TP
Tetragon Partners GP Ltd: 13F Stock Holdings & Portfolio (Q2 2026)
Tetragon Partners GP LtdCIK: 0001515070
Concentrated strategySector-focusedMomentum follower
Total reported value
$635.1M
Reporting period: 2026-06-30 · Number of holdings: 43
Tetragon Partners GP Ltd disclosed 43 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $635.1M and a quarterly turnover rate of 35.2%.
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Personality snowflake
- Concentration
- 100
- Portfolio Stability
- 35.18
- Momentum
- 100
- Sector conviction
- 100
- Diversification
- 72
- Sizing Uniformity
- 68.85
Tetragon Partners GP Ltd's disclosed holdings carry a Herfindahl concentration index of 0.290 — mathematically equivalent to about 3 equally-sized positions, well below its 43 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 3.12), with a handful of outsized bets alongside many smaller positions.
Recent activity leans toward adding more aggressively to already-large existing positions than to newly initiated ones (a 3.2 percentage-point tilt) — a pattern consistent with a momentum-following approach.
Sector classification currently covers about 66% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govTrim WBD
-72.9% -$18.7M
Trim KGEI
0.0% -$3.7M
New buy ALKT
Add DFTX
+43.5% $9.7M
Trim PATH
+22.8% $56.6M
Add RLAY
+214.1% $8.9M
Holdings Map
New buyAddUnchangedTrim
* This report is exclusively curated by the AlphaSMO team. AlphaSMO is the web's most authoritative 13F / Inside Trader database, delivering precise insider trading and institutional holdings insights.
Top 10 holdings by weight
Full holdings list this quarter
Showing top 36 holdings (of 43 total)
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | PATH | Uipath Inc - Class A | Stock-Tech | 52.98% | -1.34% | +22.78% | |
| 2 | KGEI | Kolibri Global Energy Inc | Stock-Other | 5.33% | -1.95% | — | |
| 3 | AUTL | Autolus Therapeutics PLC | Stock-Other | 2.39% | -0.16% | — | |
| 4 | LYFT | Lyft Inc-a | Stock-Tech | 2.30% | -0.28% | — | |
| 5 | DFTX | Definium Therapeutics Inc | Stock-Other | 2.13% | +1.40% | +43.50% | |
| 6 | WK | Workiva Inc | Stock-Tech | 1.91% | -0.98% | — | |
| 7 | SLN | Silence Therapeutics Plc-adr | Stock-Other | 1.84% | +1.20% | +68.89% | |
| 8 | CXM | Sprinklr Inc-a | Stock-Other | 1.79% | -0.77% | — | |
| 9 | MBX | Mbx Biosciences Inc | Stock-Other | 1.77% | +0.93% | +39.91% | |
| 10 | ALKT | Alkami Technology Inc | Stock-Other | 1.71% | +1.71% | NEW | |
| 11 | CLDX | Celldex Therapeutics Inc | Stock-Other | 1.70% | -0.22% | -7.00% | |
| 12 | RLAY | Relay Therapeutics Inc | Stock-Other | 1.68% | +1.33% | +214.15% | |
| 13 | ARWR | Arrowhead Pharmaceuticals In | Stock-Healthcare | 1.67% | +0.12% | +2.58% | |
| 14 | PHVS | Pharvaris N.V. | Stock-Other | 1.61% | +0.39% | +33.40% | |
