| Frazier Life Sciences Management, L.P. | $7.1億 | 18.25% |
| JANUS HENDERSON GROUP PLC | $6.4億 | 0.31% |
| BlackRock, Inc. | $3.6億 | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $2.2億 | 0.01% |
| FMR LLC | $1.8億 | 0.01% |
| STATE STREET CORP | $1.8億 | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.6億 | 0.02% |
| BVF INC/IL | $1.5億 | 4.66% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1.3億 | 0.01% |
| EVENTIDE ASSET MANAGEMENT, LLC | $1.3億 | 2.15% |
| WELLINGTON MANAGEMENT GROUP LLP | $1.2億 | 0.02% |
| NOVO HOLDINGS A/S | $1.2億 | 9.92% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.2億 | 0.01% |
| TANG CAPITAL MANAGEMENT LLC | $1.1億 | 5.80% |
| CITADEL ADVISORS LLC | $9825.1万 | 0.02% |
| TCG Crossover Management, LLC | $9811.2万 | 2.81% |
| Rock Springs Capital Management LP | $7494.7万 | 4.42% |
| TWO SIGMA INVESTMENTS, LP | $7158.0万 | 0.06% |
| Capital World Investors | $6692.1万 | 0.01% |
| BANK OF AMERICA CORP /DE/ | $6671.5万 | 0.00% |
| FRANKLIN RESOURCES INC | $6603.4万 | 0.02% |
| Clearbridge Investments, LLC | $6206.7万 | 0.05% |
| GOLDMAN SACHS GROUP INC | $6118.4万 | 0.01% |
| Paradigm Biocapital Advisors LP | $5773.8万 | 1.18% |
| LORD, ABBETT & CO. LLC | $5700.4万 | 0.19% |
| Bank of New York Mellon Corp | $5399.8万 | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | $5377.3万 | 0.08% |
| Woodline Partners LP | $5246.2万 | 0.20% |
| Balyasny Asset Management L.P. | $4979.6万 | 0.06% |
| MORGAN STANLEY | $4845.9万 | 0.00% |
| FEDERATED HERMES, INC. | $4676.4万 | 0.08% |
| UBS Group AG | $4572.8万 | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | $4429.4万 | 0.10% |
| LOOMIS SAYLES & CO L P | $4391.0万 | 0.06% |
| Nuveen, LLC | $4380.9万 | 0.01% |
| Candriam S.C.A. | $4288.4万 | 0.22% |
| BAKER BROS. ADVISORS LP | $4119.9万 | 0.24% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3945.5万 | 0.01% |
| Pictet Asset Management Holding SA | $3912.4万 | 0.04% |
| BOONE CAPITAL MANAGEMENT LLC | $3891.4万 | 11.92% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $3744.4万 | 0.06% |
| First Turn Management, LLC | $3699.5万 | 4.13% |
| Soleus Capital Management, L.P. | $3698.0万 | 1.50% |
| EMERALD ADVISERS, LLC | $3669.9万 | 1.16% |
| NORTHERN TRUST CORP | $3648.3万 | 0.00% |
| NEXT CENTURY GROWTH INVESTORS LLC | $3561.6万 | 2.58% |
| TimesSquare Capital Management, LLC | $3477.9万 | 0.59% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $3464.3万 | 0.05% |
| MILLENNIUM MANAGEMENT LLC | $3404.9万 | 0.01% |
| Point72 Asset Management, L.P. | $3266.5万 | 0.04% |
| Octagon Capital Advisors LP | $3130.8万 | 3.46% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $3100.9万 | 0.10% |
| VANGUARD FIDUCIARY TRUST CO | $3079.3万 | 0.01% |
| Trails Edge Capital Partners, LP | $3079.1万 | 7.05% |
| Palo Alto Investors LP | $3004.0万 | 4.59% |
| RA CAPITAL MANAGEMENT, L.P. | $2942.8万 | 0.31% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $2645.8万 | 0.01% |
| Hood River Capital Management LLC | $2636.4万 | 0.26% |
| Invesco Ltd. | $2635.0万 | 0.00% |
| Polar Capital Holdings Plc | $2618.8万 | 0.09% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $2453.9万 | 0.03% |
| Penn Capital Management Company, LLC | $2377.5万 | 1.84% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $2313.2万 | 1.12% |
| NAN FUNG TRINITY (HK) LTD | $2149.5万 | 2.36% |
| Patient Square Capital LP | $2124.7万 | 3.77% |
| RAYMOND JAMES FINANCIAL INC | $2107.9万 | 0.01% |
| AMERIPRISE FINANCIAL INC | $2025.5万 | 0.00% |
| Ensign Peak Advisors, Inc | $1870.4万 | 0.03% |
| NEW YORK STATE COMMON RETIREMENT FUND | $1858.2万 | 0.03% |
| Logos Global Management LP | $1847.6万 | 0.92% |
| Erste Asset Management GmbH | $1845.9万 | 0.17% |
| Russell Investments Group, Ltd. | $1820.8万 | 0.02% |
| Handelsbanken Fonder AB | $1792.2万 | 0.06% |
| SEGALL BRYANT & HAMILL, LLC | $1624.9万 | 0.23% |
| D. E. Shaw & Co., Inc. | $1547.3万 | 0.01% |
