| BAKER BROS. ADVISORS LP | $26.1億 | 15.00% |
| PRIMECAP MANAGEMENT CO/CA/ | $14.8億 | 1.16% |
| Capital International Investors | $12.3億 | 0.29% |
| FMR LLC | $11.0億 | 0.06% |
| Capital World Investors | $4.8億 | 0.07% |
| CITADEL ADVISORS LLC | $3.1億 | 0.05% |
| HHLR ADVISORS, LTD. | $3.1億 | 18.36% |
| Temasek Holdings (Private) Ltd | $2.6億 | 0.84% |
| BlackRock, Inc. | $2.0億 | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.6億 | 0.02% |
| Siren, L.L.C. | $1.4億 | 3.83% |
| MORGAN STANLEY | $1.4億 | 0.01% |
| UBS Group AG | $1.2億 | 0.02% |
| BANK OF AMERICA CORP /DE/ | $1.2億 | 0.01% |
| Baird Financial Group, Inc. | $1.0億 | 0.16% |
| Capital International, Inc./CA/ | $8975.7万 | 0.69% |
| Candriam S.C.A. | $7713.2万 | 0.40% |
| Man Group plc | $7184.4万 | 0.13% |
| FIRST TRUST ADVISORS LP | $7169.6万 | 0.05% |
| MILLENNIUM MANAGEMENT LLC | $6083.3万 | 0.03% |
| FRANKLIN RESOURCES INC | $5995.3万 | 0.01% |
| Nuveen, LLC | $5833.4万 | 0.02% |
| CAPITAL INTERNATIONAL SARL | $5163.7万 | 0.85% |
| MARSHALL WACE, LLP | $5127.0万 | 0.05% |
| Driehaus Capital Management LLC | $4603.1万 | 0.34% |
| JENNISON ASSOCIATES LLC | $4587.1万 | 0.03% |
| M&G PLC | $4103.4万 | 0.21% |
| Artisan Partners Limited Partnership | $4074.9万 | 0.07% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3555.5万 | 0.00% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $3284.1万 | 0.02% |
| JANE STREET GROUP, LLC | $3257.7万 | 0.00% |
| VAN ECK ASSOCIATES CORP | $3216.3万 | 0.02% |
| GOLDMAN SACHS GROUP INC | $2871.0万 | 0.00% |
| Patient Square Capital LP | $2391.9万 | 4.24% |
| CAPITAL INTERNATIONAL LTD /CA/ | $2272.3万 | 0.84% |
| JPMORGAN CHASE & CO | $2202.8万 | 0.00% |
| Squarepoint Ops LLC | $2201.3万 | 0.03% |
| ROYAL BANK OF CANADA | $2090.5万 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $2004.6万 | 0.03% |
| BARCLAYS PLC | $1963.6万 | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | $1868.4万 | 0.03% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $1787.5万 | 0.01% |
| Legal & General Group Plc | $1777.6万 | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $1770.3万 | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | $1702.2万 | 0.06% |
| DIMENSIONAL FUND ADVISORS LP | $1685.9万 | 0.00% |
| SEB Asset Management AB | $1665.3万 | 0.07% |
| WELLS FARGO & COMPANY/MN | $1546.7万 | 0.00% |
| ABN AMRO INVESTMENT SOLUTIONS | $1412.5万 | 0.18% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $1401.8万 | 0.01% |
| EDMOND DE ROTHSCHILD HOLDING S.A. | $1289.7万 | 0.19% |
| BARINGS LLC | $1271.5万 | 0.21% |
| Atle Fund Management AB | $1213.7万 | 3.92% |
| CITIGROUP INC | $1134.1万 | 0.00% |
| NORTHERN TRUST CORP | $1073.0万 | 0.00% |
| Fiera Capital Corp | $1003.2万 | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $1001.6万 | 0.01% |
| TWO SIGMA INVESTMENTS, LP | $996.1万 | 0.01% |
| OPPENHEIMER ASSET MANAGEMENT INC. | $966.1万 | 0.11% |
| NOMURA HOLDINGS INC | $918.9万 | 0.03% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $910.6万 | 0.02% |
| ASSETMARK, INC | $878.1万 | 0.02% |
| Capital Group Private Client Services, Inc. | $851.0万 | 0.14% |
| Slow Capital, Inc. | $846.1万 | 1.10% |
| DEUTSCHE BANK AG\ | $827.9万 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $810.6万 | 0.00% |
| AIA Group Ltd | $774.4万 | 0.11% |
| Mirae Asset Global Investments Co., Ltd. | $705.0万 | 0.00% |
| Russell Investments Group, Ltd. | $693.3万 | 0.01% |
| Walleye Capital LLC | $637.0万 | 0.03% |
| Asset Management One Co., Ltd. | $633.9万 | 0.02% |
| Erste Asset Management GmbH | $622.1万 | 0.06% |
| WELLINGTON MANAGEMENT GROUP LLP | $618.5万 | 0.00% |
| Invesco Ltd. | $569.5万 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $568.5万 | 0.00% |
| CAPITAL GROUP INVESTMENT MANAGEMENT PTE. LTD. | $495.6万 | 0.85% |
