| RTW INVESTMENTS, LP | $4.7億 | 4.70% |
| T. Rowe Price Investment Management, Inc. | $4.5億 | 0.31% |
| Decheng Capital LLC | $4.3億 | 65.21% |
| WELLINGTON MANAGEMENT GROUP LLP | $3.6億 | 0.07% |
| BlackRock, Inc. | $3.4億 | 0.01% |
| FMR LLC | $2.5億 | 0.01% |
| TCG Crossover Management, LLC | $2.5億 | 7.11% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $2.5億 | 0.03% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $2.1億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $2.1億 | 0.01% |
| Caption Management, LLC | $1.9億 | 1.09% |
| STATE STREET CORP | $1.8億 | 0.01% |
| Foresite Capital Management VI LLC | $1.5億 | 32.67% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.1億 | 0.01% |
| FRANKLIN RESOURCES INC | $1.0億 | 0.02% |
| BANK OF AMERICA CORP /DE/ | $9809.3万 | 0.01% |
| DV Trading LLC | $9741.8万 | 2.31% |
| UBS Group AG | $8879.5万 | 0.01% |
| Avidity Partners Management LP | $8723.6万 | 17.67% |
| GOLDMAN SACHS GROUP INC | $7845.7万 | 0.01% |
| ACORN CAPITAL ADVISORS, LLC | $7658.0万 | 21.77% |
| EcoR1 Capital, LLC | $7458.3万 | 3.17% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $7207.7万 | 0.01% |
| Foresite Capital Management V, LLC | $6795.4万 | 25.08% |
| Driehaus Capital Management LLC | $6765.4万 | 0.50% |
| BRAIDWELL LP | $6665.0万 | 2.22% |
| ORBIMED ADVISORS LLC | $6417.9万 | 1.32% |
| Caligan Partners LP | $6091.2万 | 4.05% |
| ALLIANCEBERNSTEIN L.P. | $5356.4万 | 0.02% |
| Clearbridge Investments, LLC | $4942.6万 | 0.04% |
| Polar Capital Holdings Plc | $4767.8万 | 0.17% |
| FARALLON CAPITAL MANAGEMENT LLC | $4561.6万 | 0.26% |
| Logos Global Management LP | $3891.6万 | 1.94% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3670.8万 | 0.01% |
| Candriam S.C.A. | $3668.5万 | 0.19% |
| JPMORGAN CHASE & CO | $3579.1万 | 0.00% |
| MORGAN STANLEY | $3520.8万 | 0.00% |
| NORTHERN TRUST CORP | $3517.1万 | 0.00% |
| Woodline Partners LP | $3335.9万 | 0.13% |
| JENNISON ASSOCIATES LLC | $3222.5万 | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | $3182.7万 | 0.01% |
| Fisher Asset Management, LLC | $3147.3万 | 0.01% |
| Ensign Peak Advisors, Inc | $3086.3万 | 0.06% |
| DIMENSIONAL FUND ADVISORS LP | $2968.9万 | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2928.5万 | 0.00% |
| Point72 Asset Management, L.P. | $2878.4万 | 0.04% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $2706.2万 | 0.04% |
| Pictet Asset Management Holding SA | $2693.7万 | 0.03% |
| EVENTIDE ASSET MANAGEMENT, LLC | $2502.7万 | 0.41% |
| LORD, ABBETT & CO. LLC | $2302.5万 | 0.08% |
| FIRST TRUST ADVISORS LP | $2255.0万 | 0.02% |
| AMERIPRISE FINANCIAL INC | $2108.4万 | 0.00% |
| Elmind Capital, LP | $1974.9万 | 5.61% |
| TD Asset Management Inc | $1954.3万 | 0.02% |
| CITADEL ADVISORS LLC | $1812.6万 | 0.00% |
| TimesSquare Capital Management, LLC | $1717.1万 | 0.29% |
| BOOTHBAY FUND MANAGEMENT, LLC | $1549.2万 | 0.20% |
| STEMPOINT CAPITAL LP | $1391.6万 | 2.66% |
| HSBC HOLDINGS PLC | $1270.8万 | 0.01% |
| ArrowMark Colorado Holdings LLC | $1261.0万 | 0.34% |
| ADAR1 Capital Management, LLC | $1256.8万 | 0.74% |
| Bank of New York Mellon Corp | $1130.5万 | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $1125.9万 | 1.15% |
| PFM Health Sciences, LP | $1123.0万 | 1.02% |
| Russell Investments Group, Ltd. | $1104.4万 | 0.01% |
| DEUTSCHE BANK AG\ | $1058.9万 | 0.00% |
| FEDERATED HERMES, INC. | $1006.7万 | 0.02% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $999.9万 | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $975.3万 | 0.02% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $926.1万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $924.1万 | 0.01% |
| Nuveen, LLC | $869.1万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $773.9万 | 0.00% |
| Rosalind Advisors, Inc. | $676.8万 | 2.72% |
| Opaleye Management Inc. | $641.6万 | 0.85% |
| Invesco Ltd. | $622.6万 | 0.00% |