| Legal & General Group Plc | $1421.5万 | 0.00% |
| CITIGROUP INC | $1417.8万 | 0.01% |
| FIRST TRUST ADVISORS LP | $1397.5万 | 0.01% |
| Voleon Capital Management LP | $1390.4万 | 0.30% |
| RICE HALL JAMES & ASSOCIATES, LLC | $1358.3万 | 0.76% |
| PDT Partners, LLC | $1343.0万 | 0.79% |
| Nicholas Investment Partners, LP | $1213.0万 | 0.88% |
| PANAGORA ASSET MANAGEMENT INC | $1192.8万 | 0.04% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1183.5万 | 0.00% |
| Highlander Partners, L.P. | $1136.1万 | 4.45% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | $1000.8万 | 1.58% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $961.7万 | 0.04% |
| Atle Fund Management AB | $939.8万 | 3.03% |
| Caption Management, LLC | $923.8万 | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | $882.7万 | 0.01% |
| Hennion & Walsh Asset Management, Inc. | $864.6万 | 0.29% |
| Fisher Asset Management, LLC | $860.1万 | 0.00% |
| Rhenman & Partners Asset Management AB | $855.5万 | 1.06% |
| ExodusPoint Capital Management, LP | $807.2万 | 0.07% |
| JPMORGAN CHASE & CO | $796.9万 | 0.00% |
| SEI INVESTMENTS CO | $749.3万 | 0.01% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $748.2万 | 0.05% |
| NEUBERGER BERMAN GROUP LLC | $744.1万 | 0.01% |
| Swiss National Bank | $686.4万 | 0.00% |
| PICTON MAHONEY ASSET MANAGEMENT | $684.7万 | 0.05% |
| VOYA INVESTMENT MANAGEMENT LLC | $635.7万 | 0.01% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $627.1万 | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $615.5万 | 0.00% |
| Squarepoint Ops LLC | $569.9万 | 0.01% |
| Hillsdale Investment Management Inc. | $551.8万 | 0.15% |
| PRINCIPAL FINANCIAL GROUP INC | $530.0万 | 0.00% |
| Thrivent Financial for Lutherans | $527.1万 | 0.01% |
| BANK OF MONTREAL /CAN/ | $520.9万 | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $514.5万 | 0.00% |
| RHUMBLINE ADVISERS | $479.8万 | 0.00% |
| F/m Investments LLC | $470.3万 | 0.31% |
| DEUTSCHE BANK AG\ | $462.3万 | 0.00% |
| Rafferty Asset Management, LLC | $454.1万 | 0.02% |
| ALPS ADVISORS INC | $453.8万 | 0.02% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $410.9万 | 0.00% |
| Secure Asset Management, LLC | $403.2万 | 0.64% |
| Informed Momentum Co LLC | $402.7万 | 0.46% |
| ALLIANCEBERNSTEIN L.P. | $388.5万 | 0.00% |
| Legato Capital Management LLC | $385.8万 | 0.35% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $369.8万 | 0.01% |
| Lisanti Capital Growth, LLC | $360.3万 | 0.91% |
| Cinctive Capital Management LP | $355.8万 | 0.23% |
| ZACKS INVESTMENT MANAGEMENT | $340.8万 | 0.03% |
| STATE OF WISCONSIN INVESTMENT BOARD | $315.1万 | 0.01% |
| Alyeska Investment Group, L.P. | $314.6万 | 0.01% |
| TD Asset Management Inc | $311.2万 | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $293.7万 | 0.00% |
| Allianz Asset Management GmbH | $288.7万 | 0.00% |
| Creative Planning | $283.2万 | 0.00% |
| Sofinnova Investments, Inc. | $254.9万 | 0.10% |
| MACKENZIE FINANCIAL CORP | $254.9万 | 0.00% |
| Faithward Advisors, LLC | $253.7万 | 0.36% |
| Pathstone Holdings, LLC | $236.3万 | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | $231.1万 | 0.00% |
| Knights of Columbus Asset Advisors LLC | $220.1万 | 0.12% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $213.4万 | 0.00% |
| MetLife Investment Management, LLC | $210.8万 | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | $210.0万 | 0.05% |
| ENVESTNET ASSET MANAGEMENT INC | $208.4万 | 0.00% |
| PROFUND ADVISORS LLC | $204.9万 | 0.08% |
| Vanguard Global Advisers, LLC | $197.1万 | 0.00% |
| POLEN CAPITAL MANAGEMENT LLC | $189.7万 | 0.01% |
| ROYAL BANK OF CANADA | $186.3万 | 0.00% |
| CenterBook Partners LP | $182.0万 | 0.10% |
| CAPITAL FUND MANAGEMENT S.A. | $181.4万 | 0.01% |
| NOMURA HOLDINGS INC | $181.0万 | 0.01% |
| BARCLAYS PLC | $180.4万 | 0.00% |
| Ascentis Independent Advisors | $179.0万 | 0.14% |
| XTX Topco Ltd | $178.4万 | 0.03% |
| WELLS FARGO & COMPANY/MN | $162.8万 | 0.00% |