| 15 | ALKS | Alkermes plc | Stock-Healthcare | 1.57% | +0.47% | +18.89% | |
| 16 | IMVT | Immunovant Inc | Stock-Other | 1.55% | +0.50% | +17.13% | |
| 17 | AGIO | Agios Pharmaceuticals Inc | Stock-Other | 1.49% | +0.41% | +55.05% | |
| 18 | AXSM | Axsome Therapeutics Inc | Stock-Healthcare | 1.35% | -0.46% | -36.43% | |
| 19 | DYN | Dyne Therapeutics Inc | Stock-Other | 1.25% | +0.34% | +38.17% | |
| 20 | IONS | Ionis Pharmaceuticals Inc | Stock-Healthcare | 1.21% | +0.60% | +132.67% | |
| 21 | HRMY | Harmony Biosciences Holdings | Stock-Other | 1.15% | +0.50% | +68.46% | |
| 22 | KRYS | Krystal Biotech Inc | Stock-Healthcare | 1.15% | +0.16% | — | |
| 23 | ANNX | Annexon Inc | Stock-Other | 1.12% | -0.27% | -3.87% | |
| 24 | CELC | Celcuity Inc | Stock-Other | 1.06% | +1.06% | NEW | |
| 25 | WBD | Warner Bros Discovery Inc | Stock-Comm Services | 1.05% | -3.87% | -72.94% | |
| 26 | NKTR | Nektar Therapeutics | Stock-Other | 0.96% | -0.48% | -15.57% | |
| 27 | AMLX | Amylyx Pharmaceuticals Inc | Stock-Other | 0.87% | +0.01% | -3.60% | |
| 28 | ACAD | Acadia Pharmaceuticals Inc | Stock-Healthcare | 0.67% | +0.05% | +16.08% | |
| 29 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 0.53% | +0.37% | +153.34% | |
| 30 | CUE | Cue Biopharma Inc | Stock-Other | 0.47% | +0.47% | NEW | |
| 31 | SNOW | Snowflake Inc | Stock-Tech | 0.40% | +0.11% | — | |
| 32 | KPTI | Karyopharm Therapeutics Inc | Stock-Other | 0.39% | +0.28% | +143.05% | |
| 33 | ACRS | Aclaris Therapeutics Inc | Stock-Other | 0.33% | +0.33% | NEW | |
| 34 | TECX | Tectonic Therapeutic Inc | Stock-Other | 0.25% | +0.02% | +23.75% | |
| 35 | GLUE | Monte Rosa Therapeutics Inc | Stock-Other | 0.21% | +0.21% | NEW | |
| 36 | TENX | Tenax Therapeutics Inc | Stock-Other | 0.17% | +0.17% | NEW |
Portfolio Performance
Performance for Q3 2026
+40.1%
Performance Last 4 Quarters
+54.4%
- Stdev
- +29.5%
- Beta
- +0.71
- Alpha
- 0%
- Max Drawdown
- -20.6%
- Annualized Perf
- +9.5%
- Batting Avg vs S&P
- +50%
- Sortino
- +0.82
- Stutzer
- +0.13
- Treynor
- +0.18
- Sterling
- +0.35
- Calmar
- +0.46
- Information Ratio
- -0.19
- Tracking Error
- +28.5%
- Stdev Down
- +15.9%
- Winning Months %
- +53.3%
- Losing Months %
- +46.7%
- Best 12 Months
- +54.4%
- Worst 12 Months
- -20.1%
- Efficiency Ratio
- +0.14
- Sharpe
- +0.44
- Stdev Sectors
- +38.1%
- Skewness
- +0.94
- Kurtosis
- +2.03
- Upside Potential
- +2.75
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 43 | $635.1M | 35 | ||
| 2026 Q1 | 40 | $515.1M | 24 | ||
| 2025 Q4 | 31 | $474.3M | 81 | ||
| 2025 Q3 | 47 | $747.6M | 82 | ||
| 2025 Q2 | 40 | $620.8M | 0 | ||
| 2025 Q1 | 32 | $438.2M | 100 | ||
| 2024 Q4 | 28 | $391.4M | 0 | ||
| 2024 Q3 | 26 | $354.5M | 0 | ||
| 2024 Q2 | 30 | $400.9M | 0 | ||
| 2024 Q1 | 32 | $441.5M | 0 | ||
| 2023 Q4 | 35 | $415.3M | 0 | ||
| 2023 Q3 | 50 | $548.3M | 0 | ||
| 2023 Q2 | 55 | $740.6M | 0 | ||
