 0.00% |