| Nan Fung Group Holdings Ltd | $466.9万 | 3.85% |
| Rokos Capital Management LLP | $425.6万 | 0.03% |
| Tidal Investments LLC | $375.2万 | 0.01% |
| AMERICAN CENTURY COMPANIES INC | $366.6万 | 0.00% |
| Caption Management, LLC | $365.3万 | 0.02% |
| GUGGENHEIM CAPITAL LLC | $363.6万 | 0.03% |
| ADAR1 Capital Management, LLC | $347.5万 | 0.20% |
| STIFEL FINANCIAL CORP | $340.6万 | 0.00% |
| ExodusPoint Capital Management, LP | $326.1万 | 0.03% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | $317.5万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $311.4万 | 0.00% |
| Creative Planning | $302.9万 | 0.00% |
| TD Asset Management Inc | $297.4万 | 0.00% |
| Pinpoint Asset Management (Singapore) Pte. Ltd. | $285.4万 | 0.66% |
| KBC Group NV | $281.8万 | 0.01% |
| Quantinno Capital Management LP | $246.9万 | 0.00% |
| BANK OF MONTREAL /CAN/ | $245.7万 | 0.00% |
| Crossmark Global Holdings, Inc. | $227.5万 | 0.03% |
| STATE STREET CORP | $209.8万 | 0.00% |
| Rockefeller Capital Management L.P. | $191.2万 | 0.00% |
| Jefferies Financial Group Inc. | $184.1万 | 0.01% |
| JONES FINANCIAL COMPANIES LLLP | $183.3万 | 0.00% |
| MACKENZIE FINANCIAL CORP | $180.6万 | 0.00% |
| Long Corridor Asset Management Ltd | $178.8万 | 0.43% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $174.1万 | 0.00% |
| China Universal Asset Management Co., Ltd. | $168.4万 | 0.13% |
| XTX Topco Ltd | $162.3万 | 0.03% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $157.6万 | 0.00% |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | $152.8万 | 0.06% |
| LPL Financial LLC | $151.7万 | 0.00% |
| WESPAC Advisors SoCal, LLC | $146.3万 | 0.31% |
| STOREBRAND ASSET MANAGEMENT AS | $138.6万 | 0.00% |
| Bank of New York Mellon Corp | $137.6万 | 0.00% |
| MML INVESTORS SERVICES, LLC | $134.8万 | 0.00% |
| Havemeyer Place LP | $132.8万 | 0.15% |
| Banco Santander, S.A. | $132.7万 | 0.01% |
| PROFUND ADVISORS LLC | $132.0万 | 0.05% |
| TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC | $131.8万 | 0.01% |
| NEUBERGER BERMAN GROUP LLC | $129.0万 | 0.00% |
| SEI INVESTMENTS CO | $128.3万 | 0.00% |
| Trexquant Investment LP | $119.9万 | 0.01% |
| B. Metzler seel. Sohn & Co. AG | $114.8万 | 0.01% |
| Bellevue Group AG | $113.2万 | 0.03% |
| True Light Capital Pte. Ltd. | $103.3万 | 0.52% |
| Focus Partners Wealth | $99.0万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $98.9万 | 0.06% |
| Henshaw Capital LLC | $95.7万 | 0.04% |
| Rodgers Brothers Inc. | $94.5万 | 0.11% |
| Vanguard Personalized Indexing Management, LLC | $94.5万 | 0.01% |
| Qtron Investments LLC | $94.2万 | 0.13% |
| PORTLAND INVESTMENT COUNSEL INC. | $89.1万 | 0.29% |
| Sanctuary Advisors, LLC | $88.6万 | 0.00% |
| &PARTNERS | $85.9万 | 0.00% |
| Orion Porfolio Solutions, LLC | $85.4万 | 0.01% |
| SANDERS MORRIS HARRIS LLC | $80.2万 | 0.13% |
| QUADRANT CAPITAL GROUP LLC | $79.4万 | 0.02% |
| Virtus Investment Advisers, LLC | $78.6万 | 0.22% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $78.5万 | 0.00% |
| Perigon Wealth Management, LLC | $75.3万 | 0.01% |
| Brooklyn Investment Group | $74.4万 | 0.02% |
| Vident Advisory, LLC | $73.8万 | 0.01% |
| Callan Family Office, LLC | $72.0万 | 0.02% |
| AMERIPRISE FINANCIAL INC | $71.1万 | 0.00% |
| Cetera Investment Advisers | $70.4万 | 0.00% |
| KAYNE ANDERSON RUDNICK INVESTMENT MANAGEMENT LLC | $67.7万 | 0.00% |
| SG Americas Securities, LLC | $65.2万 | 0.00% |
| Cerity Partners LLC | $64.9万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $63.5万 | 0.00% |
| SECTORAL ASSET MANAGEMENT INC | $63.1万 | 0.52% |
| TD Waterhouse Canada Inc. | $62.7万 | 0.00% |
| Laird Norton Wetherby Trust Company, LLC | $62.7万 | 0.01% |
| FOX RUN MANAGEMENT, L.L.C. | $60.7万 | 0.11% |
| VOYA INVESTMENT MANAGEMENT LLC | $60.0万 | 0.00% |
| COMMONWEALTH EQUITY SERVICES, LLC | $55.2万 | 0.00% |