| 2023 Q1 | 57 | $747.5M | 0 | ||
| 2022 Q4 | 75 | $699.0M | 0 | ||
| 2022 Q3 | 150 | $829.7M | 0 | ||
| 2022 Q2 | 199 | $1.5B | 0 | ||
| 2022 Q1 | 226 | $2.2B | 0 | ||
| 2021 Q4 | 217 | $1.7B | 0 | 1AEO 3.75 04-15-252NVST 2.375 06-01-253SNAP 0.75 08-01-26 | |
| 2021 Q3 | 206 | $1.6B | 0 | 1AEO 3.75 04-15-252SNAP 0.75 08-01-263CLF 1.5 01-15-25 | |
| 2021 Q2 | 196 | $1.8B | 87 | 1AEO 3.75 04-15-252CLF 1.5 01-15-253TER 1.25 12-15-23 | |
| 2021 Q1 | 112 | $1.4B | 68 | 1TSLA 2 05-15-242CLF 1.5 01-15-253TER 1.25 12-15-23 | |
| 2020 Q4 | 50 | $1.5B | 60 | 1TSLA 2 05-15-242DOCU 0.5 09-15-233TER 1.25 12-15-23 | |
| 2020 Q3 | 48 | $1.1B | 72 | ||
| 2020 Q2 | 43 | $751.0M | 49 | 1TSLA 2 05-15-242TER 1.25 12-15-233MCHP 1.625 02-15-25 | |
| 2020 Q1 | 41 | $577.9M | 47 | 1TSLA 2 05-15-242REGI 4 06-15-363TER 1.25 12-15-23 | |
| 2019 Q4 | 42 | $672.9M | 33 | 1REGI 4 06-15-362MCHP 1.625 02-15-253TKO 3.375 12-15-23 | |
| 2019 Q3 | 50 | $560.8M | 58 | ||
| 2019 Q2 | 58 | $688.9M | 53 | 1TKO 3.375 12-15-232WMGI 2.25 11-15-213LGIH 4.25 11-15-19 | |
| 2019 Q1 | 52 | $804.3M | 52 | 1TKO 3.375 12-15-232REGI 4 06-15-363WMGI 2.25 11-15-21 | |
| 2018 Q4 | 51 | $633.9M | 64 | 1REGI 4 06-15-362WMGI 2.25 11-15-213MCHP 1.625 02-15-25 | |
| 2018 Q3 | 59 | $835.7M | 48 | 1LGND 0.75 08-15-192REGI 4 06-15-363TDOC 3 12-15-22 | |
| 2018 Q2 | 55 | $742.8M | 44 | 1LGND 0.75 08-15-192MCHP 1.625 02-15-253MELI 2.25 07-01-19 | |
| 2018 Q1 | 45 | $646.1M | 100 | 1LGND 0.75 08-15-192MELI 2.25 07-01-193LGIH 4.25 11-15-19 | |
| 2017 Q4 | 42 | $658.5M | 0 | 1LGIH 4.25 11-15-19261166W3MELI 2.25 07-01-19 | |
| 2017 Q3 | 46 | $615.9M | 0 | 137045V2LGIH 4.25 11-15-193G0551A | |
| 2017 Q2 | 45 | $672.2M | 54 | 1TSEMIT 8 12-31-182GSAT 8 04-01-283G0551A | |
| 2017 Q1 | 38 | $533.1M | 45 | 1TSEMIT 8 12-31-182G0551A3INTC 2.95 12-15-35 | |
| 2016 Q4 | 38 | $503.5M | 48 | 1TSEMIT 8 12-31-18261166W3GSAT 8 04-01-28 | |
| 2016 Q3 | 34 | $528.3M | 70 | 161166W2G0551A3TRLA 2.75 12-15-20 | |
| 2016 Q2 | 34 | $439.1M | 72 | 1G0551A2TRLA 2.75 12-15-203ELGX 3.25 11-01-20 | |
| 2016 Q1 | 26 | $315.4M | 100 | 1G0551A2GSAT 8 04-01-283TSEMIT 8 12-31-18 | |
| 2015 Q4 | 23 | $281.2M | 0 | 1GSAT 8 04-01-28247214G3SNDK 1.5 08-15-17 | |
| 2015 Q3 | 22 | $207.7M | 46 | 1GSAT 8 04-01-28247214G3MACK 4.5 07-15-20 | |
| 2015 Q2 | 22 | $269.9M | 82 | 1GSAT 8 04-01-282MACK 4.5 07-15-20347214G | |
| 2015 Q1 | 22 | $322.1M | 37 | 1GSAT 8 04-01-28237045V3MACK 4.5 07-15-20 | |
| 2014 Q4 | 20 | $253.4M | 100 | 1GSAT 8 04-01-282MACK 4.5 07-15-203VGR V2.5 01-15-19 | |
| 2014 Q3 | 22 | $275.7M | 0 | 1GSAT 8 04-01-282VGR V2.5 01-15-193ICON 2.5 06-01-16 | |
| 2014 Q2 | 20 | $355.4M | 100 | 1GSAT 8 04-01-282MU 1.875 08-01-31 B3ICON 2.5 06-01-16 | |
| 2014 Q1 | 15 | $181.3M | 100 | 1TSLA 1.5 06-01-182MU 1.875 08-01-31 B3OCR 3.75 04-01-42 | |