| JANE STREET GROUP, LLC | $617.2万 | 0.00% |
| Swiss National Bank | $571.2万 | 0.00% |
| Seven Fleet Capital Management LP | $512.7万 | 1.63% |
| RHUMBLINE ADVISERS | $481.1万 | 0.00% |
| ALPS ADVISORS INC | $465.2万 | 0.02% |
| Rafferty Asset Management, LLC | $460.1万 | 0.02% |
| PICTON MAHONEY ASSET MANAGEMENT | $456.2万 | 0.03% |
| Blackstone Inc. | $434.0万 | 0.02% |
| Tema ETFs LLC | $427.5万 | 0.29% |
| Tidal Investments LLC | $427.5万 | 0.01% |
| Affinity Asset Advisors, LLC | $406.1万 | 0.21% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $390.7万 | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $387.7万 | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $348.5万 | 0.00% |
| Aquatic Capital Management LLC | $335.9万 | 0.10% |
| Nantahala Capital Management, LLC | $334.7万 | 0.12% |
| D. E. Shaw & Co., Inc. | $315.5万 | 0.00% |
| Informed Momentum Co LLC | $312.0万 | 0.36% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $306.9万 | 0.00% |
| SummitTX Capital, L.P. | $274.6万 | 0.09% |
| Legal & General Group Plc | $257.2万 | 0.00% |
| MetLife Investment Management, LLC | $220.7万 | 0.01% |
| Lynx1 Capital Management LP | $213.8万 | 0.34% |
| PROFUND ADVISORS LLC | $207.7万 | 0.08% |
| Vanguard Global Advisers, LLC | $204.8万 | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $195.9万 | 0.00% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $187.8万 | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $181.7万 | 0.00% |
| Cinctive Capital Management LP | $169.3万 | 0.11% |
| Sicart Associates LLC | $169.2万 | 0.43% |
| SG Americas Securities, LLC | $166.7万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $166.5万 | 0.00% |
| Knights of Columbus Asset Advisors LLC | $157.0万 | 0.09% |
| WESBANCO BANK INC | $150.9万 | 0.04% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | $147.4万 | 0.00% |
| Handelsbanken Fonder AB | $140.1万 | 0.00% |
| AMI ASSET MANAGEMENT CORP | $136.2万 | 0.09% |
| Soleus Capital Management, L.P. | $135.4万 | 0.05% |
| MILLENNIUM MANAGEMENT LLC | $135.4万 | 0.00% |
| HighVista Strategies LLC | $134.8万 | 0.37% |
| ALGERT GLOBAL LLC | $131.2万 | 0.02% |
| JANUS HENDERSON GROUP PLC | $125.3万 | 0.00% |
| SEI INVESTMENTS CO | $122.5万 | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $120.4万 | 0.00% |
| Creative Planning | $113.9万 | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $111.6万 | 0.01% |
| Police & Firemen's Retirement System of New Jersey | $109.7万 | 0.01% |
| China Universal Asset Management Co., Ltd. | $101.4万 | 0.08% |
| State of New Jersey Common Pension Fund D | $98.9万 | 0.00% |
| Bridgefront Capital, LLC | $97.5万 | 0.24% |
| CITIGROUP INC | $96.1万 | 0.00% |
| Balyasny Asset Management L.P. | $95.9万 | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $87.2万 | 0.00% |
| Voleon Capital Management LP | $87.1万 | 0.02% |
| ProShare Advisors LLC | $83.6万 | 0.00% |
| Allianz Asset Management GmbH | $83.2万 | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $79.5万 | 0.00% |
| Persistent Asset Partners Ltd | $78.8万 | 0.29% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $78.6万 | 0.00% |
| Brevan Howard Capital Management LP | $78.5万 | 0.01% |
| BARCLAYS PLC | $77.8万 | 0.00% |
| ROYAL BANK OF CANADA | $77.4万 | 0.00% |
| SBI Okasan Asset Management Co.Ltd. | $77.4万 | 0.03% |
| PDT Partners, LLC | $75.7万 | 0.04% |
| RAYMOND JAMES FINANCIAL INC | $75.1万 | 0.00% |
| Vanguard Investments Australia, Ltd. | $74.4万 | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | $71.3万 | 0.00% |
| PRUDENTIAL FINANCIAL INC | $65.6万 | 0.00% |
| KLP KAPITALFORVALTNING AS | $64.3万 | 0.00% |
| E Fund Management Co., Ltd. | $59.4万 | 0.02% |
| Eleva Capital SAS | $56.1万 | 0.16% |
| Tower Research Capital LLC (TRC) | $56.1万 | 0.01% |
| Jackson Creek Investment Advisors LLC | $52.9万 | 0.16% |
| Hudson Bay Capital Management LP | $50.6万 | 0.00% |