| Cormorant Asset Management, LP | US$1.6億 | 8.04% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | US$4372.5萬 | 0.52% |
| Omega Fund Management, LLC | US$2944.2萬 | 18.05% |
| EcoR1 Capital, LLC | US$2526.7萬 | 1.07% |
| Alphabet Inc. | US$2526.7萬 | 0.63% |
| WELLINGTON MANAGEMENT GROUP LLP | US$2522.4萬 | 0.00% |
| ENAVATE SCIENCES GP, LLC | US$2351.1萬 | 6.69% |
| CITADEL ADVISORS LLC | US$2263.2萬 | 0.00% |
| NOVO HOLDINGS A/S | US$1956.4萬 | 1.59% |
| BlackRock, Inc. | US$1869.0萬 | 0.00% |
| Laurion Capital Management LP | US$1720.8萬 | 0.75% |
| ARMISTICE CAPITAL, LLC | US$1188.6萬 | 0.21% |
| Aisling Capital Management LP | US$911.1萬 | 1.91% |
| Paradigm Biocapital Advisors LP | US$777.1萬 | 0.16% |
| Octagon Capital Advisors LP | US$643.5萬 | 0.71% |
| ROYCE & ASSOCIATES LP | US$569.7萬 | 0.06% |
| GEODE CAPITAL MANAGEMENT, LLC | US$518.7萬 | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$481.9萬 | 0.00% |
| EVENTIDE ASSET MANAGEMENT, LLC | US$469.7萬 | 0.08% |
| PRICE T ROWE ASSOCIATES INC /MD/ | US$392.0萬 | 0.00% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$358.0萬 | 0.01% |
| Ensign Peak Advisors, Inc | US$287.2萬 | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | US$260.3萬 | 0.00% |
| Casdin Capital, LLC | US$252.7萬 | 0.19% |
| Ikarian Capital, LLC | US$241.9萬 | 0.20% |
| MILLENNIUM MANAGEMENT LLC | US$238.0萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$227.6萬 | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | US$216.3萬 | 0.00% |
| FMR LLC | US$215.1萬 | 0.00% |
| Granahan Investment Management, LLC | US$206.8萬 | 0.10% |
| STATE STREET CORP | US$202.5萬 | 0.00% |
| GOLDMAN SACHS GROUP INC | US$150.0萬 | 0.00% |
| Sio Capital Management, LLC | US$116.9萬 | 0.17% |
| Hudson Bay Capital Management LP | US$98.5萬 | 0.00% |
| Woodline Partners LP | US$92.8萬 | 0.00% |
| NORTHERN TRUST CORP | US$91.5萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$91.2萬 | 0.00% |
| MOORE CAPITAL MANAGEMENT, LP | US$89.5萬 | 0.02% |
| Tema ETFs LLC | US$73.5萬 | 0.05% |
| Tidal Investments LLC | US$73.5萬 | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$72.4萬 | 0.01% |
| HighVista Strategies LLC | US$70.0萬 | 0.19% |
| Qube Research & Technologies Ltd | US$64.4萬 | 0.00% |
| XTX Topco Ltd | US$53.5萬 | 0.01% |
| TD Asset Management Inc | US$51.5萬 | 0.00% |
| Opaleye Management Inc. | US$47.7萬 | 0.06% |
| UBS Group AG | US$45.2萬 | 0.00% |
| ExodusPoint Capital Management, LP | US$43.1萬 | 0.00% |
| Avidity Partners Management LP | US$39.2萬 | 0.08% |
| MORGAN STANLEY | US$38.8萬 | 0.00% |
| Squarepoint Ops LLC | US$38.7萬 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | US$31.9萬 | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | US$26.0萬 | 0.00% |
| Vanguard Global Advisers, LLC | US$16.3萬 | 0.00% |
| AXQ CAPITAL, LP | US$15.5萬 | 0.02% |
| Diametric Capital, LP | US$14.6萬 | 0.04% |
| Brevan Howard Capital Management LP | US$12.8萬 | 0.00% |
| Quadrature Capital Ltd | US$11.9萬 | 0.00% |
| Aquatic Capital Management LLC | US$10.6萬 | 0.00% |
| Bellevue Group AG | US$6.2萬 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | US$8128.3 | 0.00% |
| Rockefeller Capital Management L.P. | US$6265.0 | 0.00% |
| WELLS FARGO & COMPANY/MN | US$2685.0 | 0.00% |
| BARCLAYS PLC | US$1897.0 | 0.00% |
| ROYAL BANK OF CANADA | US$1000.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$36.0 | 0.00% |