| 2013 Q4 | 12 | $110.6M | 100 | 137045V2MU 1.875 08-01-31 B3ICON 2.5 06-01-16 | |
| 2013 Q3 | 11 | $99.0M | 100 | ||
| 2013 Q2 | 14 | $140.9M | 0 |
Holding changes this quarter
Tetragon Partners GP Ltd's most significant position changes for 2026-06-30: New buy: Alkami Technology Inc (ALKT); New buy: Celcuity Inc (CELC); Sold out: Praxis Precision Medicines I (PRAX); Sold out: Soleno Therapeutics Inc (SLNOEUR); New buy: Cue Biopharma Inc (CUE).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ALKT | Alkami Technology Inc | +1.7% | NEW | New buy |
| 2 | DFTX | Definium Therapeutics Inc | +1.4% | +43.50% | Add |
| 3 | RLAY | Relay Therapeutics Inc | +1.3% | +214.15% | Add |
| 4 | SLN | Silence Therapeutics Plc-adr | +1.2% | +68.89% | Add |
| 5 | CELC | Celcuity Inc | +1.1% | NEW | New buy |
| 6 | MBX | Mbx Biosciences Inc | +0.9% | +39.91% | Add |
| 7 | IONS | Ionis Pharmaceuticals Inc | +0.6% | +132.67% | Add |
| 8 | IMVT | Immunovant Inc | +0.5% | +17.13% | Add |
| 9 | HRMY | Harmony Biosciences Holdings | +0.5% | +68.46% | Add |
| 10 | ALKS | Alkermes plc | +0.5% | +18.89% | Add |
| 11 | CUE | Cue Biopharma Inc | +0.5% | NEW | New buy |
| 12 | AGIO | Agios Pharmaceuticals Inc | +0.4% | +55.05% | Add |
| 13 | PHVS | Pharvaris N.V. | +0.4% | +33.40% | Add |
| 14 | RARE | Ultragenyx Pharmaceutical In | +0.4% | +153.34% | Add |
| 15 | DYN | Dyne Therapeutics Inc | +0.3% | +38.17% | Add |
| 16 | ACRS | Aclaris Therapeutics Inc | +0.3% | NEW | New buy |
| 17 | KPTI | Karyopharm Therapeutics Inc | +0.3% | +143.05% | Add |
| 18 | GLUE | Monte Rosa Therapeutics Inc | +0.2% | NEW | New buy |
| 19 | TENX | Tenax Therapeutics Inc | +0.2% | NEW | New buy |
| 20 | KRYS | Krystal Biotech Inc | +0.2% | — | Unchanged |
| 21 | ARWR | Arrowhead Pharmaceuticals In | +0.1% | +2.58% | Add |
| 22 | SNOW | Snowflake Inc | +0.1% | — | Unchanged |
| 23 | ACAD | Acadia Pharmaceuticals Inc | +0.1% | +16.08% | Add |
| 24 | TECX | Tectonic Therapeutic Inc | 0% | +23.75% | Add |
| 25 | AMLX | Amylyx Pharmaceuticals Inc | 0% | -3.60% | Trim |
| 26 | AUTL | Autolus Therapeutics PLC | -0.2% | — | Unchanged |
| 27 | CLDX | Celldex Therapeutics Inc | -0.2% | -7.00% | Trim |
| 28 | AARD | Aardvark Therapeutics Inc | -0.2% | EXIT | Sold out |
| 29 | ANNX | Annexon Inc | -0.3% | -3.87% | Trim |
| 30 | LYFT | Lyft Inc-a | -0.3% | — | Unchanged |
| 31 | MPLT | Maplight Therapeutics Inc | -0.4% | EXIT | Sold out |
| 32 | AXSM | Axsome Therapeutics Inc | -0.5% | -36.43% | Trim |
| 33 | NKTR | Nektar Therapeutics | -0.5% | -15.57% | Trim |
| 34 | SLNOEUR | Soleno Therapeutics Inc | -0.7% | EXIT | Sold out |
| 35 | CXM | Sprinklr Inc-a | -0.8% | — | Unchanged |
| 36 | WK | Workiva Inc | -1% | — | Unchanged |
| 37 | PRAX | Praxis Precision Medicines I | -1% | EXIT | Sold out |
| 38 | PATH | Uipath Inc - Class A | -1.3% | +22.78% | Add |
