| MPM BIOIMPACT LLC | US$1.1億 | 8.41% |
| Vivo Capital, LLC | US$5572.6萬 | 4.63% |
| Artisan Partners Limited Partnership | US$4636.3萬 | 0.07% |
| Siren, L.L.C. | US$3880.0萬 | 1.08% |
| BAKER BROS. ADVISORS LP | US$3052.9萬 | 0.18% |
| ADAR1 Capital Management, LLC | US$2115.9萬 | 1.25% |
| PERCEPTIVE ADVISORS LLC | US$2014.6萬 | 0.39% |
| Patient Square Capital LP | US$1448.8萬 | 2.57% |
| Octagon Capital Advisors LP | US$1199.5萬 | 1.33% |
| Redmile Group, LLC | US$1026.4萬 | 0.68% |
| Duquesne Family Office LLC | US$800.8萬 | 0.24% |
| MILLENNIUM MANAGEMENT LLC | US$666.3萬 | 0.00% |
| Atika Capital Management LLC | US$566.7萬 | 0.89% |
| Elmind Capital, LP | US$553.6萬 | 1.57% |
| Balyasny Asset Management L.P. | US$487.6萬 | 0.01% |
| AMERIPRISE FINANCIAL INC | US$483.4萬 | 0.00% |
| Yiheng Capital Management, L.P. | US$355.4萬 | 1.54% |
| NEW YORK STATE COMMON RETIREMENT FUND | US$351.3萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$341.3萬 | 0.04% |
| MORGAN STANLEY | US$305.2萬 | 0.00% |
| Russell Investments Group, Ltd. | US$268.6萬 | 0.00% |
| Ikarian Capital, LLC | US$219.9萬 | 0.18% |
| Dorsey Wright & Associates | US$214.2萬 | 0.27% |
| Ishara Investments LP | US$214.1萬 | 2.03% |
| ENVESTNET ASSET MANAGEMENT INC | US$199.9萬 | 0.00% |
| UBS Group AG | US$166.2萬 | 0.00% |
| Polymer Capital Management (HK) LTD | US$134.7萬 | 0.12% |
| DIVERSIFY WEALTH MANAGEMENT, LLC | US$129.3萬 | 0.02% |
| LPL Financial LLC | US$116.7萬 | 0.00% |
| AdvisorShares Investments LLC | US$105.2萬 | 0.19% |
| XTX Topco Ltd | US$87.9萬 | 0.02% |
| Qube Research & Technologies Ltd | US$78.2萬 | 0.00% |
| NAN FUNG TRINITY (HK) LTD | US$77.5萬 | 0.09% |
| Engineers Gate Manager LP | US$69.0萬 | 0.01% |
| STIFEL FINANCIAL CORP | US$64.2萬 | 0.00% |
| Cetera Investment Advisers | US$53.0萬 | 0.00% |
| HRT FINANCIAL LP | US$50.3萬 | 0.00% |
| Burns Matteson Capital Management, LLC | US$47.3萬 | 0.17% |
| Atria Investments, Inc | US$44.2萬 | 0.00% |
| Optiver Holding B.V. | US$39.8萬 | 0.00% |
| SEI INVESTMENTS CO | US$35.0萬 | 0.00% |
| PERSONAL CFO SOLUTIONS, LLC | US$26.4萬 | 0.04% |
| ExodusPoint Capital Management, LP | US$24.1萬 | 0.00% |
| Persistent Asset Partners Ltd | US$23.8萬 | 0.09% |
| JANE STREET GROUP, LLC | US$23.6萬 | 0.00% |
| Integrated Wealth Concepts LLC | US$22.1萬 | 0.00% |
| BARCLAYS PLC | US$16.9萬 | 0.00% |
| Brooklands Fund Management Ltd | US$14.6萬 | 0.17% |
| RHUMBLINE ADVISERS | US$12.7萬 | 0.00% |
| China Universal Asset Management Co., Ltd. | US$10.4萬 | 0.01% |
| ROYAL BANK OF CANADA | US$9.8萬 | 0.00% |
| Truvestments Capital LLC | US$8.1萬 | 0.01% |
| GAMMA Investing LLC | US$6.1萬 | 0.00% |
| Allworth Financial LP | US$3.5萬 | 0.00% |
| OSAIC HOLDINGS, INC. | US$2.3萬 | 0.00% |
| HM PAYSON & CO | US$8774.0 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$6267.0 | 0.00% |
| HARBOUR INVESTMENTS, INC. | US$5422.0 | 0.00% |
| Ascentis Wealth Management, LLC | US$5410.0 | 0.00% |
| Farther Finance Advisors, LLC | US$3362.0 | 0.00% |
| Federation des caisses Desjardins du Quebec | US$3029.0 | 0.00% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | US$2319.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$1400.0 | 0.00% |
| Pinnacle Wealth Planning Services, Inc. | US$836.0 | 0.00% |
| Advisory Services Network, LLC | US$627.0 | 0.00% |
| CURIO WEALTH, LLC | US$564.0 | 0.00% |
| Bell Investment Advisors, Inc | US$439.0 | 0.00% |
| JPMORGAN CHASE & CO | US$391.0 | 0.00% |
| EverSource Wealth Advisors, LLC | US$292.0 | 0.00% |
| TRUST CO OF TOLEDO NA /OH/ | US$209.0 | 0.00% |
| BlackRock, Inc. | US$42.0 | 0.00% |
| Tower Research Capital LLC (TRC) | US$21.0 | 0.00% |