| 39 | KGEI | Kolibri Global Energy Inc | -2% | — | Unchanged |
| 40 | WBD | Warner Bros Discovery Inc | -3.9% | -72.94% | Trim |
Filing History
FAQ
What is Tetragon Partners GP Ltd and what type of investor is it?
Tetragon Partners GP Ltd is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $635.1M, spread across 43 disclosed positions.
What are Tetragon Partners GP Ltd's largest equity positions?
Based on the latest 13F filing, Tetragon Partners GP Ltd's top holdings by market value are:
1. Uipath Inc - Class A (PATH) — $336.4M (53.0%)
2. Kolibri Global Energy Inc (KGEI) — $33.8M (5.3%)
3. Autolus Therapeutics PLC (AUTL) — $15.2M (2.4%)
4. Lyft Inc-a (LYFT) — $14.6M (2.3%)
5. Definium Therapeutics Inc (DFTX) — $13.5M (2.1%)
What changes did Tetragon Partners GP Ltd make in its most recent portfolio filing?
In the latest reported quarter, Tetragon Partners GP Ltd made 33 notable position adjustments: 6 new positions were initiated, 17 existing holdings were added to, 6 positions were partially reduced, and 4 were completely exited. The largest of these moves: New buy: Alkami Technology Inc (ALKT); New buy: Celcuity Inc (CELC); Sold out: Praxis Precision Medicines I (PRAX); Sold out: Soleno Therapeutics Inc (SLNOEUR); New buy: Cue Biopharma Inc (CUE)
What sectors does Tetragon Partners GP Ltd focus on?
Tetragon Partners GP Ltd is concentrated in the following sectors based on its current disclosed equity portfolio:
• Information Technology: 86.9%
• Health Care: 11.5%
• Communication Services: 1.6%
Investment Profile
Tetragon Partners GP Ltd returned an annualized 9.5% over the trailing 30 months — underperforming the S&P 500 by 0.0 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.71 (less volatile than the market) and a 50% quarterly batting average against the index.
Its portfolio is concentrated and moderately active, with 86.9% of the portfolio concentrated in Information Technology.
Its concentration score has risen from 59 to 100 over the past 4 quarters — a shift toward higher-conviction positions.
It has added to its SLN position over the past two quarters (+$9.5M, now $11.7M), while trimming CXM over the same stretch (-$5.8M, still holding $11.4M).
Peer Institutions
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BT
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GA
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PL
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Total reported value
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AG
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Total reported value
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Developer Access
Access Tetragon Partners GP Ltd's institutional profile programmatically:
REST API
curl https://alphasmo.com/api/v1/institutions/tetragon-partners-gp-ltdCLI
npx alphasmo institutions get tetragon-partners-gp-ltd